ROR2, a driver of “phenotype switching” in melanoma?

Autores
Lopez Bergami, Pablo Roberto
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that was shown to play a dual role in cancer. ROR2 was shown to either suppress or promote tumor progression in different tumor types by regulating the same biological processes (i.e. proliferation, invasion) in opposite ways. We have recently observed that ROR2 plays multiple and somewhat contradictory roles in melanoma where it impairs cell proliferation but promotes migration, EMT and chemoresistance. In the present article, ROR2 is proposed to be a major driver of “phenotype switching” in melanoma that can tilt the cellular behavior toward proliferative or invasive phenotypes. This function of ROR2 has therapeutic implications since it would provide an opportunity for targeting specific phenotypes such as invasive and drug-resistant ones by inhibiting ROR2.
Fil: Lopez Bergami, Pablo Roberto. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CELL PLASTICITY
EPITHELIAL TO MESENCHYMAL TRANSITION
MELANOMA
PHENOTYPE SWITCHING
ROR2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/196763
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/196763
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling ROR2, a driver of “phenotype switching” in melanoma?Lopez Bergami, Pablo RobertoCELL PLASTICITYEPITHELIAL TO MESENCHYMAL TRANSITIONMELANOMAPHENOTYPE SWITCHINGROR2https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that was shown to play a dual role in cancer. ROR2 was shown to either suppress or promote tumor progression in different tumor types by regulating the same biological processes (i.e. proliferation, invasion) in opposite ways. We have recently observed that ROR2 plays multiple and somewhat contradictory roles in melanoma where it impairs cell proliferation but promotes migration, EMT and chemoresistance. In the present article, ROR2 is proposed to be a major driver of “phenotype switching” in melanoma that can tilt the cellular behavior toward proliferative or invasive phenotypes. This function of ROR2 has therapeutic implications since it would provide an opportunity for targeting specific phenotypes such as invasive and drug-resistant ones by inhibiting ROR2.Fil: Lopez Bergami, Pablo Roberto. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBioMed Central2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196763Lopez Bergami, Pablo Roberto; ROR2, a driver of “phenotype switching” in melanoma?; BioMed Central; Cancer Cell International; 22; 1; 12-2022; 1-41475-2867CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12935-022-02711-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:12Zoai:ri.conicet.gov.ar:11336/196763instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:12.99CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ROR2, a driver of “phenotype switching” in melanoma?
title ROR2, a driver of “phenotype switching” in melanoma?
spellingShingle ROR2, a driver of “phenotype switching” in melanoma?
Lopez Bergami, Pablo Roberto
CELL PLASTICITY
EPITHELIAL TO MESENCHYMAL TRANSITION
MELANOMA
PHENOTYPE SWITCHING
ROR2
title_short ROR2, a driver of “phenotype switching” in melanoma?
title_full ROR2, a driver of “phenotype switching” in melanoma?
title_fullStr ROR2, a driver of “phenotype switching” in melanoma?
title_full_unstemmed ROR2, a driver of “phenotype switching” in melanoma?
title_sort ROR2, a driver of “phenotype switching” in melanoma?
dc.creator.none.fl_str_mv Lopez Bergami, Pablo Roberto
author Lopez Bergami, Pablo Roberto
author_facet Lopez Bergami, Pablo Roberto
author_role author
dc.subject.none.fl_str_mv CELL PLASTICITY
EPITHELIAL TO MESENCHYMAL TRANSITION
MELANOMA
PHENOTYPE SWITCHING
ROR2
topic CELL PLASTICITY
EPITHELIAL TO MESENCHYMAL TRANSITION
MELANOMA
PHENOTYPE SWITCHING
ROR2
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that was shown to play a dual role in cancer. ROR2 was shown to either suppress or promote tumor progression in different tumor types by regulating the same biological processes (i.e. proliferation, invasion) in opposite ways. We have recently observed that ROR2 plays multiple and somewhat contradictory roles in melanoma where it impairs cell proliferation but promotes migration, EMT and chemoresistance. In the present article, ROR2 is proposed to be a major driver of “phenotype switching” in melanoma that can tilt the cellular behavior toward proliferative or invasive phenotypes. This function of ROR2 has therapeutic implications since it would provide an opportunity for targeting specific phenotypes such as invasive and drug-resistant ones by inhibiting ROR2.
Fil: Lopez Bergami, Pablo Roberto. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that was shown to play a dual role in cancer. ROR2 was shown to either suppress or promote tumor progression in different tumor types by regulating the same biological processes (i.e. proliferation, invasion) in opposite ways. We have recently observed that ROR2 plays multiple and somewhat contradictory roles in melanoma where it impairs cell proliferation but promotes migration, EMT and chemoresistance. In the present article, ROR2 is proposed to be a major driver of “phenotype switching” in melanoma that can tilt the cellular behavior toward proliferative or invasive phenotypes. This function of ROR2 has therapeutic implications since it would provide an opportunity for targeting specific phenotypes such as invasive and drug-resistant ones by inhibiting ROR2.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/196763
Lopez Bergami, Pablo Roberto; ROR2, a driver of “phenotype switching” in melanoma?; BioMed Central; Cancer Cell International; 22; 1; 12-2022; 1-4
1475-2867
CONICET Digital
CONICET
url http://hdl.handle.net/11336/196763
identifier_str_mv Lopez Bergami, Pablo Roberto; ROR2, a driver of “phenotype switching” in melanoma?; BioMed Central; Cancer Cell International; 22; 1; 12-2022; 1-4
1475-2867
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s12935-022-02711-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270150856802304
score 13.13397

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