Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations

Autores
Gomes, Filomena; Ashorn, Per; Askari, Sufia; Belizan, Jose; Boy, Erick; Cormick, Gabriela; Dickin, Katherine L.; Driller Colangelo, Amalia R.; Fawzi, Wafaie; Hofmeyr, G. Justus; Humphrey, Jean; Khadilkar, Anuradha; Mandlik, Rubina; Neufeld, Lynnette M.; Palacios, Cristina; Roth, Daniel E.; Shlisky, Julie; Sudfeld, Christopher R.; Weaver, Connie; Bourassa, Megan W.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Most low- and middle-income countries present suboptimal intakes of calcium during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where ≥25% of individuals in the population have intakes less than 800 mg calcium/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500-mg doses/day). WHO recommends 1.5–2 g/day but limited evidence suggests that less than 1 g/day may be sufficient and ongoing trials with low-dose calcium supplementation (500 mg/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost-effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron-containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food-based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.
Fil: Gomes, Filomena. Universidade Nova de Lisboa. Faculdade de Ciencias Medicas.; Portugal
Fil: Ashorn, Per. Universidad de Tampere; Finlandia
Fil: Askari, Sufia. Children's Investment Fund Foundation; Reino Unido
Fil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Boy, Erick. International Food Policy Research Institute; Estados Unidos
Fil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Dickin, Katherine L.. Cornell University; Estados Unidos
Fil: Driller Colangelo, Amalia R.. Harvard University; Estados Unidos
Fil: Fawzi, Wafaie. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Hofmeyr, G. Justus. University of the Witwatersrand; Sudáfrica
Fil: Humphrey, Jean. University Johns Hopkins; Estados Unidos
Fil: Khadilkar, Anuradha. Hirabai Cowasji Jehangir Medical Research Institute; India
Fil: Mandlik, Rubina. Hirabai Cowasji Jehangir Medical Research Institute; India
Fil: Neufeld, Lynnette M.. Global Alliance For Improved Nutrition; Suiza
Fil: Palacios, Cristina. Florida International University; Estados Unidos
Fil: Roth, Daniel E.. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Shlisky, Julie. New York Academy Of Sciences; Estados Unidos
Fil: Sudfeld, Christopher R.. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Weaver, Connie. Purdue University; Estados Unidos
Fil: Bourassa, Megan W.. New York Academy Of Sciences; Estados Unidos
Materia
CALCIUM DEFICIENCY
CALCIUM SUPPLEMENTATION
HYPERTENSIVE DISORDERS
PREECLAMPSIA
PREGNANCY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214246
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/214246
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerationsGomes, FilomenaAshorn, PerAskari, SufiaBelizan, JoseBoy, ErickCormick, GabrielaDickin, Katherine L.Driller Colangelo, Amalia R.Fawzi, WafaieHofmeyr, G. JustusHumphrey, JeanKhadilkar, AnuradhaMandlik, RubinaNeufeld, Lynnette M.Palacios, CristinaRoth, Daniel E.Shlisky, JulieSudfeld, Christopher R.Weaver, ConnieBourassa, Megan W.CALCIUM DEFICIENCYCALCIUM SUPPLEMENTATIONHYPERTENSIVE DISORDERSPREECLAMPSIAPREGNANCYhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Most low- and middle-income countries present suboptimal intakes of calcium during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where ≥25% of individuals in the population have intakes less than 800 mg calcium/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500-mg doses/day). WHO recommends 1.5–2 g/day but limited evidence suggests that less than 1 g/day may be sufficient and ongoing trials with low-dose calcium supplementation (500 mg/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost-effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron-containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food-based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.Fil: Gomes, Filomena. Universidade Nova de Lisboa. Faculdade de Ciencias Medicas.; PortugalFil: Ashorn, Per. Universidad de Tampere; FinlandiaFil: Askari, Sufia. Children's Investment Fund Foundation; Reino UnidoFil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Boy, Erick. International Food Policy Research Institute; Estados UnidosFil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Dickin, Katherine L.. Cornell University; Estados UnidosFil: Driller Colangelo, Amalia R.. Harvard University; Estados UnidosFil: Fawzi, Wafaie. Harvard University. Harvard School of Public Health; Estados UnidosFil: Hofmeyr, G. Justus. University of the Witwatersrand; SudáfricaFil: Humphrey, Jean. University Johns Hopkins; Estados UnidosFil: Khadilkar, Anuradha. Hirabai Cowasji Jehangir Medical Research Institute; IndiaFil: Mandlik, Rubina. Hirabai Cowasji Jehangir Medical Research Institute; IndiaFil: Neufeld, Lynnette M.. Global Alliance For Improved Nutrition; SuizaFil: Palacios, Cristina. Florida International University; Estados UnidosFil: Roth, Daniel E.. University Of Toronto. Hospital For Sick Children; CanadáFil: Shlisky, Julie. New York Academy Of Sciences; Estados UnidosFil: Sudfeld, Christopher R.. Harvard University. Harvard School of Public Health; Estados UnidosFil: Weaver, Connie. Purdue University; Estados UnidosFil: Bourassa, Megan W.. New York Academy Of Sciences; Estados UnidosBlackwell Publishing2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214246Gomes, Filomena; Ashorn, Per; Askari, Sufia; Belizan, Jose; Boy, Erick; et al.; Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations; Blackwell Publishing; Annals of the New York Academy of Sciences; 1510; 1; 1-2022; 52-670077-8923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/nyas.14733info:eu-repo/semantics/altIdentifier/doi/10.1111/nyas.14733info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:36Zoai:ri.conicet.gov.ar:11336/214246instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:36.368CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
title Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
spellingShingle Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
Gomes, Filomena
CALCIUM DEFICIENCY
CALCIUM SUPPLEMENTATION
HYPERTENSIVE DISORDERS
PREECLAMPSIA
PREGNANCY
title_short Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
title_full Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
title_fullStr Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
title_full_unstemmed Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
title_sort Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations
dc.creator.none.fl_str_mv Gomes, Filomena
Ashorn, Per
Askari, Sufia
Belizan, Jose
Boy, Erick
Cormick, Gabriela
Dickin, Katherine L.
Driller Colangelo, Amalia R.
Fawzi, Wafaie
Hofmeyr, G. Justus
Humphrey, Jean
Khadilkar, Anuradha
Mandlik, Rubina
Neufeld, Lynnette M.
Palacios, Cristina
Roth, Daniel E.
Shlisky, Julie
Sudfeld, Christopher R.
Weaver, Connie
Bourassa, Megan W.
author Gomes, Filomena
author_facet Gomes, Filomena
Ashorn, Per
Askari, Sufia
Belizan, Jose
Boy, Erick
Cormick, Gabriela
Dickin, Katherine L.
Driller Colangelo, Amalia R.
Fawzi, Wafaie
Hofmeyr, G. Justus
Humphrey, Jean
Khadilkar, Anuradha
Mandlik, Rubina
Neufeld, Lynnette M.
Palacios, Cristina
Roth, Daniel E.
Shlisky, Julie
Sudfeld, Christopher R.
Weaver, Connie
Bourassa, Megan W.
author_role author
author2 Ashorn, Per
Askari, Sufia
Belizan, Jose
Boy, Erick
Cormick, Gabriela
Dickin, Katherine L.
Driller Colangelo, Amalia R.
Fawzi, Wafaie
Hofmeyr, G. Justus
Humphrey, Jean
Khadilkar, Anuradha
Mandlik, Rubina
Neufeld, Lynnette M.
Palacios, Cristina
Roth, Daniel E.
Shlisky, Julie
Sudfeld, Christopher R.
Weaver, Connie
Bourassa, Megan W.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CALCIUM DEFICIENCY
CALCIUM SUPPLEMENTATION
HYPERTENSIVE DISORDERS
PREECLAMPSIA
PREGNANCY
topic CALCIUM DEFICIENCY
CALCIUM SUPPLEMENTATION
HYPERTENSIVE DISORDERS
PREECLAMPSIA
PREGNANCY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Most low- and middle-income countries present suboptimal intakes of calcium during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where ≥25% of individuals in the population have intakes less than 800 mg calcium/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500-mg doses/day). WHO recommends 1.5–2 g/day but limited evidence suggests that less than 1 g/day may be sufficient and ongoing trials with low-dose calcium supplementation (500 mg/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost-effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron-containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food-based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.
Fil: Gomes, Filomena. Universidade Nova de Lisboa. Faculdade de Ciencias Medicas.; Portugal
Fil: Ashorn, Per. Universidad de Tampere; Finlandia
Fil: Askari, Sufia. Children's Investment Fund Foundation; Reino Unido
Fil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Boy, Erick. International Food Policy Research Institute; Estados Unidos
Fil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Dickin, Katherine L.. Cornell University; Estados Unidos
Fil: Driller Colangelo, Amalia R.. Harvard University; Estados Unidos
Fil: Fawzi, Wafaie. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Hofmeyr, G. Justus. University of the Witwatersrand; Sudáfrica
Fil: Humphrey, Jean. University Johns Hopkins; Estados Unidos
Fil: Khadilkar, Anuradha. Hirabai Cowasji Jehangir Medical Research Institute; India
Fil: Mandlik, Rubina. Hirabai Cowasji Jehangir Medical Research Institute; India
Fil: Neufeld, Lynnette M.. Global Alliance For Improved Nutrition; Suiza
Fil: Palacios, Cristina. Florida International University; Estados Unidos
Fil: Roth, Daniel E.. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Shlisky, Julie. New York Academy Of Sciences; Estados Unidos
Fil: Sudfeld, Christopher R.. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Weaver, Connie. Purdue University; Estados Unidos
Fil: Bourassa, Megan W.. New York Academy Of Sciences; Estados Unidos
description Most low- and middle-income countries present suboptimal intakes of calcium during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where ≥25% of individuals in the population have intakes less than 800 mg calcium/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500-mg doses/day). WHO recommends 1.5–2 g/day but limited evidence suggests that less than 1 g/day may be sufficient and ongoing trials with low-dose calcium supplementation (500 mg/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost-effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron-containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food-based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.
publishDate 2022
dc.date.none.fl_str_mv 2022-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214246
Gomes, Filomena; Ashorn, Per; Askari, Sufia; Belizan, Jose; Boy, Erick; et al.; Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations; Blackwell Publishing; Annals of the New York Academy of Sciences; 1510; 1; 1-2022; 52-67
0077-8923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214246
identifier_str_mv Gomes, Filomena; Ashorn, Per; Askari, Sufia; Belizan, Jose; Boy, Erick; et al.; Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations; Blackwell Publishing; Annals of the New York Academy of Sciences; 1510; 1; 1-2022; 52-67
0077-8923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/nyas.14733
info:eu-repo/semantics/altIdentifier/doi/10.1111/nyas.14733
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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