Cyclodextrin complexes for treatment improvement in infectious diseases

Autores
Imperiale, Julieta Celeste; Sosnik, Alejandro Dario
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented.
Fil: Imperiale, Julieta Celeste. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sosnik, Alejandro Dario. Technion - Israel Institute of Technology; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CYCLODEXTRINS
DRUG/CYCLODEXTRIN COMPLEX
INFECTIOUS DISEASES
LOW PHYSICAL STABILITY
POOR AQUEOUS SOLUBILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84671
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/84671
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cyclodextrin complexes for treatment improvement in infectious diseasesImperiale, Julieta CelesteSosnik, Alejandro DarioCYCLODEXTRINSDRUG/CYCLODEXTRIN COMPLEXINFECTIOUS DISEASESLOW PHYSICAL STABILITYPOOR AQUEOUS SOLUBILITYhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented.Fil: Imperiale, Julieta Celeste. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sosnik, Alejandro Dario. Technion - Israel Institute of Technology; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFuture Medicine2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84671Imperiale, Julieta Celeste; Sosnik, Alejandro Dario; Cyclodextrin complexes for treatment improvement in infectious diseases; Future Medicine; Nanomedicine; 10; 10; 5-2015; 1621-16411743-5889CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2217/nnm.15.16info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/nnm.15.16info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:16Zoai:ri.conicet.gov.ar:11336/84671instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:16.423CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cyclodextrin complexes for treatment improvement in infectious diseases
title Cyclodextrin complexes for treatment improvement in infectious diseases
spellingShingle Cyclodextrin complexes for treatment improvement in infectious diseases
Imperiale, Julieta Celeste
CYCLODEXTRINS
DRUG/CYCLODEXTRIN COMPLEX
INFECTIOUS DISEASES
LOW PHYSICAL STABILITY
POOR AQUEOUS SOLUBILITY
title_short Cyclodextrin complexes for treatment improvement in infectious diseases
title_full Cyclodextrin complexes for treatment improvement in infectious diseases
title_fullStr Cyclodextrin complexes for treatment improvement in infectious diseases
title_full_unstemmed Cyclodextrin complexes for treatment improvement in infectious diseases
title_sort Cyclodextrin complexes for treatment improvement in infectious diseases
dc.creator.none.fl_str_mv Imperiale, Julieta Celeste
Sosnik, Alejandro Dario
author Imperiale, Julieta Celeste
author_facet Imperiale, Julieta Celeste
Sosnik, Alejandro Dario
author_role author
author2 Sosnik, Alejandro Dario
author2_role author
dc.subject.none.fl_str_mv CYCLODEXTRINS
DRUG/CYCLODEXTRIN COMPLEX
INFECTIOUS DISEASES
LOW PHYSICAL STABILITY
POOR AQUEOUS SOLUBILITY
topic CYCLODEXTRINS
DRUG/CYCLODEXTRIN COMPLEX
INFECTIOUS DISEASES
LOW PHYSICAL STABILITY
POOR AQUEOUS SOLUBILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented.
Fil: Imperiale, Julieta Celeste. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sosnik, Alejandro Dario. Technion - Israel Institute of Technology; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84671
Imperiale, Julieta Celeste; Sosnik, Alejandro Dario; Cyclodextrin complexes for treatment improvement in infectious diseases; Future Medicine; Nanomedicine; 10; 10; 5-2015; 1621-1641
1743-5889
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84671
identifier_str_mv Imperiale, Julieta Celeste; Sosnik, Alejandro Dario; Cyclodextrin complexes for treatment improvement in infectious diseases; Future Medicine; Nanomedicine; 10; 10; 5-2015; 1621-1641
1743-5889
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2217/nnm.15.16
info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/nnm.15.16
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269084695134208
score 13.13397

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