Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting

Autores
Tasoglu, Savas; Safaee, Hooman; Zhang, Xiaohui; Kingsley, James L.; Catalano, Paolo Nicolás; Gurkan, Umut Atakan; Nureddin, Aida; Kayaalp, Emre; Anchan, Raymond M.; Maas, Richard L.; Tüzel, Erkan; Demirci, Utkan
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.
Fil: Tasoglu, Savas. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Safaee, Hooman. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Zhang, Xiaohui. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Kingsley, James L.. Worcester Polytechnic Institute. Department of Physics; Estados Unidos
Fil: Catalano, Paolo Nicolás. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gurkan, Umut Atakan. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Nureddin, Aida. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Kayaalp, Emre. Jamaica Hospital Medical Center. Department of Obstetrics and Gynecology; Estados Unidos
Fil: Anchan, Raymond M.. Harvard Medical School. Brigham and Women’s Hospital. Obstetrics Gynecology and Reproductive Biology. Center for Infertility and Reproductive Surgery ; Estados Unidos
Fil: Maas, Richard L.. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Division of Genetics; Estados Unidos
Fil: Tüzel, Erkan. Worcester Polytechnic Institute. Biomedical Engineering and Computer Science. Department of Physics; Estados Unidos
Fil: Demirci, Utkan. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos. Harvard-Massachusetts Institute of Technology Health Sciences and Technology; Estados Unidos
Materia
Sperm Exhaustion
Motility
Naturally Inspired Biodesign
Sperm Sorting
Microfluidic Sorting
Fertility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3921
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/3921
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exhaustion of racing sperm in nature-mimicking microfluidic channels during sortingTasoglu, SavasSafaee, HoomanZhang, XiaohuiKingsley, James L.Catalano, Paolo NicolásGurkan, Umut AtakanNureddin, AidaKayaalp, EmreAnchan, Raymond M.Maas, Richard L.Tüzel, ErkanDemirci, UtkanSperm ExhaustionMotilityNaturally Inspired BiodesignSperm SortingMicrofluidic SortingFertilityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.Fil: Tasoglu, Savas. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados UnidosFil: Safaee, Hooman. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados UnidosFil: Zhang, Xiaohui. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados UnidosFil: Kingsley, James L.. Worcester Polytechnic Institute. Department of Physics; Estados UnidosFil: Catalano, Paolo Nicolás. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gurkan, Umut Atakan. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados UnidosFil: Nureddin, Aida. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados UnidosFil: Kayaalp, Emre. Jamaica Hospital Medical Center. Department of Obstetrics and Gynecology; Estados UnidosFil: Anchan, Raymond M.. Harvard Medical School. Brigham and Women’s Hospital. Obstetrics Gynecology and Reproductive Biology. Center for Infertility and Reproductive Surgery ; Estados UnidosFil: Maas, Richard L.. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Division of Genetics; Estados UnidosFil: Tüzel, Erkan. Worcester Polytechnic Institute. Biomedical Engineering and Computer Science. Department of Physics; Estados UnidosFil: Demirci, Utkan. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos. Harvard-Massachusetts Institute of Technology Health Sciences and Technology; Estados UnidosWiley2013-10-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3921Tasoglu, Savas; Safaee, Hooman; Zhang, Xiaohui; Kingsley, James L.; Catalano, Paolo Nicolás; et al.; Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting; Wiley; Small; 9; 20; 25-10-2013; 3374-33841613-6810enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/smll.201300020/abstractinfo:eu-repo/semantics/altIdentifier/doi/DOI:10.1002/smll.201300020info:eu-repo/semantics/altIdentifier/issn/1613-6810info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:22:07Zoai:ri.conicet.gov.ar:11336/3921instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:22:07.476CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
title Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
spellingShingle Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
Tasoglu, Savas
Sperm Exhaustion
Motility
Naturally Inspired Biodesign
Sperm Sorting
Microfluidic Sorting
Fertility
title_short Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
title_full Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
title_fullStr Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
title_full_unstemmed Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
title_sort Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting
dc.creator.none.fl_str_mv Tasoglu, Savas
Safaee, Hooman
Zhang, Xiaohui
Kingsley, James L.
Catalano, Paolo Nicolás
Gurkan, Umut Atakan
Nureddin, Aida
Kayaalp, Emre
Anchan, Raymond M.
Maas, Richard L.
Tüzel, Erkan
Demirci, Utkan
author Tasoglu, Savas
author_facet Tasoglu, Savas
Safaee, Hooman
Zhang, Xiaohui
Kingsley, James L.
Catalano, Paolo Nicolás
Gurkan, Umut Atakan
Nureddin, Aida
Kayaalp, Emre
Anchan, Raymond M.
Maas, Richard L.
Tüzel, Erkan
Demirci, Utkan
author_role author
author2 Safaee, Hooman
Zhang, Xiaohui
Kingsley, James L.
Catalano, Paolo Nicolás
Gurkan, Umut Atakan
Nureddin, Aida
Kayaalp, Emre
Anchan, Raymond M.
Maas, Richard L.
Tüzel, Erkan
Demirci, Utkan
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sperm Exhaustion
Motility
Naturally Inspired Biodesign
Sperm Sorting
Microfluidic Sorting
Fertility
topic Sperm Exhaustion
Motility
Naturally Inspired Biodesign
Sperm Sorting
Microfluidic Sorting
Fertility
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.
Fil: Tasoglu, Savas. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Safaee, Hooman. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Zhang, Xiaohui. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Kingsley, James L.. Worcester Polytechnic Institute. Department of Physics; Estados Unidos
Fil: Catalano, Paolo Nicolás. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gurkan, Umut Atakan. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Nureddin, Aida. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos
Fil: Kayaalp, Emre. Jamaica Hospital Medical Center. Department of Obstetrics and Gynecology; Estados Unidos
Fil: Anchan, Raymond M.. Harvard Medical School. Brigham and Women’s Hospital. Obstetrics Gynecology and Reproductive Biology. Center for Infertility and Reproductive Surgery ; Estados Unidos
Fil: Maas, Richard L.. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Division of Genetics; Estados Unidos
Fil: Tüzel, Erkan. Worcester Polytechnic Institute. Biomedical Engineering and Computer Science. Department of Physics; Estados Unidos
Fil: Demirci, Utkan. Harvard Medical School. Brigham and Women’s Hospital. Department of Medicine. Laboratory Center for Bioengineering. Bio-Acoustic-MEMS in Medicine; Estados Unidos. Harvard-Massachusetts Institute of Technology Health Sciences and Technology; Estados Unidos
description Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3921
Tasoglu, Savas; Safaee, Hooman; Zhang, Xiaohui; Kingsley, James L.; Catalano, Paolo Nicolás; et al.; Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting; Wiley; Small; 9; 20; 25-10-2013; 3374-3384
1613-6810
url http://hdl.handle.net/11336/3921
identifier_str_mv Tasoglu, Savas; Safaee, Hooman; Zhang, Xiaohui; Kingsley, James L.; Catalano, Paolo Nicolás; et al.; Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting; Wiley; Small; 9; 20; 25-10-2013; 3374-3384
1613-6810
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/smll.201300020/abstract
info:eu-repo/semantics/altIdentifier/doi/DOI:10.1002/smll.201300020
info:eu-repo/semantics/altIdentifier/issn/1613-6810
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083368414871552
score 13.22299

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