Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review

Autores
Paira, Daniela Andrea; Beltramone, Fernando; Olmedo, Jose Javier; Tissera, Andrea Daniela; Molina, Rosa Isabel; Fux Otta, Carolina; Olivera, Carolina; Motrich, Ruben Dario
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
COVID-19 is known to have deleterious effects on different systems such as the respiratory, cardiovascular, central nervous, and gastrointestinal. However, conflicting data about the possible implications for male reproductive health and fertility have been reported. In addition, the long-term consequences of SARS-CoV-2 infection remain unclear. Herein, we report a case of a 42-year-old man with no known co-morbidities and normal baseline semen quality, who subsequently suffered an asymptomatic SARS-CoV-2 infection. Shortly after, the patient developed sudden oligoasthenozoospermia, even reaching azoospermia, which gradually evolved into persistent severe oligonecrozoospermia, accompanied by semen inflammation and oxidative stress. Remarkably, the latter occurred in the absence of urogenital infections, hormonal imbalances, tissue/organ obstruction/damage, medication or drug treatment, smoking, or exposure to toxins/pollutants, radiation, or high temperature. This case constitutes valuable clinical evidence that adds to the current knowledge in the field and highlights the need for further and longer follow-up studies to better understand the putative long-term consequences of SARS-CoV-2 infection on male fertility.
Fil: Paira, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Beltramone, Fernando. Centro de Medicina Reproductiva Fetal y Cirugia Ambulatoria;
Fil: Olmedo, Jose Javier. Fundación Urológica Córdoba para la Docencia e Investigación Médica; Argentina
Fil: Tissera, Andrea Daniela. Laboratorio de Andrología y Reproducción; Argentina
Fil: Molina, Rosa Isabel. Laboratorio de Andrologia y Reproduccion; Argentina
Fil: Fux Otta, Carolina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Motrich, Ruben Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
COVID-19
INFECTION
INFLAMMATION
SARS-COV-2
SPERM QUALITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226218
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/226218
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature reviewPaira, Daniela AndreaBeltramone, FernandoOlmedo, Jose JavierTissera, Andrea DanielaMolina, Rosa IsabelFux Otta, CarolinaOlivera, CarolinaMotrich, Ruben DarioCOVID-19INFECTIONINFLAMMATIONSARS-COV-2SPERM QUALITYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3COVID-19 is known to have deleterious effects on different systems such as the respiratory, cardiovascular, central nervous, and gastrointestinal. However, conflicting data about the possible implications for male reproductive health and fertility have been reported. In addition, the long-term consequences of SARS-CoV-2 infection remain unclear. Herein, we report a case of a 42-year-old man with no known co-morbidities and normal baseline semen quality, who subsequently suffered an asymptomatic SARS-CoV-2 infection. Shortly after, the patient developed sudden oligoasthenozoospermia, even reaching azoospermia, which gradually evolved into persistent severe oligonecrozoospermia, accompanied by semen inflammation and oxidative stress. Remarkably, the latter occurred in the absence of urogenital infections, hormonal imbalances, tissue/organ obstruction/damage, medication or drug treatment, smoking, or exposure to toxins/pollutants, radiation, or high temperature. This case constitutes valuable clinical evidence that adds to the current knowledge in the field and highlights the need for further and longer follow-up studies to better understand the putative long-term consequences of SARS-CoV-2 infection on male fertility.Fil: Paira, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Beltramone, Fernando. Centro de Medicina Reproductiva Fetal y Cirugia Ambulatoria;Fil: Olmedo, Jose Javier. Fundación Urológica Córdoba para la Docencia e Investigación Médica; ArgentinaFil: Tissera, Andrea Daniela. Laboratorio de Andrología y Reproducción; ArgentinaFil: Molina, Rosa Isabel. Laboratorio de Andrologia y Reproduccion; ArgentinaFil: Fux Otta, Carolina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Motrich, Ruben Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaCell Press2023-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226218Paira, Daniela Andrea; Beltramone, Fernando; Olmedo, Jose Javier; Tissera, Andrea Daniela; Molina, Rosa Isabel; et al.; Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review; Cell Press; Heliyon; 9; 9; 9-2023; 1-102405-8440CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2405844023075485info:eu-repo/semantics/altIdentifier/doi/10.1016/j.heliyon.2023.e20340info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:39Zoai:ri.conicet.gov.ar:11336/226218instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:39.996CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
title Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
spellingShingle Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
Paira, Daniela Andrea
COVID-19
INFECTION
INFLAMMATION
SARS-COV-2
SPERM QUALITY
title_short Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
title_full Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
title_fullStr Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
title_full_unstemmed Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
title_sort Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review
dc.creator.none.fl_str_mv Paira, Daniela Andrea
Beltramone, Fernando
Olmedo, Jose Javier
Tissera, Andrea Daniela
Molina, Rosa Isabel
Fux Otta, Carolina
Olivera, Carolina
Motrich, Ruben Dario
author Paira, Daniela Andrea
author_facet Paira, Daniela Andrea
Beltramone, Fernando
Olmedo, Jose Javier
Tissera, Andrea Daniela
Molina, Rosa Isabel
Fux Otta, Carolina
Olivera, Carolina
Motrich, Ruben Dario
author_role author
author2 Beltramone, Fernando
Olmedo, Jose Javier
Tissera, Andrea Daniela
Molina, Rosa Isabel
Fux Otta, Carolina
Olivera, Carolina
Motrich, Ruben Dario
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
INFECTION
INFLAMMATION
SARS-COV-2
SPERM QUALITY
topic COVID-19
INFECTION
INFLAMMATION
SARS-COV-2
SPERM QUALITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv COVID-19 is known to have deleterious effects on different systems such as the respiratory, cardiovascular, central nervous, and gastrointestinal. However, conflicting data about the possible implications for male reproductive health and fertility have been reported. In addition, the long-term consequences of SARS-CoV-2 infection remain unclear. Herein, we report a case of a 42-year-old man with no known co-morbidities and normal baseline semen quality, who subsequently suffered an asymptomatic SARS-CoV-2 infection. Shortly after, the patient developed sudden oligoasthenozoospermia, even reaching azoospermia, which gradually evolved into persistent severe oligonecrozoospermia, accompanied by semen inflammation and oxidative stress. Remarkably, the latter occurred in the absence of urogenital infections, hormonal imbalances, tissue/organ obstruction/damage, medication or drug treatment, smoking, or exposure to toxins/pollutants, radiation, or high temperature. This case constitutes valuable clinical evidence that adds to the current knowledge in the field and highlights the need for further and longer follow-up studies to better understand the putative long-term consequences of SARS-CoV-2 infection on male fertility.
Fil: Paira, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Beltramone, Fernando. Centro de Medicina Reproductiva Fetal y Cirugia Ambulatoria;
Fil: Olmedo, Jose Javier. Fundación Urológica Córdoba para la Docencia e Investigación Médica; Argentina
Fil: Tissera, Andrea Daniela. Laboratorio de Andrología y Reproducción; Argentina
Fil: Molina, Rosa Isabel. Laboratorio de Andrologia y Reproduccion; Argentina
Fil: Fux Otta, Carolina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Motrich, Ruben Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description COVID-19 is known to have deleterious effects on different systems such as the respiratory, cardiovascular, central nervous, and gastrointestinal. However, conflicting data about the possible implications for male reproductive health and fertility have been reported. In addition, the long-term consequences of SARS-CoV-2 infection remain unclear. Herein, we report a case of a 42-year-old man with no known co-morbidities and normal baseline semen quality, who subsequently suffered an asymptomatic SARS-CoV-2 infection. Shortly after, the patient developed sudden oligoasthenozoospermia, even reaching azoospermia, which gradually evolved into persistent severe oligonecrozoospermia, accompanied by semen inflammation and oxidative stress. Remarkably, the latter occurred in the absence of urogenital infections, hormonal imbalances, tissue/organ obstruction/damage, medication or drug treatment, smoking, or exposure to toxins/pollutants, radiation, or high temperature. This case constitutes valuable clinical evidence that adds to the current knowledge in the field and highlights the need for further and longer follow-up studies to better understand the putative long-term consequences of SARS-CoV-2 infection on male fertility.
publishDate 2023
dc.date.none.fl_str_mv 2023-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226218
Paira, Daniela Andrea; Beltramone, Fernando; Olmedo, Jose Javier; Tissera, Andrea Daniela; Molina, Rosa Isabel; et al.; Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review; Cell Press; Heliyon; 9; 9; 9-2023; 1-10
2405-8440
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226218
identifier_str_mv Paira, Daniela Andrea; Beltramone, Fernando; Olmedo, Jose Javier; Tissera, Andrea Daniela; Molina, Rosa Isabel; et al.; Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review; Cell Press; Heliyon; 9; 9; 9-2023; 1-10
2405-8440
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2405844023075485
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.heliyon.2023.e20340
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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