Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

Autores
Terreros Roncal, J.; Moreno Jiménez, E.P.; Flor García, M.; Rodríguez Moreno, C.B.; Trinchero, Mariela Fernanda; Cafini, F.; Rábano, A.; Llorens Martín, M.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.
Fil: Terreros Roncal, J.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Moreno Jiménez, E.P.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Flor García, M.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Rodríguez Moreno, C.B.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Trinchero, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cafini, F.. Universidad Europea de Madrid; España
Fil: Rábano, A.. No especifíca;
Fil: Llorens Martín, M.. Universidad Autónoma de Madrid; España
Materia
HUMAN ADULT NEUROGENES
NEURODEGENERATIVE DISEASES
MICROGLIA
AGING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/151271
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of neurodegenerative diseases on human adult hippocampal neurogenesisTerreros Roncal, J.Moreno Jiménez, E.P.Flor García, M.Rodríguez Moreno, C.B.Trinchero, Mariela FernandaCafini, F.Rábano, A.Llorens Martín, M.HUMAN ADULT NEUROGENESNEURODEGENERATIVE DISEASESMICROGLIAAGINGhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.Fil: Terreros Roncal, J.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Moreno Jiménez, E.P.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Flor García, M.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Rodríguez Moreno, C.B.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Trinchero, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cafini, F.. Universidad Europea de Madrid; EspañaFil: Rábano, A.. No especifíca;Fil: Llorens Martín, M.. Universidad Autónoma de Madrid; EspañaAmerican Association for the Advancement of Science2021-10-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/151271Terreros Roncal, J.; Moreno Jiménez, E.P.; Flor García, M.; Rodríguez Moreno, C.B.; Trinchero, Mariela Fernanda; et al.; Impact of neurodegenerative diseases on human adult hippocampal neurogenesis; American Association for the Advancement of Science; Science; 374; 6571; 21-10-2021; 1106-11130036-80751095-9203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/science.abl5163info:eu-repo/semantics/altIdentifier/doi/10.1126/science.abl5163info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:53Zoai:ri.conicet.gov.ar:11336/151271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:54.104CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
title Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
spellingShingle Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
Terreros Roncal, J.
HUMAN ADULT NEUROGENES
NEURODEGENERATIVE DISEASES
MICROGLIA
AGING
title_short Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
title_full Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
title_fullStr Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
title_full_unstemmed Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
title_sort Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
dc.creator.none.fl_str_mv Terreros Roncal, J.
Moreno Jiménez, E.P.
Flor García, M.
Rodríguez Moreno, C.B.
Trinchero, Mariela Fernanda
Cafini, F.
Rábano, A.
Llorens Martín, M.
author Terreros Roncal, J.
author_facet Terreros Roncal, J.
Moreno Jiménez, E.P.
Flor García, M.
Rodríguez Moreno, C.B.
Trinchero, Mariela Fernanda
Cafini, F.
Rábano, A.
Llorens Martín, M.
author_role author
author2 Moreno Jiménez, E.P.
Flor García, M.
Rodríguez Moreno, C.B.
Trinchero, Mariela Fernanda
Cafini, F.
Rábano, A.
Llorens Martín, M.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HUMAN ADULT NEUROGENES
NEURODEGENERATIVE DISEASES
MICROGLIA
AGING
topic HUMAN ADULT NEUROGENES
NEURODEGENERATIVE DISEASES
MICROGLIA
AGING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.
Fil: Terreros Roncal, J.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Moreno Jiménez, E.P.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Flor García, M.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Rodríguez Moreno, C.B.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Trinchero, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cafini, F.. Universidad Europea de Madrid; España
Fil: Rábano, A.. No especifíca;
Fil: Llorens Martín, M.. Universidad Autónoma de Madrid; España
description Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/151271
Terreros Roncal, J.; Moreno Jiménez, E.P.; Flor García, M.; Rodríguez Moreno, C.B.; Trinchero, Mariela Fernanda; et al.; Impact of neurodegenerative diseases on human adult hippocampal neurogenesis; American Association for the Advancement of Science; Science; 374; 6571; 21-10-2021; 1106-1113
0036-8075
1095-9203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/151271
identifier_str_mv Terreros Roncal, J.; Moreno Jiménez, E.P.; Flor García, M.; Rodríguez Moreno, C.B.; Trinchero, Mariela Fernanda; et al.; Impact of neurodegenerative diseases on human adult hippocampal neurogenesis; American Association for the Advancement of Science; Science; 374; 6571; 21-10-2021; 1106-1113
0036-8075
1095-9203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/science.abl5163
info:eu-repo/semantics/altIdentifier/doi/10.1126/science.abl5163
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613006660468736
score 13.070432

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