Glicogenose hereditária em bovinos Brahman no Brasil

Autores
Zlotowski, P.; Nakazato, L.; Dutra, V.; Barros, S. S.; Gimeno, Eduardo Juan; Göcks, M.; Colodel, E. M.; Driemeier, D.
Año de publicación
2005
Idioma
portugués
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An inherited disease of cattle, characterized by lysosomal storage of glycogen in several tissues, is reported. The disease was diagnosed in a Brahman herd in the municipality of Porto Lucena, Rio Grande do Sul, Brazil. Affected calves, after one month of age, showed progressive difficulty to follow their mother, retarded growth, muscular weakness and tremors, lethargy and poor body condition. All affected calves were sired by the same bull. Necropsy was performed on three affected calves. The only gross lesion detected was paleness of the skeletal muscles of the trunk and limbs. Cytoplasmic vacuoles, the main histological lesion, were particularly evident in skeletal muscles, myocardium and Purkinje fibers, in neurons of the brain and spinal cord. Large amounts of periodic acid Schiff (PAS) positive granules were also observed in these most severely affected tissues. Pretreatment with diastase completely abolished the PAS reactivity. The 1057?TA, a lethal mutation in the gene of the acid alpha-glucosidase, which causes generalized glycogenosis in Brahman cattle, was detected by PCR in paraffin embedded tissues of affected animals on which post-mortem examination was performed. Clinical, histological and molecular findings were similar to previous descriptions of generalized glycogenosis in Brahman cattle in Australia. No previous indexed reports about generalized glycogenosis of Brahman cattle in Brazil could be found.
Fil: Zlotowski, P.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Nakazato, L.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Dutra, V.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Göcks, M.. No especifíca;
Fil: Colodel, E. M.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; Brasil
Materia
BRAHMAN CATTLE
GLYCOGENOSIS
INHERITED DISEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115812
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/115812
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Glicogenose hereditária em bovinos Brahman no BrasilInherited glycogenosis in Brahman cattle in BrazilZlotowski, P.Nakazato, L.Dutra, V.Barros, S. S.Gimeno, Eduardo JuanGöcks, M.Colodel, E. M.Driemeier, D.BRAHMAN CATTLEGLYCOGENOSISINHERITED DISEASEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4An inherited disease of cattle, characterized by lysosomal storage of glycogen in several tissues, is reported. The disease was diagnosed in a Brahman herd in the municipality of Porto Lucena, Rio Grande do Sul, Brazil. Affected calves, after one month of age, showed progressive difficulty to follow their mother, retarded growth, muscular weakness and tremors, lethargy and poor body condition. All affected calves were sired by the same bull. Necropsy was performed on three affected calves. The only gross lesion detected was paleness of the skeletal muscles of the trunk and limbs. Cytoplasmic vacuoles, the main histological lesion, were particularly evident in skeletal muscles, myocardium and Purkinje fibers, in neurons of the brain and spinal cord. Large amounts of periodic acid Schiff (PAS) positive granules were also observed in these most severely affected tissues. Pretreatment with diastase completely abolished the PAS reactivity. The 1057?TA, a lethal mutation in the gene of the acid alpha-glucosidase, which causes generalized glycogenosis in Brahman cattle, was detected by PCR in paraffin embedded tissues of affected animals on which post-mortem examination was performed. Clinical, histological and molecular findings were similar to previous descriptions of generalized glycogenosis in Brahman cattle in Australia. No previous indexed reports about generalized glycogenosis of Brahman cattle in Brazil could be found.Fil: Zlotowski, P.. Universidade Federal do Rio Grande do Sul; BrasilFil: Nakazato, L.. Universidade Federal do Mato Grosso do Sul; BrasilFil: Dutra, V.. Universidade Federal do Mato Grosso do Sul; BrasilFil: Barros, S. S.. Universidade Federal de Pelotas; BrasilFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Göcks, M.. No especifíca;Fil: Colodel, E. M.. Universidade Federal do Mato Grosso do Sul; BrasilFil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; BrasilRevista Pesquisa Veterinaria Brasileira2005-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115812Zlotowski, P.; Nakazato, L.; Dutra, V.; Barros, S. S.; Gimeno, Eduardo Juan; et al.; Glicogenose hereditária em bovinos Brahman no Brasil; Revista Pesquisa Veterinaria Brasileira; Pesquisa Veterinária Brasileira; 25; 4; 12-2005; 210-2140100-736X1678-5150CONICET DigitalCONICETporinfo:eu-repo/semantics/altIdentifier/doi/10.1590/S0100-736X2005000400004info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2005000400004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:04:04Zoai:ri.conicet.gov.ar:11336/115812instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:04:05.027CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Glicogenose hereditária em bovinos Brahman no Brasil
Inherited glycogenosis in Brahman cattle in Brazil
title Glicogenose hereditária em bovinos Brahman no Brasil
spellingShingle Glicogenose hereditária em bovinos Brahman no Brasil
Zlotowski, P.
BRAHMAN CATTLE
GLYCOGENOSIS
INHERITED DISEASE
title_short Glicogenose hereditária em bovinos Brahman no Brasil
title_full Glicogenose hereditária em bovinos Brahman no Brasil
title_fullStr Glicogenose hereditária em bovinos Brahman no Brasil
title_full_unstemmed Glicogenose hereditária em bovinos Brahman no Brasil
title_sort Glicogenose hereditária em bovinos Brahman no Brasil
dc.creator.none.fl_str_mv Zlotowski, P.
Nakazato, L.
Dutra, V.
Barros, S. S.
Gimeno, Eduardo Juan
Göcks, M.
Colodel, E. M.
Driemeier, D.
author Zlotowski, P.
author_facet Zlotowski, P.
Nakazato, L.
Dutra, V.
Barros, S. S.
Gimeno, Eduardo Juan
Göcks, M.
Colodel, E. M.
Driemeier, D.
author_role author
author2 Nakazato, L.
Dutra, V.
Barros, S. S.
Gimeno, Eduardo Juan
Göcks, M.
Colodel, E. M.
Driemeier, D.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BRAHMAN CATTLE
GLYCOGENOSIS
INHERITED DISEASE
topic BRAHMAN CATTLE
GLYCOGENOSIS
INHERITED DISEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv An inherited disease of cattle, characterized by lysosomal storage of glycogen in several tissues, is reported. The disease was diagnosed in a Brahman herd in the municipality of Porto Lucena, Rio Grande do Sul, Brazil. Affected calves, after one month of age, showed progressive difficulty to follow their mother, retarded growth, muscular weakness and tremors, lethargy and poor body condition. All affected calves were sired by the same bull. Necropsy was performed on three affected calves. The only gross lesion detected was paleness of the skeletal muscles of the trunk and limbs. Cytoplasmic vacuoles, the main histological lesion, were particularly evident in skeletal muscles, myocardium and Purkinje fibers, in neurons of the brain and spinal cord. Large amounts of periodic acid Schiff (PAS) positive granules were also observed in these most severely affected tissues. Pretreatment with diastase completely abolished the PAS reactivity. The 1057?TA, a lethal mutation in the gene of the acid alpha-glucosidase, which causes generalized glycogenosis in Brahman cattle, was detected by PCR in paraffin embedded tissues of affected animals on which post-mortem examination was performed. Clinical, histological and molecular findings were similar to previous descriptions of generalized glycogenosis in Brahman cattle in Australia. No previous indexed reports about generalized glycogenosis of Brahman cattle in Brazil could be found.
Fil: Zlotowski, P.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Nakazato, L.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Dutra, V.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Göcks, M.. No especifíca;
Fil: Colodel, E. M.. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; Brasil
description An inherited disease of cattle, characterized by lysosomal storage of glycogen in several tissues, is reported. The disease was diagnosed in a Brahman herd in the municipality of Porto Lucena, Rio Grande do Sul, Brazil. Affected calves, after one month of age, showed progressive difficulty to follow their mother, retarded growth, muscular weakness and tremors, lethargy and poor body condition. All affected calves were sired by the same bull. Necropsy was performed on three affected calves. The only gross lesion detected was paleness of the skeletal muscles of the trunk and limbs. Cytoplasmic vacuoles, the main histological lesion, were particularly evident in skeletal muscles, myocardium and Purkinje fibers, in neurons of the brain and spinal cord. Large amounts of periodic acid Schiff (PAS) positive granules were also observed in these most severely affected tissues. Pretreatment with diastase completely abolished the PAS reactivity. The 1057?TA, a lethal mutation in the gene of the acid alpha-glucosidase, which causes generalized glycogenosis in Brahman cattle, was detected by PCR in paraffin embedded tissues of affected animals on which post-mortem examination was performed. Clinical, histological and molecular findings were similar to previous descriptions of generalized glycogenosis in Brahman cattle in Australia. No previous indexed reports about generalized glycogenosis of Brahman cattle in Brazil could be found.
publishDate 2005
dc.date.none.fl_str_mv 2005-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115812
Zlotowski, P.; Nakazato, L.; Dutra, V.; Barros, S. S.; Gimeno, Eduardo Juan; et al.; Glicogenose hereditária em bovinos Brahman no Brasil; Revista Pesquisa Veterinaria Brasileira; Pesquisa Veterinária Brasileira; 25; 4; 12-2005; 210-214
0100-736X
1678-5150
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115812
identifier_str_mv Zlotowski, P.; Nakazato, L.; Dutra, V.; Barros, S. S.; Gimeno, Eduardo Juan; et al.; Glicogenose hereditária em bovinos Brahman no Brasil; Revista Pesquisa Veterinaria Brasileira; Pesquisa Veterinária Brasileira; 25; 4; 12-2005; 210-214
0100-736X
1678-5150
CONICET Digital
CONICET
dc.language.none.fl_str_mv por
language por
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/S0100-736X2005000400004
info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2005000400004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Revista Pesquisa Veterinaria Brasileira
publisher.none.fl_str_mv Revista Pesquisa Veterinaria Brasileira
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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