Efficacy of a cognitive intervention program in patients with mild cognitive impairment

Autores
Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; Herrera, Jorge A.; Allegri, Ricardo Francisco
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up.
Fil: Rojas, Galeno J.. Hospital Británico de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Villar, Veronica. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Iturry, Mónica Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Harris, Paula. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Serrano, Cecilia Mariela. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Herrera, Jorge A.. Neurobehavioral Institute of Miami; Estados Unidos
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Materia
COGNITIVE INTERVENTION
COGNITIVE STRATEGIES
COGNITIVE TRAINING
CONTROLLED TRIAL
MILD COGNITIVE IMPAIRMENT
PLACEBO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/188949
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Efficacy of a cognitive intervention program in patients with mild cognitive impairmentRojas, Galeno J.Villar, VeronicaIturry, Mónica LilianaHarris, PaulaSerrano, Cecilia MarielaHerrera, Jorge A.Allegri, Ricardo FranciscoCOGNITIVE INTERVENTIONCOGNITIVE STRATEGIESCOGNITIVE TRAININGCONTROLLED TRIALMILD COGNITIVE IMPAIRMENTPLACEBOhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up.Fil: Rojas, Galeno J.. Hospital Británico de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Villar, Veronica. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Iturry, Mónica Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Harris, Paula. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Serrano, Cecilia Mariela. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Herrera, Jorge A.. Neurobehavioral Institute of Miami; Estados UnidosFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaCambridge University Press2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188949Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; et al.; Efficacy of a cognitive intervention program in patients with mild cognitive impairment; Cambridge University Press; International Psychogeriatrics / Ipa.; 25; 5; 12-2012; 825-8311041-6102CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/international-psychogeriatrics/article/abs/efficacy-of-a-cognitive-intervention-program-in-patients-with-mild-cognitive-impairment/FA3B1F2110F8529958E2C94A6262ADA0info:eu-repo/semantics/altIdentifier/doi/10.1017/S1041610213000045info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:49:55Zoai:ri.conicet.gov.ar:11336/188949instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:49:56.144CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy of a cognitive intervention program in patients with mild cognitive impairment
title Efficacy of a cognitive intervention program in patients with mild cognitive impairment
spellingShingle Efficacy of a cognitive intervention program in patients with mild cognitive impairment
Rojas, Galeno J.
COGNITIVE INTERVENTION
COGNITIVE STRATEGIES
COGNITIVE TRAINING
CONTROLLED TRIAL
MILD COGNITIVE IMPAIRMENT
PLACEBO
title_short Efficacy of a cognitive intervention program in patients with mild cognitive impairment
title_full Efficacy of a cognitive intervention program in patients with mild cognitive impairment
title_fullStr Efficacy of a cognitive intervention program in patients with mild cognitive impairment
title_full_unstemmed Efficacy of a cognitive intervention program in patients with mild cognitive impairment
title_sort Efficacy of a cognitive intervention program in patients with mild cognitive impairment
dc.creator.none.fl_str_mv Rojas, Galeno J.
Villar, Veronica
Iturry, Mónica Liliana
Harris, Paula
Serrano, Cecilia Mariela
Herrera, Jorge A.
Allegri, Ricardo Francisco
author Rojas, Galeno J.
author_facet Rojas, Galeno J.
Villar, Veronica
Iturry, Mónica Liliana
Harris, Paula
Serrano, Cecilia Mariela
Herrera, Jorge A.
Allegri, Ricardo Francisco
author_role author
author2 Villar, Veronica
Iturry, Mónica Liliana
Harris, Paula
Serrano, Cecilia Mariela
Herrera, Jorge A.
Allegri, Ricardo Francisco
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv COGNITIVE INTERVENTION
COGNITIVE STRATEGIES
COGNITIVE TRAINING
CONTROLLED TRIAL
MILD COGNITIVE IMPAIRMENT
PLACEBO
topic COGNITIVE INTERVENTION
COGNITIVE STRATEGIES
COGNITIVE TRAINING
CONTROLLED TRIAL
MILD COGNITIVE IMPAIRMENT
PLACEBO
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up.
Fil: Rojas, Galeno J.. Hospital Británico de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Villar, Veronica. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Iturry, Mónica Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Harris, Paula. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Serrano, Cecilia Mariela. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Herrera, Jorge A.. Neurobehavioral Institute of Miami; Estados Unidos
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
description Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/188949
Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; et al.; Efficacy of a cognitive intervention program in patients with mild cognitive impairment; Cambridge University Press; International Psychogeriatrics / Ipa.; 25; 5; 12-2012; 825-831
1041-6102
CONICET Digital
CONICET
url http://hdl.handle.net/11336/188949
identifier_str_mv Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; et al.; Efficacy of a cognitive intervention program in patients with mild cognitive impairment; Cambridge University Press; International Psychogeriatrics / Ipa.; 25; 5; 12-2012; 825-831
1041-6102
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/international-psychogeriatrics/article/abs/efficacy-of-a-cognitive-intervention-program-in-patients-with-mild-cognitive-impairment/FA3B1F2110F8529958E2C94A6262ADA0
info:eu-repo/semantics/altIdentifier/doi/10.1017/S1041610213000045
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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