Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy

Autores
Díaz, E.; Vázquez, N.; Fernández, C.; Durand, Daniela Elizabeth; Lasaga, Mercedes Isabel; Debeljuk, L.; Díaz, B.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of pinealectomy (PIN-X) and PIN-X + melatonin treatment during pregnancy (PIN-X + MEL) 100 μg/100 g body weight on Substance P (SP) in the striatum was investigated in offspring female rats. Female offspring were divided into control and PIN-X at the neonatal period, and studied at days 31 and 60. PIN-X mother/control offspring showed a positive influence on striatal SP values in winter, at both ages and in spring at day 31. However, this effect of maternal PIN-X was not observed in summer or fall. The effect of PIN-X on the offspring showed a positive effect in spring at day 31 and summer at the two ages studied. This effect was not observed in fall or winter. Two generations, PIN-X mother/PIN-X offspring, altered the effect of mother or offspring PIN-X and decreased the SP values in winter, spring and summer. Only striatal SP at day 60 in fall was increased. In two generations PIN-X, the striatal SP values were similar to those observed in control mother/control offspring. The effect of PIN-X + MEL treatment on mothers during pregnancy was inhibitory for the intact offspring and stimulatory for PIN-X offspring. In conclusion, the results indicate that maternal and offspring PIN-X seem to exert a rotative and positive seasonal influence from winter to spring to summer. Two generations PIN-X disrupted this rotative circuit and in fall a compensatory discharge of SP was observed.
Fil: Díaz, E.. Universidad de Oviedo; España
Fil: Vázquez, N.. Universidad de Oviedo; España
Fil: Fernández, C.. Universidad de Oviedo; España
Fil: Durand, Daniela Elizabeth. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lasaga, Mercedes Isabel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Debeljuk, L.. Southern Illinois University; Estados Unidos
Fil: Díaz, B.. Universidad de Oviedo; España
Materia
Seasonal Variations
Sp
Striatum
Material Pinealectomy
Offspring Pinealectomy
Melatonin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15220
Acceder
id CONICETDig_a80e1c7b7093d5c103302f488573ee03
oai_identifier_str oai:ri.conicet.gov.ar:11336/15220
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomyDíaz, E.Vázquez, N.Fernández, C.Durand, Daniela ElizabethLasaga, Mercedes IsabelDebeljuk, L.Díaz, B.Seasonal VariationsSpStriatumMaterial PinealectomyOffspring PinealectomyMelatoninhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The effect of pinealectomy (PIN-X) and PIN-X + melatonin treatment during pregnancy (PIN-X + MEL) 100 μg/100 g body weight on Substance P (SP) in the striatum was investigated in offspring female rats. Female offspring were divided into control and PIN-X at the neonatal period, and studied at days 31 and 60. PIN-X mother/control offspring showed a positive influence on striatal SP values in winter, at both ages and in spring at day 31. However, this effect of maternal PIN-X was not observed in summer or fall. The effect of PIN-X on the offspring showed a positive effect in spring at day 31 and summer at the two ages studied. This effect was not observed in fall or winter. Two generations, PIN-X mother/PIN-X offspring, altered the effect of mother or offspring PIN-X and decreased the SP values in winter, spring and summer. Only striatal SP at day 60 in fall was increased. In two generations PIN-X, the striatal SP values were similar to those observed in control mother/control offspring. The effect of PIN-X + MEL treatment on mothers during pregnancy was inhibitory for the intact offspring and stimulatory for PIN-X offspring. In conclusion, the results indicate that maternal and offspring PIN-X seem to exert a rotative and positive seasonal influence from winter to spring to summer. Two generations PIN-X disrupted this rotative circuit and in fall a compensatory discharge of SP was observed.Fil: Díaz, E.. Universidad de Oviedo; EspañaFil: Vázquez, N.. Universidad de Oviedo; EspañaFil: Fernández, C.. Universidad de Oviedo; EspañaFil: Durand, Daniela Elizabeth. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lasaga, Mercedes Isabel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Debeljuk, L.. Southern Illinois University; Estados UnidosFil: Díaz, B.. Universidad de Oviedo; EspañaElsevier Ireland2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15220Díaz, E.; Vázquez, N.; Fernández, C.; Durand, Daniela Elizabeth; Lasaga, Mercedes Isabel; et al.; Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy; Elsevier Ireland; Neuroscience Letters; 492; 2; 4-2011; 71-750304-3940enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0304394011000991info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neulet.2011.01.053info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:17:53Zoai:ri.conicet.gov.ar:11336/15220instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:17:53.993CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
title Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
spellingShingle Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
Díaz, E.
Seasonal Variations
Sp
Striatum
Material Pinealectomy
Offspring Pinealectomy
Melatonin
title_short Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
title_full Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
title_fullStr Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
title_full_unstemmed Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
title_sort Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy
dc.creator.none.fl_str_mv Díaz, E.
Vázquez, N.
Fernández, C.
Durand, Daniela Elizabeth
Lasaga, Mercedes Isabel
Debeljuk, L.
Díaz, B.
author Díaz, E.
author_facet Díaz, E.
Vázquez, N.
Fernández, C.
Durand, Daniela Elizabeth
Lasaga, Mercedes Isabel
Debeljuk, L.
Díaz, B.
author_role author
author2 Vázquez, N.
Fernández, C.
Durand, Daniela Elizabeth
Lasaga, Mercedes Isabel
Debeljuk, L.
Díaz, B.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Seasonal Variations
Sp
Striatum
Material Pinealectomy
Offspring Pinealectomy
Melatonin
topic Seasonal Variations
Sp
Striatum
Material Pinealectomy
Offspring Pinealectomy
Melatonin
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The effect of pinealectomy (PIN-X) and PIN-X + melatonin treatment during pregnancy (PIN-X + MEL) 100 μg/100 g body weight on Substance P (SP) in the striatum was investigated in offspring female rats. Female offspring were divided into control and PIN-X at the neonatal period, and studied at days 31 and 60. PIN-X mother/control offspring showed a positive influence on striatal SP values in winter, at both ages and in spring at day 31. However, this effect of maternal PIN-X was not observed in summer or fall. The effect of PIN-X on the offspring showed a positive effect in spring at day 31 and summer at the two ages studied. This effect was not observed in fall or winter. Two generations, PIN-X mother/PIN-X offspring, altered the effect of mother or offspring PIN-X and decreased the SP values in winter, spring and summer. Only striatal SP at day 60 in fall was increased. In two generations PIN-X, the striatal SP values were similar to those observed in control mother/control offspring. The effect of PIN-X + MEL treatment on mothers during pregnancy was inhibitory for the intact offspring and stimulatory for PIN-X offspring. In conclusion, the results indicate that maternal and offspring PIN-X seem to exert a rotative and positive seasonal influence from winter to spring to summer. Two generations PIN-X disrupted this rotative circuit and in fall a compensatory discharge of SP was observed.
Fil: Díaz, E.. Universidad de Oviedo; España
Fil: Vázquez, N.. Universidad de Oviedo; España
Fil: Fernández, C.. Universidad de Oviedo; España
Fil: Durand, Daniela Elizabeth. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lasaga, Mercedes Isabel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Debeljuk, L.. Southern Illinois University; Estados Unidos
Fil: Díaz, B.. Universidad de Oviedo; España
description The effect of pinealectomy (PIN-X) and PIN-X + melatonin treatment during pregnancy (PIN-X + MEL) 100 μg/100 g body weight on Substance P (SP) in the striatum was investigated in offspring female rats. Female offspring were divided into control and PIN-X at the neonatal period, and studied at days 31 and 60. PIN-X mother/control offspring showed a positive influence on striatal SP values in winter, at both ages and in spring at day 31. However, this effect of maternal PIN-X was not observed in summer or fall. The effect of PIN-X on the offspring showed a positive effect in spring at day 31 and summer at the two ages studied. This effect was not observed in fall or winter. Two generations, PIN-X mother/PIN-X offspring, altered the effect of mother or offspring PIN-X and decreased the SP values in winter, spring and summer. Only striatal SP at day 60 in fall was increased. In two generations PIN-X, the striatal SP values were similar to those observed in control mother/control offspring. The effect of PIN-X + MEL treatment on mothers during pregnancy was inhibitory for the intact offspring and stimulatory for PIN-X offspring. In conclusion, the results indicate that maternal and offspring PIN-X seem to exert a rotative and positive seasonal influence from winter to spring to summer. Two generations PIN-X disrupted this rotative circuit and in fall a compensatory discharge of SP was observed.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15220
Díaz, E.; Vázquez, N.; Fernández, C.; Durand, Daniela Elizabeth; Lasaga, Mercedes Isabel; et al.; Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy; Elsevier Ireland; Neuroscience Letters; 492; 2; 4-2011; 71-75
0304-3940
url http://hdl.handle.net/11336/15220
identifier_str_mv Díaz, E.; Vázquez, N.; Fernández, C.; Durand, Daniela Elizabeth; Lasaga, Mercedes Isabel; et al.; Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy; Elsevier Ireland; Neuroscience Letters; 492; 2; 4-2011; 71-75
0304-3940
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0304394011000991
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neulet.2011.01.053
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980978594676736
score 12.993085

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