Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks

Autores
Beckwith, Esteban Javier; Yanovsky, Marcelo Javier
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gene expression programs activated in response to, or in anticipation of, environmental changes involve sequential steps, from transcription and RNA processing to nuclear export and translation. Here we review recent advances in our understanding of the multiple regulatory layers that control the oscillations in gene expression associated with daily rhythms in metabolism and physiology across eukaryotic organisms. Whereas many genes show coordinated oscillations in transcription, RNA processing and translation, others show significant temporal disconnections between these processes. Thus, circadian oscillations constitute an ideal system for examining how multiple transcriptional and post-transcriptional regulatory steps are integrated to maximize organismal adjustments to environmental conditions.
Fil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
Circadian
Transcription
Post-Transcription
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23064
Acceder
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spelling Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networksBeckwith, Esteban JavierYanovsky, Marcelo JavierCircadianTranscriptionPost-Transcriptionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Gene expression programs activated in response to, or in anticipation of, environmental changes involve sequential steps, from transcription and RNA processing to nuclear export and translation. Here we review recent advances in our understanding of the multiple regulatory layers that control the oscillations in gene expression associated with daily rhythms in metabolism and physiology across eukaryotic organisms. Whereas many genes show coordinated oscillations in transcription, RNA processing and translation, others show significant temporal disconnections between these processes. Thus, circadian oscillations constitute an ideal system for examining how multiple transcriptional and post-transcriptional regulatory steps are integrated to maximize organismal adjustments to environmental conditions.Fil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaCurrent Biology Ltd2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23064Beckwith, Esteban Javier; Yanovsky, Marcelo Javier; Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks; Current Biology Ltd; Current Opinion In Genetics & Development.; 27; 8-2014; 35-420959-437X1879-0380CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0959437X14000136info:eu-repo/semantics/altIdentifier/doi/10.1016/j.gde.2014.03.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:48:26Zoai:ri.conicet.gov.ar:11336/23064instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:48:26.712CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
title Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
spellingShingle Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
Beckwith, Esteban Javier
Circadian
Transcription
Post-Transcription
title_short Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
title_full Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
title_fullStr Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
title_full_unstemmed Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
title_sort Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
dc.creator.none.fl_str_mv Beckwith, Esteban Javier
Yanovsky, Marcelo Javier
author Beckwith, Esteban Javier
author_facet Beckwith, Esteban Javier
Yanovsky, Marcelo Javier
author_role author
author2 Yanovsky, Marcelo Javier
author2_role author
dc.subject.none.fl_str_mv Circadian
Transcription
Post-Transcription
topic Circadian
Transcription
Post-Transcription
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Gene expression programs activated in response to, or in anticipation of, environmental changes involve sequential steps, from transcription and RNA processing to nuclear export and translation. Here we review recent advances in our understanding of the multiple regulatory layers that control the oscillations in gene expression associated with daily rhythms in metabolism and physiology across eukaryotic organisms. Whereas many genes show coordinated oscillations in transcription, RNA processing and translation, others show significant temporal disconnections between these processes. Thus, circadian oscillations constitute an ideal system for examining how multiple transcriptional and post-transcriptional regulatory steps are integrated to maximize organismal adjustments to environmental conditions.
Fil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description Gene expression programs activated in response to, or in anticipation of, environmental changes involve sequential steps, from transcription and RNA processing to nuclear export and translation. Here we review recent advances in our understanding of the multiple regulatory layers that control the oscillations in gene expression associated with daily rhythms in metabolism and physiology across eukaryotic organisms. Whereas many genes show coordinated oscillations in transcription, RNA processing and translation, others show significant temporal disconnections between these processes. Thus, circadian oscillations constitute an ideal system for examining how multiple transcriptional and post-transcriptional regulatory steps are integrated to maximize organismal adjustments to environmental conditions.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23064
Beckwith, Esteban Javier; Yanovsky, Marcelo Javier; Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks; Current Biology Ltd; Current Opinion In Genetics & Development.; 27; 8-2014; 35-42
0959-437X
1879-0380
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23064
identifier_str_mv Beckwith, Esteban Javier; Yanovsky, Marcelo Javier; Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks; Current Biology Ltd; Current Opinion In Genetics & Development.; 27; 8-2014; 35-42
0959-437X
1879-0380
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0959437X14000136
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.gde.2014.03.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Current Biology Ltd
publisher.none.fl_str_mv Current Biology Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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