A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study

Autores
Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; Grinberg, Daniel; Balcells, Susana
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.
Fil: Urreizti, Roser. Universidad de Barcelona; España
Fil: Asteggiano, Carla Gabriela. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Vilaseca, Maria Antonia. Hospital Sant Joan de Deu Barcelona; España
Fil: Corbella, Emili. Hospital de Bellvitge; España
Fil: Pintó, Xavier. Hospital de Bellvitge; España
Fil: Grinberg, Daniel. Universidad de Barcelona; España
Fil: Balcells, Susana. Universidad de Barcelona; España
Materia
CBS
cardiovascular disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/240759
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/240759
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control studyUrreizti, RoserAsteggiano, Carla GabrielaVilaseca, Maria AntoniaCorbella, EmiliPintó, XavierGrinberg, DanielBalcells, SusanaCBScardiovascular diseasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.Fil: Urreizti, Roser. Universidad de Barcelona; EspañaFil: Asteggiano, Carla Gabriela. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Vilaseca, Maria Antonia. Hospital Sant Joan de Deu Barcelona; EspañaFil: Corbella, Emili. Hospital de Bellvitge; EspañaFil: Pintó, Xavier. Hospital de Bellvitge; EspañaFil: Grinberg, Daniel. Universidad de Barcelona; EspañaFil: Balcells, Susana. Universidad de Barcelona; EspañaPergamon-Elsevier Science Ltd2007-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240759Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; et al.; A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 40; 12; 8-2007; 864-8680009-9120CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009912007001750info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clinbiochem.2007.04.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:19:35Zoai:ri.conicet.gov.ar:11336/240759instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:19:35.545CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
title A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
spellingShingle A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
Urreizti, Roser
CBS
cardiovascular disease
title_short A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
title_full A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
title_fullStr A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
title_full_unstemmed A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
title_sort A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
dc.creator.none.fl_str_mv Urreizti, Roser
Asteggiano, Carla Gabriela
Vilaseca, Maria Antonia
Corbella, Emili
Pintó, Xavier
Grinberg, Daniel
Balcells, Susana
author Urreizti, Roser
author_facet Urreizti, Roser
Asteggiano, Carla Gabriela
Vilaseca, Maria Antonia
Corbella, Emili
Pintó, Xavier
Grinberg, Daniel
Balcells, Susana
author_role author
author2 Asteggiano, Carla Gabriela
Vilaseca, Maria Antonia
Corbella, Emili
Pintó, Xavier
Grinberg, Daniel
Balcells, Susana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CBS
cardiovascular disease
topic CBS
cardiovascular disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.
Fil: Urreizti, Roser. Universidad de Barcelona; España
Fil: Asteggiano, Carla Gabriela. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Vilaseca, Maria Antonia. Hospital Sant Joan de Deu Barcelona; España
Fil: Corbella, Emili. Hospital de Bellvitge; España
Fil: Pintó, Xavier. Hospital de Bellvitge; España
Fil: Grinberg, Daniel. Universidad de Barcelona; España
Fil: Balcells, Susana. Universidad de Barcelona; España
description Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.
publishDate 2007
dc.date.none.fl_str_mv 2007-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/240759
Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; et al.; A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 40; 12; 8-2007; 864-868
0009-9120
CONICET Digital
CONICET
url http://hdl.handle.net/11336/240759
identifier_str_mv Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; et al.; A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 40; 12; 8-2007; 864-868
0009-9120
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009912007001750
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clinbiochem.2007.04.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782635889655808
score 12.982451

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