Communication Among Photoreceptors and the Central Clock Affects Sleep Profile

Autores
Damulewicz, Milena; Ispizua, Juan Ignacio; Ceriani, Maria Fernanda; Pyza, Elzbieta M.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Light is one of the most important factors regulating rhythmical behavior of Drosophila melanogaster. It is received by different photoreceptors and entrains the circadian clock, which controls sleep. The retina is known to be essential for light perception, as it is composed of specialized light-sensitive cells which transmit signal to deeper parts of the brain. In this study we examined the role of specific photoreceptor types and peripheral oscillators located in these cells in the regulation of sleep pattern. We showed that sleep is controlled by the visual system in a very complex way. Photoreceptors expressing Rh1, Rh3 are involved in night-time sleep regulation, while cells expressing Rh5 and Rh6 affect sleep both during the day and night. Moreover, Hofbauer-Buchner (HB) eyelets which can directly contact with s-LNvs and l-LNvs play a wake-promoting function during the day. In addition, we showed that L2 interneurons, which receive signal from R1-6, form direct synaptic contacts with l-LNvs, which provides new light input to the clock network.
Fil: Damulewicz, Milena. Jagiellonian University; Polonia
Fil: Ispizua, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Pyza, Elzbieta M.. Jagiellonian University; Polonia
Materia
DROSOPHILA
HOFBAUER-BUCHNER EYELETS
PERIPHERAL CLOCK
PHOTORECEPTORS
SLEEP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138725
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Communication Among Photoreceptors and the Central Clock Affects Sleep ProfileDamulewicz, MilenaIspizua, Juan IgnacioCeriani, Maria FernandaPyza, Elzbieta M.DROSOPHILAHOFBAUER-BUCHNER EYELETSPERIPHERAL CLOCKPHOTORECEPTORSSLEEPhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Light is one of the most important factors regulating rhythmical behavior of Drosophila melanogaster. It is received by different photoreceptors and entrains the circadian clock, which controls sleep. The retina is known to be essential for light perception, as it is composed of specialized light-sensitive cells which transmit signal to deeper parts of the brain. In this study we examined the role of specific photoreceptor types and peripheral oscillators located in these cells in the regulation of sleep pattern. We showed that sleep is controlled by the visual system in a very complex way. Photoreceptors expressing Rh1, Rh3 are involved in night-time sleep regulation, while cells expressing Rh5 and Rh6 affect sleep both during the day and night. Moreover, Hofbauer-Buchner (HB) eyelets which can directly contact with s-LNvs and l-LNvs play a wake-promoting function during the day. In addition, we showed that L2 interneurons, which receive signal from R1-6, form direct synaptic contacts with l-LNvs, which provides new light input to the clock network.Fil: Damulewicz, Milena. Jagiellonian University; PoloniaFil: Ispizua, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Pyza, Elzbieta M.. Jagiellonian University; PoloniaFrontiers Media S.A.2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138725Damulewicz, Milena; Ispizua, Juan Ignacio; Ceriani, Maria Fernanda; Pyza, Elzbieta M.; Communication Among Photoreceptors and the Central Clock Affects Sleep Profile; Frontiers Media S.A.; Frontiers in Physiology; 11; 8-2020; 1-171664-042XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2020.00993/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2020.00993info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:17Zoai:ri.conicet.gov.ar:11336/138725instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:17.267CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
title Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
spellingShingle Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
Damulewicz, Milena
DROSOPHILA
HOFBAUER-BUCHNER EYELETS
PERIPHERAL CLOCK
PHOTORECEPTORS
SLEEP
title_short Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
title_full Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
title_fullStr Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
title_full_unstemmed Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
title_sort Communication Among Photoreceptors and the Central Clock Affects Sleep Profile
dc.creator.none.fl_str_mv Damulewicz, Milena
Ispizua, Juan Ignacio
Ceriani, Maria Fernanda
Pyza, Elzbieta M.
author Damulewicz, Milena
author_facet Damulewicz, Milena
Ispizua, Juan Ignacio
Ceriani, Maria Fernanda
Pyza, Elzbieta M.
author_role author
author2 Ispizua, Juan Ignacio
Ceriani, Maria Fernanda
Pyza, Elzbieta M.
author2_role author
author
author
dc.subject.none.fl_str_mv DROSOPHILA
HOFBAUER-BUCHNER EYELETS
PERIPHERAL CLOCK
PHOTORECEPTORS
SLEEP
topic DROSOPHILA
HOFBAUER-BUCHNER EYELETS
PERIPHERAL CLOCK
PHOTORECEPTORS
SLEEP
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Light is one of the most important factors regulating rhythmical behavior of Drosophila melanogaster. It is received by different photoreceptors and entrains the circadian clock, which controls sleep. The retina is known to be essential for light perception, as it is composed of specialized light-sensitive cells which transmit signal to deeper parts of the brain. In this study we examined the role of specific photoreceptor types and peripheral oscillators located in these cells in the regulation of sleep pattern. We showed that sleep is controlled by the visual system in a very complex way. Photoreceptors expressing Rh1, Rh3 are involved in night-time sleep regulation, while cells expressing Rh5 and Rh6 affect sleep both during the day and night. Moreover, Hofbauer-Buchner (HB) eyelets which can directly contact with s-LNvs and l-LNvs play a wake-promoting function during the day. In addition, we showed that L2 interneurons, which receive signal from R1-6, form direct synaptic contacts with l-LNvs, which provides new light input to the clock network.
Fil: Damulewicz, Milena. Jagiellonian University; Polonia
Fil: Ispizua, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Ceriani, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Pyza, Elzbieta M.. Jagiellonian University; Polonia
description Light is one of the most important factors regulating rhythmical behavior of Drosophila melanogaster. It is received by different photoreceptors and entrains the circadian clock, which controls sleep. The retina is known to be essential for light perception, as it is composed of specialized light-sensitive cells which transmit signal to deeper parts of the brain. In this study we examined the role of specific photoreceptor types and peripheral oscillators located in these cells in the regulation of sleep pattern. We showed that sleep is controlled by the visual system in a very complex way. Photoreceptors expressing Rh1, Rh3 are involved in night-time sleep regulation, while cells expressing Rh5 and Rh6 affect sleep both during the day and night. Moreover, Hofbauer-Buchner (HB) eyelets which can directly contact with s-LNvs and l-LNvs play a wake-promoting function during the day. In addition, we showed that L2 interneurons, which receive signal from R1-6, form direct synaptic contacts with l-LNvs, which provides new light input to the clock network.
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138725
Damulewicz, Milena; Ispizua, Juan Ignacio; Ceriani, Maria Fernanda; Pyza, Elzbieta M.; Communication Among Photoreceptors and the Central Clock Affects Sleep Profile; Frontiers Media S.A.; Frontiers in Physiology; 11; 8-2020; 1-17
1664-042X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138725
identifier_str_mv Damulewicz, Milena; Ispizua, Juan Ignacio; Ceriani, Maria Fernanda; Pyza, Elzbieta M.; Communication Among Photoreceptors and the Central Clock Affects Sleep Profile; Frontiers Media S.A.; Frontiers in Physiology; 11; 8-2020; 1-17
1664-042X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2020.00993/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2020.00993
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269848328994816
score 13.13397

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