Immunity and vaccine development efforts against Trypanosoma cruzi

Autores
Rios, Lizette E.; Vázquez Chagoyán, Juan Carlos; Pacheco, Antonio Ortega; Zago, María Paola; Garg, Nisha J.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.
Fil: Rios, Lizette E.. University of Texas Medical Branch; Estados Unidos
Fil: Vázquez Chagoyán, Juan Carlos. Universidad Autónoma del Estado de México; México
Fil: Pacheco, Antonio Ortega. Universidad Autónoma de Yucatán; México
Fil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Garg, Nisha J.. University of Texas Medical Branch; Estados Unidos
Materia
ADJUVANTS
CHAGAS
IMMUNITY
PROPHYLACTIC
THERAPEUTIC
VACCINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/116983
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Immunity and vaccine development efforts against Trypanosoma cruziRios, Lizette E.Vázquez Chagoyán, Juan CarlosPacheco, Antonio OrtegaZago, María PaolaGarg, Nisha J.ADJUVANTSCHAGASIMMUNITYPROPHYLACTICTHERAPEUTICVACCINEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.Fil: Rios, Lizette E.. University of Texas Medical Branch; Estados UnidosFil: Vázquez Chagoyán, Juan Carlos. Universidad Autónoma del Estado de México; MéxicoFil: Pacheco, Antonio Ortega. Universidad Autónoma de Yucatán; MéxicoFil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Garg, Nisha J.. University of Texas Medical Branch; Estados UnidosElsevier Science2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/116983Rios, Lizette E.; Vázquez Chagoyán, Juan Carlos; Pacheco, Antonio Ortega; Zago, María Paola; Garg, Nisha J.; Immunity and vaccine development efforts against Trypanosoma cruzi; Elsevier Science; Acta Tropica; 200; 105168; 12-2019; 1-110001-706XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.actatropica.2019.105168info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0001706X19303572info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:34Zoai:ri.conicet.gov.ar:11336/116983instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:34.619CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunity and vaccine development efforts against Trypanosoma cruzi
title Immunity and vaccine development efforts against Trypanosoma cruzi
spellingShingle Immunity and vaccine development efforts against Trypanosoma cruzi
Rios, Lizette E.
ADJUVANTS
CHAGAS
IMMUNITY
PROPHYLACTIC
THERAPEUTIC
VACCINE
title_short Immunity and vaccine development efforts against Trypanosoma cruzi
title_full Immunity and vaccine development efforts against Trypanosoma cruzi
title_fullStr Immunity and vaccine development efforts against Trypanosoma cruzi
title_full_unstemmed Immunity and vaccine development efforts against Trypanosoma cruzi
title_sort Immunity and vaccine development efforts against Trypanosoma cruzi
dc.creator.none.fl_str_mv Rios, Lizette E.
Vázquez Chagoyán, Juan Carlos
Pacheco, Antonio Ortega
Zago, María Paola
Garg, Nisha J.
author Rios, Lizette E.
author_facet Rios, Lizette E.
Vázquez Chagoyán, Juan Carlos
Pacheco, Antonio Ortega
Zago, María Paola
Garg, Nisha J.
author_role author
author2 Vázquez Chagoyán, Juan Carlos
Pacheco, Antonio Ortega
Zago, María Paola
Garg, Nisha J.
author2_role author
author
author
author
dc.subject.none.fl_str_mv ADJUVANTS
CHAGAS
IMMUNITY
PROPHYLACTIC
THERAPEUTIC
VACCINE
topic ADJUVANTS
CHAGAS
IMMUNITY
PROPHYLACTIC
THERAPEUTIC
VACCINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.
Fil: Rios, Lizette E.. University of Texas Medical Branch; Estados Unidos
Fil: Vázquez Chagoyán, Juan Carlos. Universidad Autónoma del Estado de México; México
Fil: Pacheco, Antonio Ortega. Universidad Autónoma de Yucatán; México
Fil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Garg, Nisha J.. University of Texas Medical Branch; Estados Unidos
description Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/116983
Rios, Lizette E.; Vázquez Chagoyán, Juan Carlos; Pacheco, Antonio Ortega; Zago, María Paola; Garg, Nisha J.; Immunity and vaccine development efforts against Trypanosoma cruzi; Elsevier Science; Acta Tropica; 200; 105168; 12-2019; 1-11
0001-706X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/116983
identifier_str_mv Rios, Lizette E.; Vázquez Chagoyán, Juan Carlos; Pacheco, Antonio Ortega; Zago, María Paola; Garg, Nisha J.; Immunity and vaccine development efforts against Trypanosoma cruzi; Elsevier Science; Acta Tropica; 200; 105168; 12-2019; 1-11
0001-706X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actatropica.2019.105168
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0001706X19303572
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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