Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides

Autores
Peralta, Maria Florencia; Scolari, Ivana Romina; Granero, Gladys Ester; Crivello, Mónica Elsie; Mendieta, Silvia Nazaret
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Layered double hydroxides (LDHs) are inorganic solids composed of cationic layers and inter-lamellar spaces filled with negative ions. In the last years, LDHs have gained interest as carriers of anionic drugs, which replace the interlayers ions. Most anti-tumor drugs are systemically administered and this produces many side effects. LDHs could protect and target them to the tumor; however, most anti-tumor drugs have no charge and thus, they are not able to enter into the interlamellar space. Aiming to overcome this problem, a surfactant was used in this work. Carbamazepine (CBZ), an anticonvulsant drug with a formal charge of 0, has shown efficacy against some solid cancer cell lines; it also produces alterations in red blood cells. Here, this drug was used as a model drug to be load into the system. CBZ was incorporated into HDLs, composed of Mg2-Al-NO3, in micelles of sodium cholate (a surfactant with negative charge) by using different methods: ionic exchange, coprecipitation and reconstruction. Different amounts of surfactant were assessed, at a critical micelle concentration. X-ray powder diffractograms showed that the drug incorporated in the system when synthesized by ionic exchange and reconstruction, but not by co-precipitation. The hydrodynamic sizes of the HDLs loaded with the drug in the micelles were measured by dynamic light scattering. The amount of CBZ loaded in the system was determined by UV and found to be ~2 %, which represents almost 100 % of the original amount of drug. Assays of drug released were done in Franz Cells with a Simulated Body Fluid (pH 7.4) and an acetate buffer (pH 4.8) in order to analyze the protector role of the system in the blood and the drug release inside the tumor cells respectively. Results suggest that LDHs are promising drug delivery carriers by allowing the incorporation of all kinds of drugs and not only of that with anionic charge.
Fil: Peralta, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Crivello, Mónica Elsie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina
Fil: Mendieta, Silvia Nazaret. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina
LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LI Reunión Anual de la Asociación Argentina de Farmacología Experimenta; XXI Reunión Anual de la Sociedad Argentina de Biología; XXXI Reunión Anual de la Sociedad Argentina de Protozoología; IX Reunión Anual de la Asociación Argentina de Nanomedicinas y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Protozoología
Asociación Argentina de Farmacología Experimental
Sociedad Argentina de Biología
Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio
Asociación Argentina de Nanomedicinas
Materia
LAYERED DOUBLE HYDROXIDES
CARBAMAZEPINE
DRUG DELIVERY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/136929
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/136929
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network_name_str CONICET Digital (CONICET)
spelling Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxidesPeralta, Maria FlorenciaScolari, Ivana RominaGranero, Gladys EsterCrivello, Mónica ElsieMendieta, Silvia NazaretLAYERED DOUBLE HYDROXIDESCARBAMAZEPINEDRUG DELIVERYhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Layered double hydroxides (LDHs) are inorganic solids composed of cationic layers and inter-lamellar spaces filled with negative ions. In the last years, LDHs have gained interest as carriers of anionic drugs, which replace the interlayers ions. Most anti-tumor drugs are systemically administered and this produces many side effects. LDHs could protect and target them to the tumor; however, most anti-tumor drugs have no charge and thus, they are not able to enter into the interlamellar space. Aiming to overcome this problem, a surfactant was used in this work. Carbamazepine (CBZ), an anticonvulsant drug with a formal charge of 0, has shown efficacy against some solid cancer cell lines; it also produces alterations in red blood cells. Here, this drug was used as a model drug to be load into the system. CBZ was incorporated into HDLs, composed of Mg2-Al-NO3, in micelles of sodium cholate (a surfactant with negative charge) by using different methods: ionic exchange, coprecipitation and reconstruction. Different amounts of surfactant were assessed, at a critical micelle concentration. X-ray powder diffractograms showed that the drug incorporated in the system when synthesized by ionic exchange and reconstruction, but not by co-precipitation. The hydrodynamic sizes of the HDLs loaded with the drug in the micelles were measured by dynamic light scattering. The amount of CBZ loaded in the system was determined by UV and found to be ~2 %, which represents almost 100 % of the original amount of drug. Assays of drug released were done in Franz Cells with a Simulated Body Fluid (pH 7.4) and an acetate buffer (pH 4.8) in order to analyze the protector role of the system in the blood and the drug release inside the tumor cells respectively. Results suggest that LDHs are promising drug delivery carriers by allowing the incorporation of all kinds of drugs and not only of that with anionic charge.Fil: Peralta, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; ArgentinaFil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Crivello, Mónica Elsie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; ArgentinaFil: Mendieta, Silvia Nazaret. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; ArgentinaLXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LI Reunión Anual de la Asociación Argentina de Farmacología Experimenta; XXI Reunión Anual de la Sociedad Argentina de Biología; XXXI Reunión Anual de la Sociedad Argentina de Protozoología; IX Reunión Anual de la Asociación Argentina de Nanomedicinas y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de LaboratorioMar del PlataArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de ProtozoologíaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de BiologíaAsociación Argentina de Ciencia y Tecnología de Animales de LaboratorioAsociación Argentina de NanomedicinasFundación Revista MedicinaCostas, MónicaMarino, GabrielaAzurmendi, Pablo2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136929Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LI Reunión Anual de la Asociación Argentina de Farmacología Experimenta; XXI Reunión Anual de la Sociedad Argentina de Biología; XXXI Reunión Anual de la Sociedad Argentina de Protozoología; IX Reunión Anual de la Asociación Argentina de Nanomedicinas y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio; Mar del Plata; Argentina; 2019; 156-1560025-76801669-9106CONICET DigitalCONICETengInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:32Zoai:ri.conicet.gov.ar:11336/136929instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:32.967CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
title Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
spellingShingle Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
Peralta, Maria Florencia
LAYERED DOUBLE HYDROXIDES
CARBAMAZEPINE
DRUG DELIVERY
title_short Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
title_full Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
title_fullStr Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
title_full_unstemmed Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
title_sort Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides
dc.creator.none.fl_str_mv Peralta, Maria Florencia
Scolari, Ivana Romina
Granero, Gladys Ester
Crivello, Mónica Elsie
Mendieta, Silvia Nazaret
author Peralta, Maria Florencia
author_facet Peralta, Maria Florencia
Scolari, Ivana Romina
Granero, Gladys Ester
Crivello, Mónica Elsie
Mendieta, Silvia Nazaret
author_role author
author2 Scolari, Ivana Romina
Granero, Gladys Ester
Crivello, Mónica Elsie
Mendieta, Silvia Nazaret
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Costas, Mónica
Marino, Gabriela
Azurmendi, Pablo
dc.subject.none.fl_str_mv LAYERED DOUBLE HYDROXIDES
CARBAMAZEPINE
DRUG DELIVERY
topic LAYERED DOUBLE HYDROXIDES
CARBAMAZEPINE
DRUG DELIVERY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Layered double hydroxides (LDHs) are inorganic solids composed of cationic layers and inter-lamellar spaces filled with negative ions. In the last years, LDHs have gained interest as carriers of anionic drugs, which replace the interlayers ions. Most anti-tumor drugs are systemically administered and this produces many side effects. LDHs could protect and target them to the tumor; however, most anti-tumor drugs have no charge and thus, they are not able to enter into the interlamellar space. Aiming to overcome this problem, a surfactant was used in this work. Carbamazepine (CBZ), an anticonvulsant drug with a formal charge of 0, has shown efficacy against some solid cancer cell lines; it also produces alterations in red blood cells. Here, this drug was used as a model drug to be load into the system. CBZ was incorporated into HDLs, composed of Mg2-Al-NO3, in micelles of sodium cholate (a surfactant with negative charge) by using different methods: ionic exchange, coprecipitation and reconstruction. Different amounts of surfactant were assessed, at a critical micelle concentration. X-ray powder diffractograms showed that the drug incorporated in the system when synthesized by ionic exchange and reconstruction, but not by co-precipitation. The hydrodynamic sizes of the HDLs loaded with the drug in the micelles were measured by dynamic light scattering. The amount of CBZ loaded in the system was determined by UV and found to be ~2 %, which represents almost 100 % of the original amount of drug. Assays of drug released were done in Franz Cells with a Simulated Body Fluid (pH 7.4) and an acetate buffer (pH 4.8) in order to analyze the protector role of the system in the blood and the drug release inside the tumor cells respectively. Results suggest that LDHs are promising drug delivery carriers by allowing the incorporation of all kinds of drugs and not only of that with anionic charge.
Fil: Peralta, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina
Fil: Scolari, Ivana Romina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Crivello, Mónica Elsie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina
Fil: Mendieta, Silvia Nazaret. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina
LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LI Reunión Anual de la Asociación Argentina de Farmacología Experimenta; XXI Reunión Anual de la Sociedad Argentina de Biología; XXXI Reunión Anual de la Sociedad Argentina de Protozoología; IX Reunión Anual de la Asociación Argentina de Nanomedicinas y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Protozoología
Asociación Argentina de Farmacología Experimental
Sociedad Argentina de Biología
Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio
Asociación Argentina de Nanomedicinas
description Layered double hydroxides (LDHs) are inorganic solids composed of cationic layers and inter-lamellar spaces filled with negative ions. In the last years, LDHs have gained interest as carriers of anionic drugs, which replace the interlayers ions. Most anti-tumor drugs are systemically administered and this produces many side effects. LDHs could protect and target them to the tumor; however, most anti-tumor drugs have no charge and thus, they are not able to enter into the interlamellar space. Aiming to overcome this problem, a surfactant was used in this work. Carbamazepine (CBZ), an anticonvulsant drug with a formal charge of 0, has shown efficacy against some solid cancer cell lines; it also produces alterations in red blood cells. Here, this drug was used as a model drug to be load into the system. CBZ was incorporated into HDLs, composed of Mg2-Al-NO3, in micelles of sodium cholate (a surfactant with negative charge) by using different methods: ionic exchange, coprecipitation and reconstruction. Different amounts of surfactant were assessed, at a critical micelle concentration. X-ray powder diffractograms showed that the drug incorporated in the system when synthesized by ionic exchange and reconstruction, but not by co-precipitation. The hydrodynamic sizes of the HDLs loaded with the drug in the micelles were measured by dynamic light scattering. The amount of CBZ loaded in the system was determined by UV and found to be ~2 %, which represents almost 100 % of the original amount of drug. Assays of drug released were done in Franz Cells with a Simulated Body Fluid (pH 7.4) and an acetate buffer (pH 4.8) in order to analyze the protector role of the system in the blood and the drug release inside the tumor cells respectively. Results suggest that LDHs are promising drug delivery carriers by allowing the incorporation of all kinds of drugs and not only of that with anionic charge.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
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Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/136929
Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LI Reunión Anual de la Asociación Argentina de Farmacología Experimenta; XXI Reunión Anual de la Sociedad Argentina de Biología; XXXI Reunión Anual de la Sociedad Argentina de Protozoología; IX Reunión Anual de la Asociación Argentina de Nanomedicinas y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio; Mar del Plata; Argentina; 2019; 156-156
0025-7680
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/136929
identifier_str_mv Incorporation of carbamazepine, a non-Ionic drug, in layered double hydroxides; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LI Reunión Anual de la Asociación Argentina de Farmacología Experimenta; XXI Reunión Anual de la Sociedad Argentina de Biología; XXXI Reunión Anual de la Sociedad Argentina de Protozoología; IX Reunión Anual de la Asociación Argentina de Nanomedicinas y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio; Mar del Plata; Argentina; 2019; 156-156
0025-7680
1669-9106
CONICET Digital
CONICET
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language eng
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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