PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing

Autores
Hernandez Rivera, Gabriela; Valdez, Hugo Alberto; Arango Ospina, Marcela; Delgado, Juan Francisco; Aguilar Rabiela, Arturo E.; Gorgojo, Juan Pablo; Zhang, Huijun; Beltrán, Ana M.; Boccaccini, Aldo R.; Sanchez, Mirna Lorena
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Astaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulation of AST into hydrogels. This study focuses on innovating the wound healing potential of AST-containing hydrogels by introducing silicate mesoporous bioactive glass nanoparticles (MBGNs). These nanoparticles release biologically active ions that accelerate cell proliferation and migration. The results showcase an innovative synergistic effect between 1 μg/mL of AST with 100 μg/mL of MBGNs, outperforming the individual proliferation effect of AST or MBGNs alone. Separately, these compounds were encapsulated in physical and chemical cross-linked hydrogel for the compound protection and delivery, finding that PVA-gelatine hydrogels are a suitable matrix for the delivery of AST and MBGNs. Physically crosslinked hydrogels showed particularly convenient characteristics for potential clinical implementation while maintaining the synergetic effect of AST and MBGNs. Although chemically crosslinked hydrogels exhibited suitable characteristics as a vehicle for AST in biological assays, cell proliferation was reduced by 57 %. The results of this research open avenues for exploring the development of new composite matrices for the co-delivery of phytochemicals and MBGNs for cutting-edge biomedical applications.
Fil: Hernandez Rivera, Gabriela. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Instituto Tecnológico de Monterrey; México. Universitat Erlangen Nuremberg; Alemania
Fil: Valdez, Hugo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Arango Ospina, Marcela. Universitat Erlangen Nuremberg; Alemania
Fil: Delgado, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
Fil: Aguilar Rabiela, Arturo E.. Universitat Erlangen Nuremberg; Alemania
Fil: Gorgojo, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Zhang, Huijun. Universitat Erlangen Nuremberg; Alemania
Fil: Beltrán, Ana M.. Universidad de Sevilla; España
Fil: Boccaccini, Aldo R.. Universitat Erlangen Nuremberg; Alemania
Fil: Sanchez, Mirna Lorena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Universitat Erlangen Nuremberg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
hydrogels
astaxanthin
bioactive glass
wound healing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/247560
Acceder
id CONICETDig_ef426033a66bd74c230198353fbaa516
oai_identifier_str oai:ri.conicet.gov.ar:11336/247560
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healingHernandez Rivera, GabrielaValdez, Hugo AlbertoArango Ospina, MarcelaDelgado, Juan FranciscoAguilar Rabiela, Arturo E.Gorgojo, Juan PabloZhang, HuijunBeltrán, Ana M.Boccaccini, Aldo R.Sanchez, Mirna Lorenahydrogelsastaxanthinbioactive glasswound healinghttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Astaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulation of AST into hydrogels. This study focuses on innovating the wound healing potential of AST-containing hydrogels by introducing silicate mesoporous bioactive glass nanoparticles (MBGNs). These nanoparticles release biologically active ions that accelerate cell proliferation and migration. The results showcase an innovative synergistic effect between 1 μg/mL of AST with 100 μg/mL of MBGNs, outperforming the individual proliferation effect of AST or MBGNs alone. Separately, these compounds were encapsulated in physical and chemical cross-linked hydrogel for the compound protection and delivery, finding that PVA-gelatine hydrogels are a suitable matrix for the delivery of AST and MBGNs. Physically crosslinked hydrogels showed particularly convenient characteristics for potential clinical implementation while maintaining the synergetic effect of AST and MBGNs. Although chemically crosslinked hydrogels exhibited suitable characteristics as a vehicle for AST in biological assays, cell proliferation was reduced by 57 %. The results of this research open avenues for exploring the development of new composite matrices for the co-delivery of phytochemicals and MBGNs for cutting-edge biomedical applications.Fil: Hernandez Rivera, Gabriela. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Instituto Tecnológico de Monterrey; México. Universitat Erlangen Nuremberg; AlemaniaFil: Valdez, Hugo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Arango Ospina, Marcela. Universitat Erlangen Nuremberg; AlemaniaFil: Delgado, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; ArgentinaFil: Aguilar Rabiela, Arturo E.. Universitat Erlangen Nuremberg; AlemaniaFil: Gorgojo, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Zhang, Huijun. Universitat Erlangen Nuremberg; AlemaniaFil: Beltrán, Ana M.. Universidad de Sevilla; EspañaFil: Boccaccini, Aldo R.. Universitat Erlangen Nuremberg; AlemaniaFil: Sanchez, Mirna Lorena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Universitat Erlangen Nuremberg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaEditions Sante2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/247560Hernandez Rivera, Gabriela; Valdez, Hugo Alberto; Arango Ospina, Marcela; Delgado, Juan Francisco; Aguilar Rabiela, Arturo E.; et al.; PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing; Editions Sante; Journal of Drug Delivery Science and Technology; 101; 106235; 9-2024; 1-441773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1773224724009043info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2024.106235info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:07Zoai:ri.conicet.gov.ar:11336/247560instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:07.752CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
spellingShingle PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
Hernandez Rivera, Gabriela
hydrogels
astaxanthin
bioactive glass
wound healing
title_short PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_full PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_fullStr PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_full_unstemmed PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
title_sort PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing
dc.creator.none.fl_str_mv Hernandez Rivera, Gabriela
Valdez, Hugo Alberto
Arango Ospina, Marcela
Delgado, Juan Francisco
Aguilar Rabiela, Arturo E.
Gorgojo, Juan Pablo
Zhang, Huijun
Beltrán, Ana M.
Boccaccini, Aldo R.
Sanchez, Mirna Lorena
author Hernandez Rivera, Gabriela
author_facet Hernandez Rivera, Gabriela
Valdez, Hugo Alberto
Arango Ospina, Marcela
Delgado, Juan Francisco
Aguilar Rabiela, Arturo E.
Gorgojo, Juan Pablo
Zhang, Huijun
Beltrán, Ana M.
Boccaccini, Aldo R.
Sanchez, Mirna Lorena
author_role author
author2 Valdez, Hugo Alberto
Arango Ospina, Marcela
Delgado, Juan Francisco
Aguilar Rabiela, Arturo E.
Gorgojo, Juan Pablo
Zhang, Huijun
Beltrán, Ana M.
Boccaccini, Aldo R.
Sanchez, Mirna Lorena
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv hydrogels
astaxanthin
bioactive glass
wound healing
topic hydrogels
astaxanthin
bioactive glass
wound healing
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Astaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulation of AST into hydrogels. This study focuses on innovating the wound healing potential of AST-containing hydrogels by introducing silicate mesoporous bioactive glass nanoparticles (MBGNs). These nanoparticles release biologically active ions that accelerate cell proliferation and migration. The results showcase an innovative synergistic effect between 1 μg/mL of AST with 100 μg/mL of MBGNs, outperforming the individual proliferation effect of AST or MBGNs alone. Separately, these compounds were encapsulated in physical and chemical cross-linked hydrogel for the compound protection and delivery, finding that PVA-gelatine hydrogels are a suitable matrix for the delivery of AST and MBGNs. Physically crosslinked hydrogels showed particularly convenient characteristics for potential clinical implementation while maintaining the synergetic effect of AST and MBGNs. Although chemically crosslinked hydrogels exhibited suitable characteristics as a vehicle for AST in biological assays, cell proliferation was reduced by 57 %. The results of this research open avenues for exploring the development of new composite matrices for the co-delivery of phytochemicals and MBGNs for cutting-edge biomedical applications.
Fil: Hernandez Rivera, Gabriela. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Instituto Tecnológico de Monterrey; México. Universitat Erlangen Nuremberg; Alemania
Fil: Valdez, Hugo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Arango Ospina, Marcela. Universitat Erlangen Nuremberg; Alemania
Fil: Delgado, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
Fil: Aguilar Rabiela, Arturo E.. Universitat Erlangen Nuremberg; Alemania
Fil: Gorgojo, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Zhang, Huijun. Universitat Erlangen Nuremberg; Alemania
Fil: Beltrán, Ana M.. Universidad de Sevilla; España
Fil: Boccaccini, Aldo R.. Universitat Erlangen Nuremberg; Alemania
Fil: Sanchez, Mirna Lorena. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnologia. Laboratorio de Farmacologia Molecular.; Argentina. Universitat Erlangen Nuremberg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Astaxanthin (AST) is a potent antioxidant phytochemical used in wound healing with promising results in-vitro. However, AST incorporation into clinical practice still faces challenges related to the susceptibility of AST to instability. One of the most innovative solutions proposed is the encapsulation of AST into hydrogels. This study focuses on innovating the wound healing potential of AST-containing hydrogels by introducing silicate mesoporous bioactive glass nanoparticles (MBGNs). These nanoparticles release biologically active ions that accelerate cell proliferation and migration. The results showcase an innovative synergistic effect between 1 μg/mL of AST with 100 μg/mL of MBGNs, outperforming the individual proliferation effect of AST or MBGNs alone. Separately, these compounds were encapsulated in physical and chemical cross-linked hydrogel for the compound protection and delivery, finding that PVA-gelatine hydrogels are a suitable matrix for the delivery of AST and MBGNs. Physically crosslinked hydrogels showed particularly convenient characteristics for potential clinical implementation while maintaining the synergetic effect of AST and MBGNs. Although chemically crosslinked hydrogels exhibited suitable characteristics as a vehicle for AST in biological assays, cell proliferation was reduced by 57 %. The results of this research open avenues for exploring the development of new composite matrices for the co-delivery of phytochemicals and MBGNs for cutting-edge biomedical applications.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/247560
Hernandez Rivera, Gabriela; Valdez, Hugo Alberto; Arango Ospina, Marcela; Delgado, Juan Francisco; Aguilar Rabiela, Arturo E.; et al.; PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing; Editions Sante; Journal of Drug Delivery Science and Technology; 101; 106235; 9-2024; 1-44
1773-2247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/247560
identifier_str_mv Hernandez Rivera, Gabriela; Valdez, Hugo Alberto; Arango Ospina, Marcela; Delgado, Juan Francisco; Aguilar Rabiela, Arturo E.; et al.; PVA-gelatine based hydrogel loaded with astaxanthin and mesoporous bioactive glass nanoparticles for wound healing; Editions Sante; Journal of Drug Delivery Science and Technology; 101; 106235; 9-2024; 1-44
1773-2247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1773224724009043
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2024.106235
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editions Sante
publisher.none.fl_str_mv Editions Sante
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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