Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells
- Autores
- Almejún, María Belén; Borge, Mercedes; Colado, Ana; Elías, Esteban Enrique; Podaza, Enrique Arturo; Risnik, Denise Mariel; de Brasi, Carlos Daniel; Stanganelli, Carmen Graciela; Slavutsky, Irma Rosa; Cabrejo, María del Rosario; Fernández Grecco, Horacio; Bezares, Raimundo Fernando; Cranco, Santiago; Burgos, Rubén Ángel; Sánchez Ávalos, Julio César Américo; Oppezzo, Pablo; Giordano, Mirta Nilda; Gamberale, Romina
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which mediates several biological functions, including cell growth, differentiation, cell survival, migration, and angiogenesis among other tasks.1 S1P generation depends on the conversion of sphingosine to S1P, in a reaction catalyzed by two isoforms of SKs, SK1 and SK2, and its levels are tightly controlled via a rapid degradation by intracellular S1P lyases (S1PL) or dephosphorylated by S1P phosphatases.1 Once produced, S1P may function as an intracellular second messenger and/or can be exported outside the cells, where it binds to specific S1P receptors (S1PRs) and initiates downstream signaling pathways, in a paracrine or autocrine manner, in a process known as “inside-out” signaling.
Fil: Almejún, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Colado, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Elías, Esteban Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Podaza, Enrique Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Risnik, Denise Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: de Brasi, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Stanganelli, Carmen Graciela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Cabrejo, María. Ciudad Autónoma de Buenos Aires. Sanatorio Municipal "Dr. Julio Méndez"; Argentina
Fil: Fernández Grecco, Horacio. Ciudad Autónoma de Buenos Aires. Sanatorio Municipal "Dr. Julio Méndez"; Argentina
Fil: Bezares, Raimundo Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Cranco, Santiago. Instituto Alexander Fleming; Argentina
Fil: Burgos, Rubén Ángel. Instituto Alexander Fleming; Argentina
Fil: Sánchez Ávalos, Julio César Américo. Instituto Alexander Fleming; Argentina
Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; Uruguay
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina - Materia
-
Sphingosine 1 Phosphate
Sphingosine 1 Phosphate-Kinase
Chronic Lymphocytic Leukemia - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/40959
Ver los metadatos del registro completo
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Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia CellsAlmejún, María BelénBorge, MercedesColado, AnaElías, Esteban EnriquePodaza, Enrique ArturoRisnik, Denise Marielde Brasi, Carlos DanielStanganelli, Carmen GracielaSlavutsky, Irma RosaCabrejo, María del RosarioFernández Grecco, HoracioBezares, Raimundo FernandoCranco, SantiagoBurgos, Rubén ÁngelSánchez Ávalos, Julio César AméricoOppezzo, PabloGiordano, Mirta NildaGamberale, RominaSphingosine 1 PhosphateSphingosine 1 Phosphate-KinaseChronic Lymphocytic Leukemiahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which mediates several biological functions, including cell growth, differentiation, cell survival, migration, and angiogenesis among other tasks.1 S1P generation depends on the conversion of sphingosine to S1P, in a reaction catalyzed by two isoforms of SKs, SK1 and SK2, and its levels are tightly controlled via a rapid degradation by intracellular S1P lyases (S1PL) or dephosphorylated by S1P phosphatases.1 Once produced, S1P may function as an intracellular second messenger and/or can be exported outside the cells, where it binds to specific S1P receptors (S1PRs) and initiates downstream signaling pathways, in a paracrine or autocrine manner, in a process known as “inside-out” signaling.Fil: Almejún, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Colado, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Elías, Esteban Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Podaza, Enrique Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Risnik, Denise Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: de Brasi, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Stanganelli, Carmen Graciela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Cabrejo, María. Ciudad Autónoma de Buenos Aires. Sanatorio Municipal "Dr. Julio Méndez"; ArgentinaFil: Fernández Grecco, Horacio. Ciudad Autónoma de Buenos Aires. Sanatorio Municipal "Dr. Julio Méndez"; ArgentinaFil: Bezares, Raimundo Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Cranco, Santiago. Instituto Alexander Fleming; ArgentinaFil: Burgos, Rubén Ángel. Instituto Alexander Fleming; ArgentinaFil: Sánchez Ávalos, Julio César Américo. Instituto Alexander Fleming; ArgentinaFil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; UruguayFil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFerrata Storti Foundation2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40959Almejún, María Belén; Borge, Mercedes; Colado, Ana; Elías, Esteban Enrique; Podaza, Enrique Arturo; et al.; Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells; Ferrata Storti Foundation; Haematologica; 102; 7; 3-2017; 257-2600390-60781592-8721CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/lookup/doi/10.3324/haematol.2017.167353info:eu-repo/semantics/altIdentifier/doi/10.3324/haematol.2017.167353info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:15Zoai:ri.conicet.gov.ar:11336/40959instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:15.582CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells |
| title |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells |
| spellingShingle |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells Almejún, María Belén Sphingosine 1 Phosphate Sphingosine 1 Phosphate-Kinase Chronic Lymphocytic Leukemia |
| title_short |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells |
| title_full |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells |
| title_fullStr |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells |
| title_full_unstemmed |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells |
| title_sort |
Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells |
| dc.creator.none.fl_str_mv |
Almejún, María Belén Borge, Mercedes Colado, Ana Elías, Esteban Enrique Podaza, Enrique Arturo Risnik, Denise Mariel de Brasi, Carlos Daniel Stanganelli, Carmen Graciela Slavutsky, Irma Rosa Cabrejo, María del Rosario Fernández Grecco, Horacio Bezares, Raimundo Fernando Cranco, Santiago Burgos, Rubén Ángel Sánchez Ávalos, Julio César Américo Oppezzo, Pablo Giordano, Mirta Nilda Gamberale, Romina |
| author |
Almejún, María Belén |
| author_facet |
Almejún, María Belén Borge, Mercedes Colado, Ana Elías, Esteban Enrique Podaza, Enrique Arturo Risnik, Denise Mariel de Brasi, Carlos Daniel Stanganelli, Carmen Graciela Slavutsky, Irma Rosa Cabrejo, María del Rosario Fernández Grecco, Horacio Bezares, Raimundo Fernando Cranco, Santiago Burgos, Rubén Ángel Sánchez Ávalos, Julio César Américo Oppezzo, Pablo Giordano, Mirta Nilda Gamberale, Romina |
| author_role |
author |
| author2 |
Borge, Mercedes Colado, Ana Elías, Esteban Enrique Podaza, Enrique Arturo Risnik, Denise Mariel de Brasi, Carlos Daniel Stanganelli, Carmen Graciela Slavutsky, Irma Rosa Cabrejo, María del Rosario Fernández Grecco, Horacio Bezares, Raimundo Fernando Cranco, Santiago Burgos, Rubén Ángel Sánchez Ávalos, Julio César Américo Oppezzo, Pablo Giordano, Mirta Nilda Gamberale, Romina |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Sphingosine 1 Phosphate Sphingosine 1 Phosphate-Kinase Chronic Lymphocytic Leukemia |
| topic |
Sphingosine 1 Phosphate Sphingosine 1 Phosphate-Kinase Chronic Lymphocytic Leukemia |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which mediates several biological functions, including cell growth, differentiation, cell survival, migration, and angiogenesis among other tasks.1 S1P generation depends on the conversion of sphingosine to S1P, in a reaction catalyzed by two isoforms of SKs, SK1 and SK2, and its levels are tightly controlled via a rapid degradation by intracellular S1P lyases (S1PL) or dephosphorylated by S1P phosphatases.1 Once produced, S1P may function as an intracellular second messenger and/or can be exported outside the cells, where it binds to specific S1P receptors (S1PRs) and initiates downstream signaling pathways, in a paracrine or autocrine manner, in a process known as “inside-out” signaling. Fil: Almejún, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Colado, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Elías, Esteban Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Podaza, Enrique Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Risnik, Denise Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: de Brasi, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Stanganelli, Carmen Graciela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Cabrejo, María. Ciudad Autónoma de Buenos Aires. Sanatorio Municipal "Dr. Julio Méndez"; Argentina Fil: Fernández Grecco, Horacio. Ciudad Autónoma de Buenos Aires. Sanatorio Municipal "Dr. Julio Méndez"; Argentina Fil: Bezares, Raimundo Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina Fil: Cranco, Santiago. Instituto Alexander Fleming; Argentina Fil: Burgos, Rubén Ángel. Instituto Alexander Fleming; Argentina Fil: Sánchez Ávalos, Julio César Américo. Instituto Alexander Fleming; Argentina Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; Uruguay Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina |
| description |
Sphingosine kinases (SKs) have received the most attention as important enzymes in cancer biology. They participate in the regulation of bioactive sphingolipid metabolism by producing sphingosine-1 phosphate (S1P) which mediates several biological functions, including cell growth, differentiation, cell survival, migration, and angiogenesis among other tasks.1 S1P generation depends on the conversion of sphingosine to S1P, in a reaction catalyzed by two isoforms of SKs, SK1 and SK2, and its levels are tightly controlled via a rapid degradation by intracellular S1P lyases (S1PL) or dephosphorylated by S1P phosphatases.1 Once produced, S1P may function as an intracellular second messenger and/or can be exported outside the cells, where it binds to specific S1P receptors (S1PRs) and initiates downstream signaling pathways, in a paracrine or autocrine manner, in a process known as “inside-out” signaling. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-03 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
| status_str |
publishedVersion |
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http://hdl.handle.net/11336/40959 Almejún, María Belén; Borge, Mercedes; Colado, Ana; Elías, Esteban Enrique; Podaza, Enrique Arturo; et al.; Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells; Ferrata Storti Foundation; Haematologica; 102; 7; 3-2017; 257-260 0390-6078 1592-8721 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/40959 |
| identifier_str_mv |
Almejún, María Belén; Borge, Mercedes; Colado, Ana; Elías, Esteban Enrique; Podaza, Enrique Arturo; et al.; Sphingosine Kinase 1 Participates In The Activation, Proliferation And Survival Of Chronic Lymphocytic Leukemia Cells; Ferrata Storti Foundation; Haematologica; 102; 7; 3-2017; 257-260 0390-6078 1592-8721 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/lookup/doi/10.3324/haematol.2017.167353 info:eu-repo/semantics/altIdentifier/doi/10.3324/haematol.2017.167353 |
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Ferrata Storti Foundation |
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Ferrata Storti Foundation |
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