Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment

Autores
Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; Guinjoan, Salvador Martín; Adjouadi, Malek; Peñate, Ailyn; Barker, William W.; Goenaga, Sindy; Golde, Todd; Greig Custo, Maria T.; Hanson, Kevin S.; Li, Chunfei; Lizarraga, Gabriel; Marsiske, Michael; Duara, Ranjan
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.
Fil: Loewenstein, David A.. University of Miami; Estados Unidos
Fil: Curiel, Rosie E.. University of Miami; Estados Unidos
Fil: DeKosky, Steven. University of Miami; Estados Unidos
Fil: Bauer, Russell M.. University of Miami; Estados Unidos
Fil: Rosselli, Monica. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Adjouadi, Malek. University of Miami; Estados Unidos
Fil: Peñate, Ailyn. University of Miami; Estados Unidos
Fil: Barker, William W.. University of Miami; Estados Unidos
Fil: Goenaga, Sindy. University of Miami; Estados Unidos
Fil: Golde, Todd. University of Miami; Estados Unidos
Fil: Greig Custo, Maria T.. University of Miami; Estados Unidos
Fil: Hanson, Kevin S.. University of Miami; Estados Unidos
Fil: Li, Chunfei. University of Miami; Estados Unidos
Fil: Lizarraga, Gabriel. University of Miami; Estados Unidos
Fil: Marsiske, Michael. University of Miami; Estados Unidos
Fil: Duara, Ranjan. University of Miami; Estados Unidos
Materia
Alzheimer´s disease
Mild cognitive impairment
Amyloid
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/136905

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oai_identifier_str oai:ri.conicet.gov.ar:11336/136905
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairmentLoewenstein, David A.Curiel, Rosie E.DeKosky, StevenBauer, Russell M.Rosselli, MonicaGuinjoan, Salvador MartínAdjouadi, MalekPeñate, AilynBarker, William W.Goenaga, SindyGolde, ToddGreig Custo, Maria T.Hanson, Kevin S.Li, ChunfeiLizarraga, GabrielMarsiske, MichaelDuara, RanjanAlzheimer´s diseaseMild cognitive impairmentAmyloidhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.Fil: Loewenstein, David A.. University of Miami; Estados UnidosFil: Curiel, Rosie E.. University of Miami; Estados UnidosFil: DeKosky, Steven. University of Miami; Estados UnidosFil: Bauer, Russell M.. University of Miami; Estados UnidosFil: Rosselli, Monica. University of Miami; Estados UnidosFil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Adjouadi, Malek. University of Miami; Estados UnidosFil: Peñate, Ailyn. University of Miami; Estados UnidosFil: Barker, William W.. University of Miami; Estados UnidosFil: Goenaga, Sindy. University of Miami; Estados UnidosFil: Golde, Todd. University of Miami; Estados UnidosFil: Greig Custo, Maria T.. University of Miami; Estados UnidosFil: Hanson, Kevin S.. University of Miami; Estados UnidosFil: Li, Chunfei. University of Miami; Estados UnidosFil: Lizarraga, Gabriel. University of Miami; Estados UnidosFil: Marsiske, Michael. University of Miami; Estados UnidosFil: Duara, Ranjan. University of Miami; Estados UnidosLippincott Williams2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136905Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; et al.; Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment; Lippincott Williams; Neurology; 91; 10; 9-2018; E976-E9840028-3878CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1212/WNL.0000000000006128info:eu-repo/semantics/altIdentifier/url/https://n.neurology.org/content/91/10/e976info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:13Zoai:ri.conicet.gov.ar:11336/136905instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:13.576CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
title Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
spellingShingle Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
Loewenstein, David A.
Alzheimer´s disease
Mild cognitive impairment
Amyloid
title_short Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
title_full Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
title_fullStr Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
title_full_unstemmed Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
title_sort Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
dc.creator.none.fl_str_mv Loewenstein, David A.
Curiel, Rosie E.
DeKosky, Steven
Bauer, Russell M.
Rosselli, Monica
Guinjoan, Salvador Martín
Adjouadi, Malek
Peñate, Ailyn
Barker, William W.
Goenaga, Sindy
Golde, Todd
Greig Custo, Maria T.
Hanson, Kevin S.
Li, Chunfei
Lizarraga, Gabriel
Marsiske, Michael
Duara, Ranjan
author Loewenstein, David A.
author_facet Loewenstein, David A.
Curiel, Rosie E.
DeKosky, Steven
Bauer, Russell M.
Rosselli, Monica
Guinjoan, Salvador Martín
Adjouadi, Malek
Peñate, Ailyn
Barker, William W.
Goenaga, Sindy
Golde, Todd
Greig Custo, Maria T.
Hanson, Kevin S.
Li, Chunfei
Lizarraga, Gabriel
Marsiske, Michael
Duara, Ranjan
author_role author
author2 Curiel, Rosie E.
DeKosky, Steven
Bauer, Russell M.
Rosselli, Monica
Guinjoan, Salvador Martín
Adjouadi, Malek
Peñate, Ailyn
Barker, William W.
Goenaga, Sindy
Golde, Todd
Greig Custo, Maria T.
Hanson, Kevin S.
Li, Chunfei
Lizarraga, Gabriel
Marsiske, Michael
Duara, Ranjan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer´s disease
Mild cognitive impairment
Amyloid
topic Alzheimer´s disease
Mild cognitive impairment
Amyloid
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.
Fil: Loewenstein, David A.. University of Miami; Estados Unidos
Fil: Curiel, Rosie E.. University of Miami; Estados Unidos
Fil: DeKosky, Steven. University of Miami; Estados Unidos
Fil: Bauer, Russell M.. University of Miami; Estados Unidos
Fil: Rosselli, Monica. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Salud Mental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Adjouadi, Malek. University of Miami; Estados Unidos
Fil: Peñate, Ailyn. University of Miami; Estados Unidos
Fil: Barker, William W.. University of Miami; Estados Unidos
Fil: Goenaga, Sindy. University of Miami; Estados Unidos
Fil: Golde, Todd. University of Miami; Estados Unidos
Fil: Greig Custo, Maria T.. University of Miami; Estados Unidos
Fil: Hanson, Kevin S.. University of Miami; Estados Unidos
Fil: Li, Chunfei. University of Miami; Estados Unidos
Fil: Lizarraga, Gabriel. University of Miami; Estados Unidos
Fil: Marsiske, Michael. University of Miami; Estados Unidos
Fil: Duara, Ranjan. University of Miami; Estados Unidos
description Objective Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition. Methods Eighty-eight participants with aMCI underwent brain amyloid PET and MRI scans and were classified as early AD (Amy+), SNAP (Amy−), or other neurological/psychiatric diagnosis (Amy−). We focused on SI on the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) targeting proactive semantic interference (PSI; old semantic learning interferes with new semantic learning), failure to recover from PSI after an additional learning trial (frPSI), and retroactive semantic interference (new semantic learning interferes with memory for old semantic learning). Results SIs on measures of PSI and frPSI distinguished between Amy+ AD and SNAP and other non-AD cases. PSI and frPSI intrusions evidenced moderately high associations with reduced volumes in the entorhinal cortex, superior temporal regions, and supramarginal gyrus. No such associations were observed in cases with SNAP. Conclusions SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy− participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/136905
Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; et al.; Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment; Lippincott Williams; Neurology; 91; 10; 9-2018; E976-E984
0028-3878
CONICET Digital
CONICET
url http://hdl.handle.net/11336/136905
identifier_str_mv Loewenstein, David A.; Curiel, Rosie E.; DeKosky, Steven; Bauer, Russell M.; Rosselli, Monica; et al.; Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment; Lippincott Williams; Neurology; 91; 10; 9-2018; E976-E984
0028-3878
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1212/WNL.0000000000006128
info:eu-repo/semantics/altIdentifier/url/https://n.neurology.org/content/91/10/e976
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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