Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice

Autores
Varani, Andrés Pablo; Mailhes-Hamon, Caroline; Sala, Romain W.; Fouda, Sarah; Frontera, Jimena L.; Lena, Clement; Popa, Daniela
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Motor skill learning is a complex and gradual process that involves the cortex and basal ganglia, both crucial for the acquisition and long-term retention of skills. The cerebellum, which rapidly learns to adjust the movement, connects to the motor cortex and the striatum via the ventral and intralaminar thalamus respectively. Here, we evaluated the contribution of cerebellar neurons projecting to these thalamic nuclei in a skilled locomotion task in mice. Using a targeted chemogenetic inhibition that preserves the motor abilities, we found that cerebellar nuclei neurons projecting to the intralaminar thalamus contribute to learning and expression, while cerebellar nuclei neurons projecting to the ventral thalamus contribute to offline consolidation. Asymptotic performance, however, required each type of neurons. Thus, our results show that cerebellar neurons belonging to two parallel cerebello-thalamic pathways play distinct, but complementary, roles functioning on different timescales and both necessary for motor skill learning.
Fil: Varani, Andrés Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Ecole Normale Supérieure; Francia
Fil: Mailhes-Hamon, Caroline. Ecole Normale Supérieure; Francia
Fil: Sala, Romain W.. Ecole Normale Supérieure; Francia
Fil: Fouda, Sarah. Ecole Normale Supérieure; Francia
Fil: Frontera, Jimena L.. Ecole Normale Supérieure; Francia
Fil: Lena, Clement. Ecole Normale Supérieure; Francia
Fil: Popa, Daniela. Ecole Normale Supérieure; Francia
Materia
CEREBELLUM
THALAMUS
LEARNING
CONSOLIDATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256960
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in miceVarani, Andrés PabloMailhes-Hamon, CarolineSala, Romain W.Fouda, SarahFrontera, Jimena L.Lena, ClementPopa, DanielaCEREBELLUMTHALAMUSLEARNINGCONSOLIDATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Motor skill learning is a complex and gradual process that involves the cortex and basal ganglia, both crucial for the acquisition and long-term retention of skills. The cerebellum, which rapidly learns to adjust the movement, connects to the motor cortex and the striatum via the ventral and intralaminar thalamus respectively. Here, we evaluated the contribution of cerebellar neurons projecting to these thalamic nuclei in a skilled locomotion task in mice. Using a targeted chemogenetic inhibition that preserves the motor abilities, we found that cerebellar nuclei neurons projecting to the intralaminar thalamus contribute to learning and expression, while cerebellar nuclei neurons projecting to the ventral thalamus contribute to offline consolidation. Asymptotic performance, however, required each type of neurons. Thus, our results show that cerebellar neurons belonging to two parallel cerebello-thalamic pathways play distinct, but complementary, roles functioning on different timescales and both necessary for motor skill learning.Fil: Varani, Andrés Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Ecole Normale Supérieure; FranciaFil: Mailhes-Hamon, Caroline. Ecole Normale Supérieure; FranciaFil: Sala, Romain W.. Ecole Normale Supérieure; FranciaFil: Fouda, Sarah. Ecole Normale Supérieure; FranciaFil: Frontera, Jimena L.. Ecole Normale Supérieure; FranciaFil: Lena, Clement. Ecole Normale Supérieure; FranciaFil: Popa, Daniela. Ecole Normale Supérieure; FranciaeLife Sciences Publications2024-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256960Varani, Andrés Pablo; Mailhes-Hamon, Caroline; Sala, Romain W.; Fouda, Sarah; Frontera, Jimena L.; et al.; Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice; eLife Sciences Publications; E-Life; 2024; 2-2024; 1-392050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/reviewed-preprints/102813v1info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.102813.1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:43Zoai:ri.conicet.gov.ar:11336/256960instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:43.885CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
title Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
spellingShingle Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
Varani, Andrés Pablo
CEREBELLUM
THALAMUS
LEARNING
CONSOLIDATION
title_short Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
title_full Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
title_fullStr Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
title_full_unstemmed Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
title_sort Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice
dc.creator.none.fl_str_mv Varani, Andrés Pablo
Mailhes-Hamon, Caroline
Sala, Romain W.
Fouda, Sarah
Frontera, Jimena L.
Lena, Clement
Popa, Daniela
author Varani, Andrés Pablo
author_facet Varani, Andrés Pablo
Mailhes-Hamon, Caroline
Sala, Romain W.
Fouda, Sarah
Frontera, Jimena L.
Lena, Clement
Popa, Daniela
author_role author
author2 Mailhes-Hamon, Caroline
Sala, Romain W.
Fouda, Sarah
Frontera, Jimena L.
Lena, Clement
Popa, Daniela
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CEREBELLUM
THALAMUS
LEARNING
CONSOLIDATION
topic CEREBELLUM
THALAMUS
LEARNING
CONSOLIDATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Motor skill learning is a complex and gradual process that involves the cortex and basal ganglia, both crucial for the acquisition and long-term retention of skills. The cerebellum, which rapidly learns to adjust the movement, connects to the motor cortex and the striatum via the ventral and intralaminar thalamus respectively. Here, we evaluated the contribution of cerebellar neurons projecting to these thalamic nuclei in a skilled locomotion task in mice. Using a targeted chemogenetic inhibition that preserves the motor abilities, we found that cerebellar nuclei neurons projecting to the intralaminar thalamus contribute to learning and expression, while cerebellar nuclei neurons projecting to the ventral thalamus contribute to offline consolidation. Asymptotic performance, however, required each type of neurons. Thus, our results show that cerebellar neurons belonging to two parallel cerebello-thalamic pathways play distinct, but complementary, roles functioning on different timescales and both necessary for motor skill learning.
Fil: Varani, Andrés Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Ecole Normale Supérieure; Francia
Fil: Mailhes-Hamon, Caroline. Ecole Normale Supérieure; Francia
Fil: Sala, Romain W.. Ecole Normale Supérieure; Francia
Fil: Fouda, Sarah. Ecole Normale Supérieure; Francia
Fil: Frontera, Jimena L.. Ecole Normale Supérieure; Francia
Fil: Lena, Clement. Ecole Normale Supérieure; Francia
Fil: Popa, Daniela. Ecole Normale Supérieure; Francia
description Motor skill learning is a complex and gradual process that involves the cortex and basal ganglia, both crucial for the acquisition and long-term retention of skills. The cerebellum, which rapidly learns to adjust the movement, connects to the motor cortex and the striatum via the ventral and intralaminar thalamus respectively. Here, we evaluated the contribution of cerebellar neurons projecting to these thalamic nuclei in a skilled locomotion task in mice. Using a targeted chemogenetic inhibition that preserves the motor abilities, we found that cerebellar nuclei neurons projecting to the intralaminar thalamus contribute to learning and expression, while cerebellar nuclei neurons projecting to the ventral thalamus contribute to offline consolidation. Asymptotic performance, however, required each type of neurons. Thus, our results show that cerebellar neurons belonging to two parallel cerebello-thalamic pathways play distinct, but complementary, roles functioning on different timescales and both necessary for motor skill learning.
publishDate 2024
dc.date.none.fl_str_mv 2024-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256960
Varani, Andrés Pablo; Mailhes-Hamon, Caroline; Sala, Romain W.; Fouda, Sarah; Frontera, Jimena L.; et al.; Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice; eLife Sciences Publications; E-Life; 2024; 2-2024; 1-39
2050-084X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256960
identifier_str_mv Varani, Andrés Pablo; Mailhes-Hamon, Caroline; Sala, Romain W.; Fouda, Sarah; Frontera, Jimena L.; et al.; Multiple Functions of Cerebello-Thalamic Neurons in Learning and Offline Consolidation of a Motor Skill in mice; eLife Sciences Publications; E-Life; 2024; 2-2024; 1-39
2050-084X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/reviewed-preprints/102813v1
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.102813.1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269925628968960
score 13.13397

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