Neurocognitive correlates of semantic memory navigation in Parkinson’s disease

Autores
Toro Hernández, Felipe Diego; Migeot, Joaquín; Marchant, Nicolás; Olivares, Daniela; Ferrante, Franco Javier; González Gómez, Raúl; Gonzalez Campo, Cecilia; Fittipaldi, Sol; Rojas Costa, Gonzalo M.; Moguilner, Sebastian Gabriel; Slachevsky, Andrea; Chaná Cuevas, Pedro; Ibañez, Agustin Mariano; Chaigneau, Sergio; García, Adolfo Martín
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cognitive studies on Parkinson’s disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients’ neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., ‘sun’) and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive status. PD and bvFTD patients showed reduced semantic variability, an anomaly which predicted semantic inhibition outcomes. Word-property patterns robustly classified PD (but not bvFTD) patients and correlated with disease-specific hypoconnectivity along the sensorimotor and salience networks. Fine-grained semantic assessments, then, can reveal distinct neurocognitive signatures of PD.
Fil: Toro Hernández, Felipe Diego. Universidad Federal do Abc; Brasil. Universidad Adolfo Ibañez; Chile
Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile
Fil: Marchant, Nicolás. Universidad Adolfo Ibañez; Chile
Fil: Olivares, Daniela. Universidad Adolfo Ibañez; Chile. Universidad de Chile; Chile
Fil: Ferrante, Franco Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
Fil: González Gómez, Raúl. Universidad Adolfo Ibañez; Chile
Fil: Gonzalez Campo, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina
Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos
Fil: Rojas Costa, Gonzalo M.. Clínica Las Condes; Chile. Centro de Investigaciones Príncipe Felipe; España. Universidad Finis Terrae; Chile
Fil: Moguilner, Sebastian Gabriel. University of California; Estados Unidos. Trinity College; Irlanda
Fil: Slachevsky, Andrea. Universidad de Chile; Chile. Clínica Alemana-Universidad Desarrollo; Chile. Centro de Gerociencia, Salud Mental y Metabolismo; Chile
Fil: Chaná Cuevas, Pedro. Universidad de Santiago de Chile; Chile
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos
Fil: Chaigneau, Sergio. Universidad Adolfo Ibañez; Chile
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad de Santiago de Chile; Chile
Materia
PARKINSON'S DISEASE
SEMANTIC MEMORY NAVIGATION
COGNITIVE STUDIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257251
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neurocognitive correlates of semantic memory navigation in Parkinson’s diseaseToro Hernández, Felipe DiegoMigeot, JoaquínMarchant, NicolásOlivares, DanielaFerrante, Franco JavierGonzález Gómez, RaúlGonzalez Campo, CeciliaFittipaldi, SolRojas Costa, Gonzalo M.Moguilner, Sebastian GabrielSlachevsky, AndreaChaná Cuevas, PedroIbañez, Agustin MarianoChaigneau, SergioGarcía, Adolfo MartínPARKINSON'S DISEASESEMANTIC MEMORY NAVIGATIONCOGNITIVE STUDIEShttps://purl.org/becyt/ford/6.2https://purl.org/becyt/ford/6https://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Cognitive studies on Parkinson’s disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients’ neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., ‘sun’) and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive status. PD and bvFTD patients showed reduced semantic variability, an anomaly which predicted semantic inhibition outcomes. Word-property patterns robustly classified PD (but not bvFTD) patients and correlated with disease-specific hypoconnectivity along the sensorimotor and salience networks. Fine-grained semantic assessments, then, can reveal distinct neurocognitive signatures of PD.Fil: Toro Hernández, Felipe Diego. Universidad Federal do Abc; Brasil. Universidad Adolfo Ibañez; ChileFil: Migeot, Joaquín. Universidad Adolfo Ibañez; ChileFil: Marchant, Nicolás. Universidad Adolfo Ibañez; ChileFil: Olivares, Daniela. Universidad Adolfo Ibañez; Chile. Universidad de Chile; ChileFil: Ferrante, Franco Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; ArgentinaFil: González Gómez, Raúl. Universidad Adolfo Ibañez; ChileFil: Gonzalez Campo, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados UnidosFil: Rojas Costa, Gonzalo M.. Clínica Las Condes; Chile. Centro de Investigaciones Príncipe Felipe; España. Universidad Finis Terrae; ChileFil: Moguilner, Sebastian Gabriel. University of California; Estados Unidos. Trinity College; IrlandaFil: Slachevsky, Andrea. Universidad de Chile; Chile. Clínica Alemana-Universidad Desarrollo; Chile. Centro de Gerociencia, Salud Mental y Metabolismo; ChileFil: Chaná Cuevas, Pedro. Universidad de Santiago de Chile; ChileFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados UnidosFil: Chaigneau, Sergio. Universidad Adolfo Ibañez; ChileFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad de Santiago de Chile; ChileNature2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257251Toro Hernández, Felipe Diego; Migeot, Joaquín; Marchant, Nicolás; Olivares, Daniela; Ferrante, Franco Javier; et al.; Neurocognitive correlates of semantic memory navigation in Parkinson’s disease; Nature; npj Parkinson's Disease; 10; 1; 1-2024; 1-122373-8057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41531-024-00630-4info:eu-repo/semantics/altIdentifier/doi/10.1038/s41531-024-00630-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:10:44Zoai:ri.conicet.gov.ar:11336/257251instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:10:45.116CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
title Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
spellingShingle Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
Toro Hernández, Felipe Diego
PARKINSON'S DISEASE
SEMANTIC MEMORY NAVIGATION
COGNITIVE STUDIES
title_short Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
title_full Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
title_fullStr Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
title_full_unstemmed Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
title_sort Neurocognitive correlates of semantic memory navigation in Parkinson’s disease
dc.creator.none.fl_str_mv Toro Hernández, Felipe Diego
Migeot, Joaquín
Marchant, Nicolás
Olivares, Daniela
Ferrante, Franco Javier
González Gómez, Raúl
Gonzalez Campo, Cecilia
Fittipaldi, Sol
Rojas Costa, Gonzalo M.
Moguilner, Sebastian Gabriel
Slachevsky, Andrea
Chaná Cuevas, Pedro
Ibañez, Agustin Mariano
Chaigneau, Sergio
García, Adolfo Martín
author Toro Hernández, Felipe Diego
author_facet Toro Hernández, Felipe Diego
Migeot, Joaquín
Marchant, Nicolás
Olivares, Daniela
Ferrante, Franco Javier
González Gómez, Raúl
Gonzalez Campo, Cecilia
Fittipaldi, Sol
Rojas Costa, Gonzalo M.
Moguilner, Sebastian Gabriel
Slachevsky, Andrea
Chaná Cuevas, Pedro
Ibañez, Agustin Mariano
Chaigneau, Sergio
García, Adolfo Martín
author_role author
author2 Migeot, Joaquín
Marchant, Nicolás
Olivares, Daniela
Ferrante, Franco Javier
González Gómez, Raúl
Gonzalez Campo, Cecilia
Fittipaldi, Sol
Rojas Costa, Gonzalo M.
Moguilner, Sebastian Gabriel
Slachevsky, Andrea
Chaná Cuevas, Pedro
Ibañez, Agustin Mariano
Chaigneau, Sergio
García, Adolfo Martín
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PARKINSON'S DISEASE
SEMANTIC MEMORY NAVIGATION
COGNITIVE STUDIES
topic PARKINSON'S DISEASE
SEMANTIC MEMORY NAVIGATION
COGNITIVE STUDIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/6.2
https://purl.org/becyt/ford/6
https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Cognitive studies on Parkinson’s disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients’ neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., ‘sun’) and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive status. PD and bvFTD patients showed reduced semantic variability, an anomaly which predicted semantic inhibition outcomes. Word-property patterns robustly classified PD (but not bvFTD) patients and correlated with disease-specific hypoconnectivity along the sensorimotor and salience networks. Fine-grained semantic assessments, then, can reveal distinct neurocognitive signatures of PD.
Fil: Toro Hernández, Felipe Diego. Universidad Federal do Abc; Brasil. Universidad Adolfo Ibañez; Chile
Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile
Fil: Marchant, Nicolás. Universidad Adolfo Ibañez; Chile
Fil: Olivares, Daniela. Universidad Adolfo Ibañez; Chile. Universidad de Chile; Chile
Fil: Ferrante, Franco Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
Fil: González Gómez, Raúl. Universidad Adolfo Ibañez; Chile
Fil: Gonzalez Campo, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina
Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos
Fil: Rojas Costa, Gonzalo M.. Clínica Las Condes; Chile. Centro de Investigaciones Príncipe Felipe; España. Universidad Finis Terrae; Chile
Fil: Moguilner, Sebastian Gabriel. University of California; Estados Unidos. Trinity College; Irlanda
Fil: Slachevsky, Andrea. Universidad de Chile; Chile. Clínica Alemana-Universidad Desarrollo; Chile. Centro de Gerociencia, Salud Mental y Metabolismo; Chile
Fil: Chaná Cuevas, Pedro. Universidad de Santiago de Chile; Chile
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos
Fil: Chaigneau, Sergio. Universidad Adolfo Ibañez; Chile
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad de Santiago de Chile; Chile
description Cognitive studies on Parkinson’s disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients’ neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., ‘sun’) and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive status. PD and bvFTD patients showed reduced semantic variability, an anomaly which predicted semantic inhibition outcomes. Word-property patterns robustly classified PD (but not bvFTD) patients and correlated with disease-specific hypoconnectivity along the sensorimotor and salience networks. Fine-grained semantic assessments, then, can reveal distinct neurocognitive signatures of PD.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257251
Toro Hernández, Felipe Diego; Migeot, Joaquín; Marchant, Nicolás; Olivares, Daniela; Ferrante, Franco Javier; et al.; Neurocognitive correlates of semantic memory navigation in Parkinson’s disease; Nature; npj Parkinson's Disease; 10; 1; 1-2024; 1-12
2373-8057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257251
identifier_str_mv Toro Hernández, Felipe Diego; Migeot, Joaquín; Marchant, Nicolás; Olivares, Daniela; Ferrante, Franco Javier; et al.; Neurocognitive correlates of semantic memory navigation in Parkinson’s disease; Nature; npj Parkinson's Disease; 10; 1; 1-2024; 1-12
2373-8057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41531-024-00630-4
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41531-024-00630-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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