Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)

Autores
Avila Rodríguez, María Isabela; Meléndez Martínez, David; Licona Cassani, Cuauhtemoc; Aguilar Yañez, José Manuel; Benavides, Jorge; Sanchez, Mirna Lorena
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Chronic wounds affect 6.5 million patients in the United States with an annual estimated expense of $25 billion for the health care system. Among wound treatment categories, active wound care represents the fastest‑growing category due to its specific actions and lower costs. Within this category, proteases from various sources have been used as successful agents in debridement wound care. The wound healing process is predominantly mediated by matrix metalloproteinases (MMPs) that, when dysregulated, result in defective wound healing. Therapeutic activity has been described for animal secretions including fish epithelial mucus, maggot secretory products and snake venom, which contain secreted proteases (SPs). No further alternatives for use, sources or types of proteases used for wound healing have been found in the literature to date. Through the present review, the context of enzymatic wound care alternatives will be discussed. In addition, substrate homology of SPs and human MMPs will be compared and contrasted. The purpose of these discussions is to identify and propose the stages of wound healing in which SPs may be used as therapeutic agents to improve the wound healing process.
Fil: Avila Rodríguez, María Isabela. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Meléndez Martínez, David. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Licona Cassani, Cuauhtemoc. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Aguilar Yañez, José Manuel. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México. Scicore Medical SAPI de CV; México
Fil: Benavides, Jorge. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Sanchez, Mirna Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Materia
WOUND-HEALING
FISH-EPITHELIAL-MUCUS
METALLOPROTEASES
PROTEASES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/154450
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)Avila Rodríguez, María IsabelaMeléndez Martínez, DavidLicona Cassani, CuauhtemocAguilar Yañez, José ManuelBenavides, JorgeSanchez, Mirna LorenaWOUND-HEALINGFISH-EPITHELIAL-MUCUSMETALLOPROTEASESPROTEASEShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Chronic wounds affect 6.5 million patients in the United States with an annual estimated expense of $25 billion for the health care system. Among wound treatment categories, active wound care represents the fastest‑growing category due to its specific actions and lower costs. Within this category, proteases from various sources have been used as successful agents in debridement wound care. The wound healing process is predominantly mediated by matrix metalloproteinases (MMPs) that, when dysregulated, result in defective wound healing. Therapeutic activity has been described for animal secretions including fish epithelial mucus, maggot secretory products and snake venom, which contain secreted proteases (SPs). No further alternatives for use, sources or types of proteases used for wound healing have been found in the literature to date. Through the present review, the context of enzymatic wound care alternatives will be discussed. In addition, substrate homology of SPs and human MMPs will be compared and contrasted. The purpose of these discussions is to identify and propose the stages of wound healing in which SPs may be used as therapeutic agents to improve the wound healing process.Fil: Avila Rodríguez, María Isabela. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; MéxicoFil: Meléndez Martínez, David. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; MéxicoFil: Licona Cassani, Cuauhtemoc. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; MéxicoFil: Aguilar Yañez, José Manuel. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México. Scicore Medical SAPI de CV; MéxicoFil: Benavides, Jorge. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; MéxicoFil: Sanchez, Mirna Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaSpandidos Publications2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154450Avila Rodríguez, María Isabela; Meléndez Martínez, David; Licona Cassani, Cuauhtemoc; Aguilar Yañez, José Manuel; Benavides, Jorge; et al.; Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review); Spandidos Publications; Biomedical Reports; 13; 7-2020; 3-142049-94342049-9442CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.spandidos-publications.com/10.3892/br.2020.1300info:eu-repo/semantics/altIdentifier/doi/10.3892/br.2020.1300info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:09Zoai:ri.conicet.gov.ar:11336/154450instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:10.148CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
title Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
spellingShingle Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
Avila Rodríguez, María Isabela
WOUND-HEALING
FISH-EPITHELIAL-MUCUS
METALLOPROTEASES
PROTEASES
title_short Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
title_full Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
title_fullStr Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
title_full_unstemmed Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
title_sort Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)
dc.creator.none.fl_str_mv Avila Rodríguez, María Isabela
Meléndez Martínez, David
Licona Cassani, Cuauhtemoc
Aguilar Yañez, José Manuel
Benavides, Jorge
Sanchez, Mirna Lorena
author Avila Rodríguez, María Isabela
author_facet Avila Rodríguez, María Isabela
Meléndez Martínez, David
Licona Cassani, Cuauhtemoc
Aguilar Yañez, José Manuel
Benavides, Jorge
Sanchez, Mirna Lorena
author_role author
author2 Meléndez Martínez, David
Licona Cassani, Cuauhtemoc
Aguilar Yañez, José Manuel
Benavides, Jorge
Sanchez, Mirna Lorena
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv WOUND-HEALING
FISH-EPITHELIAL-MUCUS
METALLOPROTEASES
PROTEASES
topic WOUND-HEALING
FISH-EPITHELIAL-MUCUS
METALLOPROTEASES
PROTEASES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Chronic wounds affect 6.5 million patients in the United States with an annual estimated expense of $25 billion for the health care system. Among wound treatment categories, active wound care represents the fastest‑growing category due to its specific actions and lower costs. Within this category, proteases from various sources have been used as successful agents in debridement wound care. The wound healing process is predominantly mediated by matrix metalloproteinases (MMPs) that, when dysregulated, result in defective wound healing. Therapeutic activity has been described for animal secretions including fish epithelial mucus, maggot secretory products and snake venom, which contain secreted proteases (SPs). No further alternatives for use, sources or types of proteases used for wound healing have been found in the literature to date. Through the present review, the context of enzymatic wound care alternatives will be discussed. In addition, substrate homology of SPs and human MMPs will be compared and contrasted. The purpose of these discussions is to identify and propose the stages of wound healing in which SPs may be used as therapeutic agents to improve the wound healing process.
Fil: Avila Rodríguez, María Isabela. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Meléndez Martínez, David. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Licona Cassani, Cuauhtemoc. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Aguilar Yañez, José Manuel. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México. Scicore Medical SAPI de CV; México
Fil: Benavides, Jorge. Instituto Tecnologico de Monterrey. Escuela de Ingenieria y Ciencias.; México
Fil: Sanchez, Mirna Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
description Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Chronic wounds affect 6.5 million patients in the United States with an annual estimated expense of $25 billion for the health care system. Among wound treatment categories, active wound care represents the fastest‑growing category due to its specific actions and lower costs. Within this category, proteases from various sources have been used as successful agents in debridement wound care. The wound healing process is predominantly mediated by matrix metalloproteinases (MMPs) that, when dysregulated, result in defective wound healing. Therapeutic activity has been described for animal secretions including fish epithelial mucus, maggot secretory products and snake venom, which contain secreted proteases (SPs). No further alternatives for use, sources or types of proteases used for wound healing have been found in the literature to date. Through the present review, the context of enzymatic wound care alternatives will be discussed. In addition, substrate homology of SPs and human MMPs will be compared and contrasted. The purpose of these discussions is to identify and propose the stages of wound healing in which SPs may be used as therapeutic agents to improve the wound healing process.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/154450
Avila Rodríguez, María Isabela; Meléndez Martínez, David; Licona Cassani, Cuauhtemoc; Aguilar Yañez, José Manuel; Benavides, Jorge; et al.; Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review); Spandidos Publications; Biomedical Reports; 13; 7-2020; 3-14
2049-9434
2049-9442
CONICET Digital
CONICET
url http://hdl.handle.net/11336/154450
identifier_str_mv Avila Rodríguez, María Isabela; Meléndez Martínez, David; Licona Cassani, Cuauhtemoc; Aguilar Yañez, José Manuel; Benavides, Jorge; et al.; Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review); Spandidos Publications; Biomedical Reports; 13; 7-2020; 3-14
2049-9434
2049-9442
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.spandidos-publications.com/10.3892/br.2020.1300
info:eu-repo/semantics/altIdentifier/doi/10.3892/br.2020.1300
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Spandidos Publications
publisher.none.fl_str_mv Spandidos Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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