Ghrelin effects expression of several genes associated with depression-like behavior

Autores
Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana Elizabeth; Fiol, Marta Haydee; Schiöth, Helgi B.; Carlini, Valeria Paola
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxietylike behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol/μl administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol/μl administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals.
Fil: Poretti, María Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Rask Andersen, Mathias. Uppsala University; Suecia
Fil: Kumar, Praveen. Uppsala University; Suecia
Fil: Rubiales, Susana Elizabeth. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina
Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Schiöth, Helgi B.. Uppsala University; Suecia
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Materia
Ghrelin
Olfatory Bulbectomy
Opioid Receptors
Vasopresin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11510
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/11510
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ghrelin effects expression of several genes associated with depression-like behaviorPoretti, María BelénRask Andersen, MathiasKumar, PraveenRubiales, Susana ElizabethFiol, Marta HaydeeSchiöth, Helgi B.Carlini, Valeria PaolaGhrelinOlfatory BulbectomyOpioid ReceptorsVasopresinhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxietylike behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol/μl administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol/μl administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals.Fil: Poretti, María Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; ArgentinaFil: Rask Andersen, Mathias. Uppsala University; SueciaFil: Kumar, Praveen. Uppsala University; SueciaFil: Rubiales, Susana Elizabeth. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; ArgentinaFil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; ArgentinaFil: Schiöth, Helgi B.. Uppsala University; SueciaFil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; ArgentinaElsevier Inc2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11510Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana Elizabeth; Fiol, Marta Haydee; et al.; Ghrelin effects expression of several genes associated with depression-like behavior; Elsevier Inc; Progress Of Neuro-psychopharmacology And Biological Psychiatry; 56; 1-2015; 227–2340278-5846enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2014.09.012info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584614001882info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:16Zoai:ri.conicet.gov.ar:11336/11510instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:16.495CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ghrelin effects expression of several genes associated with depression-like behavior
title Ghrelin effects expression of several genes associated with depression-like behavior
spellingShingle Ghrelin effects expression of several genes associated with depression-like behavior
Poretti, María Belén
Ghrelin
Olfatory Bulbectomy
Opioid Receptors
Vasopresin
title_short Ghrelin effects expression of several genes associated with depression-like behavior
title_full Ghrelin effects expression of several genes associated with depression-like behavior
title_fullStr Ghrelin effects expression of several genes associated with depression-like behavior
title_full_unstemmed Ghrelin effects expression of several genes associated with depression-like behavior
title_sort Ghrelin effects expression of several genes associated with depression-like behavior
dc.creator.none.fl_str_mv Poretti, María Belén
Rask Andersen, Mathias
Kumar, Praveen
Rubiales, Susana Elizabeth
Fiol, Marta Haydee
Schiöth, Helgi B.
Carlini, Valeria Paola
author Poretti, María Belén
author_facet Poretti, María Belén
Rask Andersen, Mathias
Kumar, Praveen
Rubiales, Susana Elizabeth
Fiol, Marta Haydee
Schiöth, Helgi B.
Carlini, Valeria Paola
author_role author
author2 Rask Andersen, Mathias
Kumar, Praveen
Rubiales, Susana Elizabeth
Fiol, Marta Haydee
Schiöth, Helgi B.
Carlini, Valeria Paola
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ghrelin
Olfatory Bulbectomy
Opioid Receptors
Vasopresin
topic Ghrelin
Olfatory Bulbectomy
Opioid Receptors
Vasopresin
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxietylike behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol/μl administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol/μl administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals.
Fil: Poretti, María Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Rask Andersen, Mathias. Uppsala University; Suecia
Fil: Kumar, Praveen. Uppsala University; Suecia
Fil: Rubiales, Susana Elizabeth. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina
Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Schiöth, Helgi B.. Uppsala University; Suecia
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
description Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxietylike behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol/μl administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol/μl administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11510
Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana Elizabeth; Fiol, Marta Haydee; et al.; Ghrelin effects expression of several genes associated with depression-like behavior; Elsevier Inc; Progress Of Neuro-psychopharmacology And Biological Psychiatry; 56; 1-2015; 227–234
0278-5846
url http://hdl.handle.net/11336/11510
identifier_str_mv Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana Elizabeth; Fiol, Marta Haydee; et al.; Ghrelin effects expression of several genes associated with depression-like behavior; Elsevier Inc; Progress Of Neuro-psychopharmacology And Biological Psychiatry; 56; 1-2015; 227–234
0278-5846
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2014.09.012
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584614001882
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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