Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine
- Autores
- Aloisio, Carolina; Oliveira, Anselmo Gomes de; Longhi, Marcela Raquel
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) using meglumine (MEG) as the ternary component. The combination of MEG with MβCD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and MβCD or HPβCD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MβCD or HPβCD in the ternary lyophilized systems. The ternary complexes with βCD and MβCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation.
Fil: Aloisio, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Oliveira, Anselmo Gomes de. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina - Materia
-
Sulfamerazine
Cyclodextrin
Ternary Complexes
Solubility - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/32330
Ver los metadatos del registro completo
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Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumineAloisio, CarolinaOliveira, Anselmo Gomes deLonghi, Marcela RaquelSulfamerazineCyclodextrinTernary ComplexesSolubilityhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) using meglumine (MEG) as the ternary component. The combination of MEG with MβCD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and MβCD or HPβCD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MβCD or HPβCD in the ternary lyophilized systems. The ternary complexes with βCD and MβCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation.Fil: Aloisio, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Oliveira, Anselmo Gomes de. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaElsevier Science2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32330Longhi, Marcela Raquel; Oliveira, Anselmo Gomes de; Aloisio, Carolina; Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 100; 7-2014; 64-730731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2014.07.008info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S073170851400329Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:04Zoai:ri.conicet.gov.ar:11336/32330instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:04.643CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine |
title |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine |
spellingShingle |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine Aloisio, Carolina Sulfamerazine Cyclodextrin Ternary Complexes Solubility |
title_short |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine |
title_full |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine |
title_fullStr |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine |
title_full_unstemmed |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine |
title_sort |
Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine |
dc.creator.none.fl_str_mv |
Aloisio, Carolina Oliveira, Anselmo Gomes de Longhi, Marcela Raquel |
author |
Aloisio, Carolina |
author_facet |
Aloisio, Carolina Oliveira, Anselmo Gomes de Longhi, Marcela Raquel |
author_role |
author |
author2 |
Oliveira, Anselmo Gomes de Longhi, Marcela Raquel |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Sulfamerazine Cyclodextrin Ternary Complexes Solubility |
topic |
Sulfamerazine Cyclodextrin Ternary Complexes Solubility |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) using meglumine (MEG) as the ternary component. The combination of MEG with MβCD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and MβCD or HPβCD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MβCD or HPβCD in the ternary lyophilized systems. The ternary complexes with βCD and MβCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation. Fil: Aloisio, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Oliveira, Anselmo Gomes de. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina |
description |
This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) using meglumine (MEG) as the ternary component. The combination of MEG with MβCD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and MβCD or HPβCD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and MβCD or HPβCD in the ternary lyophilized systems. The ternary complexes with βCD and MβCD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/32330 Longhi, Marcela Raquel; Oliveira, Anselmo Gomes de; Aloisio, Carolina; Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 100; 7-2014; 64-73 0731-7085 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/32330 |
identifier_str_mv |
Longhi, Marcela Raquel; Oliveira, Anselmo Gomes de; Aloisio, Carolina; Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 100; 7-2014; 64-73 0731-7085 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2014.07.008 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S073170851400329X |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269988195401728 |
score |
13.13397 |