MAGE Proteins and the Regulation of E2F Pathway

Autores
Ladelfa, Maria Fatima; Monte, Martín
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Melanoma Antigens Genes (MAGE) constitutes a mutagenic family divided in two subfamilies, MAGE-I and MAGE-II, according to its tissue pattern expression. While MAGE-I in adult humans are only expressed in testis and tumors tissues, those belonging to MAGE-II subfamily are ubiquitously expressed. During the last decade, functional characterization of MAGE proteins points to a role in transcription regulation. E2F1 is a member of the E2F family and is among the transcription factors reported to be modulated by MAGE proteins. In this article we will focus on reported cases of E2F1 modulation by members of MAGE-I and MAGE-II subfamilies and the resulting biological consequences observed in normal and tumor cells.
Fil: Ladelfa, Maria Fatima. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Monte, Martín. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Materia
CANCER
E2F
MAGE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102422
Acceder
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spelling MAGE Proteins and the Regulation of E2F PathwayLadelfa, Maria FatimaMonte, MartínCANCERE2FMAGEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Melanoma Antigens Genes (MAGE) constitutes a mutagenic family divided in two subfamilies, MAGE-I and MAGE-II, according to its tissue pattern expression. While MAGE-I in adult humans are only expressed in testis and tumors tissues, those belonging to MAGE-II subfamily are ubiquitously expressed. During the last decade, functional characterization of MAGE proteins points to a role in transcription regulation. E2F1 is a member of the E2F family and is among the transcription factors reported to be modulated by MAGE proteins. In this article we will focus on reported cases of E2F1 modulation by members of MAGE-I and MAGE-II subfamilies and the resulting biological consequences observed in normal and tumor cells.Fil: Ladelfa, Maria Fatima. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Monte, Martín. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaSciMed Central2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102422Ladelfa, Maria Fatima; Monte, Martín; MAGE Proteins and the Regulation of E2F Pathway; SciMed Central; JSM Clinical Oncology and Research; 5; 1; 4-2017; 1-42373-938XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/Oncology/vol5issue1.phpinfo:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/Oncology/oncology-5-1052.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:43Zoai:ri.conicet.gov.ar:11336/102422instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:43.725CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MAGE Proteins and the Regulation of E2F Pathway
title MAGE Proteins and the Regulation of E2F Pathway
spellingShingle MAGE Proteins and the Regulation of E2F Pathway
Ladelfa, Maria Fatima
CANCER
E2F
MAGE
title_short MAGE Proteins and the Regulation of E2F Pathway
title_full MAGE Proteins and the Regulation of E2F Pathway
title_fullStr MAGE Proteins and the Regulation of E2F Pathway
title_full_unstemmed MAGE Proteins and the Regulation of E2F Pathway
title_sort MAGE Proteins and the Regulation of E2F Pathway
dc.creator.none.fl_str_mv Ladelfa, Maria Fatima
Monte, Martín
author Ladelfa, Maria Fatima
author_facet Ladelfa, Maria Fatima
Monte, Martín
author_role author
author2 Monte, Martín
author2_role author
dc.subject.none.fl_str_mv CANCER
E2F
MAGE
topic CANCER
E2F
MAGE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Melanoma Antigens Genes (MAGE) constitutes a mutagenic family divided in two subfamilies, MAGE-I and MAGE-II, according to its tissue pattern expression. While MAGE-I in adult humans are only expressed in testis and tumors tissues, those belonging to MAGE-II subfamily are ubiquitously expressed. During the last decade, functional characterization of MAGE proteins points to a role in transcription regulation. E2F1 is a member of the E2F family and is among the transcription factors reported to be modulated by MAGE proteins. In this article we will focus on reported cases of E2F1 modulation by members of MAGE-I and MAGE-II subfamilies and the resulting biological consequences observed in normal and tumor cells.
Fil: Ladelfa, Maria Fatima. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Monte, Martín. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
description Melanoma Antigens Genes (MAGE) constitutes a mutagenic family divided in two subfamilies, MAGE-I and MAGE-II, according to its tissue pattern expression. While MAGE-I in adult humans are only expressed in testis and tumors tissues, those belonging to MAGE-II subfamily are ubiquitously expressed. During the last decade, functional characterization of MAGE proteins points to a role in transcription regulation. E2F1 is a member of the E2F family and is among the transcription factors reported to be modulated by MAGE proteins. In this article we will focus on reported cases of E2F1 modulation by members of MAGE-I and MAGE-II subfamilies and the resulting biological consequences observed in normal and tumor cells.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102422
Ladelfa, Maria Fatima; Monte, Martín; MAGE Proteins and the Regulation of E2F Pathway; SciMed Central; JSM Clinical Oncology and Research; 5; 1; 4-2017; 1-4
2373-938X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102422
identifier_str_mv Ladelfa, Maria Fatima; Monte, Martín; MAGE Proteins and the Regulation of E2F Pathway; SciMed Central; JSM Clinical Oncology and Research; 5; 1; 4-2017; 1-4
2373-938X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/Oncology/vol5issue1.php
info:eu-repo/semantics/altIdentifier/url/https://www.jscimedcentral.com/Oncology/oncology-5-1052.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SciMed Central
publisher.none.fl_str_mv SciMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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