Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V

Autores
Vera, Maria Laura; Schuster, Jonathan Maximiliano; Rosenberger, Mario Roberto; Bernard, Haydee; Schvezov, Carlos Enrique; Ares, Alicia Esther
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The blood compatibility (haemocompatibility) is a requirement in materials used in prosthetic heart valves. No standardized methods are available to measure haemocompatibility in solid materials. However, a material could be considered haemocompatible if its surface does not modify the normal activation of the coagulation pathway and produces no damage in the blood components. In this work, the haemocompatibility of coatings obtained by anodic oxidation of Ti-6Al-4 V (with H2SO41 M and 40 to 70 V) with and without heat treatment (1 h for 500 °C), is evaluated and compared with the haemocompatibility of the Ti-6Al-4 V substrate and pyrolytic carbon. Standard clinical trials for clothing: Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were adapted to evaluate the haemocompatibility of solid materials. Besides, the interaction between blood platelets and solid material were performed through an analysis of interfacial tension (γi,j), this parameter could indicate the degree of preferential adsorption of each protein of the blood plasma. The ratio between albumin-material and fibrinogen-material interfacial tension, (γs,Alb/ γs,Fib), is an important parameter used to predict the platelets adhesion and the trend at the formation of cloth. The results of the clothing trials indicate that the tested surfaces would be haemocompatibles due to the values of PT and APTT obtained which were in range of the normal ones. In addition, the measured values of γs,Alb/ γs,Fib indicate that all the tested surfaces are more haemocompatible than pyrolitic carbon. The recrystalized films by heat treatment which produce some rutile crystals are the most haemocompatibles.
Fil: Vera, Maria Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Schuster, Jonathan Maximiliano. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Rosenberger, Mario Roberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Bernard, Haydee. Sanatorio Integral Instituto de Ortopedia y Traumatología, Misiones; Argentina
Fil: Schvezov, Carlos Enrique. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Ares, Alicia Esther. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fuente
International Congress of Science and Technology of Metallurgy and Materials, SAM - CONAMET 2013
Materia
Hemocompatibility
Prosthetic heart valve
TiO2 coatings
Anodic oxidation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9755
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/9755
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4VVera, Maria LauraSchuster, Jonathan MaximilianoRosenberger, Mario RobertoBernard, HaydeeSchvezov, Carlos EnriqueAres, Alicia EstherHemocompatibilityProsthetic heart valveTiO2 coatingsAnodic oxidationhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The blood compatibility (haemocompatibility) is a requirement in materials used in prosthetic heart valves. No standardized methods are available to measure haemocompatibility in solid materials. However, a material could be considered haemocompatible if its surface does not modify the normal activation of the coagulation pathway and produces no damage in the blood components. In this work, the haemocompatibility of coatings obtained by anodic oxidation of Ti-6Al-4 V (with H2SO41 M and 40 to 70 V) with and without heat treatment (1 h for 500 °C), is evaluated and compared with the haemocompatibility of the Ti-6Al-4 V substrate and pyrolytic carbon. Standard clinical trials for clothing: Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were adapted to evaluate the haemocompatibility of solid materials. Besides, the interaction between blood platelets and solid material were performed through an analysis of interfacial tension (γi,j), this parameter could indicate the degree of preferential adsorption of each protein of the blood plasma. The ratio between albumin-material and fibrinogen-material interfacial tension, (γs,Alb/ γs,Fib), is an important parameter used to predict the platelets adhesion and the trend at the formation of cloth. The results of the clothing trials indicate that the tested surfaces would be haemocompatibles due to the values of PT and APTT obtained which were in range of the normal ones. In addition, the measured values of γs,Alb/ γs,Fib indicate that all the tested surfaces are more haemocompatible than pyrolitic carbon. The recrystalized films by heat treatment which produce some rutile crystals are the most haemocompatibles.Fil: Vera, Maria Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; ArgentinaFil: Schuster, Jonathan Maximiliano. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; ArgentinaFil: Rosenberger, Mario Roberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; ArgentinaFil: Bernard, Haydee. Sanatorio Integral Instituto de Ortopedia y Traumatología, Misiones; ArgentinaFil: Schvezov, Carlos Enrique. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; ArgentinaFil: Ares, Alicia Esther. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; ArgentinaElsevier2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9755Vera, Maria Laura; Schuster, Jonathan Maximiliano; Rosenberger, Mario Roberto; Bernard, Haydee; Schvezov, Carlos Enrique; et al.; Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V; Elsevier; Procedia Materials Science; 8; 6-2014; 366–3742211-8128International Congress of Science and Technology of Metallurgy and Materials, SAM - CONAMET 2013reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicasenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2211812815000875info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mspro.2015.04.086info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/2025-09-03T10:09:32Zoai:ri.conicet.gov.ar:11336/9755instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:32.713CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
title Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
spellingShingle Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
Vera, Maria Laura
Hemocompatibility
Prosthetic heart valve
TiO2 coatings
Anodic oxidation
title_short Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
title_full Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
title_fullStr Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
title_full_unstemmed Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
title_sort Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V
dc.creator.none.fl_str_mv Vera, Maria Laura
Schuster, Jonathan Maximiliano
Rosenberger, Mario Roberto
Bernard, Haydee
Schvezov, Carlos Enrique
Ares, Alicia Esther
author Vera, Maria Laura
author_facet Vera, Maria Laura
Schuster, Jonathan Maximiliano
Rosenberger, Mario Roberto
Bernard, Haydee
Schvezov, Carlos Enrique
Ares, Alicia Esther
author_role author
author2 Schuster, Jonathan Maximiliano
Rosenberger, Mario Roberto
Bernard, Haydee
Schvezov, Carlos Enrique
Ares, Alicia Esther
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hemocompatibility
Prosthetic heart valve
TiO2 coatings
Anodic oxidation
topic Hemocompatibility
Prosthetic heart valve
TiO2 coatings
Anodic oxidation
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The blood compatibility (haemocompatibility) is a requirement in materials used in prosthetic heart valves. No standardized methods are available to measure haemocompatibility in solid materials. However, a material could be considered haemocompatible if its surface does not modify the normal activation of the coagulation pathway and produces no damage in the blood components. In this work, the haemocompatibility of coatings obtained by anodic oxidation of Ti-6Al-4 V (with H2SO41 M and 40 to 70 V) with and without heat treatment (1 h for 500 °C), is evaluated and compared with the haemocompatibility of the Ti-6Al-4 V substrate and pyrolytic carbon. Standard clinical trials for clothing: Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were adapted to evaluate the haemocompatibility of solid materials. Besides, the interaction between blood platelets and solid material were performed through an analysis of interfacial tension (γi,j), this parameter could indicate the degree of preferential adsorption of each protein of the blood plasma. The ratio between albumin-material and fibrinogen-material interfacial tension, (γs,Alb/ γs,Fib), is an important parameter used to predict the platelets adhesion and the trend at the formation of cloth. The results of the clothing trials indicate that the tested surfaces would be haemocompatibles due to the values of PT and APTT obtained which were in range of the normal ones. In addition, the measured values of γs,Alb/ γs,Fib indicate that all the tested surfaces are more haemocompatible than pyrolitic carbon. The recrystalized films by heat treatment which produce some rutile crystals are the most haemocompatibles.
Fil: Vera, Maria Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Schuster, Jonathan Maximiliano. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Rosenberger, Mario Roberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Bernard, Haydee. Sanatorio Integral Instituto de Ortopedia y Traumatología, Misiones; Argentina
Fil: Schvezov, Carlos Enrique. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
Fil: Ares, Alicia Esther. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Nordeste. Instituto de Materiales de Misiones; Argentina
description The blood compatibility (haemocompatibility) is a requirement in materials used in prosthetic heart valves. No standardized methods are available to measure haemocompatibility in solid materials. However, a material could be considered haemocompatible if its surface does not modify the normal activation of the coagulation pathway and produces no damage in the blood components. In this work, the haemocompatibility of coatings obtained by anodic oxidation of Ti-6Al-4 V (with H2SO41 M and 40 to 70 V) with and without heat treatment (1 h for 500 °C), is evaluated and compared with the haemocompatibility of the Ti-6Al-4 V substrate and pyrolytic carbon. Standard clinical trials for clothing: Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were adapted to evaluate the haemocompatibility of solid materials. Besides, the interaction between blood platelets and solid material were performed through an analysis of interfacial tension (γi,j), this parameter could indicate the degree of preferential adsorption of each protein of the blood plasma. The ratio between albumin-material and fibrinogen-material interfacial tension, (γs,Alb/ γs,Fib), is an important parameter used to predict the platelets adhesion and the trend at the formation of cloth. The results of the clothing trials indicate that the tested surfaces would be haemocompatibles due to the values of PT and APTT obtained which were in range of the normal ones. In addition, the measured values of γs,Alb/ γs,Fib indicate that all the tested surfaces are more haemocompatible than pyrolitic carbon. The recrystalized films by heat treatment which produce some rutile crystals are the most haemocompatibles.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9755
Vera, Maria Laura; Schuster, Jonathan Maximiliano; Rosenberger, Mario Roberto; Bernard, Haydee; Schvezov, Carlos Enrique; et al.; Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V; Elsevier; Procedia Materials Science; 8; 6-2014; 366–374
2211-8128
url http://hdl.handle.net/11336/9755
identifier_str_mv Vera, Maria Laura; Schuster, Jonathan Maximiliano; Rosenberger, Mario Roberto; Bernard, Haydee; Schvezov, Carlos Enrique; et al.; Evaluation of the haemocompatibility of TiO2 coatings obtained by anodic oxidation of Ti-6Al-4V; Elsevier; Procedia Materials Science; 8; 6-2014; 366–374
2211-8128
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2211812815000875
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mspro.2015.04.086
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv International Congress of Science and Technology of Metallurgy and Materials, SAM - CONAMET 2013
reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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