Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb

Autores
Rivera, Oscar Edgardo; Varayoud, Jorgelina Guadalupe; Rodríguez, Angel Horacio; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERα, ERβ, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.
Fil: Rivera, Oscar Edgardo. Universidad Nacional de Lomas de Zamora; Argentina
Fil: Varayoud, Jorgelina Guadalupe. Universidad Nacional del Litoral; Argentina
Fil: Rodríguez, Angel Horacio. Universidad Nacional del Litoral; Argentina
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; Argentina
Fil: Luque, Enrique Hugo. Universidad Nacional del Litoral; Argentina
Materia
BISPHENOL A
DIETHYLSTILBESTROL
OVARIAN FOLLICULAR DYNAMICS IN LAMBS
SHEEP FERTILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/100836
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lambRivera, Oscar EdgardoVarayoud, Jorgelina GuadalupeRodríguez, Angel HoracioMuñoz de Toro, Monica MilagrosLuque, Enrique HugoBISPHENOL ADIETHYLSTILBESTROLOVARIAN FOLLICULAR DYNAMICS IN LAMBSSHEEP FERTILITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERα, ERβ, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.Fil: Rivera, Oscar Edgardo. Universidad Nacional de Lomas de Zamora; ArgentinaFil: Varayoud, Jorgelina Guadalupe. Universidad Nacional del Litoral; ArgentinaFil: Rodríguez, Angel Horacio. Universidad Nacional del Litoral; ArgentinaFil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; ArgentinaFil: Luque, Enrique Hugo. Universidad Nacional del Litoral; ArgentinaPergamon-Elsevier Science Ltd2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/100836Rivera, Oscar Edgardo; Varayoud, Jorgelina Guadalupe; Rodríguez, Angel Horacio; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo; Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 32; 3; 11-2011; 304-3120890-6238CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0890623811002917info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reprotox.2011.06.118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:18Zoai:ri.conicet.gov.ar:11336/100836instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:18.768CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
title Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
spellingShingle Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
Rivera, Oscar Edgardo
BISPHENOL A
DIETHYLSTILBESTROL
OVARIAN FOLLICULAR DYNAMICS IN LAMBS
SHEEP FERTILITY
title_short Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
title_full Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
title_fullStr Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
title_full_unstemmed Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
title_sort Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb
dc.creator.none.fl_str_mv Rivera, Oscar Edgardo
Varayoud, Jorgelina Guadalupe
Rodríguez, Angel Horacio
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
author Rivera, Oscar Edgardo
author_facet Rivera, Oscar Edgardo
Varayoud, Jorgelina Guadalupe
Rodríguez, Angel Horacio
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
author_role author
author2 Varayoud, Jorgelina Guadalupe
Rodríguez, Angel Horacio
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
author2_role author
author
author
author
dc.subject.none.fl_str_mv BISPHENOL A
DIETHYLSTILBESTROL
OVARIAN FOLLICULAR DYNAMICS IN LAMBS
SHEEP FERTILITY
topic BISPHENOL A
DIETHYLSTILBESTROL
OVARIAN FOLLICULAR DYNAMICS IN LAMBS
SHEEP FERTILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERα, ERβ, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.
Fil: Rivera, Oscar Edgardo. Universidad Nacional de Lomas de Zamora; Argentina
Fil: Varayoud, Jorgelina Guadalupe. Universidad Nacional del Litoral; Argentina
Fil: Rodríguez, Angel Horacio. Universidad Nacional del Litoral; Argentina
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; Argentina
Fil: Luque, Enrique Hugo. Universidad Nacional del Litoral; Argentina
description We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERα, ERβ, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/100836
Rivera, Oscar Edgardo; Varayoud, Jorgelina Guadalupe; Rodríguez, Angel Horacio; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo; Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 32; 3; 11-2011; 304-312
0890-6238
CONICET Digital
CONICET
url http://hdl.handle.net/11336/100836
identifier_str_mv Rivera, Oscar Edgardo; Varayoud, Jorgelina Guadalupe; Rodríguez, Angel Horacio; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo; Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 32; 3; 11-2011; 304-312
0890-6238
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0890623811002917
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reprotox.2011.06.118
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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