Great achievements and new landscapes in medical cancer therapy

Autores
Gandía, Daniel; Suárez, Cecilia Ana
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chemotherapy rapidly proved its worth in different clinical cancer settings, begining with hematologic malignancies. Many pediatric and young adult tumors achieved complete remission with chemotherapy, but its use as concomitant, adjuvant and/or neoadjuvant treatment also resulted in beneficial results. The new milenium developed new techniques in molecular drug design creating novel drugs specially directed to specific cell targets, which was a solution for some traditionally chemoresistant tumors. César Milstein begun a new road with the discovery of the monoclonal antibodies, opening the landscape of the immuno-oncology that lead to present check-point-inhibitors. In the last decades, mathematical oncology and the “omics” sciences, also came to help as complementary tools for the management of this extremely complex disease in the context of a personalized medicine. Indeed, the possibility of introducing information derived from these sciences into hybrid and/or multiscalar mathematical models are nowadays the approaches most interesting and promising; with good perspectives in the diagnosis, prognosis, treatment design and follow-up of different kinds of tumors. Although at present many tumor types can be completely cured, other ones are much more difficult to eradicate, and they would be better considered as chronic diseases. In this context, some new important concepts emerge in the metronomics field, as keeping a stable tumor burden, a more benign tumor grade and a good quality of life. This minireview addreses all these mentioned issues.
Fil: Gandía, Daniel. Sanatorio Los Arcos; Argentina
Fil: Suárez, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Materia
CANCER
CHEMOTHERAPY
DRUG DESIGN
IMMUNO-ONGOLOGY
METRONOMICS
MATHEMATICAL ONCOLOGY
"OMICS" SCIENCES
PERSONALIZED MEDICINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147757
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Great achievements and new landscapes in medical cancer therapyGandía, DanielSuárez, Cecilia AnaCANCERCHEMOTHERAPYDRUG DESIGNIMMUNO-ONGOLOGYMETRONOMICSMATHEMATICAL ONCOLOGY"OMICS" SCIENCESPERSONALIZED MEDICINEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Chemotherapy rapidly proved its worth in different clinical cancer settings, begining with hematologic malignancies. Many pediatric and young adult tumors achieved complete remission with chemotherapy, but its use as concomitant, adjuvant and/or neoadjuvant treatment also resulted in beneficial results. The new milenium developed new techniques in molecular drug design creating novel drugs specially directed to specific cell targets, which was a solution for some traditionally chemoresistant tumors. César Milstein begun a new road with the discovery of the monoclonal antibodies, opening the landscape of the immuno-oncology that lead to present check-point-inhibitors. In the last decades, mathematical oncology and the “omics” sciences, also came to help as complementary tools for the management of this extremely complex disease in the context of a personalized medicine. Indeed, the possibility of introducing information derived from these sciences into hybrid and/or multiscalar mathematical models are nowadays the approaches most interesting and promising; with good perspectives in the diagnosis, prognosis, treatment design and follow-up of different kinds of tumors. Although at present many tumor types can be completely cured, other ones are much more difficult to eradicate, and they would be better considered as chronic diseases. In this context, some new important concepts emerge in the metronomics field, as keeping a stable tumor burden, a more benign tumor grade and a good quality of life. This minireview addreses all these mentioned issues.Fil: Gandía, Daniel. Sanatorio Los Arcos; ArgentinaFil: Suárez, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaThe Society of Adaptive Science in Taiwan2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147757Gandía, Daniel; Suárez, Cecilia Ana; Great achievements and new landscapes in medical cancer therapy; The Society of Adaptive Science in Taiwan; Adaptive Medicine; 11; 3; 2019; 75-782076-944XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4247/AM.2019.ABJ230info:eu-repo/semantics/altIdentifier/url/http://www.sastam.org.tw/adaptive_medicine/2019075.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:54Zoai:ri.conicet.gov.ar:11336/147757instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:54.353CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Great achievements and new landscapes in medical cancer therapy
title Great achievements and new landscapes in medical cancer therapy
spellingShingle Great achievements and new landscapes in medical cancer therapy
Gandía, Daniel
CANCER
CHEMOTHERAPY
DRUG DESIGN
IMMUNO-ONGOLOGY
METRONOMICS
MATHEMATICAL ONCOLOGY
"OMICS" SCIENCES
PERSONALIZED MEDICINE
title_short Great achievements and new landscapes in medical cancer therapy
title_full Great achievements and new landscapes in medical cancer therapy
title_fullStr Great achievements and new landscapes in medical cancer therapy
title_full_unstemmed Great achievements and new landscapes in medical cancer therapy
title_sort Great achievements and new landscapes in medical cancer therapy
dc.creator.none.fl_str_mv Gandía, Daniel
Suárez, Cecilia Ana
author Gandía, Daniel
author_facet Gandía, Daniel
Suárez, Cecilia Ana
author_role author
author2 Suárez, Cecilia Ana
author2_role author
dc.subject.none.fl_str_mv CANCER
CHEMOTHERAPY
DRUG DESIGN
IMMUNO-ONGOLOGY
METRONOMICS
MATHEMATICAL ONCOLOGY
"OMICS" SCIENCES
PERSONALIZED MEDICINE
topic CANCER
CHEMOTHERAPY
DRUG DESIGN
IMMUNO-ONGOLOGY
METRONOMICS
MATHEMATICAL ONCOLOGY
"OMICS" SCIENCES
PERSONALIZED MEDICINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chemotherapy rapidly proved its worth in different clinical cancer settings, begining with hematologic malignancies. Many pediatric and young adult tumors achieved complete remission with chemotherapy, but its use as concomitant, adjuvant and/or neoadjuvant treatment also resulted in beneficial results. The new milenium developed new techniques in molecular drug design creating novel drugs specially directed to specific cell targets, which was a solution for some traditionally chemoresistant tumors. César Milstein begun a new road with the discovery of the monoclonal antibodies, opening the landscape of the immuno-oncology that lead to present check-point-inhibitors. In the last decades, mathematical oncology and the “omics” sciences, also came to help as complementary tools for the management of this extremely complex disease in the context of a personalized medicine. Indeed, the possibility of introducing information derived from these sciences into hybrid and/or multiscalar mathematical models are nowadays the approaches most interesting and promising; with good perspectives in the diagnosis, prognosis, treatment design and follow-up of different kinds of tumors. Although at present many tumor types can be completely cured, other ones are much more difficult to eradicate, and they would be better considered as chronic diseases. In this context, some new important concepts emerge in the metronomics field, as keeping a stable tumor burden, a more benign tumor grade and a good quality of life. This minireview addreses all these mentioned issues.
Fil: Gandía, Daniel. Sanatorio Los Arcos; Argentina
Fil: Suárez, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
description Chemotherapy rapidly proved its worth in different clinical cancer settings, begining with hematologic malignancies. Many pediatric and young adult tumors achieved complete remission with chemotherapy, but its use as concomitant, adjuvant and/or neoadjuvant treatment also resulted in beneficial results. The new milenium developed new techniques in molecular drug design creating novel drugs specially directed to specific cell targets, which was a solution for some traditionally chemoresistant tumors. César Milstein begun a new road with the discovery of the monoclonal antibodies, opening the landscape of the immuno-oncology that lead to present check-point-inhibitors. In the last decades, mathematical oncology and the “omics” sciences, also came to help as complementary tools for the management of this extremely complex disease in the context of a personalized medicine. Indeed, the possibility of introducing information derived from these sciences into hybrid and/or multiscalar mathematical models are nowadays the approaches most interesting and promising; with good perspectives in the diagnosis, prognosis, treatment design and follow-up of different kinds of tumors. Although at present many tumor types can be completely cured, other ones are much more difficult to eradicate, and they would be better considered as chronic diseases. In this context, some new important concepts emerge in the metronomics field, as keeping a stable tumor burden, a more benign tumor grade and a good quality of life. This minireview addreses all these mentioned issues.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147757
Gandía, Daniel; Suárez, Cecilia Ana; Great achievements and new landscapes in medical cancer therapy; The Society of Adaptive Science in Taiwan; Adaptive Medicine; 11; 3; 2019; 75-78
2076-944X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147757
identifier_str_mv Gandía, Daniel; Suárez, Cecilia Ana; Great achievements and new landscapes in medical cancer therapy; The Society of Adaptive Science in Taiwan; Adaptive Medicine; 11; 3; 2019; 75-78
2076-944X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4247/AM.2019.ABJ230
info:eu-repo/semantics/altIdentifier/url/http://www.sastam.org.tw/adaptive_medicine/2019075.aspx
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Society of Adaptive Science in Taiwan
publisher.none.fl_str_mv The Society of Adaptive Science in Taiwan
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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