Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism
- Autores
- Yakar, Shoshana; Rosen, Clifford J.; Bouxsein, Mary L.; Sun, Hui; Mejia, Wilson; Kawashima, Yuki; Wu, Yingjie; Emerton, Kelly; Williams, Valerie; Jepsen, Karl; Schaffler, Mitchell B.; Majeska, Robert J.; Gavrilova, Oksana; Gutierrez, Mariana; Hwang, David; Pennisi, Patricia Alejandra; Frystyk, Jan; Boisclair, Yves; Pintar, John; Jasper, Hector Guillermo; Domene, Horacio Mario; Cohen, Pinchas; Clemmons, David; LeRoith, Derek
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Serum insulin-like growth factor (IGF) -1 is secreted mainly by the liver and circulates bound to IGF-binding proteins (IGFBPs), either as binary complexes or ternary complexes with IGFBP-3 or IGFBP-5 and an acid-labile subunit (ALS). The purpose of this study was to genetically dissect the role of IGF-1 circulatory complexes in somatic growth, skeletal integrity, and metabolism. Phenotypic comparisons of controls and four mouse lines with genetic IGF-1 deficits liver-specific IGF-1 deficiency (LID), ALS knockout (ALSKO), IGFBP-3 (BP3) knockout, and a triply deficient LID/ALSKO/BP3 line?produced several novel findings. 1) All deficient strains had decreased serum IGF-1 levels, but this neither predicted growth potential or skeletal integrity nor defined growth hormone secretion or metabolic abnormalities. 2) IGF-1 deficiency affected development of both cortical and trabecular bone differently, effects apparently dependent on the presence of different circulating IGF-1 complexes. 3) IGFBP-3 deficiency resulted in increased linear growth. In summary, each IGF-1 complex constituent appears to play a distinct role in determining skeletal phenotype, with different effects on cortical and trabecular bone compartments.
Fil: Yakar, Shoshana. Mount Sinai School Of Medicine; Estados Unidos
Fil: Rosen, Clifford J.. Maine Medical Center Research Institute; Estados Unidos
Fil: Bouxsein, Mary L.. Harvard Medical School; Estados Unidos
Fil: Sun, Hui. Mount Sinai School Of Medicine; Estados Unidos
Fil: Mejia, Wilson. Mount Sinai School Of Medicine; Estados Unidos
Fil: Kawashima, Yuki. Mount Sinai School Of Medicine; Estados Unidos
Fil: Wu, Yingjie. Mount Sinai School Of Medicine; Estados Unidos
Fil: Emerton, Kelly. Mount Sinai School Of Medicine; Estados Unidos
Fil: Williams, Valerie. Mount Sinai School Of Medicine; Estados Unidos
Fil: Jepsen, Karl. Mount Sinai School Of Medicine; Estados Unidos
Fil: Schaffler, Mitchell B.. Mount Sinai School Of Medicine; Estados Unidos
Fil: Majeska, Robert J.. Mount Sinai School Of Medicine; Estados Unidos
Fil: Gavrilova, Oksana. National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health; Estados Unidos
Fil: Gutierrez, Mariana. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Hwang, David. David Geffen School of Medicine; Estados Unidos
Fil: Pennisi, Patricia Alejandra. National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Frystyk, Jan. Aarhus University Hospital; Dinamarca
Fil: Boisclair, Yves. Cornell University; Estados Unidos
Fil: Pintar, John. University of Medicine and Dentistry of New Jersey; Estados Unidos
Fil: Jasper, Hector Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Domene, Horacio Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Cohen, Pinchas. David Geffen School of Medicine; Estados Unidos
Fil: Clemmons, David. University of North Carolina at Chapel Hil; Estados Unidos
Fil: LeRoith, Derek. Mount Sinai School Of Medicine; Estados Unidos - Materia
-
CORTICAL BONE
TRABECULAR BONE
OSTEOCLAST
OSTEOBLAST
TERNARY COMPLEX
BINARY COMPLEX - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/103902
Ver los metadatos del registro completo
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Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolismYakar, ShoshanaRosen, Clifford J.Bouxsein, Mary L.Sun, HuiMejia, WilsonKawashima, YukiWu, YingjieEmerton, KellyWilliams, ValerieJepsen, KarlSchaffler, Mitchell B.Majeska, Robert J.Gavrilova, OksanaGutierrez, MarianaHwang, DavidPennisi, Patricia AlejandraFrystyk, JanBoisclair, YvesPintar, JohnJasper, Hector GuillermoDomene, Horacio MarioCohen, PinchasClemmons, DavidLeRoith, DerekCORTICAL BONETRABECULAR BONEOSTEOCLASTOSTEOBLASTTERNARY COMPLEXBINARY COMPLEXhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Serum insulin-like growth factor (IGF) -1 is secreted mainly by the liver and circulates bound to IGF-binding proteins (IGFBPs), either as binary complexes or ternary complexes with IGFBP-3 or IGFBP-5 and an acid-labile subunit (ALS). The purpose of this study was to genetically dissect the role of IGF-1 circulatory complexes in somatic growth, skeletal integrity, and metabolism. Phenotypic comparisons of controls and four mouse lines with genetic IGF-1 deficits liver-specific IGF-1 deficiency (LID), ALS knockout (ALSKO), IGFBP-3 (BP3) knockout, and a triply deficient LID/ALSKO/BP3 line?produced several novel findings. 1) All deficient strains had decreased serum IGF-1 levels, but this neither predicted growth potential or skeletal integrity nor defined growth hormone secretion or metabolic abnormalities. 2) IGF-1 deficiency affected development of both cortical and trabecular bone differently, effects apparently dependent on the presence of different circulating IGF-1 complexes. 3) IGFBP-3 deficiency resulted in increased linear growth. In summary, each IGF-1 complex constituent appears to play a distinct role in determining skeletal phenotype, with different effects on cortical and trabecular bone compartments.Fil: Yakar, Shoshana. Mount Sinai School Of Medicine; Estados UnidosFil: Rosen, Clifford J.. Maine Medical Center Research Institute; Estados UnidosFil: Bouxsein, Mary L.. Harvard Medical School; Estados UnidosFil: Sun, Hui. Mount Sinai School Of Medicine; Estados UnidosFil: Mejia, Wilson. Mount Sinai School Of Medicine; Estados UnidosFil: Kawashima, Yuki. Mount Sinai School Of Medicine; Estados UnidosFil: Wu, Yingjie. Mount Sinai School Of Medicine; Estados UnidosFil: Emerton, Kelly. Mount Sinai School Of Medicine; Estados UnidosFil: Williams, Valerie. Mount Sinai School Of Medicine; Estados UnidosFil: Jepsen, Karl. Mount Sinai School Of Medicine; Estados UnidosFil: Schaffler, Mitchell B.. Mount Sinai School Of Medicine; Estados UnidosFil: Majeska, Robert J.. Mount Sinai School Of Medicine; Estados UnidosFil: Gavrilova, Oksana. National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health; Estados UnidosFil: Gutierrez, Mariana. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Hwang, David. David Geffen School of Medicine; Estados UnidosFil: Pennisi, Patricia Alejandra. National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Frystyk, Jan. Aarhus University Hospital; DinamarcaFil: Boisclair, Yves. Cornell University; Estados UnidosFil: Pintar, John. University of Medicine and Dentistry of New Jersey; Estados UnidosFil: Jasper, Hector Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Domene, Horacio Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Cohen, Pinchas. David Geffen School of Medicine; Estados UnidosFil: Clemmons, David. University of North Carolina at Chapel Hil; Estados UnidosFil: LeRoith, Derek. Mount Sinai School Of Medicine; Estados UnidosFederation of American Societies for Experimental Biology2008-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103902Yakar, Shoshana; Rosen, Clifford J.; Bouxsein, Mary L.; Sun, Hui; Mejia, Wilson; et al.; Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism; Federation of American Societies for Experimental Biology; FASEB Journal; 23; 3; 10-2008; 709-7190892-6638CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.fasebj.org/content/23/3/709.longinfo:eu-repo/semantics/altIdentifier/doi/10.1096/fj.08-118976info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:02Zoai:ri.conicet.gov.ar:11336/103902instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:02.575CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism |
| title |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism |
| spellingShingle |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism Yakar, Shoshana CORTICAL BONE TRABECULAR BONE OSTEOCLAST OSTEOBLAST TERNARY COMPLEX BINARY COMPLEX |
| title_short |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism |
| title_full |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism |
| title_fullStr |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism |
| title_full_unstemmed |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism |
| title_sort |
Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism |
| dc.creator.none.fl_str_mv |
Yakar, Shoshana Rosen, Clifford J. Bouxsein, Mary L. Sun, Hui Mejia, Wilson Kawashima, Yuki Wu, Yingjie Emerton, Kelly Williams, Valerie Jepsen, Karl Schaffler, Mitchell B. Majeska, Robert J. Gavrilova, Oksana Gutierrez, Mariana Hwang, David Pennisi, Patricia Alejandra Frystyk, Jan Boisclair, Yves Pintar, John Jasper, Hector Guillermo Domene, Horacio Mario Cohen, Pinchas Clemmons, David LeRoith, Derek |
| author |
Yakar, Shoshana |
| author_facet |
Yakar, Shoshana Rosen, Clifford J. Bouxsein, Mary L. Sun, Hui Mejia, Wilson Kawashima, Yuki Wu, Yingjie Emerton, Kelly Williams, Valerie Jepsen, Karl Schaffler, Mitchell B. Majeska, Robert J. Gavrilova, Oksana Gutierrez, Mariana Hwang, David Pennisi, Patricia Alejandra Frystyk, Jan Boisclair, Yves Pintar, John Jasper, Hector Guillermo Domene, Horacio Mario Cohen, Pinchas Clemmons, David LeRoith, Derek |
| author_role |
author |
| author2 |
Rosen, Clifford J. Bouxsein, Mary L. Sun, Hui Mejia, Wilson Kawashima, Yuki Wu, Yingjie Emerton, Kelly Williams, Valerie Jepsen, Karl Schaffler, Mitchell B. Majeska, Robert J. Gavrilova, Oksana Gutierrez, Mariana Hwang, David Pennisi, Patricia Alejandra Frystyk, Jan Boisclair, Yves Pintar, John Jasper, Hector Guillermo Domene, Horacio Mario Cohen, Pinchas Clemmons, David LeRoith, Derek |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CORTICAL BONE TRABECULAR BONE OSTEOCLAST OSTEOBLAST TERNARY COMPLEX BINARY COMPLEX |
| topic |
CORTICAL BONE TRABECULAR BONE OSTEOCLAST OSTEOBLAST TERNARY COMPLEX BINARY COMPLEX |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Serum insulin-like growth factor (IGF) -1 is secreted mainly by the liver and circulates bound to IGF-binding proteins (IGFBPs), either as binary complexes or ternary complexes with IGFBP-3 or IGFBP-5 and an acid-labile subunit (ALS). The purpose of this study was to genetically dissect the role of IGF-1 circulatory complexes in somatic growth, skeletal integrity, and metabolism. Phenotypic comparisons of controls and four mouse lines with genetic IGF-1 deficits liver-specific IGF-1 deficiency (LID), ALS knockout (ALSKO), IGFBP-3 (BP3) knockout, and a triply deficient LID/ALSKO/BP3 line?produced several novel findings. 1) All deficient strains had decreased serum IGF-1 levels, but this neither predicted growth potential or skeletal integrity nor defined growth hormone secretion or metabolic abnormalities. 2) IGF-1 deficiency affected development of both cortical and trabecular bone differently, effects apparently dependent on the presence of different circulating IGF-1 complexes. 3) IGFBP-3 deficiency resulted in increased linear growth. In summary, each IGF-1 complex constituent appears to play a distinct role in determining skeletal phenotype, with different effects on cortical and trabecular bone compartments. Fil: Yakar, Shoshana. Mount Sinai School Of Medicine; Estados Unidos Fil: Rosen, Clifford J.. Maine Medical Center Research Institute; Estados Unidos Fil: Bouxsein, Mary L.. Harvard Medical School; Estados Unidos Fil: Sun, Hui. Mount Sinai School Of Medicine; Estados Unidos Fil: Mejia, Wilson. Mount Sinai School Of Medicine; Estados Unidos Fil: Kawashima, Yuki. Mount Sinai School Of Medicine; Estados Unidos Fil: Wu, Yingjie. Mount Sinai School Of Medicine; Estados Unidos Fil: Emerton, Kelly. Mount Sinai School Of Medicine; Estados Unidos Fil: Williams, Valerie. Mount Sinai School Of Medicine; Estados Unidos Fil: Jepsen, Karl. Mount Sinai School Of Medicine; Estados Unidos Fil: Schaffler, Mitchell B.. Mount Sinai School Of Medicine; Estados Unidos Fil: Majeska, Robert J.. Mount Sinai School Of Medicine; Estados Unidos Fil: Gavrilova, Oksana. National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health; Estados Unidos Fil: Gutierrez, Mariana. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina Fil: Hwang, David. David Geffen School of Medicine; Estados Unidos Fil: Pennisi, Patricia Alejandra. National Institute of Diabetes and Digestive and Kidney Diseases. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Frystyk, Jan. Aarhus University Hospital; Dinamarca Fil: Boisclair, Yves. Cornell University; Estados Unidos Fil: Pintar, John. University of Medicine and Dentistry of New Jersey; Estados Unidos Fil: Jasper, Hector Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina Fil: Domene, Horacio Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina Fil: Cohen, Pinchas. David Geffen School of Medicine; Estados Unidos Fil: Clemmons, David. University of North Carolina at Chapel Hil; Estados Unidos Fil: LeRoith, Derek. Mount Sinai School Of Medicine; Estados Unidos |
| description |
Serum insulin-like growth factor (IGF) -1 is secreted mainly by the liver and circulates bound to IGF-binding proteins (IGFBPs), either as binary complexes or ternary complexes with IGFBP-3 or IGFBP-5 and an acid-labile subunit (ALS). The purpose of this study was to genetically dissect the role of IGF-1 circulatory complexes in somatic growth, skeletal integrity, and metabolism. Phenotypic comparisons of controls and four mouse lines with genetic IGF-1 deficits liver-specific IGF-1 deficiency (LID), ALS knockout (ALSKO), IGFBP-3 (BP3) knockout, and a triply deficient LID/ALSKO/BP3 line?produced several novel findings. 1) All deficient strains had decreased serum IGF-1 levels, but this neither predicted growth potential or skeletal integrity nor defined growth hormone secretion or metabolic abnormalities. 2) IGF-1 deficiency affected development of both cortical and trabecular bone differently, effects apparently dependent on the presence of different circulating IGF-1 complexes. 3) IGFBP-3 deficiency resulted in increased linear growth. In summary, each IGF-1 complex constituent appears to play a distinct role in determining skeletal phenotype, with different effects on cortical and trabecular bone compartments. |
| publishDate |
2008 |
| dc.date.none.fl_str_mv |
2008-10 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/103902 Yakar, Shoshana; Rosen, Clifford J.; Bouxsein, Mary L.; Sun, Hui; Mejia, Wilson; et al.; Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism; Federation of American Societies for Experimental Biology; FASEB Journal; 23; 3; 10-2008; 709-719 0892-6638 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/103902 |
| identifier_str_mv |
Yakar, Shoshana; Rosen, Clifford J.; Bouxsein, Mary L.; Sun, Hui; Mejia, Wilson; et al.; Serum complexes of insulin‐like growth factor‐1 modulate skeletal integrity and carbohydrate metabolism; Federation of American Societies for Experimental Biology; FASEB Journal; 23; 3; 10-2008; 709-719 0892-6638 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/altIdentifier/url/http://www.fasebj.org/content/23/3/709.long info:eu-repo/semantics/altIdentifier/doi/10.1096/fj.08-118976 |
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Federation of American Societies for Experimental Biology |
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Federation of American Societies for Experimental Biology |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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