Efficacy of a cognitive intervention program in patients with mild cognitive impairment
- Autores
- Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; Herrera, Jorge A.; Allegri, Ricardo Francisco
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up.
Fil: Rojas, Galeno J.. Hospital Británico de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Villar, Veronica. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Iturry, Mónica Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Harris, Paula. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Serrano, Cecilia Mariela. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina
Fil: Herrera, Jorge A.. Neurobehavioral Institute of Miami; Estados Unidos
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina - Materia
-
COGNITIVE INTERVENTION
COGNITIVE STRATEGIES
COGNITIVE TRAINING
CONTROLLED TRIAL
MILD COGNITIVE IMPAIRMENT
PLACEBO - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/188949
Ver los metadatos del registro completo
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Efficacy of a cognitive intervention program in patients with mild cognitive impairmentRojas, Galeno J.Villar, VeronicaIturry, Mónica LilianaHarris, PaulaSerrano, Cecilia MarielaHerrera, Jorge A.Allegri, Ricardo FranciscoCOGNITIVE INTERVENTIONCOGNITIVE STRATEGIESCOGNITIVE TRAININGCONTROLLED TRIALMILD COGNITIVE IMPAIRMENTPLACEBOhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up.Fil: Rojas, Galeno J.. Hospital Británico de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Villar, Veronica. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Iturry, Mónica Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Harris, Paula. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Serrano, Cecilia Mariela. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaFil: Herrera, Jorge A.. Neurobehavioral Institute of Miami; Estados UnidosFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; ArgentinaCambridge University Press2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188949Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; et al.; Efficacy of a cognitive intervention program in patients with mild cognitive impairment; Cambridge University Press; International Psychogeriatrics / Ipa.; 25; 5; 12-2012; 825-8311041-6102CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/international-psychogeriatrics/article/abs/efficacy-of-a-cognitive-intervention-program-in-patients-with-mild-cognitive-impairment/FA3B1F2110F8529958E2C94A6262ADA0info:eu-repo/semantics/altIdentifier/doi/10.1017/S1041610213000045info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:05Zoai:ri.conicet.gov.ar:11336/188949instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:05.91CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment |
title |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment |
spellingShingle |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment Rojas, Galeno J. COGNITIVE INTERVENTION COGNITIVE STRATEGIES COGNITIVE TRAINING CONTROLLED TRIAL MILD COGNITIVE IMPAIRMENT PLACEBO |
title_short |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment |
title_full |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment |
title_fullStr |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment |
title_full_unstemmed |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment |
title_sort |
Efficacy of a cognitive intervention program in patients with mild cognitive impairment |
dc.creator.none.fl_str_mv |
Rojas, Galeno J. Villar, Veronica Iturry, Mónica Liliana Harris, Paula Serrano, Cecilia Mariela Herrera, Jorge A. Allegri, Ricardo Francisco |
author |
Rojas, Galeno J. |
author_facet |
Rojas, Galeno J. Villar, Veronica Iturry, Mónica Liliana Harris, Paula Serrano, Cecilia Mariela Herrera, Jorge A. Allegri, Ricardo Francisco |
author_role |
author |
author2 |
Villar, Veronica Iturry, Mónica Liliana Harris, Paula Serrano, Cecilia Mariela Herrera, Jorge A. Allegri, Ricardo Francisco |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
COGNITIVE INTERVENTION COGNITIVE STRATEGIES COGNITIVE TRAINING CONTROLLED TRIAL MILD COGNITIVE IMPAIRMENT PLACEBO |
topic |
COGNITIVE INTERVENTION COGNITIVE STRATEGIES COGNITIVE TRAINING CONTROLLED TRIAL MILD COGNITIVE IMPAIRMENT PLACEBO |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up. Fil: Rojas, Galeno J.. Hospital Británico de Buenos Aires; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina Fil: Villar, Veronica. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina Fil: Iturry, Mónica Liliana. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina Fil: Harris, Paula. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Serrano, Cecilia Mariela. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina Fil: Herrera, Jorge A.. Neurobehavioral Institute of Miami; Estados Unidos Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina |
description |
Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up. Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the trained group) underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year. Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up. Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/188949 Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; et al.; Efficacy of a cognitive intervention program in patients with mild cognitive impairment; Cambridge University Press; International Psychogeriatrics / Ipa.; 25; 5; 12-2012; 825-831 1041-6102 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/188949 |
identifier_str_mv |
Rojas, Galeno J.; Villar, Veronica; Iturry, Mónica Liliana; Harris, Paula; Serrano, Cecilia Mariela; et al.; Efficacy of a cognitive intervention program in patients with mild cognitive impairment; Cambridge University Press; International Psychogeriatrics / Ipa.; 25; 5; 12-2012; 825-831 1041-6102 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/international-psychogeriatrics/article/abs/efficacy-of-a-cognitive-intervention-program-in-patients-with-mild-cognitive-impairment/FA3B1F2110F8529958E2C94A6262ADA0 info:eu-repo/semantics/altIdentifier/doi/10.1017/S1041610213000045 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Cambridge University Press |
publisher.none.fl_str_mv |
Cambridge University Press |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |