Status and forecast of leprosy in the still endemic province of formosa in northern Argentina

Autores
Arnaiz, Maria Rosa; Iglesias, Mónica Sandra; Franco, José I; Arzamendia, Lucila; Santini, Maria Soledad; Recalde, Hugo C.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background The province of Formosa, Argentina, is endemic for leprosy. In the present paper, we assessed the trend (T, 2002–2016 time series) and the forecast for 2022 of new case detection rate (NCDR) and determined the spatial distribution of new cases detected (NCD) of leprosy. Methodology/Principal findings This is a descriptive observational study of 713 NCD of leprosy from provincial medical records between January 2002 and December 2016. The whole dataset from the provincial medical record was used to independently estimate the NCDR trends of the general population, age groups, sexes and Departments. This same database was used to estimate the NCDR forecast of the general population for 2022, applying a dynamic linear model with a local linear trend, using the MCMC algorithm. The NCDR was higher in men (p<0.05), increased with age (0.20, 8.17, 21.04, and 29.49 for the 0–14, 15–44, 45–64 and over 65-year-old age groups, respectively; p<0.05) and showed a downward trend (negative values) of estimated slopes for the whole province and each Department. Bermejo Department showed the highest (T:-1.02, 95%CI: [-1.42,-0.66]) and Patiño the lowest decreasing trend (T:-0.45, 95%CI: [-0.74,-0.11]). The NCDR trend for both sexes was similar (T:-0.55, 95% CI: [-0.64,-0.46]), and age groups showed a decreasing trend (S15-44:-103, S45-64:-81, S>65:-61, p<0.05), except for the 0–14 age group (S:-3, p>0.05), which showed no trend. Forecasts predicted that leprosy will not be eliminated by 2022 (3.64, 95%CI: [1.22, 10.25]). Conclusions/Significance Our results highlight the status of leprosy in Formosa and provide information to the provincial public health authorities on high-risk populations, stressing the importance of timely detection of new cases for further elimination of the disease in the province.
Fil: Arnaiz, Maria Rosa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán". Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben"; Argentina
Fil: Iglesias, Mónica Sandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Franco, José I. No especifíca;
Fil: Arzamendia, Lucila. No especifíca;
Fil: Santini, Maria Soledad. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán". Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Recalde, Hugo C.. No especifíca;
Materia
Lepra
Enfermedad endémica
Enfermedad Infecciosa
Formosa
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163682

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network_name_str CONICET Digital (CONICET)
spelling Status and forecast of leprosy in the still endemic province of formosa in northern ArgentinaArnaiz, Maria RosaIglesias, Mónica SandraFranco, José IArzamendia, LucilaSantini, Maria SoledadRecalde, Hugo C.LepraEnfermedad endémicaEnfermedad InfecciosaFormosahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background The province of Formosa, Argentina, is endemic for leprosy. In the present paper, we assessed the trend (T, 2002–2016 time series) and the forecast for 2022 of new case detection rate (NCDR) and determined the spatial distribution of new cases detected (NCD) of leprosy. Methodology/Principal findings This is a descriptive observational study of 713 NCD of leprosy from provincial medical records between January 2002 and December 2016. The whole dataset from the provincial medical record was used to independently estimate the NCDR trends of the general population, age groups, sexes and Departments. This same database was used to estimate the NCDR forecast of the general population for 2022, applying a dynamic linear model with a local linear trend, using the MCMC algorithm. The NCDR was higher in men (p<0.05), increased with age (0.20, 8.17, 21.04, and 29.49 for the 0–14, 15–44, 45–64 and over 65-year-old age groups, respectively; p<0.05) and showed a downward trend (negative values) of estimated slopes for the whole province and each Department. Bermejo Department showed the highest (T:-1.02, 95%CI: [-1.42,-0.66]) and Patiño the lowest decreasing trend (T:-0.45, 95%CI: [-0.74,-0.11]). The NCDR trend for both sexes was similar (T:-0.55, 95% CI: [-0.64,-0.46]), and age groups showed a decreasing trend (S15-44:-103, S45-64:-81, S>65:-61, p<0.05), except for the 0–14 age group (S:-3, p>0.05), which showed no trend. Forecasts predicted that leprosy will not be eliminated by 2022 (3.64, 95%CI: [1.22, 10.25]). Conclusions/Significance Our results highlight the status of leprosy in Formosa and provide information to the provincial public health authorities on high-risk populations, stressing the importance of timely detection of new cases for further elimination of the disease in the province.Fil: Arnaiz, Maria Rosa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán". Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben"; ArgentinaFil: Iglesias, Mónica Sandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Franco, José I. No especifíca;Fil: Arzamendia, Lucila. No especifíca;Fil: Santini, Maria Soledad. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán". Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Recalde, Hugo C.. No especifíca;Public Library of Science2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163682Arnaiz, Maria Rosa; Iglesias, Mónica Sandra; Franco, José I; Arzamendia, Lucila; Santini, Maria Soledad; et al.; Status and forecast of leprosy in the still endemic province of formosa in northern Argentina; Public Library of Science; PLoS Neglected Tropical Diseases; 15; 1; 1-2021; 1-131935-27271935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008881info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0008881info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:35Zoai:ri.conicet.gov.ar:11336/163682instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:35.427CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
title Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
spellingShingle Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
Arnaiz, Maria Rosa
Lepra
Enfermedad endémica
Enfermedad Infecciosa
Formosa
title_short Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
title_full Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
title_fullStr Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
title_full_unstemmed Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
title_sort Status and forecast of leprosy in the still endemic province of formosa in northern Argentina
dc.creator.none.fl_str_mv Arnaiz, Maria Rosa
Iglesias, Mónica Sandra
Franco, José I
Arzamendia, Lucila
Santini, Maria Soledad
Recalde, Hugo C.
author Arnaiz, Maria Rosa
author_facet Arnaiz, Maria Rosa
Iglesias, Mónica Sandra
Franco, José I
Arzamendia, Lucila
Santini, Maria Soledad
Recalde, Hugo C.
author_role author
author2 Iglesias, Mónica Sandra
Franco, José I
Arzamendia, Lucila
Santini, Maria Soledad
Recalde, Hugo C.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Lepra
Enfermedad endémica
Enfermedad Infecciosa
Formosa
topic Lepra
Enfermedad endémica
Enfermedad Infecciosa
Formosa
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background The province of Formosa, Argentina, is endemic for leprosy. In the present paper, we assessed the trend (T, 2002–2016 time series) and the forecast for 2022 of new case detection rate (NCDR) and determined the spatial distribution of new cases detected (NCD) of leprosy. Methodology/Principal findings This is a descriptive observational study of 713 NCD of leprosy from provincial medical records between January 2002 and December 2016. The whole dataset from the provincial medical record was used to independently estimate the NCDR trends of the general population, age groups, sexes and Departments. This same database was used to estimate the NCDR forecast of the general population for 2022, applying a dynamic linear model with a local linear trend, using the MCMC algorithm. The NCDR was higher in men (p<0.05), increased with age (0.20, 8.17, 21.04, and 29.49 for the 0–14, 15–44, 45–64 and over 65-year-old age groups, respectively; p<0.05) and showed a downward trend (negative values) of estimated slopes for the whole province and each Department. Bermejo Department showed the highest (T:-1.02, 95%CI: [-1.42,-0.66]) and Patiño the lowest decreasing trend (T:-0.45, 95%CI: [-0.74,-0.11]). The NCDR trend for both sexes was similar (T:-0.55, 95% CI: [-0.64,-0.46]), and age groups showed a decreasing trend (S15-44:-103, S45-64:-81, S>65:-61, p<0.05), except for the 0–14 age group (S:-3, p>0.05), which showed no trend. Forecasts predicted that leprosy will not be eliminated by 2022 (3.64, 95%CI: [1.22, 10.25]). Conclusions/Significance Our results highlight the status of leprosy in Formosa and provide information to the provincial public health authorities on high-risk populations, stressing the importance of timely detection of new cases for further elimination of the disease in the province.
Fil: Arnaiz, Maria Rosa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán". Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben"; Argentina
Fil: Iglesias, Mónica Sandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Franco, José I. No especifíca;
Fil: Arzamendia, Lucila. No especifíca;
Fil: Santini, Maria Soledad. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán". Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Recalde, Hugo C.. No especifíca;
description Background The province of Formosa, Argentina, is endemic for leprosy. In the present paper, we assessed the trend (T, 2002–2016 time series) and the forecast for 2022 of new case detection rate (NCDR) and determined the spatial distribution of new cases detected (NCD) of leprosy. Methodology/Principal findings This is a descriptive observational study of 713 NCD of leprosy from provincial medical records between January 2002 and December 2016. The whole dataset from the provincial medical record was used to independently estimate the NCDR trends of the general population, age groups, sexes and Departments. This same database was used to estimate the NCDR forecast of the general population for 2022, applying a dynamic linear model with a local linear trend, using the MCMC algorithm. The NCDR was higher in men (p<0.05), increased with age (0.20, 8.17, 21.04, and 29.49 for the 0–14, 15–44, 45–64 and over 65-year-old age groups, respectively; p<0.05) and showed a downward trend (negative values) of estimated slopes for the whole province and each Department. Bermejo Department showed the highest (T:-1.02, 95%CI: [-1.42,-0.66]) and Patiño the lowest decreasing trend (T:-0.45, 95%CI: [-0.74,-0.11]). The NCDR trend for both sexes was similar (T:-0.55, 95% CI: [-0.64,-0.46]), and age groups showed a decreasing trend (S15-44:-103, S45-64:-81, S>65:-61, p<0.05), except for the 0–14 age group (S:-3, p>0.05), which showed no trend. Forecasts predicted that leprosy will not be eliminated by 2022 (3.64, 95%CI: [1.22, 10.25]). Conclusions/Significance Our results highlight the status of leprosy in Formosa and provide information to the provincial public health authorities on high-risk populations, stressing the importance of timely detection of new cases for further elimination of the disease in the province.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163682
Arnaiz, Maria Rosa; Iglesias, Mónica Sandra; Franco, José I; Arzamendia, Lucila; Santini, Maria Soledad; et al.; Status and forecast of leprosy in the still endemic province of formosa in northern Argentina; Public Library of Science; PLoS Neglected Tropical Diseases; 15; 1; 1-2021; 1-13
1935-2727
1935-2735
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163682
identifier_str_mv Arnaiz, Maria Rosa; Iglesias, Mónica Sandra; Franco, José I; Arzamendia, Lucila; Santini, Maria Soledad; et al.; Status and forecast of leprosy in the still endemic province of formosa in northern Argentina; Public Library of Science; PLoS Neglected Tropical Diseases; 15; 1; 1-2021; 1-13
1935-2727
1935-2735
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0008881
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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