Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules

Autores
Vicente, Filipa A.; Pellegrini Malpiedi, Luciana; e Silva, Francisca A.; Pessoa, Adalberto Jr.; Coutinho, João A.P.; Ventura, Sónia P.M.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aqueous micellar two-phase systems (AMTPS) using surfactants have been widely applied as an advantageous extraction technology for a wide range of (bio)molecules. When composed by two surfactants (the second one used as the co-surfactant), the extractive performance of such systems is considerably boosted. In this context, this work looks at ionic liquids (ILs) as a new class of tunable co-surfactants to be applied in AMTPS. Three distinct families of ILs, namely imidazolium, phosphonium and quaternary ammonium were applied in the design of the binodal curves of novel AMTPS based on the nonionic surfactant Triton X-114. On these systems it was investigated the impact of the IL absence/presence, concentration and structural features on the binodal curves behavior. Aiming at evaluating their applicability as extraction systems, partitioning studies of two targeted (bio)molecules, namely the protein Cytochrome c (Cyt c) and the dye/model drug Rhodamine 6G (R6G), were carried out. It is shown that the presence of ILs as co-surfactants is able not only to enhance the partition coefficients of Cyt c (indicated as logKCyt c) from 0.59 ± 0.12 up to 1.51 ± 0.14, but also to improve the selectivity parameter (SR6G/Cyt c) from 925.25 up to 3418.89. The results here obtained open new perspectives in the design of liquid–liquid separation processes, transversal to various fields and a wide range of applications
Fil: Vicente, Filipa A.. Universidade de Aveiro; Portugal. Universidade de Sao Paulo; Brasil
Fil: Pellegrini Malpiedi, Luciana. Universidad Nacional de Rosario; Argentina. Universidade de Sao Paulo; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: e Silva, Francisca A.. Universidade de Aveiro; Portugal
Fil: Pessoa, Adalberto Jr.. Universidade de Sao Paulo; Brasil
Fil: Coutinho, João A.P.. Universidade de Aveiro; Portugal
Fil: Ventura, Sónia P.M.. Universidade de Aveiro; Portugal
Materia
Aqueous Micellar Two-Phase System
Triton X-114
Ionic Liquids
Co-Surfactant
Selective Extraction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30182
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)moleculesVicente, Filipa A.Pellegrini Malpiedi, Lucianae Silva, Francisca A.Pessoa, Adalberto Jr.Coutinho, João A.P.Ventura, Sónia P.M.Aqueous Micellar Two-Phase SystemTriton X-114Ionic LiquidsCo-SurfactantSelective Extractionhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Aqueous micellar two-phase systems (AMTPS) using surfactants have been widely applied as an advantageous extraction technology for a wide range of (bio)molecules. When composed by two surfactants (the second one used as the co-surfactant), the extractive performance of such systems is considerably boosted. In this context, this work looks at ionic liquids (ILs) as a new class of tunable co-surfactants to be applied in AMTPS. Three distinct families of ILs, namely imidazolium, phosphonium and quaternary ammonium were applied in the design of the binodal curves of novel AMTPS based on the nonionic surfactant Triton X-114. On these systems it was investigated the impact of the IL absence/presence, concentration and structural features on the binodal curves behavior. Aiming at evaluating their applicability as extraction systems, partitioning studies of two targeted (bio)molecules, namely the protein Cytochrome c (Cyt c) and the dye/model drug Rhodamine 6G (R6G), were carried out. It is shown that the presence of ILs as co-surfactants is able not only to enhance the partition coefficients of Cyt c (indicated as logKCyt c) from 0.59 ± 0.12 up to 1.51 ± 0.14, but also to improve the selectivity parameter (SR6G/Cyt c) from 925.25 up to 3418.89. The results here obtained open new perspectives in the design of liquid–liquid separation processes, transversal to various fields and a wide range of applicationsFil: Vicente, Filipa A.. Universidade de Aveiro; Portugal. Universidade de Sao Paulo; BrasilFil: Pellegrini Malpiedi, Luciana. Universidad Nacional de Rosario; Argentina. Universidade de Sao Paulo; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: e Silva, Francisca A.. Universidade de Aveiro; PortugalFil: Pessoa, Adalberto Jr.. Universidade de Sao Paulo; BrasilFil: Coutinho, João A.P.. Universidade de Aveiro; PortugalFil: Ventura, Sónia P.M.. Universidade de Aveiro; PortugalElsevier Science2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30182Vicente, Filipa A.; Pellegrini Malpiedi, Luciana; e Silva, Francisca A.; Pessoa, Adalberto Jr.; Coutinho, João A.P.; et al.; Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules; Elsevier Science; Separation and Purification Technology; 135; 10-2014; 259-2671383-5866CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.seppur.2014.06.045info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1383586614003931info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:04Zoai:ri.conicet.gov.ar:11336/30182instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:04.856CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
title Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
spellingShingle Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
Vicente, Filipa A.
Aqueous Micellar Two-Phase System
Triton X-114
Ionic Liquids
Co-Surfactant
Selective Extraction
title_short Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
title_full Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
title_fullStr Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
title_full_unstemmed Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
title_sort Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules
dc.creator.none.fl_str_mv Vicente, Filipa A.
Pellegrini Malpiedi, Luciana
e Silva, Francisca A.
Pessoa, Adalberto Jr.
Coutinho, João A.P.
Ventura, Sónia P.M.
author Vicente, Filipa A.
author_facet Vicente, Filipa A.
Pellegrini Malpiedi, Luciana
e Silva, Francisca A.
Pessoa, Adalberto Jr.
Coutinho, João A.P.
Ventura, Sónia P.M.
author_role author
author2 Pellegrini Malpiedi, Luciana
e Silva, Francisca A.
Pessoa, Adalberto Jr.
Coutinho, João A.P.
Ventura, Sónia P.M.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Aqueous Micellar Two-Phase System
Triton X-114
Ionic Liquids
Co-Surfactant
Selective Extraction
topic Aqueous Micellar Two-Phase System
Triton X-114
Ionic Liquids
Co-Surfactant
Selective Extraction
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Aqueous micellar two-phase systems (AMTPS) using surfactants have been widely applied as an advantageous extraction technology for a wide range of (bio)molecules. When composed by two surfactants (the second one used as the co-surfactant), the extractive performance of such systems is considerably boosted. In this context, this work looks at ionic liquids (ILs) as a new class of tunable co-surfactants to be applied in AMTPS. Three distinct families of ILs, namely imidazolium, phosphonium and quaternary ammonium were applied in the design of the binodal curves of novel AMTPS based on the nonionic surfactant Triton X-114. On these systems it was investigated the impact of the IL absence/presence, concentration and structural features on the binodal curves behavior. Aiming at evaluating their applicability as extraction systems, partitioning studies of two targeted (bio)molecules, namely the protein Cytochrome c (Cyt c) and the dye/model drug Rhodamine 6G (R6G), were carried out. It is shown that the presence of ILs as co-surfactants is able not only to enhance the partition coefficients of Cyt c (indicated as logKCyt c) from 0.59 ± 0.12 up to 1.51 ± 0.14, but also to improve the selectivity parameter (SR6G/Cyt c) from 925.25 up to 3418.89. The results here obtained open new perspectives in the design of liquid–liquid separation processes, transversal to various fields and a wide range of applications
Fil: Vicente, Filipa A.. Universidade de Aveiro; Portugal. Universidade de Sao Paulo; Brasil
Fil: Pellegrini Malpiedi, Luciana. Universidad Nacional de Rosario; Argentina. Universidade de Sao Paulo; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: e Silva, Francisca A.. Universidade de Aveiro; Portugal
Fil: Pessoa, Adalberto Jr.. Universidade de Sao Paulo; Brasil
Fil: Coutinho, João A.P.. Universidade de Aveiro; Portugal
Fil: Ventura, Sónia P.M.. Universidade de Aveiro; Portugal
description Aqueous micellar two-phase systems (AMTPS) using surfactants have been widely applied as an advantageous extraction technology for a wide range of (bio)molecules. When composed by two surfactants (the second one used as the co-surfactant), the extractive performance of such systems is considerably boosted. In this context, this work looks at ionic liquids (ILs) as a new class of tunable co-surfactants to be applied in AMTPS. Three distinct families of ILs, namely imidazolium, phosphonium and quaternary ammonium were applied in the design of the binodal curves of novel AMTPS based on the nonionic surfactant Triton X-114. On these systems it was investigated the impact of the IL absence/presence, concentration and structural features on the binodal curves behavior. Aiming at evaluating their applicability as extraction systems, partitioning studies of two targeted (bio)molecules, namely the protein Cytochrome c (Cyt c) and the dye/model drug Rhodamine 6G (R6G), were carried out. It is shown that the presence of ILs as co-surfactants is able not only to enhance the partition coefficients of Cyt c (indicated as logKCyt c) from 0.59 ± 0.12 up to 1.51 ± 0.14, but also to improve the selectivity parameter (SR6G/Cyt c) from 925.25 up to 3418.89. The results here obtained open new perspectives in the design of liquid–liquid separation processes, transversal to various fields and a wide range of applications
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30182
Vicente, Filipa A.; Pellegrini Malpiedi, Luciana; e Silva, Francisca A.; Pessoa, Adalberto Jr.; Coutinho, João A.P.; et al.; Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules; Elsevier Science; Separation and Purification Technology; 135; 10-2014; 259-267
1383-5866
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30182
identifier_str_mv Vicente, Filipa A.; Pellegrini Malpiedi, Luciana; e Silva, Francisca A.; Pessoa, Adalberto Jr.; Coutinho, João A.P.; et al.; Design of novel aqueous micellar two-phase systems using ionic liquids as co-surfactants for the selective extraction of (bio)molecules; Elsevier Science; Separation and Purification Technology; 135; 10-2014; 259-267
1383-5866
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.seppur.2014.06.045
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1383586614003931
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269499101806592
score 13.13397

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