The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study

Autores
Hofmeyr, G. J.; Seuc, A. H.; Betrán, A. P.; Purnat, T. D.; Ciganda, Álvaro; Munjanja, S. P.; Manyame, S.; Singata, M.; Fawcus, S.; Frank, K.; Hall, D. R.; Cormick, Gabriela; Roberts, J. M.; Bergel, Eduardo F.; Drebit, S.K.; von Dadelszen, P.; Belizan, Jose; Calcium and Pre-eclampsia Study Group
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP). Methods This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500 mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24 weeks after randomization were included. Results Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5 mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6 mmHg) was statistically larger than in the placebo group (+0.8 mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p = 0.025). The effect of calcium on diastolic BP at 12 weeks was greater than in those with non-severe pre-eclampsia (p = 0.020, ANOVA analysis). Conclusions There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution.
Fil: Hofmeyr, G. J.. University of the Witwatersrand; Sudáfrica
Fil: Seuc, A. H.. World Health Organization; Suiza
Fil: Betrán, A. P.. World Health Organization; Suiza
Fil: Purnat, T. D.. World Health Organization; Dinamarca
Fil: Ciganda, Álvaro. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Munjanja, S. P.. University of Zimbabwe; Zimbabue
Fil: Manyame, S.. University of Zimbabwe; Zimbabue
Fil: Singata, M.. Fort Hare University; Sudáfrica
Fil: Fawcus, S.. University of Cape Town; Sudáfrica. Mowbray Maternity Hospital; Sudáfrica
Fil: Frank, K.. University of the Witwatersrand; Sudáfrica
Fil: Hall, D. R.. Stellenbosch University; Sudáfrica. Tygerberg Hospital; Sudáfrica
Fil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Roberts, J. M.. University of Pittsburgh; Estados Unidos
Fil: Bergel, Eduardo F.. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Drebit, S.K.. University of British Columbia; Canadá
Fil: von Dadelszen, P.. University of British Columbia; Canadá
Fil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Calcium and Pre-eclampsia Study Group. No especifica;
Materia
Blood Pressure
Calcium
Hypertension
Preeclampsia
Supplementation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/70125
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/70125
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled studyHofmeyr, G. J.Seuc, A. H.Betrán, A. P.Purnat, T. D.Ciganda, ÁlvaroMunjanja, S. P.Manyame, S.Singata, M.Fawcus, S.Frank, K.Hall, D. R.Cormick, GabrielaRoberts, J. M.Bergel, Eduardo F.Drebit, S.K.von Dadelszen, P.Belizan, JoseCalcium and Pre-eclampsia Study GroupBlood PressureCalciumHypertensionPreeclampsiaSupplementationhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP). Methods This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500 mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24 weeks after randomization were included. Results Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5 mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6 mmHg) was statistically larger than in the placebo group (+0.8 mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p = 0.025). The effect of calcium on diastolic BP at 12 weeks was greater than in those with non-severe pre-eclampsia (p = 0.020, ANOVA analysis). Conclusions There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution.Fil: Hofmeyr, G. J.. University of the Witwatersrand; SudáfricaFil: Seuc, A. H.. World Health Organization; SuizaFil: Betrán, A. P.. World Health Organization; SuizaFil: Purnat, T. D.. World Health Organization; DinamarcaFil: Ciganda, Álvaro. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Munjanja, S. P.. University of Zimbabwe; ZimbabueFil: Manyame, S.. University of Zimbabwe; ZimbabueFil: Singata, M.. Fort Hare University; SudáfricaFil: Fawcus, S.. University of Cape Town; Sudáfrica. Mowbray Maternity Hospital; SudáfricaFil: Frank, K.. University of the Witwatersrand; SudáfricaFil: Hall, D. R.. Stellenbosch University; Sudáfrica. Tygerberg Hospital; SudáfricaFil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Roberts, J. M.. University of Pittsburgh; Estados UnidosFil: Bergel, Eduardo F.. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Drebit, S.K.. University of British Columbia; CanadáFil: von Dadelszen, P.. University of British Columbia; CanadáFil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Calcium and Pre-eclampsia Study Group. No especifica;Elsevier B.V.2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/70125Hofmeyr, G. J.; Seuc, A. H.; Betrán, A. P.; Purnat, T. D.; Ciganda, Álvaro; et al.; The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study; Elsevier B.V.; Pregnancy Hypertension; 5; 4; 10-2015; 273-2792210-77892210-7797CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210778915000227info:eu-repo/semantics/altIdentifier/doi/10.1016/j.preghy.2015.04.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:05Zoai:ri.conicet.gov.ar:11336/70125instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:05.976CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
title The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
spellingShingle The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
Hofmeyr, G. J.
Blood Pressure
Calcium
Hypertension
Preeclampsia
Supplementation
title_short The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
title_full The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
title_fullStr The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
title_full_unstemmed The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
title_sort The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study
dc.creator.none.fl_str_mv Hofmeyr, G. J.
Seuc, A. H.
Betrán, A. P.
Purnat, T. D.
Ciganda, Álvaro
Munjanja, S. P.
Manyame, S.
Singata, M.
Fawcus, S.
Frank, K.
Hall, D. R.
Cormick, Gabriela
Roberts, J. M.
Bergel, Eduardo F.
Drebit, S.K.
von Dadelszen, P.
Belizan, Jose
Calcium and Pre-eclampsia Study Group
author Hofmeyr, G. J.
author_facet Hofmeyr, G. J.
Seuc, A. H.
Betrán, A. P.
Purnat, T. D.
Ciganda, Álvaro
Munjanja, S. P.
Manyame, S.
Singata, M.
Fawcus, S.
Frank, K.
Hall, D. R.
Cormick, Gabriela
Roberts, J. M.
Bergel, Eduardo F.
Drebit, S.K.
von Dadelszen, P.
Belizan, Jose
Calcium and Pre-eclampsia Study Group
author_role author
author2 Seuc, A. H.
Betrán, A. P.
Purnat, T. D.
Ciganda, Álvaro
Munjanja, S. P.
Manyame, S.
Singata, M.
Fawcus, S.
Frank, K.
Hall, D. R.
Cormick, Gabriela
Roberts, J. M.
Bergel, Eduardo F.
Drebit, S.K.
von Dadelszen, P.
Belizan, Jose
Calcium and Pre-eclampsia Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Blood Pressure
Calcium
Hypertension
Preeclampsia
Supplementation
topic Blood Pressure
Calcium
Hypertension
Preeclampsia
Supplementation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP). Methods This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500 mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24 weeks after randomization were included. Results Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5 mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6 mmHg) was statistically larger than in the placebo group (+0.8 mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p = 0.025). The effect of calcium on diastolic BP at 12 weeks was greater than in those with non-severe pre-eclampsia (p = 0.020, ANOVA analysis). Conclusions There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution.
Fil: Hofmeyr, G. J.. University of the Witwatersrand; Sudáfrica
Fil: Seuc, A. H.. World Health Organization; Suiza
Fil: Betrán, A. P.. World Health Organization; Suiza
Fil: Purnat, T. D.. World Health Organization; Dinamarca
Fil: Ciganda, Álvaro. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Munjanja, S. P.. University of Zimbabwe; Zimbabue
Fil: Manyame, S.. University of Zimbabwe; Zimbabue
Fil: Singata, M.. Fort Hare University; Sudáfrica
Fil: Fawcus, S.. University of Cape Town; Sudáfrica. Mowbray Maternity Hospital; Sudáfrica
Fil: Frank, K.. University of the Witwatersrand; Sudáfrica
Fil: Hall, D. R.. Stellenbosch University; Sudáfrica. Tygerberg Hospital; Sudáfrica
Fil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Roberts, J. M.. University of Pittsburgh; Estados Unidos
Fil: Bergel, Eduardo F.. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Drebit, S.K.. University of British Columbia; Canadá
Fil: von Dadelszen, P.. University of British Columbia; Canadá
Fil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Calcium and Pre-eclampsia Study Group. No especifica;
description Background Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP). Methods This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500 mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24 weeks after randomization were included. Results Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5 mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6 mmHg) was statistically larger than in the placebo group (+0.8 mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p = 0.025). The effect of calcium on diastolic BP at 12 weeks was greater than in those with non-severe pre-eclampsia (p = 0.020, ANOVA analysis). Conclusions There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/70125
Hofmeyr, G. J.; Seuc, A. H.; Betrán, A. P.; Purnat, T. D.; Ciganda, Álvaro; et al.; The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study; Elsevier B.V.; Pregnancy Hypertension; 5; 4; 10-2015; 273-279
2210-7789
2210-7797
CONICET Digital
CONICET
url http://hdl.handle.net/11336/70125
identifier_str_mv Hofmeyr, G. J.; Seuc, A. H.; Betrán, A. P.; Purnat, T. D.; Ciganda, Álvaro; et al.; The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study; Elsevier B.V.; Pregnancy Hypertension; 5; 4; 10-2015; 273-279
2210-7789
2210-7797
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210778915000227
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.preghy.2015.04.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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