Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders

Autores
Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; Seri, Marco; Melazzini, Federica; Loffreddo, Giuseppe; Russo, Giovana; Bozzi, Valeria; Notarangelo, Lucia Dora; Gresele, Paolo; Heller, Paula Graciela; Pujol Moix, Nuria; Kunishima, Shinji; Cattaneo, Marco; Bussel, James; de Candia, Erica; Cagioni, Claudia; Ramenghi, Ugo; Barozzi, Serena; Fabris, Fabrizio; Balduini, Carlo L.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.
Fil: Noris, Patrizia. University of Pavia; Italia
Fil: Biino, Ginevra. Consiglio Nazionale Delle Ricerche. Istituto di Genetica Molecolare; Italia
Fil: Pecci, Alessandro. University of Pavia; Italia
Fil: Civaschi, Elisa. University of Pavia; Italia
Fil: Savoia, Anna. Università degli Studi di Trieste; Italia. Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo; Italia
Fil: Seri, Marco. Università di Bologna; Italia
Fil: Melazzini, Federica. University of Pavia; Italia
Fil: Loffreddo, Giuseppe. Pausilipon Hospital; Italia
Fil: Russo, Giovana. Università degli Studi di Catania; Italia
Fil: Bozzi, Valeria. University of Pavia; Italia
Fil: Notarangelo, Lucia Dora. Spedali Civili. Ospedale dei Bambini; Italia
Fil: Gresele, Paolo. Università di Perugia; Italia
Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pujol Moix, Nuria. Universitat Autònoma de Barcelona; España
Fil: Kunishima, Shinji. National Hospital Organization Nagoya Medical Center; Japón
Fil: Cattaneo, Marco. Università degli Studi di Milano; Italia
Fil: Bussel, James. Cornell University; Estados Unidos
Fil: de Candia, Erica. Universita Cattolica del Sacro Cuore; Italia
Fil: Cagioni, Claudia. University of Pavia; Italia
Fil: Ramenghi, Ugo. Università di Torino; Italia
Fil: Barozzi, Serena. University of Pavia; Italia
Fil: Fabris, Fabrizio. Università di Padova; Italia
Fil: Balduini, Carlo L.. University of Pavia; Italia
Materia
Plaquetas
Trombocitopenias
Dpm
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21509
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/21509
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disordersNoris, PatriziaBiino, GinevraPecci, AlessandroCivaschi, ElisaSavoia, AnnaSeri, MarcoMelazzini, FedericaLoffreddo, GiuseppeRusso, GiovanaBozzi, ValeriaNotarangelo, Lucia DoraGresele, PaoloHeller, Paula GracielaPujol Moix, NuriaKunishima, ShinjiCattaneo, MarcoBussel, Jamesde Candia, EricaCagioni, ClaudiaRamenghi, UgoBarozzi, SerenaFabris, FabrizioBalduini, Carlo L.PlaquetasTrombocitopeniasDpmhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.Fil: Noris, Patrizia. University of Pavia; ItaliaFil: Biino, Ginevra. Consiglio Nazionale Delle Ricerche. Istituto di Genetica Molecolare; ItaliaFil: Pecci, Alessandro. University of Pavia; ItaliaFil: Civaschi, Elisa. University of Pavia; ItaliaFil: Savoia, Anna. Università degli Studi di Trieste; Italia. Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo; ItaliaFil: Seri, Marco. Università di Bologna; ItaliaFil: Melazzini, Federica. University of Pavia; ItaliaFil: Loffreddo, Giuseppe. Pausilipon Hospital; ItaliaFil: Russo, Giovana. Università degli Studi di Catania; ItaliaFil: Bozzi, Valeria. University of Pavia; ItaliaFil: Notarangelo, Lucia Dora. Spedali Civili. Ospedale dei Bambini; ItaliaFil: Gresele, Paolo. Università di Perugia; ItaliaFil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pujol Moix, Nuria. Universitat Autònoma de Barcelona; EspañaFil: Kunishima, Shinji. National Hospital Organization Nagoya Medical Center; JapónFil: Cattaneo, Marco. Università degli Studi di Milano; ItaliaFil: Bussel, James. Cornell University; Estados UnidosFil: de Candia, Erica. Universita Cattolica del Sacro Cuore; ItaliaFil: Cagioni, Claudia. University of Pavia; ItaliaFil: Ramenghi, Ugo. Università di Torino; ItaliaFil: Barozzi, Serena. University of Pavia; ItaliaFil: Fabris, Fabrizio. Università di Padova; ItaliaFil: Balduini, Carlo L.. University of Pavia; ItaliaAmerican Society of Hematology2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21509Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-100006-49711528-0020CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1182/blood-2014-03-564328info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/124/6/e4?sso-checked=trueinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:55Zoai:ri.conicet.gov.ar:11336/21509instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:55.728CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
title Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
spellingShingle Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
Noris, Patrizia
Plaquetas
Trombocitopenias
Dpm
title_short Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
title_full Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
title_fullStr Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
title_full_unstemmed Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
title_sort Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
dc.creator.none.fl_str_mv Noris, Patrizia
Biino, Ginevra
Pecci, Alessandro
Civaschi, Elisa
Savoia, Anna
Seri, Marco
Melazzini, Federica
Loffreddo, Giuseppe
Russo, Giovana
Bozzi, Valeria
Notarangelo, Lucia Dora
Gresele, Paolo
Heller, Paula Graciela
Pujol Moix, Nuria
Kunishima, Shinji
Cattaneo, Marco
Bussel, James
de Candia, Erica
Cagioni, Claudia
Ramenghi, Ugo
Barozzi, Serena
Fabris, Fabrizio
Balduini, Carlo L.
author Noris, Patrizia
author_facet Noris, Patrizia
Biino, Ginevra
Pecci, Alessandro
Civaschi, Elisa
Savoia, Anna
Seri, Marco
Melazzini, Federica
Loffreddo, Giuseppe
Russo, Giovana
Bozzi, Valeria
Notarangelo, Lucia Dora
Gresele, Paolo
Heller, Paula Graciela
Pujol Moix, Nuria
Kunishima, Shinji
Cattaneo, Marco
Bussel, James
de Candia, Erica
Cagioni, Claudia
Ramenghi, Ugo
Barozzi, Serena
Fabris, Fabrizio
Balduini, Carlo L.
author_role author
author2 Biino, Ginevra
Pecci, Alessandro
Civaschi, Elisa
Savoia, Anna
Seri, Marco
Melazzini, Federica
Loffreddo, Giuseppe
Russo, Giovana
Bozzi, Valeria
Notarangelo, Lucia Dora
Gresele, Paolo
Heller, Paula Graciela
Pujol Moix, Nuria
Kunishima, Shinji
Cattaneo, Marco
Bussel, James
de Candia, Erica
Cagioni, Claudia
Ramenghi, Ugo
Barozzi, Serena
Fabris, Fabrizio
Balduini, Carlo L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Plaquetas
Trombocitopenias
Dpm
topic Plaquetas
Trombocitopenias
Dpm
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.
Fil: Noris, Patrizia. University of Pavia; Italia
Fil: Biino, Ginevra. Consiglio Nazionale Delle Ricerche. Istituto di Genetica Molecolare; Italia
Fil: Pecci, Alessandro. University of Pavia; Italia
Fil: Civaschi, Elisa. University of Pavia; Italia
Fil: Savoia, Anna. Università degli Studi di Trieste; Italia. Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo; Italia
Fil: Seri, Marco. Università di Bologna; Italia
Fil: Melazzini, Federica. University of Pavia; Italia
Fil: Loffreddo, Giuseppe. Pausilipon Hospital; Italia
Fil: Russo, Giovana. Università degli Studi di Catania; Italia
Fil: Bozzi, Valeria. University of Pavia; Italia
Fil: Notarangelo, Lucia Dora. Spedali Civili. Ospedale dei Bambini; Italia
Fil: Gresele, Paolo. Università di Perugia; Italia
Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pujol Moix, Nuria. Universitat Autònoma de Barcelona; España
Fil: Kunishima, Shinji. National Hospital Organization Nagoya Medical Center; Japón
Fil: Cattaneo, Marco. Università degli Studi di Milano; Italia
Fil: Bussel, James. Cornell University; Estados Unidos
Fil: de Candia, Erica. Universita Cattolica del Sacro Cuore; Italia
Fil: Cagioni, Claudia. University of Pavia; Italia
Fil: Ramenghi, Ugo. Università di Torino; Italia
Fil: Barozzi, Serena. University of Pavia; Italia
Fil: Fabris, Fabrizio. Università di Padova; Italia
Fil: Balduini, Carlo L.. University of Pavia; Italia
description Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21509
Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-10
0006-4971
1528-0020
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21509
identifier_str_mv Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-10
0006-4971
1528-0020
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1182/blood-2014-03-564328
info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/124/6/e4?sso-checked=true
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society of Hematology
publisher.none.fl_str_mv American Society of Hematology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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