SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection

Autores
Castro-Grijalba, Alexander; Montes-García, Verónica; Cordero-Ferradás, María José; Coronado, Eduardo A.; Pérez-Juste, Jorge; Pastoriza-Santos, Isabel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A novel hybrid plasmonic platform based on the synergetic combination of a molecularly imprinted polymer (MIP) thin film with Au nanoparticle (NPs) assemblies, noted as Au@MIP, was developed for surface-enhanced Raman scattering (SERS) spectroscopy recognition of polycyclic aromatic hydrocarbons (PAHs). While the MIP trapped the PAH close to the Au surface, the plasmonic NPs enhanced the molecule's Raman signal. The Au@MIP fabrication comprises a two-step procedure, first, the layer-by-layer deposition of Au NPs on glass and their further coating with a uniform MIP thin film. Profilometry analysis demonstrated that the thickness and homogeneity of the MIP film could be finely tailored by tuning different parameters such as prepolymerization time or spin-coating rate. Two different PAH molecules, pyrene or fluoranthene, were used as templates for the fabrication of pyrene- or fluoranthene-based Au@MIP substrates. The use of pyrene or fluoranthene, as the template molecule to fabricate the Au@MIP thin films, enabled its ultradetection in the nM regime with a 100-fold improvement compared with the nonimprinted plasmonic sensors (Au@NIPs). The SERS data analysis allowed to estimate the binding constant of the template molecule to the MIP. The selectivity of both pyrene- and fluoranthene-based Au@MIPs was analyzed against three PAHs of different sizes. The results displayed the important role of the template molecule used for the Au@MIPs fabrication in the selectivity of the system. Finally, the practical applicability of pyrene-based Au@MIPs was shown by performing the detection of pyrene in two real samples: creek water and seawater. The design and optimization of this type of plasmonic platform will pave the way for the detection of other relevant (bio)molecules in a broad range of fields such as environmental control, food safety, or biomedicine.
Fil: Castro-Grijalba, Alexander. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias de la Salud. Laboratorio de Quimica Analitica Ambiental.; Argentina. Universidad de Vigo; España
Fil: Montes-García, Verónica. Universidad de Vigo; España
Fil: Cordero-Ferradás, María José. Universidad de Vigo; España
Fil: Coronado, Eduardo A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Pérez-Juste, Jorge. Universidad de Vigo; España
Fil: Pastoriza-Santos, Isabel. Universidad de Vigo; España
Materia
ENVIRONMENTAL ANALYSIS
HYBRID NANOSTRUCTURES
MOLECULARLY IMPRINTED POLYMERS
PLASMONIC SENSORS
POLYCYCLIC AROMATIC HYDROCARBONS
SERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/144537
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/144537
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detectionCastro-Grijalba, AlexanderMontes-García, VerónicaCordero-Ferradás, María JoséCoronado, Eduardo A.Pérez-Juste, JorgePastoriza-Santos, IsabelENVIRONMENTAL ANALYSISHYBRID NANOSTRUCTURESMOLECULARLY IMPRINTED POLYMERSPLASMONIC SENSORSPOLYCYCLIC AROMATIC HYDROCARBONSSERShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2A novel hybrid plasmonic platform based on the synergetic combination of a molecularly imprinted polymer (MIP) thin film with Au nanoparticle (NPs) assemblies, noted as Au@MIP, was developed for surface-enhanced Raman scattering (SERS) spectroscopy recognition of polycyclic aromatic hydrocarbons (PAHs). While the MIP trapped the PAH close to the Au surface, the plasmonic NPs enhanced the molecule's Raman signal. The Au@MIP fabrication comprises a two-step procedure, first, the layer-by-layer deposition of Au NPs on glass and their further coating with a uniform MIP thin film. Profilometry analysis demonstrated that the thickness and homogeneity of the MIP film could be finely tailored by tuning different parameters such as prepolymerization time or spin-coating rate. Two different PAH molecules, pyrene or fluoranthene, were used as templates for the fabrication of pyrene- or fluoranthene-based Au@MIP substrates. The use of pyrene or fluoranthene, as the template molecule to fabricate the Au@MIP thin films, enabled its ultradetection in the nM regime with a 100-fold improvement compared with the nonimprinted plasmonic sensors (Au@NIPs). The SERS data analysis allowed to estimate the binding constant of the template molecule to the MIP. The selectivity of both pyrene- and fluoranthene-based Au@MIPs was analyzed against three PAHs of different sizes. The results displayed the important role of the template molecule used for the Au@MIPs fabrication in the selectivity of the system. Finally, the practical applicability of pyrene-based Au@MIPs was shown by performing the detection of pyrene in two real samples: creek water and seawater. The design and optimization of this type of plasmonic platform will pave the way for the detection of other relevant (bio)molecules in a broad range of fields such as environmental control, food safety, or biomedicine.Fil: Castro-Grijalba, Alexander. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias de la Salud. Laboratorio de Quimica Analitica Ambiental.; Argentina. Universidad de Vigo; EspañaFil: Montes-García, Verónica. Universidad de Vigo; EspañaFil: Cordero-Ferradás, María José. Universidad de Vigo; EspañaFil: Coronado, Eduardo A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Pérez-Juste, Jorge. Universidad de Vigo; EspañaFil: Pastoriza-Santos, Isabel. Universidad de Vigo; EspañaAmerican Chemical Society2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/144537Castro-Grijalba, Alexander; Montes-García, Verónica; Cordero-Ferradás, María José; Coronado, Eduardo A.; Pérez-Juste, Jorge; et al.; SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection; American Chemical Society; ACS Sensors; 5; 3; 3-2020; 693-7022379-3694CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/acssensors.9b01882info:eu-repo/semantics/altIdentifier/doi/10.1021/acssensors.9b01882info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:55Zoai:ri.conicet.gov.ar:11336/144537instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:55.57CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
title SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
spellingShingle SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
Castro-Grijalba, Alexander
ENVIRONMENTAL ANALYSIS
HYBRID NANOSTRUCTURES
MOLECULARLY IMPRINTED POLYMERS
PLASMONIC SENSORS
POLYCYCLIC AROMATIC HYDROCARBONS
SERS
title_short SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
title_full SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
title_fullStr SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
title_full_unstemmed SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
title_sort SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
dc.creator.none.fl_str_mv Castro-Grijalba, Alexander
Montes-García, Verónica
Cordero-Ferradás, María José
Coronado, Eduardo A.
Pérez-Juste, Jorge
Pastoriza-Santos, Isabel
author Castro-Grijalba, Alexander
author_facet Castro-Grijalba, Alexander
Montes-García, Verónica
Cordero-Ferradás, María José
Coronado, Eduardo A.
Pérez-Juste, Jorge
Pastoriza-Santos, Isabel
author_role author
author2 Montes-García, Verónica
Cordero-Ferradás, María José
Coronado, Eduardo A.
Pérez-Juste, Jorge
Pastoriza-Santos, Isabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ENVIRONMENTAL ANALYSIS
HYBRID NANOSTRUCTURES
MOLECULARLY IMPRINTED POLYMERS
PLASMONIC SENSORS
POLYCYCLIC AROMATIC HYDROCARBONS
SERS
topic ENVIRONMENTAL ANALYSIS
HYBRID NANOSTRUCTURES
MOLECULARLY IMPRINTED POLYMERS
PLASMONIC SENSORS
POLYCYCLIC AROMATIC HYDROCARBONS
SERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv A novel hybrid plasmonic platform based on the synergetic combination of a molecularly imprinted polymer (MIP) thin film with Au nanoparticle (NPs) assemblies, noted as Au@MIP, was developed for surface-enhanced Raman scattering (SERS) spectroscopy recognition of polycyclic aromatic hydrocarbons (PAHs). While the MIP trapped the PAH close to the Au surface, the plasmonic NPs enhanced the molecule's Raman signal. The Au@MIP fabrication comprises a two-step procedure, first, the layer-by-layer deposition of Au NPs on glass and their further coating with a uniform MIP thin film. Profilometry analysis demonstrated that the thickness and homogeneity of the MIP film could be finely tailored by tuning different parameters such as prepolymerization time or spin-coating rate. Two different PAH molecules, pyrene or fluoranthene, were used as templates for the fabrication of pyrene- or fluoranthene-based Au@MIP substrates. The use of pyrene or fluoranthene, as the template molecule to fabricate the Au@MIP thin films, enabled its ultradetection in the nM regime with a 100-fold improvement compared with the nonimprinted plasmonic sensors (Au@NIPs). The SERS data analysis allowed to estimate the binding constant of the template molecule to the MIP. The selectivity of both pyrene- and fluoranthene-based Au@MIPs was analyzed against three PAHs of different sizes. The results displayed the important role of the template molecule used for the Au@MIPs fabrication in the selectivity of the system. Finally, the practical applicability of pyrene-based Au@MIPs was shown by performing the detection of pyrene in two real samples: creek water and seawater. The design and optimization of this type of plasmonic platform will pave the way for the detection of other relevant (bio)molecules in a broad range of fields such as environmental control, food safety, or biomedicine.
Fil: Castro-Grijalba, Alexander. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias de la Salud. Laboratorio de Quimica Analitica Ambiental.; Argentina. Universidad de Vigo; España
Fil: Montes-García, Verónica. Universidad de Vigo; España
Fil: Cordero-Ferradás, María José. Universidad de Vigo; España
Fil: Coronado, Eduardo A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Pérez-Juste, Jorge. Universidad de Vigo; España
Fil: Pastoriza-Santos, Isabel. Universidad de Vigo; España
description A novel hybrid plasmonic platform based on the synergetic combination of a molecularly imprinted polymer (MIP) thin film with Au nanoparticle (NPs) assemblies, noted as Au@MIP, was developed for surface-enhanced Raman scattering (SERS) spectroscopy recognition of polycyclic aromatic hydrocarbons (PAHs). While the MIP trapped the PAH close to the Au surface, the plasmonic NPs enhanced the molecule's Raman signal. The Au@MIP fabrication comprises a two-step procedure, first, the layer-by-layer deposition of Au NPs on glass and their further coating with a uniform MIP thin film. Profilometry analysis demonstrated that the thickness and homogeneity of the MIP film could be finely tailored by tuning different parameters such as prepolymerization time or spin-coating rate. Two different PAH molecules, pyrene or fluoranthene, were used as templates for the fabrication of pyrene- or fluoranthene-based Au@MIP substrates. The use of pyrene or fluoranthene, as the template molecule to fabricate the Au@MIP thin films, enabled its ultradetection in the nM regime with a 100-fold improvement compared with the nonimprinted plasmonic sensors (Au@NIPs). The SERS data analysis allowed to estimate the binding constant of the template molecule to the MIP. The selectivity of both pyrene- and fluoranthene-based Au@MIPs was analyzed against three PAHs of different sizes. The results displayed the important role of the template molecule used for the Au@MIPs fabrication in the selectivity of the system. Finally, the practical applicability of pyrene-based Au@MIPs was shown by performing the detection of pyrene in two real samples: creek water and seawater. The design and optimization of this type of plasmonic platform will pave the way for the detection of other relevant (bio)molecules in a broad range of fields such as environmental control, food safety, or biomedicine.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/144537
Castro-Grijalba, Alexander; Montes-García, Verónica; Cordero-Ferradás, María José; Coronado, Eduardo A.; Pérez-Juste, Jorge; et al.; SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection; American Chemical Society; ACS Sensors; 5; 3; 3-2020; 693-702
2379-3694
CONICET Digital
CONICET
url http://hdl.handle.net/11336/144537
identifier_str_mv Castro-Grijalba, Alexander; Montes-García, Verónica; Cordero-Ferradás, María José; Coronado, Eduardo A.; Pérez-Juste, Jorge; et al.; SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection; American Chemical Society; ACS Sensors; 5; 3; 3-2020; 693-702
2379-3694
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/acssensors.9b01882
info:eu-repo/semantics/altIdentifier/doi/10.1021/acssensors.9b01882
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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