Spongiform leukoencephalopathy in an adult mixed breed female dog

Autores
García, Juan Agustín; Batlle, Martí P.; Romero, Agustín; Alvarez, Eduardo; Dutra, Fernando
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Leukoencephalomyelopathy is a nonspecific lesion characterized by widespread vacuolation of central nervous system white matter. It is mainly of genetic basis, occurring in young pure breed dogs. This report describes a neurodegenerative disease associated to demyelination in an adult mixed breed female dog. After 20 days in a kennel with 12 other dogs, the dog showed progressive nervous signs with ataxia and inability to maintain balance. No other dog was affected. After 15 days, the animal was euthanized in extremis and necropsied. No macroscopic lesions of diagnostic relevance were present. Microscopically, status espongiosus was observed in white matter throughout the length of the neuroaxis, from frontal brain lobe to lumbar spinal cord. Specific stains of Kluver Barrera and immunohistochemistry for the detection of phosphorylated and non-phosphorylated neurofilaments, microglia, astrocytosis, oligodendrocytosis and myelin proteins in brain and spinal cord sections showed demyelination, axonal fragmentation and degeneration, microgliosis and decrease of oligodendrocytes. The anatomopathological study and epidemiological data suggests a primary demyelination due to decrease in number and function of oligodendrocytes, which is probably of genetic basis with late onset.
Fil: García, Juan Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible - Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Batlle, Martí P.. Universitat Autònoma de Barcelona; España
Fil: Romero, Agustín. División de Laboratorios Veterinarios; Uruguay
Fil: Alvarez, Eduardo. Universidad de la República; Uruguay
Fil: Dutra, Fernando. División de Laboratorios Veterinarios; Uruguay
Materia
DOMESTIC ANIMALS
GENETIC DISEASE
NEURODEGENERATIVE DISEASE
NEUROPATHOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/170579
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Spongiform leukoencephalopathy in an adult mixed breed female dogGarcía, Juan AgustínBatlle, Martí P.Romero, AgustínAlvarez, EduardoDutra, FernandoDOMESTIC ANIMALSGENETIC DISEASENEURODEGENERATIVE DISEASENEUROPATHOLOGYhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Leukoencephalomyelopathy is a nonspecific lesion characterized by widespread vacuolation of central nervous system white matter. It is mainly of genetic basis, occurring in young pure breed dogs. This report describes a neurodegenerative disease associated to demyelination in an adult mixed breed female dog. After 20 days in a kennel with 12 other dogs, the dog showed progressive nervous signs with ataxia and inability to maintain balance. No other dog was affected. After 15 days, the animal was euthanized in extremis and necropsied. No macroscopic lesions of diagnostic relevance were present. Microscopically, status espongiosus was observed in white matter throughout the length of the neuroaxis, from frontal brain lobe to lumbar spinal cord. Specific stains of Kluver Barrera and immunohistochemistry for the detection of phosphorylated and non-phosphorylated neurofilaments, microglia, astrocytosis, oligodendrocytosis and myelin proteins in brain and spinal cord sections showed demyelination, axonal fragmentation and degeneration, microgliosis and decrease of oligodendrocytes. The anatomopathological study and epidemiological data suggests a primary demyelination due to decrease in number and function of oligodendrocytes, which is probably of genetic basis with late onset.Fil: García, Juan Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible - Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; ArgentinaFil: Batlle, Martí P.. Universitat Autònoma de Barcelona; EspañaFil: Romero, Agustín. División de Laboratorios Veterinarios; UruguayFil: Alvarez, Eduardo. Universidad de la República; UruguayFil: Dutra, Fernando. División de Laboratorios Veterinarios; UruguayBrazilian Association of Veterinary Pathology2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170579García, Juan Agustín; Batlle, Martí P.; Romero, Agustín; Alvarez, Eduardo; Dutra, Fernando; Spongiform leukoencephalopathy in an adult mixed breed female dog; Brazilian Association of Veterinary Pathology; Brazilian Journal of Veterinary Pathology; 13; 2; 7-2020; 519-5231983-0246CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.24070/bjvp.1983-0246.v13i2p519-523info:eu-repo/semantics/altIdentifier/url/https://www.bvs-vet.org.br/vetindex/periodicos/brazilian-journal-veterinary-pathology/13-(2020)-2/spongiform-leukoencephalopathy-in-an-adult-mixed-breed-female-dog/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:23Zoai:ri.conicet.gov.ar:11336/170579instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:24.03CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Spongiform leukoencephalopathy in an adult mixed breed female dog
title Spongiform leukoencephalopathy in an adult mixed breed female dog
spellingShingle Spongiform leukoencephalopathy in an adult mixed breed female dog
García, Juan Agustín
DOMESTIC ANIMALS
GENETIC DISEASE
NEURODEGENERATIVE DISEASE
NEUROPATHOLOGY
title_short Spongiform leukoencephalopathy in an adult mixed breed female dog
title_full Spongiform leukoencephalopathy in an adult mixed breed female dog
title_fullStr Spongiform leukoencephalopathy in an adult mixed breed female dog
title_full_unstemmed Spongiform leukoencephalopathy in an adult mixed breed female dog
title_sort Spongiform leukoencephalopathy in an adult mixed breed female dog
dc.creator.none.fl_str_mv García, Juan Agustín
Batlle, Martí P.
Romero, Agustín
Alvarez, Eduardo
Dutra, Fernando
author García, Juan Agustín
author_facet García, Juan Agustín
Batlle, Martí P.
Romero, Agustín
Alvarez, Eduardo
Dutra, Fernando
author_role author
author2 Batlle, Martí P.
Romero, Agustín
Alvarez, Eduardo
Dutra, Fernando
author2_role author
author
author
author
dc.subject.none.fl_str_mv DOMESTIC ANIMALS
GENETIC DISEASE
NEURODEGENERATIVE DISEASE
NEUROPATHOLOGY
topic DOMESTIC ANIMALS
GENETIC DISEASE
NEURODEGENERATIVE DISEASE
NEUROPATHOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Leukoencephalomyelopathy is a nonspecific lesion characterized by widespread vacuolation of central nervous system white matter. It is mainly of genetic basis, occurring in young pure breed dogs. This report describes a neurodegenerative disease associated to demyelination in an adult mixed breed female dog. After 20 days in a kennel with 12 other dogs, the dog showed progressive nervous signs with ataxia and inability to maintain balance. No other dog was affected. After 15 days, the animal was euthanized in extremis and necropsied. No macroscopic lesions of diagnostic relevance were present. Microscopically, status espongiosus was observed in white matter throughout the length of the neuroaxis, from frontal brain lobe to lumbar spinal cord. Specific stains of Kluver Barrera and immunohistochemistry for the detection of phosphorylated and non-phosphorylated neurofilaments, microglia, astrocytosis, oligodendrocytosis and myelin proteins in brain and spinal cord sections showed demyelination, axonal fragmentation and degeneration, microgliosis and decrease of oligodendrocytes. The anatomopathological study and epidemiological data suggests a primary demyelination due to decrease in number and function of oligodendrocytes, which is probably of genetic basis with late onset.
Fil: García, Juan Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible - Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Batlle, Martí P.. Universitat Autònoma de Barcelona; España
Fil: Romero, Agustín. División de Laboratorios Veterinarios; Uruguay
Fil: Alvarez, Eduardo. Universidad de la República; Uruguay
Fil: Dutra, Fernando. División de Laboratorios Veterinarios; Uruguay
description Leukoencephalomyelopathy is a nonspecific lesion characterized by widespread vacuolation of central nervous system white matter. It is mainly of genetic basis, occurring in young pure breed dogs. This report describes a neurodegenerative disease associated to demyelination in an adult mixed breed female dog. After 20 days in a kennel with 12 other dogs, the dog showed progressive nervous signs with ataxia and inability to maintain balance. No other dog was affected. After 15 days, the animal was euthanized in extremis and necropsied. No macroscopic lesions of diagnostic relevance were present. Microscopically, status espongiosus was observed in white matter throughout the length of the neuroaxis, from frontal brain lobe to lumbar spinal cord. Specific stains of Kluver Barrera and immunohistochemistry for the detection of phosphorylated and non-phosphorylated neurofilaments, microglia, astrocytosis, oligodendrocytosis and myelin proteins in brain and spinal cord sections showed demyelination, axonal fragmentation and degeneration, microgliosis and decrease of oligodendrocytes. The anatomopathological study and epidemiological data suggests a primary demyelination due to decrease in number and function of oligodendrocytes, which is probably of genetic basis with late onset.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/170579
García, Juan Agustín; Batlle, Martí P.; Romero, Agustín; Alvarez, Eduardo; Dutra, Fernando; Spongiform leukoencephalopathy in an adult mixed breed female dog; Brazilian Association of Veterinary Pathology; Brazilian Journal of Veterinary Pathology; 13; 2; 7-2020; 519-523
1983-0246
CONICET Digital
CONICET
url http://hdl.handle.net/11336/170579
identifier_str_mv García, Juan Agustín; Batlle, Martí P.; Romero, Agustín; Alvarez, Eduardo; Dutra, Fernando; Spongiform leukoencephalopathy in an adult mixed breed female dog; Brazilian Association of Veterinary Pathology; Brazilian Journal of Veterinary Pathology; 13; 2; 7-2020; 519-523
1983-0246
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.24070/bjvp.1983-0246.v13i2p519-523
info:eu-repo/semantics/altIdentifier/url/https://www.bvs-vet.org.br/vetindex/periodicos/brazilian-journal-veterinary-pathology/13-(2020)-2/spongiform-leukoencephalopathy-in-an-adult-mixed-breed-female-dog/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Brazilian Association of Veterinary Pathology
publisher.none.fl_str_mv Brazilian Association of Veterinary Pathology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614276126343168
score 13.070432

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