Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma

Autores
Piñero, Federico; Tanno, Mario; Aballay Soteras, Gabriel; Tisi Baña, Matías; Dirchwolf, Melisa; Fassio, Eduardo; Ruf, Andrés; Mengarelli, Silvia Estela; Borzi, Silvia; Fernández, Nora; Ridruejo, Ezequiel; Descalzi, Valeria; Anders, Margarita; Mazzolini, Guillermo; Reggiardo, Virginia; Marciano, Sebastian; Perazzo, Florencia; Spina, Juan Carlos; McCormack, Lucas; Maraschio, Martín Alejandro; Lagues, Cecilia; Gadano, Adrián Carlos; Villamil, Federico; Silva, Marcelo; Cairo, Fernando; Ameigeiras, Beatriz
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The A.A.E.E.H has developed this guideline for the best care of patients with hepatocellular carcinoma (HCC) from Argentina. It was done from May 2018 to March 2020. Specific clinical research questions were systematically searched. The quality of evidence and level of recommendations were organized according to GRADE. HCC surveillance is strongly recommended with abdominal ultrasound (US) every six months in the population at risk for HCC (cirrhosis, hepatitis B or hepatitis C); it is suggested to add alpha-feto protein (AFP) levels in case of inexeperienced sonographers. Imaging diagnosis in patients at risk for HCC has high specificity and tumor biopsy is not mandatory. The Barcelona Clinic Liver Cancer algorithm is strongly recommended for HCC staging and treatment-decision processes. Liver resection is strongly recommended for patients without portal hypertension and preserved liver function. Composite models are suggested for liver transplant selection criteria. Therapies for HCC with robust clinical evidence include transarterial chemoembolization (TACE) and first to second line systemic treatment options (sorafenib, lenvatinib, regorafenib, cabozantinib and ramucirumab). Immunotherapy with nivolumab and pembrolizumab has failed to show statistical benefit but the novel combination of atezolizumab plus bevacizumab has recently shown survival benefit over sorafenib in frontline.
Fil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Tanno, Mario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Hospital Nacional del Centenario; Argentina
Fil: Aballay Soteras, Gabriel. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina
Fil: Tisi Baña, Matías. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Dirchwolf, Melisa. Hospital Privado de Rosario; Argentina
Fil: Fassio, Eduardo. Hospital Nacional Profesor Alejandro Posadas.; Argentina
Fil: Ruf, Andrés. Hospital Privado de Rosario; Argentina
Fil: Mengarelli, Silvia Estela. Gobierno de la Provincia de Entre Rios. Hospital San Roque.; Argentina
Fil: Borzi, Silvia. Hospital Privado de Cordoba; Argentina
Fil: Fernández, Nora. Hospital Británico de Buenos Aires; Argentina
Fil: Ridruejo, Ezequiel. Universidad Austral. Hospital Universitario Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Descalzi, Valeria. Fundación Favaloro; Argentina
Fil: Anders, Margarita. Hospital Alemán; Argentina
Fil: Mazzolini, Guillermo. Universidad Austral; Argentina
Fil: Reggiardo, Virginia. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
Fil: Marciano, Sebastian. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perazzo, Florencia. Hospital Británico de Buenos Aires; Argentina
Fil: Spina, Juan Carlos. Hospital Italiano; Argentina
Fil: McCormack, Lucas. Hospital Alemán; Argentina
Fil: Maraschio, Martín Alejandro. Hospital Privado de Cordoba; Argentina
Fil: Lagues, Cecilia. Universidad Austral; Argentina
Fil: Gadano, Adrián Carlos. Hospital Italiano. Departamento de Medicina.; Argentina
Fil: Villamil, Federico. Hospital Italiano. Departamento de Medicina.; Argentina. Hospital Británico de Buenos Aires; Argentina
Fil: Silva, Marcelo. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Cairo, Fernando. Hospital Británico de Buenos Aires; Argentina
Fil: Ameigeiras, Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Materia
ARGENTINA
LATIN AMERICA
LIVER CANCER
PRACTICE GUIDELINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146226
Acceder
id CONICETDig_a4f6c272c810debc7556b02966ce0458
oai_identifier_str oai:ri.conicet.gov.ar:11336/146226
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinomaPiñero, FedericoTanno, MarioAballay Soteras, GabrielTisi Baña, MatíasDirchwolf, MelisaFassio, EduardoRuf, AndrésMengarelli, Silvia EstelaBorzi, SilviaFernández, NoraRidruejo, EzequielDescalzi, ValeriaAnders, MargaritaMazzolini, GuillermoReggiardo, VirginiaMarciano, SebastianPerazzo, FlorenciaSpina, Juan CarlosMcCormack, LucasMaraschio, Martín AlejandroLagues, CeciliaGadano, Adrián CarlosVillamil, FedericoSilva, MarceloCairo, FernandoAmeigeiras, BeatrizARGENTINALATIN AMERICALIVER CANCERPRACTICE GUIDELINEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The A.A.E.E.H has developed this guideline for the best care of patients with hepatocellular carcinoma (HCC) from Argentina. It was done from May 2018 to March 2020. Specific clinical research questions were systematically searched. The quality of evidence and level of recommendations were organized according to GRADE. HCC surveillance is strongly recommended with abdominal ultrasound (US) every six months in the population at risk for HCC (cirrhosis, hepatitis B or hepatitis C); it is suggested to add alpha-feto protein (AFP) levels in case of inexeperienced sonographers. Imaging diagnosis in patients at risk for HCC has high specificity and tumor biopsy is not mandatory. The Barcelona Clinic Liver Cancer algorithm is strongly recommended for HCC staging and treatment-decision processes. Liver resection is strongly recommended for patients without portal hypertension and preserved liver function. Composite models are suggested for liver transplant selection criteria. Therapies for HCC with robust clinical evidence include transarterial chemoembolization (TACE) and first to second line systemic treatment options (sorafenib, lenvatinib, regorafenib, cabozantinib and ramucirumab). Immunotherapy with nivolumab and pembrolizumab has failed to show statistical benefit but the novel combination of atezolizumab plus bevacizumab has recently shown survival benefit over sorafenib in frontline.Fil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Tanno, Mario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Hospital Nacional del Centenario; ArgentinaFil: Aballay Soteras, Gabriel. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; ArgentinaFil: Tisi Baña, Matías. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Dirchwolf, Melisa. Hospital Privado de Rosario; ArgentinaFil: Fassio, Eduardo. Hospital Nacional Profesor Alejandro Posadas.; ArgentinaFil: Ruf, Andrés. Hospital Privado de Rosario; ArgentinaFil: Mengarelli, Silvia Estela. Gobierno de la Provincia de Entre Rios. Hospital San Roque.; ArgentinaFil: Borzi, Silvia. Hospital Privado de Cordoba; ArgentinaFil: Fernández, Nora. Hospital Británico de Buenos Aires; ArgentinaFil: Ridruejo, Ezequiel. Universidad Austral. Hospital Universitario Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Descalzi, Valeria. Fundación Favaloro; ArgentinaFil: Anders, Margarita. Hospital Alemán; ArgentinaFil: Mazzolini, Guillermo. Universidad Austral; ArgentinaFil: Reggiardo, Virginia. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; ArgentinaFil: Marciano, Sebastian. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perazzo, Florencia. Hospital Británico de Buenos Aires; ArgentinaFil: Spina, Juan Carlos. Hospital Italiano; ArgentinaFil: McCormack, Lucas. Hospital Alemán; ArgentinaFil: Maraschio, Martín Alejandro. Hospital Privado de Cordoba; ArgentinaFil: Lagues, Cecilia. Universidad Austral; ArgentinaFil: Gadano, Adrián Carlos. Hospital Italiano. Departamento de Medicina.; ArgentinaFil: Villamil, Federico. Hospital Italiano. Departamento de Medicina.; Argentina. Hospital Británico de Buenos Aires; ArgentinaFil: Silva, Marcelo. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Cairo, Fernando. Hospital Británico de Buenos Aires; ArgentinaFil: Ameigeiras, Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaSpringer2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146226Piñero, Federico; Tanno, Mario; Aballay Soteras, Gabriel; Tisi Baña, Matías; Dirchwolf, Melisa; et al.; Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma; Springer; Annals of Hepatology; 19; 5; 9-2020; 546-5691665-2681CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/urn/https://linkinghub.elsevier.com/retrieve/pii/S1665268120300636info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aohep.2020.06.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:56:08Zoai:ri.conicet.gov.ar:11336/146226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:56:08.312CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
title Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
spellingShingle Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
Piñero, Federico
ARGENTINA
LATIN AMERICA
LIVER CANCER
PRACTICE GUIDELINE
title_short Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
title_full Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
title_fullStr Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
title_full_unstemmed Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
title_sort Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
dc.creator.none.fl_str_mv Piñero, Federico
Tanno, Mario
Aballay Soteras, Gabriel
Tisi Baña, Matías
Dirchwolf, Melisa
Fassio, Eduardo
Ruf, Andrés
Mengarelli, Silvia Estela
Borzi, Silvia
Fernández, Nora
Ridruejo, Ezequiel
Descalzi, Valeria
Anders, Margarita
Mazzolini, Guillermo
Reggiardo, Virginia
Marciano, Sebastian
Perazzo, Florencia
Spina, Juan Carlos
McCormack, Lucas
Maraschio, Martín Alejandro
Lagues, Cecilia
Gadano, Adrián Carlos
Villamil, Federico
Silva, Marcelo
Cairo, Fernando
Ameigeiras, Beatriz
author Piñero, Federico
author_facet Piñero, Federico
Tanno, Mario
Aballay Soteras, Gabriel
Tisi Baña, Matías
Dirchwolf, Melisa
Fassio, Eduardo
Ruf, Andrés
Mengarelli, Silvia Estela
Borzi, Silvia
Fernández, Nora
Ridruejo, Ezequiel
Descalzi, Valeria
Anders, Margarita
Mazzolini, Guillermo
Reggiardo, Virginia
Marciano, Sebastian
Perazzo, Florencia
Spina, Juan Carlos
McCormack, Lucas
Maraschio, Martín Alejandro
Lagues, Cecilia
Gadano, Adrián Carlos
Villamil, Federico
Silva, Marcelo
Cairo, Fernando
Ameigeiras, Beatriz
author_role author
author2 Tanno, Mario
Aballay Soteras, Gabriel
Tisi Baña, Matías
Dirchwolf, Melisa
Fassio, Eduardo
Ruf, Andrés
Mengarelli, Silvia Estela
Borzi, Silvia
Fernández, Nora
Ridruejo, Ezequiel
Descalzi, Valeria
Anders, Margarita
Mazzolini, Guillermo
Reggiardo, Virginia
Marciano, Sebastian
Perazzo, Florencia
Spina, Juan Carlos
McCormack, Lucas
Maraschio, Martín Alejandro
Lagues, Cecilia
Gadano, Adrián Carlos
Villamil, Federico
Silva, Marcelo
Cairo, Fernando
Ameigeiras, Beatriz
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARGENTINA
LATIN AMERICA
LIVER CANCER
PRACTICE GUIDELINE
topic ARGENTINA
LATIN AMERICA
LIVER CANCER
PRACTICE GUIDELINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The A.A.E.E.H has developed this guideline for the best care of patients with hepatocellular carcinoma (HCC) from Argentina. It was done from May 2018 to March 2020. Specific clinical research questions were systematically searched. The quality of evidence and level of recommendations were organized according to GRADE. HCC surveillance is strongly recommended with abdominal ultrasound (US) every six months in the population at risk for HCC (cirrhosis, hepatitis B or hepatitis C); it is suggested to add alpha-feto protein (AFP) levels in case of inexeperienced sonographers. Imaging diagnosis in patients at risk for HCC has high specificity and tumor biopsy is not mandatory. The Barcelona Clinic Liver Cancer algorithm is strongly recommended for HCC staging and treatment-decision processes. Liver resection is strongly recommended for patients without portal hypertension and preserved liver function. Composite models are suggested for liver transplant selection criteria. Therapies for HCC with robust clinical evidence include transarterial chemoembolization (TACE) and first to second line systemic treatment options (sorafenib, lenvatinib, regorafenib, cabozantinib and ramucirumab). Immunotherapy with nivolumab and pembrolizumab has failed to show statistical benefit but the novel combination of atezolizumab plus bevacizumab has recently shown survival benefit over sorafenib in frontline.
Fil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Tanno, Mario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Hospital Nacional del Centenario; Argentina
Fil: Aballay Soteras, Gabriel. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor "Dr. Cosme Argerich"; Argentina
Fil: Tisi Baña, Matías. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Dirchwolf, Melisa. Hospital Privado de Rosario; Argentina
Fil: Fassio, Eduardo. Hospital Nacional Profesor Alejandro Posadas.; Argentina
Fil: Ruf, Andrés. Hospital Privado de Rosario; Argentina
Fil: Mengarelli, Silvia Estela. Gobierno de la Provincia de Entre Rios. Hospital San Roque.; Argentina
Fil: Borzi, Silvia. Hospital Privado de Cordoba; Argentina
Fil: Fernández, Nora. Hospital Británico de Buenos Aires; Argentina
Fil: Ridruejo, Ezequiel. Universidad Austral. Hospital Universitario Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Descalzi, Valeria. Fundación Favaloro; Argentina
Fil: Anders, Margarita. Hospital Alemán; Argentina
Fil: Mazzolini, Guillermo. Universidad Austral; Argentina
Fil: Reggiardo, Virginia. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
Fil: Marciano, Sebastian. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perazzo, Florencia. Hospital Británico de Buenos Aires; Argentina
Fil: Spina, Juan Carlos. Hospital Italiano; Argentina
Fil: McCormack, Lucas. Hospital Alemán; Argentina
Fil: Maraschio, Martín Alejandro. Hospital Privado de Cordoba; Argentina
Fil: Lagues, Cecilia. Universidad Austral; Argentina
Fil: Gadano, Adrián Carlos. Hospital Italiano. Departamento de Medicina.; Argentina
Fil: Villamil, Federico. Hospital Italiano. Departamento de Medicina.; Argentina. Hospital Británico de Buenos Aires; Argentina
Fil: Silva, Marcelo. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Cairo, Fernando. Hospital Británico de Buenos Aires; Argentina
Fil: Ameigeiras, Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
description The A.A.E.E.H has developed this guideline for the best care of patients with hepatocellular carcinoma (HCC) from Argentina. It was done from May 2018 to March 2020. Specific clinical research questions were systematically searched. The quality of evidence and level of recommendations were organized according to GRADE. HCC surveillance is strongly recommended with abdominal ultrasound (US) every six months in the population at risk for HCC (cirrhosis, hepatitis B or hepatitis C); it is suggested to add alpha-feto protein (AFP) levels in case of inexeperienced sonographers. Imaging diagnosis in patients at risk for HCC has high specificity and tumor biopsy is not mandatory. The Barcelona Clinic Liver Cancer algorithm is strongly recommended for HCC staging and treatment-decision processes. Liver resection is strongly recommended for patients without portal hypertension and preserved liver function. Composite models are suggested for liver transplant selection criteria. Therapies for HCC with robust clinical evidence include transarterial chemoembolization (TACE) and first to second line systemic treatment options (sorafenib, lenvatinib, regorafenib, cabozantinib and ramucirumab). Immunotherapy with nivolumab and pembrolizumab has failed to show statistical benefit but the novel combination of atezolizumab plus bevacizumab has recently shown survival benefit over sorafenib in frontline.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146226
Piñero, Federico; Tanno, Mario; Aballay Soteras, Gabriel; Tisi Baña, Matías; Dirchwolf, Melisa; et al.; Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma; Springer; Annals of Hepatology; 19; 5; 9-2020; 546-569
1665-2681
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146226
identifier_str_mv Piñero, Federico; Tanno, Mario; Aballay Soteras, Gabriel; Tisi Baña, Matías; Dirchwolf, Melisa; et al.; Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma; Springer; Annals of Hepatology; 19; 5; 9-2020; 546-569
1665-2681
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/urn/https://linkinghub.elsevier.com/retrieve/pii/S1665268120300636
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aohep.2020.06.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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