Tumor-specific MAGE proteins as regulators of p53 function

Autores
Ladelfa, Maria Fatima; Peche, Leticia Yamila; Toledo, Maria Fernanda; Laiseca, Julieta Eva; Schneider, Claudio; Monte, Martin
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
Fil: Ladelfa, Maria Fatima. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Peche, Leticia Yamila. Consorzio Interuniversitario per le Biotecnologie; Italia
Fil: Toledo, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Laiseca, Julieta Eva. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Schneider, Claudio. Consorzio Interuniversitario per le Biotecnologie; Italia
Fil: Monte, Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Anticancer Therapies
Mage
P53
Transcriptional Inhibition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/74924
Acceder
id CONICETDig_9c89db3d9f574b50eb9400a0fd291fdb
oai_identifier_str oai:ri.conicet.gov.ar:11336/74924
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tumor-specific MAGE proteins as regulators of p53 functionLadelfa, Maria FatimaPeche, Leticia YamilaToledo, Maria FernandaLaiseca, Julieta EvaSchneider, ClaudioMonte, MartinAnticancer TherapiesMageP53Transcriptional Inhibitionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.Fil: Ladelfa, Maria Fatima. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Peche, Leticia Yamila. Consorzio Interuniversitario per le Biotecnologie; ItaliaFil: Toledo, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Laiseca, Julieta Eva. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Schneider, Claudio. Consorzio Interuniversitario per le Biotecnologie; ItaliaFil: Monte, Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Ireland2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/74924Ladelfa, Maria Fatima; Peche, Leticia Yamila; Toledo, Maria Fernanda; Laiseca, Julieta Eva; Schneider, Claudio; et al.; Tumor-specific MAGE proteins as regulators of p53 function; Elsevier Ireland; Cancer Letters; 325; 1; 12-2012; 11-170304-3835CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304383512003503info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2012.05.031info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:13Zoai:ri.conicet.gov.ar:11336/74924instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:13.988CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tumor-specific MAGE proteins as regulators of p53 function
title Tumor-specific MAGE proteins as regulators of p53 function
spellingShingle Tumor-specific MAGE proteins as regulators of p53 function
Ladelfa, Maria Fatima
Anticancer Therapies
Mage
P53
Transcriptional Inhibition
title_short Tumor-specific MAGE proteins as regulators of p53 function
title_full Tumor-specific MAGE proteins as regulators of p53 function
title_fullStr Tumor-specific MAGE proteins as regulators of p53 function
title_full_unstemmed Tumor-specific MAGE proteins as regulators of p53 function
title_sort Tumor-specific MAGE proteins as regulators of p53 function
dc.creator.none.fl_str_mv Ladelfa, Maria Fatima
Peche, Leticia Yamila
Toledo, Maria Fernanda
Laiseca, Julieta Eva
Schneider, Claudio
Monte, Martin
author Ladelfa, Maria Fatima
author_facet Ladelfa, Maria Fatima
Peche, Leticia Yamila
Toledo, Maria Fernanda
Laiseca, Julieta Eva
Schneider, Claudio
Monte, Martin
author_role author
author2 Peche, Leticia Yamila
Toledo, Maria Fernanda
Laiseca, Julieta Eva
Schneider, Claudio
Monte, Martin
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Anticancer Therapies
Mage
P53
Transcriptional Inhibition
topic Anticancer Therapies
Mage
P53
Transcriptional Inhibition
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
Fil: Ladelfa, Maria Fatima. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Peche, Leticia Yamila. Consorzio Interuniversitario per le Biotecnologie; Italia
Fil: Toledo, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Laiseca, Julieta Eva. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Schneider, Claudio. Consorzio Interuniversitario per le Biotecnologie; Italia
Fil: Monte, Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/74924
Ladelfa, Maria Fatima; Peche, Leticia Yamila; Toledo, Maria Fernanda; Laiseca, Julieta Eva; Schneider, Claudio; et al.; Tumor-specific MAGE proteins as regulators of p53 function; Elsevier Ireland; Cancer Letters; 325; 1; 12-2012; 11-17
0304-3835
CONICET Digital
CONICET
url http://hdl.handle.net/11336/74924
identifier_str_mv Ladelfa, Maria Fatima; Peche, Leticia Yamila; Toledo, Maria Fernanda; Laiseca, Julieta Eva; Schneider, Claudio; et al.; Tumor-specific MAGE proteins as regulators of p53 function; Elsevier Ireland; Cancer Letters; 325; 1; 12-2012; 11-17
0304-3835
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304383512003503
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2012.05.031
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268778811883520
score 13.13397

Publicaciones similares