Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.

Autores
Wentzel, Jolanda J.; Gijsen, Frank J.H.; der Giessen, Rosevan; Rodriguez Granillo, Gaston Alfredo; Schuurbiers, Johan C.H.; Regar, E.; de Feyter, Pim J.; van der Steenac, Antonius F.W.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims At present it is unknown what limits the arterial remodeling process during atherosclerotic plaque formation. In healthy arteries remodeling is regulated by the shear stress induced response by the endothelium. As endothelium at the plaque site is assumed to be dysfunctional, we tested the hypothesis that plaque free wall (PFW) determines vascular remodeling during atherosclerotic plaque build-up. Methods & results 66 human coronary ROIs (38 patients) were studied at baseline and at 3 years follow up applying intravascular ultrasound (IVUS). From the IVUS images the lumen and external elastic membrane contours were delineated to assess wall thickness (WT), vessel area (VA), Plaque Area (PA) and plaque burden (PA/VA*100%). WT < 0.5 mm was defined as normal and determined the arc of the PFW (0–360°). Positive remodeling was defined as relative difference of VA over time >5%. At baseline, IVUS-PFW was inversely related to plaque burden (p < 0.05). Positive remodeling was most frequently observed in ROIs with IVUS-PFW > 180° (i.e. larger than half of the circumference) compared to PFW < 180° (55% vs. 12%, p < 0.05). Accordingly, plaques with IVUS-PFW > 180° at baseline had the largest change in VA (1.1 ± 2.1 vs. −0.4 ± 0.6 mm2, p < 0.05) with an odds ratio of 9.2 to develop positive remodeling. Conclusions Our serial IVUS data show that IVUS-PFW is a determinant of vascular remodeling. ROIs with PFW > 180 at baseline had the highest probability to undergo positive remodeling.
Fil: Wentzel, Jolanda J.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países Bajos
Fil: Gijsen, Frank J.H.. ErasmusMC. Rotterdam; Países Bajos
Fil: der Giessen, Rosevan. ErasmusMC. Rotterdam; Países Bajos
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ErasmusMC. Rotterdam; Países Bajos
Fil: Schuurbiers, Johan C.H.. ErasmusMC. Rotterdam; Países Bajos
Fil: Regar, E.. ErasmusMC. Rotterdam; Países Bajos
Fil: de Feyter, Pim J.. ErasmusMC. Rotterdam; Países Bajos
Fil: van der Steenac, Antonius F.W.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países Bajos
Materia
Remodeling
Ivus
Atherosclerosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/35471
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/35471
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.Wentzel, Jolanda J.Gijsen, Frank J.H.der Giessen, RosevanRodriguez Granillo, Gaston AlfredoSchuurbiers, Johan C.H.Regar, E.de Feyter, Pim J.van der Steenac, Antonius F.W.RemodelingIvusAtherosclerosishttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aims At present it is unknown what limits the arterial remodeling process during atherosclerotic plaque formation. In healthy arteries remodeling is regulated by the shear stress induced response by the endothelium. As endothelium at the plaque site is assumed to be dysfunctional, we tested the hypothesis that plaque free wall (PFW) determines vascular remodeling during atherosclerotic plaque build-up. Methods & results 66 human coronary ROIs (38 patients) were studied at baseline and at 3 years follow up applying intravascular ultrasound (IVUS). From the IVUS images the lumen and external elastic membrane contours were delineated to assess wall thickness (WT), vessel area (VA), Plaque Area (PA) and plaque burden (PA/VA*100%). WT < 0.5 mm was defined as normal and determined the arc of the PFW (0–360°). Positive remodeling was defined as relative difference of VA over time >5%. At baseline, IVUS-PFW was inversely related to plaque burden (p < 0.05). Positive remodeling was most frequently observed in ROIs with IVUS-PFW > 180° (i.e. larger than half of the circumference) compared to PFW < 180° (55% vs. 12%, p < 0.05). Accordingly, plaques with IVUS-PFW > 180° at baseline had the largest change in VA (1.1 ± 2.1 vs. −0.4 ± 0.6 mm2, p < 0.05) with an odds ratio of 9.2 to develop positive remodeling. Conclusions Our serial IVUS data show that IVUS-PFW is a determinant of vascular remodeling. ROIs with PFW > 180 at baseline had the highest probability to undergo positive remodeling.Fil: Wentzel, Jolanda J.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países BajosFil: Gijsen, Frank J.H.. ErasmusMC. Rotterdam; Países BajosFil: der Giessen, Rosevan. ErasmusMC. Rotterdam; Países BajosFil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ErasmusMC. Rotterdam; Países BajosFil: Schuurbiers, Johan C.H.. ErasmusMC. Rotterdam; Países BajosFil: Regar, E.. ErasmusMC. Rotterdam; Países BajosFil: de Feyter, Pim J.. ErasmusMC. Rotterdam; Países BajosFil: van der Steenac, Antonius F.W.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países BajosElsevier Ireland2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/35471Wentzel, Jolanda J.; Gijsen, Frank J.H.; der Giessen, Rosevan; Rodriguez Granillo, Gaston Alfredo; Schuurbiers, Johan C.H.; et al.; Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.; Elsevier Ireland; Atherosclerosis; 236; 1; 6-2014; 82-900021-9150CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2014.06.013info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S002191501401243Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:23Zoai:ri.conicet.gov.ar:11336/35471instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:24.029CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
title Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
spellingShingle Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
Wentzel, Jolanda J.
Remodeling
Ivus
Atherosclerosis
title_short Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
title_full Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
title_fullStr Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
title_full_unstemmed Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
title_sort Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.
dc.creator.none.fl_str_mv Wentzel, Jolanda J.
Gijsen, Frank J.H.
der Giessen, Rosevan
Rodriguez Granillo, Gaston Alfredo
Schuurbiers, Johan C.H.
Regar, E.
de Feyter, Pim J.
van der Steenac, Antonius F.W.
author Wentzel, Jolanda J.
author_facet Wentzel, Jolanda J.
Gijsen, Frank J.H.
der Giessen, Rosevan
Rodriguez Granillo, Gaston Alfredo
Schuurbiers, Johan C.H.
Regar, E.
de Feyter, Pim J.
van der Steenac, Antonius F.W.
author_role author
author2 Gijsen, Frank J.H.
der Giessen, Rosevan
Rodriguez Granillo, Gaston Alfredo
Schuurbiers, Johan C.H.
Regar, E.
de Feyter, Pim J.
van der Steenac, Antonius F.W.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Remodeling
Ivus
Atherosclerosis
topic Remodeling
Ivus
Atherosclerosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims At present it is unknown what limits the arterial remodeling process during atherosclerotic plaque formation. In healthy arteries remodeling is regulated by the shear stress induced response by the endothelium. As endothelium at the plaque site is assumed to be dysfunctional, we tested the hypothesis that plaque free wall (PFW) determines vascular remodeling during atherosclerotic plaque build-up. Methods & results 66 human coronary ROIs (38 patients) were studied at baseline and at 3 years follow up applying intravascular ultrasound (IVUS). From the IVUS images the lumen and external elastic membrane contours were delineated to assess wall thickness (WT), vessel area (VA), Plaque Area (PA) and plaque burden (PA/VA*100%). WT < 0.5 mm was defined as normal and determined the arc of the PFW (0–360°). Positive remodeling was defined as relative difference of VA over time >5%. At baseline, IVUS-PFW was inversely related to plaque burden (p < 0.05). Positive remodeling was most frequently observed in ROIs with IVUS-PFW > 180° (i.e. larger than half of the circumference) compared to PFW < 180° (55% vs. 12%, p < 0.05). Accordingly, plaques with IVUS-PFW > 180° at baseline had the largest change in VA (1.1 ± 2.1 vs. −0.4 ± 0.6 mm2, p < 0.05) with an odds ratio of 9.2 to develop positive remodeling. Conclusions Our serial IVUS data show that IVUS-PFW is a determinant of vascular remodeling. ROIs with PFW > 180 at baseline had the highest probability to undergo positive remodeling.
Fil: Wentzel, Jolanda J.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países Bajos
Fil: Gijsen, Frank J.H.. ErasmusMC. Rotterdam; Países Bajos
Fil: der Giessen, Rosevan. ErasmusMC. Rotterdam; Países Bajos
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ErasmusMC. Rotterdam; Países Bajos
Fil: Schuurbiers, Johan C.H.. ErasmusMC. Rotterdam; Países Bajos
Fil: Regar, E.. ErasmusMC. Rotterdam; Países Bajos
Fil: de Feyter, Pim J.. ErasmusMC. Rotterdam; Países Bajos
Fil: van der Steenac, Antonius F.W.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países Bajos
description Aims At present it is unknown what limits the arterial remodeling process during atherosclerotic plaque formation. In healthy arteries remodeling is regulated by the shear stress induced response by the endothelium. As endothelium at the plaque site is assumed to be dysfunctional, we tested the hypothesis that plaque free wall (PFW) determines vascular remodeling during atherosclerotic plaque build-up. Methods & results 66 human coronary ROIs (38 patients) were studied at baseline and at 3 years follow up applying intravascular ultrasound (IVUS). From the IVUS images the lumen and external elastic membrane contours were delineated to assess wall thickness (WT), vessel area (VA), Plaque Area (PA) and plaque burden (PA/VA*100%). WT < 0.5 mm was defined as normal and determined the arc of the PFW (0–360°). Positive remodeling was defined as relative difference of VA over time >5%. At baseline, IVUS-PFW was inversely related to plaque burden (p < 0.05). Positive remodeling was most frequently observed in ROIs with IVUS-PFW > 180° (i.e. larger than half of the circumference) compared to PFW < 180° (55% vs. 12%, p < 0.05). Accordingly, plaques with IVUS-PFW > 180° at baseline had the largest change in VA (1.1 ± 2.1 vs. −0.4 ± 0.6 mm2, p < 0.05) with an odds ratio of 9.2 to develop positive remodeling. Conclusions Our serial IVUS data show that IVUS-PFW is a determinant of vascular remodeling. ROIs with PFW > 180 at baseline had the highest probability to undergo positive remodeling.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/35471
Wentzel, Jolanda J.; Gijsen, Frank J.H.; der Giessen, Rosevan; Rodriguez Granillo, Gaston Alfredo; Schuurbiers, Johan C.H.; et al.; Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.; Elsevier Ireland; Atherosclerosis; 236; 1; 6-2014; 82-90
0021-9150
CONICET Digital
CONICET
url http://hdl.handle.net/11336/35471
identifier_str_mv Wentzel, Jolanda J.; Gijsen, Frank J.H.; der Giessen, Rosevan; Rodriguez Granillo, Gaston Alfredo; Schuurbiers, Johan C.H.; et al.; Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.; Elsevier Ireland; Atherosclerosis; 236; 1; 6-2014; 82-90
0021-9150
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2014.06.013
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S002191501401243X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.260194

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