A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study
- Autores
- Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; Grinberg, Daniel; Balcells, Susana
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.
Fil: Urreizti, Roser. Universidad de Barcelona; España
Fil: Asteggiano, Carla Gabriela. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Vilaseca, Maria Antonia. Hospital Sant Joan de Deu Barcelona; España
Fil: Corbella, Emili. Hospital de Bellvitge; España
Fil: Pintó, Xavier. Hospital de Bellvitge; España
Fil: Grinberg, Daniel. Universidad de Barcelona; España
Fil: Balcells, Susana. Universidad de Barcelona; España - Materia
-
CBS
cardiovascular disease - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/240759
Ver los metadatos del registro completo
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A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control studyUrreizti, RoserAsteggiano, Carla GabrielaVilaseca, Maria AntoniaCorbella, EmiliPintó, XavierGrinberg, DanielBalcells, SusanaCBScardiovascular diseasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies.Fil: Urreizti, Roser. Universidad de Barcelona; EspañaFil: Asteggiano, Carla Gabriela. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Vilaseca, Maria Antonia. Hospital Sant Joan de Deu Barcelona; EspañaFil: Corbella, Emili. Hospital de Bellvitge; EspañaFil: Pintó, Xavier. Hospital de Bellvitge; EspañaFil: Grinberg, Daniel. Universidad de Barcelona; EspañaFil: Balcells, Susana. Universidad de Barcelona; EspañaPergamon-Elsevier Science Ltd2007-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240759Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; et al.; A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 40; 12; 8-2007; 864-8680009-9120CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009912007001750info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clinbiochem.2007.04.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:14Zoai:ri.conicet.gov.ar:11336/240759instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:15.052CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study |
title |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study |
spellingShingle |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study Urreizti, Roser CBS cardiovascular disease |
title_short |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study |
title_full |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study |
title_fullStr |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study |
title_full_unstemmed |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study |
title_sort |
A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study |
dc.creator.none.fl_str_mv |
Urreizti, Roser Asteggiano, Carla Gabriela Vilaseca, Maria Antonia Corbella, Emili Pintó, Xavier Grinberg, Daniel Balcells, Susana |
author |
Urreizti, Roser |
author_facet |
Urreizti, Roser Asteggiano, Carla Gabriela Vilaseca, Maria Antonia Corbella, Emili Pintó, Xavier Grinberg, Daniel Balcells, Susana |
author_role |
author |
author2 |
Asteggiano, Carla Gabriela Vilaseca, Maria Antonia Corbella, Emili Pintó, Xavier Grinberg, Daniel Balcells, Susana |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
CBS cardiovascular disease |
topic |
CBS cardiovascular disease |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies. Fil: Urreizti, Roser. Universidad de Barcelona; España Fil: Asteggiano, Carla Gabriela. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Vilaseca, Maria Antonia. Hospital Sant Joan de Deu Barcelona; España Fil: Corbella, Emili. Hospital de Bellvitge; España Fil: Pintó, Xavier. Hospital de Bellvitge; España Fil: Grinberg, Daniel. Universidad de Barcelona; España Fil: Balcells, Susana. Universidad de Barcelona; España |
description |
Objectives: The aim of this study was to evaluate the association of polymorphisms present in genes related to homocysteine (Hcy) metabolism with coronary artery disease (CAD). Design and methods: We examined 8 polymorphisms in the cystathionine β-synthase (CBS), glutamate carboxypeptidase II (GCPII), methionine synthase (MS), methionine synthase reductase (MSR) and methylenetetrahydrofolate reductase (MTHFR) genes in 140 CAD patients and 113 controls, by means of Chi-square, logistic regression, ANOVA and the Mann–Whitney U test. Results: The c.66 G allele of MSR conferred an odds-ratio for CAD of 1.76 (95% CI 1.12–2.77), while a CBS haplotype [c.699C–c.844wt– c.1080C] was found over-represented in CAD [OR of 2.16 (1.29–3.63)]. Conclusions: Our results not only highlight the involvement of the MSR and CBS genes in the etiology of cardiovascular disease, but also emphasize the strength of haplotype analyses in association studies. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/240759 Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; et al.; A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 40; 12; 8-2007; 864-868 0009-9120 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/240759 |
identifier_str_mv |
Urreizti, Roser; Asteggiano, Carla Gabriela; Vilaseca, Maria Antonia; Corbella, Emili; Pintó, Xavier; et al.; A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case–control study; Pergamon-Elsevier Science Ltd; Clinical Biochemistry; 40; 12; 8-2007; 864-868 0009-9120 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009912007001750 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clinbiochem.2007.04.008 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614503316062208 |
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13.070432 |