Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy

Autores
Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry.
Fil: Castilla, Viviana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Piccini, Luana Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Materia
ANTIVIRAL AGENTS
DENGUE VIRUS
ENTRY INHIBITORS
FLAVIVIRUS
INTERNALIZATION
RECEPTORS
VIRAL BINDING
VIRAL ENTRY
VIRUS TRAFFICKING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/188555

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network_name_str CONICET Digital (CONICET)
spelling Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapyCastilla, VivianaPiccini, Luana ÉricaDamonte, Elsa BeatrizANTIVIRAL AGENTSDENGUE VIRUSENTRY INHIBITORSFLAVIVIRUSINTERNALIZATIONRECEPTORSVIRAL BINDINGVIRAL ENTRYVIRUS TRAFFICKINGhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry.Fil: Castilla, Viviana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Piccini, Luana Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFuture Medicine2015-05-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188555Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz; Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy; Future Medicine; Future Virology; 10; 5; 29-5-2015; 625-6451746-07941746-0808CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.15.35info:eu-repo/semantics/altIdentifier/doi/10.2217/FVL.15.35info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:06:07Zoai:ri.conicet.gov.ar:11336/188555instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:06:08.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
title Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
spellingShingle Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
Castilla, Viviana
ANTIVIRAL AGENTS
DENGUE VIRUS
ENTRY INHIBITORS
FLAVIVIRUS
INTERNALIZATION
RECEPTORS
VIRAL BINDING
VIRAL ENTRY
VIRUS TRAFFICKING
title_short Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
title_full Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
title_fullStr Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
title_full_unstemmed Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
title_sort Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy
dc.creator.none.fl_str_mv Castilla, Viviana
Piccini, Luana Érica
Damonte, Elsa Beatriz
author Castilla, Viviana
author_facet Castilla, Viviana
Piccini, Luana Érica
Damonte, Elsa Beatriz
author_role author
author2 Piccini, Luana Érica
Damonte, Elsa Beatriz
author2_role author
author
dc.subject.none.fl_str_mv ANTIVIRAL AGENTS
DENGUE VIRUS
ENTRY INHIBITORS
FLAVIVIRUS
INTERNALIZATION
RECEPTORS
VIRAL BINDING
VIRAL ENTRY
VIRUS TRAFFICKING
topic ANTIVIRAL AGENTS
DENGUE VIRUS
ENTRY INHIBITORS
FLAVIVIRUS
INTERNALIZATION
RECEPTORS
VIRAL BINDING
VIRAL ENTRY
VIRUS TRAFFICKING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry.
Fil: Castilla, Viviana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Piccini, Luana Érica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
description Dengue virus (DENV) is the etiological agent of the most important human viral infection transmitted by mosquitoes in the world. In spite of the serious health threat that dengue represents, at present there are no vaccine or antiviral agents available and treatment of patients consists of supportive therapy. This review will focus on the process of DENV entry into the host cell as a potential target for antiviral therapy. The recent advances in the knowledge of viral and cellular molecules and mechanisms involved in binding, internalization and trafficking of DENV into the host cell until virion uncoating are discussed, together with an overview of the strategies and compounds evaluated for development of antiviral agents targeted to DENV entry.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/188555
Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz; Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy; Future Medicine; Future Virology; 10; 5; 29-5-2015; 625-645
1746-0794
1746-0808
CONICET Digital
CONICET
url http://hdl.handle.net/11336/188555
identifier_str_mv Castilla, Viviana; Piccini, Luana Érica; Damonte, Elsa Beatriz; Dengue virus entry and trafficking: Perspectives as antiviral target for prevention and therapy; Future Medicine; Future Virology; 10; 5; 29-5-2015; 625-645
1746-0794
1746-0808
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.15.35
info:eu-repo/semantics/altIdentifier/doi/10.2217/FVL.15.35
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
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instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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