Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes

Autores
Czarneski, Jennifer; Berguer, Paula Mercedes; Bekinschtein, Pedro Alejandro; Kim, David C.; Hakimpour, Paul; Wagner, Norbert; Nepomnaschy, Irene; Piazzon, Margarita Isabel; Ross, Susan R.
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer’s patches. We show here that newborn mice lacking 7 integrin or Lselectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer’s patch lymphocytes in wildtype mice were 7 and 1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than 7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
Fil: Czarneski, Jennifer. State University of Pennsylvania; Estados Unidos
Fil: Berguer, Paula Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Kim, David C.. State University of Pennsylvania; Estados Unidos
Fil: Hakimpour, Paul. State University of Pennsylvania; Estados Unidos
Fil: Wagner, Norbert. State University of Pennsylvania; Estados Unidos
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Ross, Susan R.. State University of Pennsylvania; Estados Unidos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/54947
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytesCzarneski, JenniferBerguer, Paula MercedesBekinschtein, Pedro AlejandroKim, David C.Hakimpour, PaulWagner, NorbertNepomnaschy, IrenePiazzon, Margarita IsabelRoss, Susan R.https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer’s patches. We show here that newborn mice lacking 7 integrin or Lselectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer’s patch lymphocytes in wildtype mice were 7 and 1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than 7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.Fil: Czarneski, Jennifer. State University of Pennsylvania; Estados UnidosFil: Berguer, Paula Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Kim, David C.. State University of Pennsylvania; Estados UnidosFil: Hakimpour, Paul. State University of Pennsylvania; Estados UnidosFil: Wagner, Norbert. State University of Pennsylvania; Estados UnidosFil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Ross, Susan R.. State University of Pennsylvania; Estados UnidosWiley VCH Verlag2002-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54947Czarneski, Jennifer; Berguer, Paula Mercedes; Bekinschtein, Pedro Alejandro; Kim, David C.; Hakimpour, Paul; et al.; Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes; Wiley VCH Verlag; European Journal of Immunology; 32; 4; 4-2002; 945-9560014-2980CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0.CO;2-Minfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/1521-4141%28200204%2932%3A4%3C945%3A%3AAID-IMMU945%3E3.0.CO%3B2-Minfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:09:58Zoai:ri.conicet.gov.ar:11336/54947instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:09:58.45CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
title Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
spellingShingle Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
Czarneski, Jennifer
title_short Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
title_full Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
title_fullStr Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
title_full_unstemmed Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
title_sort Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes
dc.creator.none.fl_str_mv Czarneski, Jennifer
Berguer, Paula Mercedes
Bekinschtein, Pedro Alejandro
Kim, David C.
Hakimpour, Paul
Wagner, Norbert
Nepomnaschy, Irene
Piazzon, Margarita Isabel
Ross, Susan R.
author Czarneski, Jennifer
author_facet Czarneski, Jennifer
Berguer, Paula Mercedes
Bekinschtein, Pedro Alejandro
Kim, David C.
Hakimpour, Paul
Wagner, Norbert
Nepomnaschy, Irene
Piazzon, Margarita Isabel
Ross, Susan R.
author_role author
author2 Berguer, Paula Mercedes
Bekinschtein, Pedro Alejandro
Kim, David C.
Hakimpour, Paul
Wagner, Norbert
Nepomnaschy, Irene
Piazzon, Margarita Isabel
Ross, Susan R.
author2_role author
author
author
author
author
author
author
author
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer’s patches. We show here that newborn mice lacking 7 integrin or Lselectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer’s patch lymphocytes in wildtype mice were 7 and 1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than 7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
Fil: Czarneski, Jennifer. State University of Pennsylvania; Estados Unidos
Fil: Berguer, Paula Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Bekinschtein, Pedro Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Kim, David C.. State University of Pennsylvania; Estados Unidos
Fil: Hakimpour, Paul. State University of Pennsylvania; Estados Unidos
Fil: Wagner, Norbert. State University of Pennsylvania; Estados Unidos
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Ross, Susan R.. State University of Pennsylvania; Estados Unidos
description Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer’s patches. We show here that newborn mice lacking 7 integrin or Lselectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer’s patch lymphocytes in wildtype mice were 7 and 1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than 7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.
publishDate 2002
dc.date.none.fl_str_mv 2002-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/54947
Czarneski, Jennifer; Berguer, Paula Mercedes; Bekinschtein, Pedro Alejandro; Kim, David C.; Hakimpour, Paul; et al.; Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes; Wiley VCH Verlag; European Journal of Immunology; 32; 4; 4-2002; 945-956
0014-2980
CONICET Digital
CONICET
url http://hdl.handle.net/11336/54947
identifier_str_mv Czarneski, Jennifer; Berguer, Paula Mercedes; Bekinschtein, Pedro Alejandro; Kim, David C.; Hakimpour, Paul; et al.; Neonatal infection with a milk-borne virus is independent of β7 integrin- and L-selectin-expressing lymphocytes; Wiley VCH Verlag; European Journal of Immunology; 32; 4; 4-2002; 945-956
0014-2980
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0.CO;2-M
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/1521-4141%28200204%2932%3A4%3C945%3A%3AAID-IMMU945%3E3.0.CO%3B2-M
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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