Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
- Autores
- Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; Guinjoan, Salvador Martín; Adjouadi, Malek; Peñate, Ailyn; Barker, William W.; Goenaga, Sindy; Golde, Todd; Greig Custo, Maria T.; Hanson, Kevin S.; Li, Chunfei; Lizarraga, Gabriel; Marsiske, Michael; Duara, Ranjan
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.
Fil: Loewenstein, David A.. University of Miami; Estados Unidos
Fil: Curiel, Rosie E.. University of Miami; Estados Unidos
Fil: DeKosky, Steven. University of Miami; Estados Unidos
Fil: Bauer, Russell M.. University of Miami; Estados Unidos
Fil: Rosselli, Monica. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Adjouadi, Malek. University of Miami; Estados Unidos
Fil: Peñate, Ailyn. University of Miami; Estados Unidos
Fil: Barker, William W.. University of Miami; Estados Unidos
Fil: Goenaga, Sindy. University of Miami; Estados Unidos
Fil: Golde, Todd. University of Miami; Estados Unidos
Fil: Greig Custo, Maria T.. University of Miami; Estados Unidos
Fil: Hanson, Kevin S.. University of Miami; Estados Unidos
Fil: Li, Chunfei. University of Miami; Estados Unidos
Fil: Lizarraga, Gabriel. University of Miami; Estados Unidos
Fil: Marsiske, Michael. University of Miami; Estados Unidos
Fil: Duara, Ranjan. University of Miami; Estados Unidos - Materia
-
Alzheimer´s disease
Mild cognitive impairment
Amyloid - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/136905
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/136905 |
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Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairmentLoewenstein, David A.Curiel, Rosie E.DeKosky, StevenBauer, Russell M.Rosselli, MonicaGuinjoan, Salvador MartínAdjouadi, MalekPeñate, AilynBarker, William W.Goenaga, SindyGolde, ToddGreig Custo, Maria T.Hanson, Kevin S.Li, ChunfeiLizarraga, GabrielMarsiske, MichaelDuara, RanjanAlzheimer´s diseaseMild cognitive impairmentAmyloidhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.Fil: Loewenstein, David A.. University of Miami; Estados UnidosFil: Curiel, Rosie E.. University of Miami; Estados UnidosFil: DeKosky, Steven. University of Miami; Estados UnidosFil: Bauer, Russell M.. University of Miami; Estados UnidosFil: Rosselli, Monica. University of Miami; Estados UnidosFil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Adjouadi, Malek. University of Miami; Estados UnidosFil: Peñate, Ailyn. University of Miami; Estados UnidosFil: Barker, William W.. University of Miami; Estados UnidosFil: Goenaga, Sindy. University of Miami; Estados UnidosFil: Golde, Todd. University of Miami; Estados UnidosFil: Greig Custo, Maria T.. University of Miami; Estados UnidosFil: Hanson, Kevin S.. University of Miami; Estados UnidosFil: Li, Chunfei. University of Miami; Estados UnidosFil: Lizarraga, Gabriel. University of Miami; Estados UnidosFil: Marsiske, Michael. University of Miami; Estados UnidosFil: Duara, Ranjan. University of Miami; Estados UnidosLippincott Williams2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136905Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; et al.; Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment; Lippincott Williams; Neurology; 91; 10; 9-2018; E976-E9840028-3878CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1212/WNL.0000000000006128info:eu-repo/semantics/altIdentifier/url/https://n.neurology.org/content/91/10/e976info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:13Zoai:ri.conicet.gov.ar:11336/136905instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:13.576CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment |
title |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment |
spellingShingle |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment Loewenstein, David A. Alzheimer´s disease Mild cognitive impairment Amyloid |
title_short |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment |
title_full |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment |
title_fullStr |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment |
title_full_unstemmed |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment |
title_sort |
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment |
dc.creator.none.fl_str_mv |
Loewenstein, David A. Curiel, Rosie E. DeKosky, Steven Bauer, Russell M. Rosselli, Monica Guinjoan, Salvador Martín Adjouadi, Malek Peñate, Ailyn Barker, William W. Goenaga, Sindy Golde, Todd Greig Custo, Maria T. Hanson, Kevin S. Li, Chunfei Lizarraga, Gabriel Marsiske, Michael Duara, Ranjan |
author |
Loewenstein, David A. |
author_facet |
Loewenstein, David A. Curiel, Rosie E. DeKosky, Steven Bauer, Russell M. Rosselli, Monica Guinjoan, Salvador Martín Adjouadi, Malek Peñate, Ailyn Barker, William W. Goenaga, Sindy Golde, Todd Greig Custo, Maria T. Hanson, Kevin S. Li, Chunfei Lizarraga, Gabriel Marsiske, Michael Duara, Ranjan |
author_role |
author |
author2 |
Curiel, Rosie E. DeKosky, Steven Bauer, Russell M. Rosselli, Monica Guinjoan, Salvador Martín Adjouadi, Malek Peñate, Ailyn Barker, William W. Goenaga, Sindy Golde, Todd Greig Custo, Maria T. Hanson, Kevin S. Li, Chunfei Lizarraga, Gabriel Marsiske, Michael Duara, Ranjan |
author2_role |
author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Alzheimer´s disease Mild cognitive impairment Amyloid |
topic |
Alzheimer´s disease Mild cognitive impairment Amyloid |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP. Fil: Loewenstein, David A.. University of Miami; Estados Unidos Fil: Curiel, Rosie E.. University of Miami; Estados Unidos Fil: DeKosky, Steven. University of Miami; Estados Unidos Fil: Bauer, Russell M.. University of Miami; Estados Unidos Fil: Rosselli, Monica. University of Miami; Estados Unidos Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Adjouadi, Malek. University of Miami; Estados Unidos Fil: Peñate, Ailyn. University of Miami; Estados Unidos Fil: Barker, William W.. University of Miami; Estados Unidos Fil: Goenaga, Sindy. University of Miami; Estados Unidos Fil: Golde, Todd. University of Miami; Estados Unidos Fil: Greig Custo, Maria T.. University of Miami; Estados Unidos Fil: Hanson, Kevin S.. University of Miami; Estados Unidos Fil: Li, Chunfei. University of Miami; Estados Unidos Fil: Lizarraga, Gabriel. University of Miami; Estados Unidos Fil: Marsiske, Michael. University of Miami; Estados Unidos Fil: Duara, Ranjan. University of Miami; Estados Unidos |
description |
Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/136905 Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; et al.; Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment; Lippincott Williams; Neurology; 91; 10; 9-2018; E976-E984 0028-3878 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/136905 |
identifier_str_mv |
Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; et al.; Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment; Lippincott Williams; Neurology; 91; 10; 9-2018; E976-E984 0028-3878 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1212/WNL.0000000000006128 info:eu-repo/semantics/altIdentifier/url/https://n.neurology.org/content/91/10/e976 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Lippincott Williams |
publisher.none.fl_str_mv |
Lippincott Williams |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269391773761536 |
score |
13.13397 |