Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations

Autores
Lebed, Pablo Jorge; Keunchkarian, Sonia; Osorio Grisales, Jaiver; Castells, Cecilia Beatriz Marta
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The association constants of several volatile enantiomers with octakis(3-O-butanoyl-2,6-di-O-pentyl)-γ-cyclodextrin at temperatures between 50 and 100 °C were measured by gas–liquid chromatography using capillary columns coated with different amounts of chiral selector dissolved in polysiloxane OV-1701 and prepared with a precisely determined phase ratio. Simple expressions were deduced to estimate the apparent distribution constants from accurate hold-up and retention times along with that known phase ratio at each temperature. The enantiomer-chiral selector association constants were then calculated from the linear regression of the apparent constants as a function of the chiral selector concentration. One aim of this study consisted in discussing all the experimental uncertainties inherent in the determination of enantiomer/selector association constants with chiral analytes, and how these fundamental measurements can be performed precisely without resorting to the use of reference solutes.
Fil: Lebed, Pablo Jorge. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Keunchkarian, Sonia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Osorio Grisales, Jaiver. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castells, Cecilia Beatriz Marta. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Chiral Gas-Liquid Chromatography
Association Constants
Capillary Columns
Octakis(3-O-Butanoyl-2,6-Di-O-Pentyl)-Γ-Cyclodextrin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11177
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerationsLebed, Pablo JorgeKeunchkarian, SoniaOsorio Grisales, JaiverCastells, Cecilia Beatriz MartaChiral Gas-Liquid ChromatographyAssociation ConstantsCapillary ColumnsOctakis(3-O-Butanoyl-2,6-Di-O-Pentyl)-Γ-Cyclodextrinhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The association constants of several volatile enantiomers with octakis(3-O-butanoyl-2,6-di-O-pentyl)-γ-cyclodextrin at temperatures between 50 and 100 °C were measured by gas–liquid chromatography using capillary columns coated with different amounts of chiral selector dissolved in polysiloxane OV-1701 and prepared with a precisely determined phase ratio. Simple expressions were deduced to estimate the apparent distribution constants from accurate hold-up and retention times along with that known phase ratio at each temperature. The enantiomer-chiral selector association constants were then calculated from the linear regression of the apparent constants as a function of the chiral selector concentration. One aim of this study consisted in discussing all the experimental uncertainties inherent in the determination of enantiomer/selector association constants with chiral analytes, and how these fundamental measurements can be performed precisely without resorting to the use of reference solutes.Fil: Lebed, Pablo Jorge. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Keunchkarian, Sonia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Osorio Grisales, Jaiver. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castells, Cecilia Beatriz Marta. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/11177Lebed, Pablo Jorge; Keunchkarian, Sonia; Osorio Grisales, Jaiver; Castells, Cecilia Beatriz Marta; Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations; Elsevier Science; Journal Of Chromatography - A; 1324; 1-2014; 198-2060021-9673enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.chroma.2013.11.007info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0021967313017627info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:00Zoai:ri.conicet.gov.ar:11336/11177instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:00.499CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
title Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
spellingShingle Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
Lebed, Pablo Jorge
Chiral Gas-Liquid Chromatography
Association Constants
Capillary Columns
Octakis(3-O-Butanoyl-2,6-Di-O-Pentyl)-Γ-Cyclodextrin
title_short Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
title_full Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
title_fullStr Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
title_full_unstemmed Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
title_sort Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations
dc.creator.none.fl_str_mv Lebed, Pablo Jorge
Keunchkarian, Sonia
Osorio Grisales, Jaiver
Castells, Cecilia Beatriz Marta
author Lebed, Pablo Jorge
author_facet Lebed, Pablo Jorge
Keunchkarian, Sonia
Osorio Grisales, Jaiver
Castells, Cecilia Beatriz Marta
author_role author
author2 Keunchkarian, Sonia
Osorio Grisales, Jaiver
Castells, Cecilia Beatriz Marta
author2_role author
author
author
dc.subject.none.fl_str_mv Chiral Gas-Liquid Chromatography
Association Constants
Capillary Columns
Octakis(3-O-Butanoyl-2,6-Di-O-Pentyl)-Γ-Cyclodextrin
topic Chiral Gas-Liquid Chromatography
Association Constants
Capillary Columns
Octakis(3-O-Butanoyl-2,6-Di-O-Pentyl)-Γ-Cyclodextrin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The association constants of several volatile enantiomers with octakis(3-O-butanoyl-2,6-di-O-pentyl)-γ-cyclodextrin at temperatures between 50 and 100 °C were measured by gas–liquid chromatography using capillary columns coated with different amounts of chiral selector dissolved in polysiloxane OV-1701 and prepared with a precisely determined phase ratio. Simple expressions were deduced to estimate the apparent distribution constants from accurate hold-up and retention times along with that known phase ratio at each temperature. The enantiomer-chiral selector association constants were then calculated from the linear regression of the apparent constants as a function of the chiral selector concentration. One aim of this study consisted in discussing all the experimental uncertainties inherent in the determination of enantiomer/selector association constants with chiral analytes, and how these fundamental measurements can be performed precisely without resorting to the use of reference solutes.
Fil: Lebed, Pablo Jorge. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Keunchkarian, Sonia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Osorio Grisales, Jaiver. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castells, Cecilia Beatriz Marta. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Laboratorio de Investigación y Desarrollo de Métodos Analíticos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The association constants of several volatile enantiomers with octakis(3-O-butanoyl-2,6-di-O-pentyl)-γ-cyclodextrin at temperatures between 50 and 100 °C were measured by gas–liquid chromatography using capillary columns coated with different amounts of chiral selector dissolved in polysiloxane OV-1701 and prepared with a precisely determined phase ratio. Simple expressions were deduced to estimate the apparent distribution constants from accurate hold-up and retention times along with that known phase ratio at each temperature. The enantiomer-chiral selector association constants were then calculated from the linear regression of the apparent constants as a function of the chiral selector concentration. One aim of this study consisted in discussing all the experimental uncertainties inherent in the determination of enantiomer/selector association constants with chiral analytes, and how these fundamental measurements can be performed precisely without resorting to the use of reference solutes.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11177
Lebed, Pablo Jorge; Keunchkarian, Sonia; Osorio Grisales, Jaiver; Castells, Cecilia Beatriz Marta; Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations; Elsevier Science; Journal Of Chromatography - A; 1324; 1-2014; 198-206
0021-9673
url http://hdl.handle.net/11336/11177
identifier_str_mv Lebed, Pablo Jorge; Keunchkarian, Sonia; Osorio Grisales, Jaiver; Castells, Cecilia Beatriz Marta; Measurements of association constants between enantiomers and chiral selectors by capillary gas chromatography. Theoretical and practical considerations; Elsevier Science; Journal Of Chromatography - A; 1324; 1-2014; 198-206
0021-9673
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chroma.2013.11.007
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0021967313017627
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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