Pegylation: an overview and recent advances reported in the patent literature

Autores
Gonzalez, Marianela; Vaillard, Santiago Eduardo; Grau, Ricardo Jose Antonio
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pegylation technologies have improved since chemistry and purification processes have advanced over the years. Furthermore, a gradual better understanding of the clinical responses has spurred the need for more effective therapeutic agents. Nowadays, it is necessary to early identify therapy needs and technical capabilities to develop customized, innovative products that reach the market successfully. Consequently, the main technical efforts are directed to solve some intricate problems associated with the drug delivery where improved solubility, in vivo stability, targeted delivery, and enhanced efficacy and safety are the major challenges. Too many alternative approaches for too many needs open up the possibility for follow-on developers and competitors, and provide opportunities for innovation that provoke an intense worldwide competition in a complex intellectual property environment. This paper presents an overview of general trends and patents supporting PEGylation platforms. Since the golden rule is that PEGylation has to be tailored to each specific drug and application, the review format is structured by specific conjugated species alphabetically sorted within the following groups: PEG-protein conjugates, PEG-antibody and antibody fragment conjugates, PEG-oligonucleotide conjugates, PEG-small molecule drug conjugates, and PEGylated materials and miscellaneous applications.
Fil: Gonzalez, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Materia
Pegylation
Drug Delivery
Patented Conjugates
Pegylated Drugs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13353
Acceder
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spelling Pegylation: an overview and recent advances reported in the patent literatureGonzalez, MarianelaVaillard, Santiago EduardoGrau, Ricardo Jose AntonioPegylationDrug DeliveryPatented ConjugatesPegylated Drugshttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Pegylation technologies have improved since chemistry and purification processes have advanced over the years. Furthermore, a gradual better understanding of the clinical responses has spurred the need for more effective therapeutic agents. Nowadays, it is necessary to early identify therapy needs and technical capabilities to develop customized, innovative products that reach the market successfully. Consequently, the main technical efforts are directed to solve some intricate problems associated with the drug delivery where improved solubility, in vivo stability, targeted delivery, and enhanced efficacy and safety are the major challenges. Too many alternative approaches for too many needs open up the possibility for follow-on developers and competitors, and provide opportunities for innovation that provoke an intense worldwide competition in a complex intellectual property environment. This paper presents an overview of general trends and patents supporting PEGylation platforms. Since the golden rule is that PEGylation has to be tailored to each specific drug and application, the review format is structured by specific conjugated species alphabetically sorted within the following groups: PEG-protein conjugates, PEG-antibody and antibody fragment conjugates, PEG-oligonucleotide conjugates, PEG-small molecule drug conjugates, and PEGylated materials and miscellaneous applications.Fil: Gonzalez, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaBentham Science Publishers2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13353Gonzalez, Marianela; Vaillard, Santiago Eduardo; Grau, Ricardo Jose Antonio; Pegylation: an overview and recent advances reported in the patent literature; Bentham Science Publishers; Recent Patents on Chemical Engineering; 4; 3; 12-2011; 241-2642211-3347enginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1874478811104030241info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/94769/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:10:02Zoai:ri.conicet.gov.ar:11336/13353instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:10:02.407CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pegylation: an overview and recent advances reported in the patent literature
title Pegylation: an overview and recent advances reported in the patent literature
spellingShingle Pegylation: an overview and recent advances reported in the patent literature
Gonzalez, Marianela
Pegylation
Drug Delivery
Patented Conjugates
Pegylated Drugs
title_short Pegylation: an overview and recent advances reported in the patent literature
title_full Pegylation: an overview and recent advances reported in the patent literature
title_fullStr Pegylation: an overview and recent advances reported in the patent literature
title_full_unstemmed Pegylation: an overview and recent advances reported in the patent literature
title_sort Pegylation: an overview and recent advances reported in the patent literature
dc.creator.none.fl_str_mv Gonzalez, Marianela
Vaillard, Santiago Eduardo
Grau, Ricardo Jose Antonio
author Gonzalez, Marianela
author_facet Gonzalez, Marianela
Vaillard, Santiago Eduardo
Grau, Ricardo Jose Antonio
author_role author
author2 Vaillard, Santiago Eduardo
Grau, Ricardo Jose Antonio
author2_role author
author
dc.subject.none.fl_str_mv Pegylation
Drug Delivery
Patented Conjugates
Pegylated Drugs
topic Pegylation
Drug Delivery
Patented Conjugates
Pegylated Drugs
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Pegylation technologies have improved since chemistry and purification processes have advanced over the years. Furthermore, a gradual better understanding of the clinical responses has spurred the need for more effective therapeutic agents. Nowadays, it is necessary to early identify therapy needs and technical capabilities to develop customized, innovative products that reach the market successfully. Consequently, the main technical efforts are directed to solve some intricate problems associated with the drug delivery where improved solubility, in vivo stability, targeted delivery, and enhanced efficacy and safety are the major challenges. Too many alternative approaches for too many needs open up the possibility for follow-on developers and competitors, and provide opportunities for innovation that provoke an intense worldwide competition in a complex intellectual property environment. This paper presents an overview of general trends and patents supporting PEGylation platforms. Since the golden rule is that PEGylation has to be tailored to each specific drug and application, the review format is structured by specific conjugated species alphabetically sorted within the following groups: PEG-protein conjugates, PEG-antibody and antibody fragment conjugates, PEG-oligonucleotide conjugates, PEG-small molecule drug conjugates, and PEGylated materials and miscellaneous applications.
Fil: Gonzalez, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
description Pegylation technologies have improved since chemistry and purification processes have advanced over the years. Furthermore, a gradual better understanding of the clinical responses has spurred the need for more effective therapeutic agents. Nowadays, it is necessary to early identify therapy needs and technical capabilities to develop customized, innovative products that reach the market successfully. Consequently, the main technical efforts are directed to solve some intricate problems associated with the drug delivery where improved solubility, in vivo stability, targeted delivery, and enhanced efficacy and safety are the major challenges. Too many alternative approaches for too many needs open up the possibility for follow-on developers and competitors, and provide opportunities for innovation that provoke an intense worldwide competition in a complex intellectual property environment. This paper presents an overview of general trends and patents supporting PEGylation platforms. Since the golden rule is that PEGylation has to be tailored to each specific drug and application, the review format is structured by specific conjugated species alphabetically sorted within the following groups: PEG-protein conjugates, PEG-antibody and antibody fragment conjugates, PEG-oligonucleotide conjugates, PEG-small molecule drug conjugates, and PEGylated materials and miscellaneous applications.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13353
Gonzalez, Marianela; Vaillard, Santiago Eduardo; Grau, Ricardo Jose Antonio; Pegylation: an overview and recent advances reported in the patent literature; Bentham Science Publishers; Recent Patents on Chemical Engineering; 4; 3; 12-2011; 241-264
2211-3347
url http://hdl.handle.net/11336/13353
identifier_str_mv Gonzalez, Marianela; Vaillard, Santiago Eduardo; Grau, Ricardo Jose Antonio; Pegylation: an overview and recent advances reported in the patent literature; Bentham Science Publishers; Recent Patents on Chemical Engineering; 4; 3; 12-2011; 241-264
2211-3347
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/1874478811104030241
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/94769/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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