Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
- Autores
- Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry.
Fil: Castilla, Viviana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Piccini, Luana Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina - Materia
-
ANTIVIRAL AGENTS
DENGUE VIRUS
ENTRY INHIBITORS
FLAVIVIRUS
INTERNALIZATION
RECEPTORS
VIRAL BINDING
VIRAL ENTRY
VIRUS TRAFFICKING - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/188555
Ver los metadatos del registro completo
id |
CONICETDig_ab20ddc72b4e841c234ad053813c104b |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/188555 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapyCastilla, VivianaPiccini, Luana ÉricaDamonte, Elsa BeatrizANTIVIRAL AGENTSDENGUE VIRUSENTRY INHIBITORSFLAVIVIRUSINTERNALIZATIONRECEPTORSVIRAL BINDINGVIRAL ENTRYVIRUS TRAFFICKINGhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry.Fil: Castilla, Viviana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Piccini, Luana Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFuture Medicine2015-05-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188555Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz; Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy; Future Medicine; Future Virology; 10; 5; 29-5-2015; 625-6451746-07941746-0808CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.15.35info:eu-repo/semantics/altIdentifier/doi/10.2217/FVL.15.35info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:06:07Zoai:ri.conicet.gov.ar:11336/188555instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:06:08.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy |
title |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy |
spellingShingle |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy Castilla, Viviana ANTIVIRAL AGENTS DENGUE VIRUS ENTRY INHIBITORS FLAVIVIRUS INTERNALIZATION RECEPTORS VIRAL BINDING VIRAL ENTRY VIRUS TRAFFICKING |
title_short |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy |
title_full |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy |
title_fullStr |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy |
title_full_unstemmed |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy |
title_sort |
Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy |
dc.creator.none.fl_str_mv |
Castilla, Viviana Piccini, Luana Érica Damonte, Elsa Beatriz |
author |
Castilla, Viviana |
author_facet |
Castilla, Viviana Piccini, Luana Érica Damonte, Elsa Beatriz |
author_role |
author |
author2 |
Piccini, Luana Érica Damonte, Elsa Beatriz |
author2_role |
author author |
dc.subject.none.fl_str_mv |
ANTIVIRAL AGENTS DENGUE VIRUS ENTRY INHIBITORS FLAVIVIRUS INTERNALIZATION RECEPTORS VIRAL BINDING VIRAL ENTRY VIRUS TRAFFICKING |
topic |
ANTIVIRAL AGENTS DENGUE VIRUS ENTRY INHIBITORS FLAVIVIRUS INTERNALIZATION RECEPTORS VIRAL BINDING VIRAL ENTRY VIRUS TRAFFICKING |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry. Fil: Castilla, Viviana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Piccini, Luana Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina |
description |
Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-05-29 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/188555 Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz; Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy; Future Medicine; Future Virology; 10; 5; 29-5-2015; 625-645 1746-0794 1746-0808 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/188555 |
identifier_str_mv |
Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz; Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy; Future Medicine; Future Virology; 10; 5; 29-5-2015; 625-645 1746-0794 1746-0808 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.15.35 info:eu-repo/semantics/altIdentifier/doi/10.2217/FVL.15.35 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Future Medicine |
publisher.none.fl_str_mv |
Future Medicine |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846083204538171392 |
score |
13.22299 |