Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?

Autores
Mozgovoj, Marina Valeria; Didier Garnham, Mercedes Monica; Ferrufino, Cecilia Gabriela Paola; Blanc, Sofia; Fernández Souto, Adriana Beatriz; Pilloff, Marcela Gabriela; Dus Santos, Maria Jose
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Asymptomatic and presymptomatic patients played a critical role in the maintenance and spread of infection during COVID pandemic. However, conflicting views about the infectiousness of asymptomatic patients have been raised.Identification of asymptomatic cases relies on SARS-CoV-2 genome detection and, in the absence of common epidemiological variables, quantification of viral load (VL) has been proposed as an estimator for SARS-CoV-2 transmission.Comparison of VLs from symptomatic and asymptomatic patients displayed variable results according to the studied population, the experimental design and the sampling, among other variables.The aim of this work was to determine VLs in symptomatic and asymptomatic patients at the time of sampling and to retrospectively determine their relationship with severity of disease and other parameters that affected the course of COVID-19, in two towns located in Buenos Aires, Argentina.Results from our study showed that VLs from symptomatic and asymptomatic patients were significantly different when analyzed globally. In addition, significant differences were found when VLs from each COVID-19 wave were analyzed. In the first wave VLs from asymptomatic patients (log10 8,21 gc/µl) were significantly higher than in symptomatic ones (log10 6,51 gc/µl) while; in the second wave, VLs from asymptomatic patients resulted significantly lower than in symptomatic patients (log10 4,51 gc/µl and log10 5,23 gc/µl, respectively). In the third wave, no significant differences were observed between VLs from both types of patients.Results from this work demonstrated that the screening of both symptomatic and asymptomatic patients was of utmost importance in order to reduce SARS-CoV-2 transmission to communities.
Fil: Mozgovoj, Marina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de Alimentos; Argentina. Universidad Nacional de Hurlingham.; Argentina
Fil: Didier Garnham, Mercedes Monica. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Ferrufino, Cecilia Gabriela Paola. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Blanc, Sofia. Universidad Nacional de Hurlingham.; Argentina
Fil: Fernández Souto, Adriana Beatriz. Universidad Nacional de Hurlingham.; Argentina
Fil: Pilloff, Marcela Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Hurlingham.; Argentina
Fil: Dus Santos, Maria Jose. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Materia
SARS-CoV-2
COVID-19
VIRAL LOADS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/248580

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spelling Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?Mozgovoj, Marina ValeriaDidier Garnham, Mercedes MonicaFerrufino, Cecilia Gabriela PaolaBlanc, SofiaFernández Souto, Adriana BeatrizPilloff, Marcela GabrielaDus Santos, Maria JoseSARS-CoV-2COVID-19VIRAL LOADShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Asymptomatic and presymptomatic patients played a critical role in the maintenance and spread of infection during COVID pandemic. However, conflicting views about the infectiousness of asymptomatic patients have been raised.Identification of asymptomatic cases relies on SARS-CoV-2 genome detection and, in the absence of common epidemiological variables, quantification of viral load (VL) has been proposed as an estimator for SARS-CoV-2 transmission.Comparison of VLs from symptomatic and asymptomatic patients displayed variable results according to the studied population, the experimental design and the sampling, among other variables.The aim of this work was to determine VLs in symptomatic and asymptomatic patients at the time of sampling and to retrospectively determine their relationship with severity of disease and other parameters that affected the course of COVID-19, in two towns located in Buenos Aires, Argentina.Results from our study showed that VLs from symptomatic and asymptomatic patients were significantly different when analyzed globally. In addition, significant differences were found when VLs from each COVID-19 wave were analyzed. In the first wave VLs from asymptomatic patients (log10 8,21 gc/µl) were significantly higher than in symptomatic ones (log10 6,51 gc/µl) while; in the second wave, VLs from asymptomatic patients resulted significantly lower than in symptomatic patients (log10 4,51 gc/µl and log10 5,23 gc/µl, respectively). In the third wave, no significant differences were observed between VLs from both types of patients.Results from this work demonstrated that the screening of both symptomatic and asymptomatic patients was of utmost importance in order to reduce SARS-CoV-2 transmission to communities.Fil: Mozgovoj, Marina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de Alimentos; Argentina. Universidad Nacional de Hurlingham.; ArgentinaFil: Didier Garnham, Mercedes Monica. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Ferrufino, Cecilia Gabriela Paola. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; ArgentinaFil: Blanc, Sofia. Universidad Nacional de Hurlingham.; ArgentinaFil: Fernández Souto, Adriana Beatriz. Universidad Nacional de Hurlingham.; ArgentinaFil: Pilloff, Marcela Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Hurlingham.; ArgentinaFil: Dus Santos, Maria Jose. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; ArgentinaElsevier2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/248580Mozgovoj, Marina Valeria; Didier Garnham, Mercedes Monica; Ferrufino, Cecilia Gabriela Paola; Blanc, Sofia; Fernández Souto, Adriana Beatriz; et al.; Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?; Elsevier; Journal of Clinical Virology Plus; 3; 4; 11-20232667-0380CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2667038023000339info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcvp.2023.100166info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:32Zoai:ri.conicet.gov.ar:11336/248580instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:33.148CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
title Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
spellingShingle Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
Mozgovoj, Marina Valeria
SARS-CoV-2
COVID-19
VIRAL LOADS
title_short Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
title_full Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
title_fullStr Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
title_full_unstemmed Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
title_sort Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?
dc.creator.none.fl_str_mv Mozgovoj, Marina Valeria
Didier Garnham, Mercedes Monica
Ferrufino, Cecilia Gabriela Paola
Blanc, Sofia
Fernández Souto, Adriana Beatriz
Pilloff, Marcela Gabriela
Dus Santos, Maria Jose
author Mozgovoj, Marina Valeria
author_facet Mozgovoj, Marina Valeria
Didier Garnham, Mercedes Monica
Ferrufino, Cecilia Gabriela Paola
Blanc, Sofia
Fernández Souto, Adriana Beatriz
Pilloff, Marcela Gabriela
Dus Santos, Maria Jose
author_role author
author2 Didier Garnham, Mercedes Monica
Ferrufino, Cecilia Gabriela Paola
Blanc, Sofia
Fernández Souto, Adriana Beatriz
Pilloff, Marcela Gabriela
Dus Santos, Maria Jose
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
COVID-19
VIRAL LOADS
topic SARS-CoV-2
COVID-19
VIRAL LOADS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Asymptomatic and presymptomatic patients played a critical role in the maintenance and spread of infection during COVID pandemic. However, conflicting views about the infectiousness of asymptomatic patients have been raised.Identification of asymptomatic cases relies on SARS-CoV-2 genome detection and, in the absence of common epidemiological variables, quantification of viral load (VL) has been proposed as an estimator for SARS-CoV-2 transmission.Comparison of VLs from symptomatic and asymptomatic patients displayed variable results according to the studied population, the experimental design and the sampling, among other variables.The aim of this work was to determine VLs in symptomatic and asymptomatic patients at the time of sampling and to retrospectively determine their relationship with severity of disease and other parameters that affected the course of COVID-19, in two towns located in Buenos Aires, Argentina.Results from our study showed that VLs from symptomatic and asymptomatic patients were significantly different when analyzed globally. In addition, significant differences were found when VLs from each COVID-19 wave were analyzed. In the first wave VLs from asymptomatic patients (log10 8,21 gc/µl) were significantly higher than in symptomatic ones (log10 6,51 gc/µl) while; in the second wave, VLs from asymptomatic patients resulted significantly lower than in symptomatic patients (log10 4,51 gc/µl and log10 5,23 gc/µl, respectively). In the third wave, no significant differences were observed between VLs from both types of patients.Results from this work demonstrated that the screening of both symptomatic and asymptomatic patients was of utmost importance in order to reduce SARS-CoV-2 transmission to communities.
Fil: Mozgovoj, Marina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Agroindustria. Instituto de Tecnología de Alimentos; Argentina. Universidad Nacional de Hurlingham.; Argentina
Fil: Didier Garnham, Mercedes Monica. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Ferrufino, Cecilia Gabriela Paola. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Blanc, Sofia. Universidad Nacional de Hurlingham.; Argentina
Fil: Fernández Souto, Adriana Beatriz. Universidad Nacional de Hurlingham.; Argentina
Fil: Pilloff, Marcela Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Hurlingham.; Argentina
Fil: Dus Santos, Maria Jose. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
description Asymptomatic and presymptomatic patients played a critical role in the maintenance and spread of infection during COVID pandemic. However, conflicting views about the infectiousness of asymptomatic patients have been raised.Identification of asymptomatic cases relies on SARS-CoV-2 genome detection and, in the absence of common epidemiological variables, quantification of viral load (VL) has been proposed as an estimator for SARS-CoV-2 transmission.Comparison of VLs from symptomatic and asymptomatic patients displayed variable results according to the studied population, the experimental design and the sampling, among other variables.The aim of this work was to determine VLs in symptomatic and asymptomatic patients at the time of sampling and to retrospectively determine their relationship with severity of disease and other parameters that affected the course of COVID-19, in two towns located in Buenos Aires, Argentina.Results from our study showed that VLs from symptomatic and asymptomatic patients were significantly different when analyzed globally. In addition, significant differences were found when VLs from each COVID-19 wave were analyzed. In the first wave VLs from asymptomatic patients (log10 8,21 gc/µl) were significantly higher than in symptomatic ones (log10 6,51 gc/µl) while; in the second wave, VLs from asymptomatic patients resulted significantly lower than in symptomatic patients (log10 4,51 gc/µl and log10 5,23 gc/µl, respectively). In the third wave, no significant differences were observed between VLs from both types of patients.Results from this work demonstrated that the screening of both symptomatic and asymptomatic patients was of utmost importance in order to reduce SARS-CoV-2 transmission to communities.
publishDate 2023
dc.date.none.fl_str_mv 2023-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/248580
Mozgovoj, Marina Valeria; Didier Garnham, Mercedes Monica; Ferrufino, Cecilia Gabriela Paola; Blanc, Sofia; Fernández Souto, Adriana Beatriz; et al.; Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?; Elsevier; Journal of Clinical Virology Plus; 3; 4; 11-2023
2667-0380
CONICET Digital
CONICET
url http://hdl.handle.net/11336/248580
identifier_str_mv Mozgovoj, Marina Valeria; Didier Garnham, Mercedes Monica; Ferrufino, Cecilia Gabriela Paola; Blanc, Sofia; Fernández Souto, Adriana Beatriz; et al.; Viral load in symptomatic and asymptomatic patients infected with SARS-CoV-2: What have we learned?; Elsevier; Journal of Clinical Virology Plus; 3; 4; 11-2023
2667-0380
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2667038023000339
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcvp.2023.100166
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
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application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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