Behavioral and immune changes in v-HA-ras transgenic mice

Autores
Colombo, Lucas Luis; Stazzone, Anthony; Chen, Guan Jie; Lopez, Maria C.; Watson, Ronald R.
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Transgenic mice (Oncomice) with an activated v-Ha-ras oncogene under the control of the mouse mammary tumor virus promoter develop mammary tumors. We wondered if the expression of the v-Ha-ras oncogene product would induce changes in mice behavioral activity, that could be associated with alterations in their immune system. Behavior was evaluated in an open field study considering line crossings and rears. Oncomice consistently showed less activity than FVB mice. Lieber-DeCarli diet decreased both types of activity in both strains. Cocaine treatment increased line crossings in both strains. Oncomice spleen and thymus cell supernatants contained higher levels of IL-2. Oncomice serum had higher levels of IL-1α. Our results suggest a direct association between higher levels of IL-1α and lower open field activity. Therefore, we can infer that the increased level of IL-1α found in Oncomice, could have a key role in oncogene induced immune and behavioral changes, and could be a requirement to facilitate its transforming activity.
Fil: Colombo, Lucas Luis. University of Arizona; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stazzone, Anthony. University of Arizona; Estados Unidos
Fil: Chen, Guan Jie. University of Arizona; Estados Unidos
Fil: Lopez, Maria C.. University of Arizona; Estados Unidos
Fil: Watson, Ronald R.. University of Arizona; Estados Unidos
Materia
Behavior
Immunity
Ha-Ras Transgenic Mice
Oncogene
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39223
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavioral and immune changes in v-HA-ras transgenic miceColombo, Lucas LuisStazzone, AnthonyChen, Guan JieLopez, Maria C.Watson, Ronald R.BehaviorImmunityHa-Ras Transgenic MiceOncogenehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Transgenic mice (Oncomice) with an activated v-Ha-ras oncogene under the control of the mouse mammary tumor virus promoter develop mammary tumors. We wondered if the expression of the v-Ha-ras oncogene product would induce changes in mice behavioral activity, that could be associated with alterations in their immune system. Behavior was evaluated in an open field study considering line crossings and rears. Oncomice consistently showed less activity than FVB mice. Lieber-DeCarli diet decreased both types of activity in both strains. Cocaine treatment increased line crossings in both strains. Oncomice spleen and thymus cell supernatants contained higher levels of IL-2. Oncomice serum had higher levels of IL-1α. Our results suggest a direct association between higher levels of IL-1α and lower open field activity. Therefore, we can infer that the increased level of IL-1α found in Oncomice, could have a key role in oncogene induced immune and behavioral changes, and could be a requirement to facilitate its transforming activity.Fil: Colombo, Lucas Luis. University of Arizona; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Stazzone, Anthony. University of Arizona; Estados UnidosFil: Chen, Guan Jie. University of Arizona; Estados UnidosFil: Lopez, Maria C.. University of Arizona; Estados UnidosFil: Watson, Ronald R.. University of Arizona; Estados UnidosTaylor2000-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39223Colombo, Lucas Luis; Stazzone, Anthony; Chen, Guan Jie; Lopez, Maria C.; Watson, Ronald R.; Behavioral and immune changes in v-HA-ras transgenic mice; Taylor ; Immunopharmacology And Immunotoxicology; 22; 2; 3-2000; 339-3560892-3973CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/08923970009016424info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/08923970009016424info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:11Zoai:ri.conicet.gov.ar:11336/39223instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:11.604CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavioral and immune changes in v-HA-ras transgenic mice
title Behavioral and immune changes in v-HA-ras transgenic mice
spellingShingle Behavioral and immune changes in v-HA-ras transgenic mice
Colombo, Lucas Luis
Behavior
Immunity
Ha-Ras Transgenic Mice
Oncogene
title_short Behavioral and immune changes in v-HA-ras transgenic mice
title_full Behavioral and immune changes in v-HA-ras transgenic mice
title_fullStr Behavioral and immune changes in v-HA-ras transgenic mice
title_full_unstemmed Behavioral and immune changes in v-HA-ras transgenic mice
title_sort Behavioral and immune changes in v-HA-ras transgenic mice
dc.creator.none.fl_str_mv Colombo, Lucas Luis
Stazzone, Anthony
Chen, Guan Jie
Lopez, Maria C.
Watson, Ronald R.
author Colombo, Lucas Luis
author_facet Colombo, Lucas Luis
Stazzone, Anthony
Chen, Guan Jie
Lopez, Maria C.
Watson, Ronald R.
author_role author
author2 Stazzone, Anthony
Chen, Guan Jie
Lopez, Maria C.
Watson, Ronald R.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Behavior
Immunity
Ha-Ras Transgenic Mice
Oncogene
topic Behavior
Immunity
Ha-Ras Transgenic Mice
Oncogene
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Transgenic mice (Oncomice) with an activated v-Ha-ras oncogene under the control of the mouse mammary tumor virus promoter develop mammary tumors. We wondered if the expression of the v-Ha-ras oncogene product would induce changes in mice behavioral activity, that could be associated with alterations in their immune system. Behavior was evaluated in an open field study considering line crossings and rears. Oncomice consistently showed less activity than FVB mice. Lieber-DeCarli diet decreased both types of activity in both strains. Cocaine treatment increased line crossings in both strains. Oncomice spleen and thymus cell supernatants contained higher levels of IL-2. Oncomice serum had higher levels of IL-1α. Our results suggest a direct association between higher levels of IL-1α and lower open field activity. Therefore, we can infer that the increased level of IL-1α found in Oncomice, could have a key role in oncogene induced immune and behavioral changes, and could be a requirement to facilitate its transforming activity.
Fil: Colombo, Lucas Luis. University of Arizona; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stazzone, Anthony. University of Arizona; Estados Unidos
Fil: Chen, Guan Jie. University of Arizona; Estados Unidos
Fil: Lopez, Maria C.. University of Arizona; Estados Unidos
Fil: Watson, Ronald R.. University of Arizona; Estados Unidos
description Transgenic mice (Oncomice) with an activated v-Ha-ras oncogene under the control of the mouse mammary tumor virus promoter develop mammary tumors. We wondered if the expression of the v-Ha-ras oncogene product would induce changes in mice behavioral activity, that could be associated with alterations in their immune system. Behavior was evaluated in an open field study considering line crossings and rears. Oncomice consistently showed less activity than FVB mice. Lieber-DeCarli diet decreased both types of activity in both strains. Cocaine treatment increased line crossings in both strains. Oncomice spleen and thymus cell supernatants contained higher levels of IL-2. Oncomice serum had higher levels of IL-1α. Our results suggest a direct association between higher levels of IL-1α and lower open field activity. Therefore, we can infer that the increased level of IL-1α found in Oncomice, could have a key role in oncogene induced immune and behavioral changes, and could be a requirement to facilitate its transforming activity.
publishDate 2000
dc.date.none.fl_str_mv 2000-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39223
Colombo, Lucas Luis; Stazzone, Anthony; Chen, Guan Jie; Lopez, Maria C.; Watson, Ronald R.; Behavioral and immune changes in v-HA-ras transgenic mice; Taylor ; Immunopharmacology And Immunotoxicology; 22; 2; 3-2000; 339-356
0892-3973
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39223
identifier_str_mv Colombo, Lucas Luis; Stazzone, Anthony; Chen, Guan Jie; Lopez, Maria C.; Watson, Ronald R.; Behavioral and immune changes in v-HA-ras transgenic mice; Taylor ; Immunopharmacology And Immunotoxicology; 22; 2; 3-2000; 339-356
0892-3973
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/08923970009016424
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/08923970009016424
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor
publisher.none.fl_str_mv Taylor
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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