Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model

Autores
Biagetti, Marcelo; Arini, Pedro David; Valverde, Esteban Raul; Bertran, Guillermo Claudio; Quinteiro, Ricardo Alberto
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Repolarization heterogeneity has been shown to constitute a substrate for malignant ventricular arrhythmias. Noninvasive measurement of abnormal repolarization through assessment of QT interval dispersion from the resting standard 12-lead ECG initially had shown promise in assessing arrhythmia risk but was challenged recently. The relative T wave residuum (TWR) has been proposed recently to reflect regional repolarization dispersion more accurately. We analyzed the role played by the dipolar and nondipolar components in determining TWR. Methods and Results: Singular value decomposition was applied to the repolarization signals obtained from isolated rabbit hearts using a 5 × 8 array multielectrode recording system during premature beats (N = 11) and after d-sotalol (N = 9) exposure. Both the dipolar and nondipolar components of the T wave increased significantly during premature stimulation and after d-sotalol exposure. The relative TWR decreased significantly during premature stimulation but did not change after d-sotalol. Changes in the dipolar and nondipolar components of the second half of the T wave were significantly greater than those corresponding to the first half during premature stimulation, and a significant correlation was observed between the nondipolar components of the second half of the T wave and the Tpeak?end interval. Conclusion: Conditions exist during which both the dipolar and nondipolar components can change simultaneously. Under these conditions, the relative TWR may not reflect regional heterogeneity of repolarization with accuracy. The nondipolar components of the second half of the T wave can be linked to assessment of the transmural dispersion of repolarization.
Fil: Biagetti, Marcelo. Universidad Favaloro; Argentina
Fil: Arini, Pedro David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina. Universidad Favaloro; Argentina
Fil: Valverde, Esteban Raul. Universidad Favaloro; Argentina
Fil: Bertran, Guillermo Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Quinteiro, Ricardo Alberto. Universidad Favaloro; Argentina
Materia
T WAVE RESIDUUM
ELECTROCARDIOGRAPHIC REPOLARIZATION SIGNAL ANALYSIS
TRANSMURAL REPOLARIZATION DISPERSION
SOTALOL
PREMATURE VENTRICULAR STIMULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/109655
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/109655
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart ModelBiagetti, MarceloArini, Pedro DavidValverde, Esteban RaulBertran, Guillermo ClaudioQuinteiro, Ricardo AlbertoT WAVE RESIDUUMELECTROCARDIOGRAPHIC REPOLARIZATION SIGNAL ANALYSISTRANSMURAL REPOLARIZATION DISPERSIONSOTALOLPREMATURE VENTRICULAR STIMULATIONhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2Introduction: Repolarization heterogeneity has been shown to constitute a substrate for malignant ventricular arrhythmias. Noninvasive measurement of abnormal repolarization through assessment of QT interval dispersion from the resting standard 12-lead ECG initially had shown promise in assessing arrhythmia risk but was challenged recently. The relative T wave residuum (TWR) has been proposed recently to reflect regional repolarization dispersion more accurately. We analyzed the role played by the dipolar and nondipolar components in determining TWR. Methods and Results: Singular value decomposition was applied to the repolarization signals obtained from isolated rabbit hearts using a 5 × 8 array multielectrode recording system during premature beats (N = 11) and after d-sotalol (N = 9) exposure. Both the dipolar and nondipolar components of the T wave increased significantly during premature stimulation and after d-sotalol exposure. The relative TWR decreased significantly during premature stimulation but did not change after d-sotalol. Changes in the dipolar and nondipolar components of the second half of the T wave were significantly greater than those corresponding to the first half during premature stimulation, and a significant correlation was observed between the nondipolar components of the second half of the T wave and the Tpeak?end interval. Conclusion: Conditions exist during which both the dipolar and nondipolar components can change simultaneously. Under these conditions, the relative TWR may not reflect regional heterogeneity of repolarization with accuracy. The nondipolar components of the second half of the T wave can be linked to assessment of the transmural dispersion of repolarization.Fil: Biagetti, Marcelo. Universidad Favaloro; ArgentinaFil: Arini, Pedro David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina. Universidad Favaloro; ArgentinaFil: Valverde, Esteban Raul. Universidad Favaloro; ArgentinaFil: Bertran, Guillermo Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Quinteiro, Ricardo Alberto. Universidad Favaloro; ArgentinaWiley Blackwell Publishing, Inc2004-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/109655Biagetti, Marcelo; Arini, Pedro David; Valverde, Esteban Raul; Bertran, Guillermo Claudio; Quinteiro, Ricardo Alberto; Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model; Wiley Blackwell Publishing, Inc; Journal Of Cardiovascular Electrophysiology.; 15; 3; 3-2004; 356-3631045-3873CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1540-8167.2004.03466.xinfo:eu-repo/semantics/altIdentifier/doi/10.1046/j.1540-8167.2004.03466.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:23Zoai:ri.conicet.gov.ar:11336/109655instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:23.463CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
title Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
spellingShingle Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
Biagetti, Marcelo
T WAVE RESIDUUM
ELECTROCARDIOGRAPHIC REPOLARIZATION SIGNAL ANALYSIS
TRANSMURAL REPOLARIZATION DISPERSION
SOTALOL
PREMATURE VENTRICULAR STIMULATION
title_short Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
title_full Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
title_fullStr Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
title_full_unstemmed Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
title_sort Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model
dc.creator.none.fl_str_mv Biagetti, Marcelo
Arini, Pedro David
Valverde, Esteban Raul
Bertran, Guillermo Claudio
Quinteiro, Ricardo Alberto
author Biagetti, Marcelo
author_facet Biagetti, Marcelo
Arini, Pedro David
Valverde, Esteban Raul
Bertran, Guillermo Claudio
Quinteiro, Ricardo Alberto
author_role author
author2 Arini, Pedro David
Valverde, Esteban Raul
Bertran, Guillermo Claudio
Quinteiro, Ricardo Alberto
author2_role author
author
author
author
dc.subject.none.fl_str_mv T WAVE RESIDUUM
ELECTROCARDIOGRAPHIC REPOLARIZATION SIGNAL ANALYSIS
TRANSMURAL REPOLARIZATION DISPERSION
SOTALOL
PREMATURE VENTRICULAR STIMULATION
topic T WAVE RESIDUUM
ELECTROCARDIOGRAPHIC REPOLARIZATION SIGNAL ANALYSIS
TRANSMURAL REPOLARIZATION DISPERSION
SOTALOL
PREMATURE VENTRICULAR STIMULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Introduction: Repolarization heterogeneity has been shown to constitute a substrate for malignant ventricular arrhythmias. Noninvasive measurement of abnormal repolarization through assessment of QT interval dispersion from the resting standard 12-lead ECG initially had shown promise in assessing arrhythmia risk but was challenged recently. The relative T wave residuum (TWR) has been proposed recently to reflect regional repolarization dispersion more accurately. We analyzed the role played by the dipolar and nondipolar components in determining TWR. Methods and Results: Singular value decomposition was applied to the repolarization signals obtained from isolated rabbit hearts using a 5 × 8 array multielectrode recording system during premature beats (N = 11) and after d-sotalol (N = 9) exposure. Both the dipolar and nondipolar components of the T wave increased significantly during premature stimulation and after d-sotalol exposure. The relative TWR decreased significantly during premature stimulation but did not change after d-sotalol. Changes in the dipolar and nondipolar components of the second half of the T wave were significantly greater than those corresponding to the first half during premature stimulation, and a significant correlation was observed between the nondipolar components of the second half of the T wave and the Tpeak?end interval. Conclusion: Conditions exist during which both the dipolar and nondipolar components can change simultaneously. Under these conditions, the relative TWR may not reflect regional heterogeneity of repolarization with accuracy. The nondipolar components of the second half of the T wave can be linked to assessment of the transmural dispersion of repolarization.
Fil: Biagetti, Marcelo. Universidad Favaloro; Argentina
Fil: Arini, Pedro David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina. Universidad Favaloro; Argentina
Fil: Valverde, Esteban Raul. Universidad Favaloro; Argentina
Fil: Bertran, Guillermo Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Quinteiro, Ricardo Alberto. Universidad Favaloro; Argentina
description Introduction: Repolarization heterogeneity has been shown to constitute a substrate for malignant ventricular arrhythmias. Noninvasive measurement of abnormal repolarization through assessment of QT interval dispersion from the resting standard 12-lead ECG initially had shown promise in assessing arrhythmia risk but was challenged recently. The relative T wave residuum (TWR) has been proposed recently to reflect regional repolarization dispersion more accurately. We analyzed the role played by the dipolar and nondipolar components in determining TWR. Methods and Results: Singular value decomposition was applied to the repolarization signals obtained from isolated rabbit hearts using a 5 × 8 array multielectrode recording system during premature beats (N = 11) and after d-sotalol (N = 9) exposure. Both the dipolar and nondipolar components of the T wave increased significantly during premature stimulation and after d-sotalol exposure. The relative TWR decreased significantly during premature stimulation but did not change after d-sotalol. Changes in the dipolar and nondipolar components of the second half of the T wave were significantly greater than those corresponding to the first half during premature stimulation, and a significant correlation was observed between the nondipolar components of the second half of the T wave and the Tpeak?end interval. Conclusion: Conditions exist during which both the dipolar and nondipolar components can change simultaneously. Under these conditions, the relative TWR may not reflect regional heterogeneity of repolarization with accuracy. The nondipolar components of the second half of the T wave can be linked to assessment of the transmural dispersion of repolarization.
publishDate 2004
dc.date.none.fl_str_mv 2004-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/109655
Biagetti, Marcelo; Arini, Pedro David; Valverde, Esteban Raul; Bertran, Guillermo Claudio; Quinteiro, Ricardo Alberto; Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model; Wiley Blackwell Publishing, Inc; Journal Of Cardiovascular Electrophysiology.; 15; 3; 3-2004; 356-363
1045-3873
CONICET Digital
CONICET
url http://hdl.handle.net/11336/109655
identifier_str_mv Biagetti, Marcelo; Arini, Pedro David; Valverde, Esteban Raul; Bertran, Guillermo Claudio; Quinteiro, Ricardo Alberto; Role of Dipolar and Nondipolar Components of the T Wave in Determining the T Wave Residuum in an Isolated Rabbit Heart Model; Wiley Blackwell Publishing, Inc; Journal Of Cardiovascular Electrophysiology.; 15; 3; 3-2004; 356-363
1045-3873
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1540-8167.2004.03466.x
info:eu-repo/semantics/altIdentifier/doi/10.1046/j.1540-8167.2004.03466.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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