A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-...

Autores: Teglia, Carla Mariela; Brasca, Romina; Vera Candioti, Luciana; Goicoechea, Hector Casimiro
Año de publicación: 2016
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: The determination of the dissociation constant of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin was carried out by means of capillary electrophoresis using a dynamic coating of a fused-silica capillary with high-molecular-mass poly(diallyldimethylammonium chloride) (PDDA) implementing two methods: (a) fitting the effective mobility determined from different electrophoretic runs at a single wavelength as a function of pH and (b) a novel modeling strategy of the spectrophotometric second-order data generated with the diode array detector at several wavelengths as a function of pH. The accuracy of the proposed methodologies was verified using robenidine as a model compound with known value of pKa.
Fil: Teglia, Carla Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina
Fil: Brasca, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina
Fil: Vera Candioti, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina
Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina
Materia: 2-Hydroxy-4,6-Dimethylpyrimidine
Augmented Multivariate Curve Resolution
Capillary Electrophoresis
Nicarbazin
Second-Order Data
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/50582

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spelling	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazinTeglia, Carla MarielaBrasca, RominaVera Candioti, LucianaGoicoechea, Hector Casimiro2-Hydroxy-4,6-DimethylpyrimidineAugmented Multivariate Curve ResolutionCapillary ElectrophoresisNicarbazinSecond-Order Datahttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The determination of the dissociation constant of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin was carried out by means of capillary electrophoresis using a dynamic coating of a fused-silica capillary with high-molecular-mass poly(diallyldimethylammonium chloride) (PDDA) implementing two methods: (a) fitting the effective mobility determined from different electrophoretic runs at a single wavelength as a function of pH and (b) a novel modeling strategy of the spectrophotometric second-order data generated with the diode array detector at several wavelengths as a function of pH. The accuracy of the proposed methodologies was verified using robenidine as a model compound with known value of pKa.Fil: Teglia, Carla Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; ArgentinaFil: Brasca, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; ArgentinaFil: Vera Candioti, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; ArgentinaFil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; ArgentinaElsevier Science2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/50582Teglia, Carla Mariela; Brasca, Romina; Vera Candioti, Luciana; Goicoechea, Hector Casimiro; A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin; Elsevier Science; Chemometrics and Intelligent Laboratory Systems; 150; 1-2016; 1-80169-7439CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.chemolab.2015.11.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0169743915002713info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:47:55Zoai:ri.conicet.gov.ar:11336/50582instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:47:55.296CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
title	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
spellingShingle	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin Teglia, Carla Mariela 2-Hydroxy-4,6-Dimethylpyrimidine Augmented Multivariate Curve Resolution Capillary Electrophoresis Nicarbazin Second-Order Data
title_short	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
title_full	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
title_fullStr	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
title_full_unstemmed	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
title_sort	A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin
dc.creator.none.fl_str_mv	Teglia, Carla Mariela Brasca, Romina Vera Candioti, Luciana Goicoechea, Hector Casimiro
author	Teglia, Carla Mariela
author_facet	Teglia, Carla Mariela Brasca, Romina Vera Candioti, Luciana Goicoechea, Hector Casimiro
author_role	author
author2	Brasca, Romina Vera Candioti, Luciana Goicoechea, Hector Casimiro
author2_role	author author author
dc.subject.none.fl_str_mv	2-Hydroxy-4,6-Dimethylpyrimidine Augmented Multivariate Curve Resolution Capillary Electrophoresis Nicarbazin Second-Order Data
topic	2-Hydroxy-4,6-Dimethylpyrimidine Augmented Multivariate Curve Resolution Capillary Electrophoresis Nicarbazin Second-Order Data
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	The determination of the dissociation constant of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin was carried out by means of capillary electrophoresis using a dynamic coating of a fused-silica capillary with high-molecular-mass poly(diallyldimethylammonium chloride) (PDDA) implementing two methods: (a) fitting the effective mobility determined from different electrophoretic runs at a single wavelength as a function of pH and (b) a novel modeling strategy of the spectrophotometric second-order data generated with the diode array detector at several wavelengths as a function of pH. The accuracy of the proposed methodologies was verified using robenidine as a model compound with known value of pKa. Fil: Teglia, Carla Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina Fil: Brasca, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina Fil: Vera Candioti, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina
description	The determination of the dissociation constant of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin was carried out by means of capillary electrophoresis using a dynamic coating of a fused-silica capillary with high-molecular-mass poly(diallyldimethylammonium chloride) (PDDA) implementing two methods: (a) fitting the effective mobility determined from different electrophoretic runs at a single wavelength as a function of pH and (b) a novel modeling strategy of the spectrophotometric second-order data generated with the diode array detector at several wavelengths as a function of pH. The accuracy of the proposed methodologies was verified using robenidine as a model compound with known value of pKa.
publishDate	2016
dc.date.none.fl_str_mv	2016-01
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/50582 Teglia, Carla Mariela; Brasca, Romina; Vera Candioti, Luciana; Goicoechea, Hector Casimiro; A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin; Elsevier Science; Chemometrics and Intelligent Laboratory Systems; 150; 1-2016; 1-8 0169-7439 CONICET Digital CONICET
url	http://hdl.handle.net/11336/50582
identifier_str_mv	Teglia, Carla Mariela; Brasca, Romina; Vera Candioti, Luciana; Goicoechea, Hector Casimiro; A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-4,6-dimethylpyrimidine in nicarbazin; Elsevier Science; Chemometrics and Intelligent Laboratory Systems; 150; 1-2016; 1-8 0169-7439 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chemolab.2015.11.001 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0169743915002713
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier Science
publisher.none.fl_str_mv	Elsevier Science
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.011256

A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of pKa of 2-hydroxy-...

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