Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development

Autores
Costa Oliveira, Sergio; Costa Macedo, Gilson; de Almeida, Leonardo Augusto; Souza de Oliveira, Fernanda; Oñate, Angel; Cassataro, Juliana; Giambartolomei, Guillermo Hernan
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in cattle and undulant fever, arthritis, endocarditis and meningitis in human. The immune response against B. abortus involves innate and adaptive immunity involving antigen-presenting cells, NK cells and CD4+ and CD8+ T cells. IFN- is a crucial immune component that results from Brucella recognition by host immune receptors such as Toll-like receptors (TLRs) that lead to IL-12 production. Although great efforts to elucidate immunity against Brucella have been employed, the subset of cells and factors involved in host immune response remains not completely understood. Our group and others have been working in an attempt to understand the mechanisms involved in innate responses to Brucella. Understanding the requirements for immune protection can help the design of alternative vaccines that would avoid the drawbacks of currently available vaccines to Brucella. This review discusses recent studies in host immunity to Brucella and new approaches for vaccine development.
Fil: Costa Oliveira, Sergio. Universidade Federal de Minas Gerais; Brasil
Fil: Costa Macedo, Gilson. Universidade Federal de Minas Gerais; Brasil
Fil: de Almeida, Leonardo Augusto. Universidade Federal de Minas Gerais; Brasil
Fil: Souza de Oliveira, Fernanda. Universidade Federal de Minas Gerais; Brasil
Fil: Oñate, Angel. Universidad de Concepción; Chile
Fil: Cassataro, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Giambartolomei, Guillermo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Materia
Brucellosis
Immunity
Proteins
VAccine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67628

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network_name_str CONICET Digital (CONICET)
spelling Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine DevelopmentCosta Oliveira, SergioCosta Macedo, Gilsonde Almeida, Leonardo AugustoSouza de Oliveira, FernandaOñate, AngelCassataro, JulianaGiambartolomei, Guillermo HernanBrucellosisImmunityProteinsVAccinehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in cattle and undulant fever, arthritis, endocarditis and meningitis in human. The immune response against B. abortus involves innate and adaptive immunity involving antigen-presenting cells, NK cells and CD4+ and CD8+ T cells. IFN- is a crucial immune component that results from Brucella recognition by host immune receptors such as Toll-like receptors (TLRs) that lead to IL-12 production. Although great efforts to elucidate immunity against Brucella have been employed, the subset of cells and factors involved in host immune response remains not completely understood. Our group and others have been working in an attempt to understand the mechanisms involved in innate responses to Brucella. Understanding the requirements for immune protection can help the design of alternative vaccines that would avoid the drawbacks of currently available vaccines to Brucella. This review discusses recent studies in host immunity to Brucella and new approaches for vaccine development.Fil: Costa Oliveira, Sergio. Universidade Federal de Minas Gerais; BrasilFil: Costa Macedo, Gilson. Universidade Federal de Minas Gerais; BrasilFil: de Almeida, Leonardo Augusto. Universidade Federal de Minas Gerais; BrasilFil: Souza de Oliveira, Fernanda. Universidade Federal de Minas Gerais; BrasilFil: Oñate, Angel. Universidad de Concepción; ChileFil: Cassataro, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Giambartolomei, Guillermo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaBentham Science Publishers2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67628Costa Oliveira, Sergio; Costa Macedo, Gilson; de Almeida, Leonardo Augusto; Souza de Oliveira, Fernanda; Oñate, Angel; et al.; Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development; Bentham Science Publishers; The Open Veterinary Science Journal; 4; 1; 5-2010; 102-1081874-3188CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1874318801004010102info:eu-repo/semantics/altIdentifier/url/https://benthamopen.com/ABSTRACT/TOVSJ-4-102info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:13Zoai:ri.conicet.gov.ar:11336/67628instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:13.295CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
title Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
spellingShingle Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
Costa Oliveira, Sergio
Brucellosis
Immunity
Proteins
VAccine
title_short Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
title_full Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
title_fullStr Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
title_full_unstemmed Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
title_sort Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
dc.creator.none.fl_str_mv Costa Oliveira, Sergio
Costa Macedo, Gilson
de Almeida, Leonardo Augusto
Souza de Oliveira, Fernanda
Oñate, Angel
Cassataro, Juliana
Giambartolomei, Guillermo Hernan
author Costa Oliveira, Sergio
author_facet Costa Oliveira, Sergio
Costa Macedo, Gilson
de Almeida, Leonardo Augusto
Souza de Oliveira, Fernanda
Oñate, Angel
Cassataro, Juliana
Giambartolomei, Guillermo Hernan
author_role author
author2 Costa Macedo, Gilson
de Almeida, Leonardo Augusto
Souza de Oliveira, Fernanda
Oñate, Angel
Cassataro, Juliana
Giambartolomei, Guillermo Hernan
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Brucellosis
Immunity
Proteins
VAccine
topic Brucellosis
Immunity
Proteins
VAccine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in cattle and undulant fever, arthritis, endocarditis and meningitis in human. The immune response against B. abortus involves innate and adaptive immunity involving antigen-presenting cells, NK cells and CD4+ and CD8+ T cells. IFN- is a crucial immune component that results from Brucella recognition by host immune receptors such as Toll-like receptors (TLRs) that lead to IL-12 production. Although great efforts to elucidate immunity against Brucella have been employed, the subset of cells and factors involved in host immune response remains not completely understood. Our group and others have been working in an attempt to understand the mechanisms involved in innate responses to Brucella. Understanding the requirements for immune protection can help the design of alternative vaccines that would avoid the drawbacks of currently available vaccines to Brucella. This review discusses recent studies in host immunity to Brucella and new approaches for vaccine development.
Fil: Costa Oliveira, Sergio. Universidade Federal de Minas Gerais; Brasil
Fil: Costa Macedo, Gilson. Universidade Federal de Minas Gerais; Brasil
Fil: de Almeida, Leonardo Augusto. Universidade Federal de Minas Gerais; Brasil
Fil: Souza de Oliveira, Fernanda. Universidade Federal de Minas Gerais; Brasil
Fil: Oñate, Angel. Universidad de Concepción; Chile
Fil: Cassataro, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Giambartolomei, Guillermo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
description Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in cattle and undulant fever, arthritis, endocarditis and meningitis in human. The immune response against B. abortus involves innate and adaptive immunity involving antigen-presenting cells, NK cells and CD4+ and CD8+ T cells. IFN- is a crucial immune component that results from Brucella recognition by host immune receptors such as Toll-like receptors (TLRs) that lead to IL-12 production. Although great efforts to elucidate immunity against Brucella have been employed, the subset of cells and factors involved in host immune response remains not completely understood. Our group and others have been working in an attempt to understand the mechanisms involved in innate responses to Brucella. Understanding the requirements for immune protection can help the design of alternative vaccines that would avoid the drawbacks of currently available vaccines to Brucella. This review discusses recent studies in host immunity to Brucella and new approaches for vaccine development.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67628
Costa Oliveira, Sergio; Costa Macedo, Gilson; de Almeida, Leonardo Augusto; Souza de Oliveira, Fernanda; Oñate, Angel; et al.; Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development; Bentham Science Publishers; The Open Veterinary Science Journal; 4; 1; 5-2010; 102-108
1874-3188
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67628
identifier_str_mv Costa Oliveira, Sergio; Costa Macedo, Gilson; de Almeida, Leonardo Augusto; Souza de Oliveira, Fernanda; Oñate, Angel; et al.; Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development; Bentham Science Publishers; The Open Veterinary Science Journal; 4; 1; 5-2010; 102-108
1874-3188
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/1874318801004010102
info:eu-repo/semantics/altIdentifier/url/https://benthamopen.com/ABSTRACT/TOVSJ-4-102
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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