Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
- Autores
- Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; Seri, Marco; Melazzini, Federica; Loffreddo, Giuseppe; Russo, Giovana; Bozzi, Valeria; Notarangelo, Lucia Dora; Gresele, Paolo; Heller, Paula Graciela; Pujol Moix, Nuria; Kunishima, Shinji; Cattaneo, Marco; Bussel, James; de Candia, Erica; Cagioni, Claudia; Ramenghi, Ugo; Barozzi, Serena; Fabris, Fabrizio; Balduini, Carlo L.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.
Fil: Noris, Patrizia. University of Pavia; Italia
Fil: Biino, Ginevra. Consiglio Nazionale Delle Ricerche. Istituto di Genetica Molecolare; Italia
Fil: Pecci, Alessandro. University of Pavia; Italia
Fil: Civaschi, Elisa. University of Pavia; Italia
Fil: Savoia, Anna. Università degli Studi di Trieste; Italia. Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo; Italia
Fil: Seri, Marco. Università di Bologna; Italia
Fil: Melazzini, Federica. University of Pavia; Italia
Fil: Loffreddo, Giuseppe. Pausilipon Hospital; Italia
Fil: Russo, Giovana. Università degli Studi di Catania; Italia
Fil: Bozzi, Valeria. University of Pavia; Italia
Fil: Notarangelo, Lucia Dora. Spedali Civili. Ospedale dei Bambini; Italia
Fil: Gresele, Paolo. Università di Perugia; Italia
Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pujol Moix, Nuria. Universitat Autònoma de Barcelona; España
Fil: Kunishima, Shinji. National Hospital Organization Nagoya Medical Center; Japón
Fil: Cattaneo, Marco. Università degli Studi di Milano; Italia
Fil: Bussel, James. Cornell University; Estados Unidos
Fil: de Candia, Erica. Universita Cattolica del Sacro Cuore; Italia
Fil: Cagioni, Claudia. University of Pavia; Italia
Fil: Ramenghi, Ugo. Università di Torino; Italia
Fil: Barozzi, Serena. University of Pavia; Italia
Fil: Fabris, Fabrizio. Università di Padova; Italia
Fil: Balduini, Carlo L.. University of Pavia; Italia - Materia
-
Plaquetas
Trombocitopenias
Dpm - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/21509
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CONICET Digital (CONICET) |
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Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disordersNoris, PatriziaBiino, GinevraPecci, AlessandroCivaschi, ElisaSavoia, AnnaSeri, MarcoMelazzini, FedericaLoffreddo, GiuseppeRusso, GiovanaBozzi, ValeriaNotarangelo, Lucia DoraGresele, PaoloHeller, Paula GracielaPujol Moix, NuriaKunishima, ShinjiCattaneo, MarcoBussel, Jamesde Candia, EricaCagioni, ClaudiaRamenghi, UgoBarozzi, SerenaFabris, FabrizioBalduini, Carlo L.PlaquetasTrombocitopeniasDpmhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.Fil: Noris, Patrizia. University of Pavia; ItaliaFil: Biino, Ginevra. Consiglio Nazionale Delle Ricerche. Istituto di Genetica Molecolare; ItaliaFil: Pecci, Alessandro. University of Pavia; ItaliaFil: Civaschi, Elisa. University of Pavia; ItaliaFil: Savoia, Anna. Università degli Studi di Trieste; Italia. Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo; ItaliaFil: Seri, Marco. Università di Bologna; ItaliaFil: Melazzini, Federica. University of Pavia; ItaliaFil: Loffreddo, Giuseppe. Pausilipon Hospital; ItaliaFil: Russo, Giovana. Università degli Studi di Catania; ItaliaFil: Bozzi, Valeria. University of Pavia; ItaliaFil: Notarangelo, Lucia Dora. Spedali Civili. Ospedale dei Bambini; ItaliaFil: Gresele, Paolo. Università di Perugia; ItaliaFil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pujol Moix, Nuria. Universitat Autònoma de Barcelona; EspañaFil: Kunishima, Shinji. National Hospital Organization Nagoya Medical Center; JapónFil: Cattaneo, Marco. Università degli Studi di Milano; ItaliaFil: Bussel, James. Cornell University; Estados UnidosFil: de Candia, Erica. Universita Cattolica del Sacro Cuore; ItaliaFil: Cagioni, Claudia. University of Pavia; ItaliaFil: Ramenghi, Ugo. Università di Torino; ItaliaFil: Barozzi, Serena. University of Pavia; ItaliaFil: Fabris, Fabrizio. Università di Padova; ItaliaFil: Balduini, Carlo L.. University of Pavia; ItaliaAmerican Society of Hematology2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21509Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-100006-49711528-0020CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1182/blood-2014-03-564328info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/124/6/e4?sso-checked=trueinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:11Zoai:ri.conicet.gov.ar:11336/21509instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:11.91CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders |
title |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders |
spellingShingle |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders Noris, Patrizia Plaquetas Trombocitopenias Dpm |
title_short |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders |
title_full |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders |
title_fullStr |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders |
title_full_unstemmed |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders |
title_sort |
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders |
dc.creator.none.fl_str_mv |
Noris, Patrizia Biino, Ginevra Pecci, Alessandro Civaschi, Elisa Savoia, Anna Seri, Marco Melazzini, Federica Loffreddo, Giuseppe Russo, Giovana Bozzi, Valeria Notarangelo, Lucia Dora Gresele, Paolo Heller, Paula Graciela Pujol Moix, Nuria Kunishima, Shinji Cattaneo, Marco Bussel, James de Candia, Erica Cagioni, Claudia Ramenghi, Ugo Barozzi, Serena Fabris, Fabrizio Balduini, Carlo L. |
author |
Noris, Patrizia |
author_facet |
Noris, Patrizia Biino, Ginevra Pecci, Alessandro Civaschi, Elisa Savoia, Anna Seri, Marco Melazzini, Federica Loffreddo, Giuseppe Russo, Giovana Bozzi, Valeria Notarangelo, Lucia Dora Gresele, Paolo Heller, Paula Graciela Pujol Moix, Nuria Kunishima, Shinji Cattaneo, Marco Bussel, James de Candia, Erica Cagioni, Claudia Ramenghi, Ugo Barozzi, Serena Fabris, Fabrizio Balduini, Carlo L. |
author_role |
author |
author2 |
Biino, Ginevra Pecci, Alessandro Civaschi, Elisa Savoia, Anna Seri, Marco Melazzini, Federica Loffreddo, Giuseppe Russo, Giovana Bozzi, Valeria Notarangelo, Lucia Dora Gresele, Paolo Heller, Paula Graciela Pujol Moix, Nuria Kunishima, Shinji Cattaneo, Marco Bussel, James de Candia, Erica Cagioni, Claudia Ramenghi, Ugo Barozzi, Serena Fabris, Fabrizio Balduini, Carlo L. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Plaquetas Trombocitopenias Dpm |
topic |
Plaquetas Trombocitopenias Dpm |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT. Fil: Noris, Patrizia. University of Pavia; Italia Fil: Biino, Ginevra. Consiglio Nazionale Delle Ricerche. Istituto di Genetica Molecolare; Italia Fil: Pecci, Alessandro. University of Pavia; Italia Fil: Civaschi, Elisa. University of Pavia; Italia Fil: Savoia, Anna. Università degli Studi di Trieste; Italia. Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo; Italia Fil: Seri, Marco. Università di Bologna; Italia Fil: Melazzini, Federica. University of Pavia; Italia Fil: Loffreddo, Giuseppe. Pausilipon Hospital; Italia Fil: Russo, Giovana. Università degli Studi di Catania; Italia Fil: Bozzi, Valeria. University of Pavia; Italia Fil: Notarangelo, Lucia Dora. Spedali Civili. Ospedale dei Bambini; Italia Fil: Gresele, Paolo. Università di Perugia; Italia Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Pujol Moix, Nuria. Universitat Autònoma de Barcelona; España Fil: Kunishima, Shinji. National Hospital Organization Nagoya Medical Center; Japón Fil: Cattaneo, Marco. Università degli Studi di Milano; Italia Fil: Bussel, James. Cornell University; Estados Unidos Fil: de Candia, Erica. Universita Cattolica del Sacro Cuore; Italia Fil: Cagioni, Claudia. University of Pavia; Italia Fil: Ramenghi, Ugo. Università di Torino; Italia Fil: Barozzi, Serena. University of Pavia; Italia Fil: Fabris, Fabrizio. Università di Padova; Italia Fil: Balduini, Carlo L.. University of Pavia; Italia |
description |
Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/21509 Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-10 0006-4971 1528-0020 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/21509 |
identifier_str_mv |
Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-10 0006-4971 1528-0020 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1182/blood-2014-03-564328 info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/124/6/e4?sso-checked=true |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society of Hematology |
publisher.none.fl_str_mv |
American Society of Hematology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269787311308800 |
score |
13.13397 |