Glutathione depleting drugs, antioxidants and intestinal calcium absorption

Autores
Moine, Luciana Beatriz; Rivoira, Maria Angelica; Díaz de Barboza, Gabriela Edith; Pérez, Adriana; Tolosa, Nori Graciela
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Glutathione (GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them.
Fil: Moine, Luciana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rivoira, Maria Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Díaz de Barboza, Gabriela Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Pérez, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Tolosa, Nori Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
DL-BUTHIONINE-S,R-SULFOXIMINE
FRUCTOSE RICH DIET
GLUTAMINE
GLUTATHIONE
MELATONIN
MENADIONE
NARINGIN
QUERCETIN
SODIUM DEOXYCHOLATE
TRANSCELLULAR AND PARACELLULAR CA2+PATHWAYS
URSODEOXYCHOLIC ACID
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91553
Acceder
id CONICETDig_9e59030eaae592df9d9663099a2d8058
oai_identifier_str oai:ri.conicet.gov.ar:11336/91553
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Glutathione depleting drugs, antioxidants and intestinal calcium absorptionMoine, Luciana BeatrizRivoira, Maria AngelicaDíaz de Barboza, Gabriela EdithPérez, AdrianaTolosa, Nori GracielaDL-BUTHIONINE-S,R-SULFOXIMINEFRUCTOSE RICH DIETGLUTAMINEGLUTATHIONEMELATONINMENADIONENARINGINQUERCETINSODIUM DEOXYCHOLATETRANSCELLULAR AND PARACELLULAR CA2+PATHWAYSURSODEOXYCHOLIC ACIDhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Glutathione (GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them.Fil: Moine, Luciana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Rivoira, Maria Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Díaz de Barboza, Gabriela Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Pérez, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Tolosa, Nori Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaW J G Press2018-11-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91553Moine, Luciana Beatriz; Rivoira, Maria Angelica; Díaz de Barboza, Gabriela Edith; Pérez, Adriana; Tolosa, Nori Graciela; Glutathione depleting drugs, antioxidants and intestinal calcium absorption; W J G Press; World Journal of Gastroenterology; 24; 44; 2-11-2018; 4979-49881007-93272219-2840CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262252/info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v24/i44/4979.htminfo:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v24.i44.4979info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:21:17Zoai:ri.conicet.gov.ar:11336/91553instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:21:18.218CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Glutathione depleting drugs, antioxidants and intestinal calcium absorption
title Glutathione depleting drugs, antioxidants and intestinal calcium absorption
spellingShingle Glutathione depleting drugs, antioxidants and intestinal calcium absorption
Moine, Luciana Beatriz
DL-BUTHIONINE-S,R-SULFOXIMINE
FRUCTOSE RICH DIET
GLUTAMINE
GLUTATHIONE
MELATONIN
MENADIONE
NARINGIN
QUERCETIN
SODIUM DEOXYCHOLATE
TRANSCELLULAR AND PARACELLULAR CA2+PATHWAYS
URSODEOXYCHOLIC ACID
title_short Glutathione depleting drugs, antioxidants and intestinal calcium absorption
title_full Glutathione depleting drugs, antioxidants and intestinal calcium absorption
title_fullStr Glutathione depleting drugs, antioxidants and intestinal calcium absorption
title_full_unstemmed Glutathione depleting drugs, antioxidants and intestinal calcium absorption
title_sort Glutathione depleting drugs, antioxidants and intestinal calcium absorption
dc.creator.none.fl_str_mv Moine, Luciana Beatriz
Rivoira, Maria Angelica
Díaz de Barboza, Gabriela Edith
Pérez, Adriana
Tolosa, Nori Graciela
author Moine, Luciana Beatriz
author_facet Moine, Luciana Beatriz
Rivoira, Maria Angelica
Díaz de Barboza, Gabriela Edith
Pérez, Adriana
Tolosa, Nori Graciela
author_role author
author2 Rivoira, Maria Angelica
Díaz de Barboza, Gabriela Edith
Pérez, Adriana
Tolosa, Nori Graciela
author2_role author
author
author
author
dc.subject.none.fl_str_mv DL-BUTHIONINE-S,R-SULFOXIMINE
FRUCTOSE RICH DIET
GLUTAMINE
GLUTATHIONE
MELATONIN
MENADIONE
NARINGIN
QUERCETIN
SODIUM DEOXYCHOLATE
TRANSCELLULAR AND PARACELLULAR CA2+PATHWAYS
URSODEOXYCHOLIC ACID
topic DL-BUTHIONINE-S,R-SULFOXIMINE
FRUCTOSE RICH DIET
GLUTAMINE
GLUTATHIONE
MELATONIN
MENADIONE
NARINGIN
QUERCETIN
SODIUM DEOXYCHOLATE
TRANSCELLULAR AND PARACELLULAR CA2+PATHWAYS
URSODEOXYCHOLIC ACID
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Glutathione (GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them.
Fil: Moine, Luciana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rivoira, Maria Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Díaz de Barboza, Gabriela Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Pérez, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Tolosa, Nori Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description Glutathione (GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91553
Moine, Luciana Beatriz; Rivoira, Maria Angelica; Díaz de Barboza, Gabriela Edith; Pérez, Adriana; Tolosa, Nori Graciela; Glutathione depleting drugs, antioxidants and intestinal calcium absorption; W J G Press; World Journal of Gastroenterology; 24; 44; 2-11-2018; 4979-4988
1007-9327
2219-2840
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91553
identifier_str_mv Moine, Luciana Beatriz; Rivoira, Maria Angelica; Díaz de Barboza, Gabriela Edith; Pérez, Adriana; Tolosa, Nori Graciela; Glutathione depleting drugs, antioxidants and intestinal calcium absorption; W J G Press; World Journal of Gastroenterology; 24; 44; 2-11-2018; 4979-4988
1007-9327
2219-2840
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262252/
info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v24/i44/4979.htm
info:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v24.i44.4979
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv W J G Press
publisher.none.fl_str_mv W J G Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.084122

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