Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering

Autores
Zanin, Juan Pablo; Gil, German Alejandro; García, Mónica Cristina; Rojas Delgado, Ricardo
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alginate (Alg) is increasingly studied as a constitutive material of scaffolds for tissue engineering because of its easy gelation and biocompatibility, and the incorporation of drugs into its formulation allows for its functionality to be extended. However, Alg presents a low cell adhesion and proliferation capacity, and the incorporation of drugs may further reduce its biocompatibility. Layered double hydroxides (LDH) are promising fillers for Alg-based biomaterials, as they increase cell adhesion and interaction and provide drug storage and controlled release. In this work, LDH containing ibuprofen or naproxen were synthesized by coprecipitation at a constant pH and their properties upon their incorporation in Alg dispersions (LDH-Drug/Alg) were explored. Drug release profiles in simulated body fluid and the proliferation of pre-osteoblastic MC3T3-E1 cells by LDH-Drug/Alg dispersions were then evaluated, leading to results that confirm their potential as biomaterials for tissue engineering. They showed a controlled release with diffusive control, modulated by the in-situ formation of an Alg hydrogel in the presence of Ca2+ ions. Additionally, LDH-Drug/Alg dispersions mitigated the cytotoxic effects of the pure drugs, especially in the case of markedly cytotoxic drugs such as naproxen.
Fil: Zanin, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Gil, German Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina
Fil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina
Materia
CYTOTOXICITY
DRUG DELIVERY SYSTEMS
HYDROGEL
SCAFFOLDING BIOMATERIALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210922
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/210922
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue EngineeringZanin, Juan PabloGil, German AlejandroGarcía, Mónica CristinaRojas Delgado, RicardoCYTOTOXICITYDRUG DELIVERY SYSTEMSHYDROGELSCAFFOLDING BIOMATERIALShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Alginate (Alg) is increasingly studied as a constitutive material of scaffolds for tissue engineering because of its easy gelation and biocompatibility, and the incorporation of drugs into its formulation allows for its functionality to be extended. However, Alg presents a low cell adhesion and proliferation capacity, and the incorporation of drugs may further reduce its biocompatibility. Layered double hydroxides (LDH) are promising fillers for Alg-based biomaterials, as they increase cell adhesion and interaction and provide drug storage and controlled release. In this work, LDH containing ibuprofen or naproxen were synthesized by coprecipitation at a constant pH and their properties upon their incorporation in Alg dispersions (LDH-Drug/Alg) were explored. Drug release profiles in simulated body fluid and the proliferation of pre-osteoblastic MC3T3-E1 cells by LDH-Drug/Alg dispersions were then evaluated, leading to results that confirm their potential as biomaterials for tissue engineering. They showed a controlled release with diffusive control, modulated by the in-situ formation of an Alg hydrogel in the presence of Ca2+ ions. Additionally, LDH-Drug/Alg dispersions mitigated the cytotoxic effects of the pure drugs, especially in the case of markedly cytotoxic drugs such as naproxen.Fil: Zanin, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Gil, German Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; ArgentinaFil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; ArgentinaMultidisciplinary Digital Publishing Institute2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210922Zanin, Juan Pablo; Gil, German Alejandro; García, Mónica Cristina; Rojas Delgado, Ricardo; Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering; Multidisciplinary Digital Publishing Institute; ChemEngineering; 6; 5; 10-2022; 70-842305-7084CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2305-7084/6/5/70info:eu-repo/semantics/altIdentifier/doi/10.3390/chemengineering6050070info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:03Zoai:ri.conicet.gov.ar:11336/210922instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:04.107CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
title Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
spellingShingle Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
Zanin, Juan Pablo
CYTOTOXICITY
DRUG DELIVERY SYSTEMS
HYDROGEL
SCAFFOLDING BIOMATERIALS
title_short Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
title_full Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
title_fullStr Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
title_full_unstemmed Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
title_sort Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering
dc.creator.none.fl_str_mv Zanin, Juan Pablo
Gil, German Alejandro
García, Mónica Cristina
Rojas Delgado, Ricardo
author Zanin, Juan Pablo
author_facet Zanin, Juan Pablo
Gil, German Alejandro
García, Mónica Cristina
Rojas Delgado, Ricardo
author_role author
author2 Gil, German Alejandro
García, Mónica Cristina
Rojas Delgado, Ricardo
author2_role author
author
author
dc.subject.none.fl_str_mv CYTOTOXICITY
DRUG DELIVERY SYSTEMS
HYDROGEL
SCAFFOLDING BIOMATERIALS
topic CYTOTOXICITY
DRUG DELIVERY SYSTEMS
HYDROGEL
SCAFFOLDING BIOMATERIALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Alginate (Alg) is increasingly studied as a constitutive material of scaffolds for tissue engineering because of its easy gelation and biocompatibility, and the incorporation of drugs into its formulation allows for its functionality to be extended. However, Alg presents a low cell adhesion and proliferation capacity, and the incorporation of drugs may further reduce its biocompatibility. Layered double hydroxides (LDH) are promising fillers for Alg-based biomaterials, as they increase cell adhesion and interaction and provide drug storage and controlled release. In this work, LDH containing ibuprofen or naproxen were synthesized by coprecipitation at a constant pH and their properties upon their incorporation in Alg dispersions (LDH-Drug/Alg) were explored. Drug release profiles in simulated body fluid and the proliferation of pre-osteoblastic MC3T3-E1 cells by LDH-Drug/Alg dispersions were then evaluated, leading to results that confirm their potential as biomaterials for tissue engineering. They showed a controlled release with diffusive control, modulated by the in-situ formation of an Alg hydrogel in the presence of Ca2+ ions. Additionally, LDH-Drug/Alg dispersions mitigated the cytotoxic effects of the pure drugs, especially in the case of markedly cytotoxic drugs such as naproxen.
Fil: Zanin, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Gil, German Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica; Argentina
Fil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Rojas Delgado, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina
description Alginate (Alg) is increasingly studied as a constitutive material of scaffolds for tissue engineering because of its easy gelation and biocompatibility, and the incorporation of drugs into its formulation allows for its functionality to be extended. However, Alg presents a low cell adhesion and proliferation capacity, and the incorporation of drugs may further reduce its biocompatibility. Layered double hydroxides (LDH) are promising fillers for Alg-based biomaterials, as they increase cell adhesion and interaction and provide drug storage and controlled release. In this work, LDH containing ibuprofen or naproxen were synthesized by coprecipitation at a constant pH and their properties upon their incorporation in Alg dispersions (LDH-Drug/Alg) were explored. Drug release profiles in simulated body fluid and the proliferation of pre-osteoblastic MC3T3-E1 cells by LDH-Drug/Alg dispersions were then evaluated, leading to results that confirm their potential as biomaterials for tissue engineering. They showed a controlled release with diffusive control, modulated by the in-situ formation of an Alg hydrogel in the presence of Ca2+ ions. Additionally, LDH-Drug/Alg dispersions mitigated the cytotoxic effects of the pure drugs, especially in the case of markedly cytotoxic drugs such as naproxen.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210922
Zanin, Juan Pablo; Gil, German Alejandro; García, Mónica Cristina; Rojas Delgado, Ricardo; Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering; Multidisciplinary Digital Publishing Institute; ChemEngineering; 6; 5; 10-2022; 70-84
2305-7084
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210922
identifier_str_mv Zanin, Juan Pablo; Gil, German Alejandro; García, Mónica Cristina; Rojas Delgado, Ricardo; Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering; Multidisciplinary Digital Publishing Institute; ChemEngineering; 6; 5; 10-2022; 70-84
2305-7084
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2305-7084/6/5/70
info:eu-repo/semantics/altIdentifier/doi/10.3390/chemengineering6050070
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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