Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis

Autores
Eldholm, Vegard; Rieux, Adrien; Monteserin, Johana; Montana Lopez, Juliana; Palmero, Domingo; López, Beatriz Graciela; Ritacco, Gloria Viviana; Didelot, Xavier; Balloux, Francois
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.
Fil: Eldholm, Vegard. Norwegian Institute of Public Health; Noruega
Fil: Rieux, Adrien. University College London; Estados Unidos
Fil: Monteserin, Johana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Montana Lopez, Juliana. University College London; Estados Unidos
Fil: Palmero, Domingo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: López, Beatriz Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Didelot, Xavier. Imperial College London; Reino Unido
Fil: Balloux, Francois. University College London; Estados Unidos
Materia
HIV
MYCOBACTERIUM TUBERCULOSIS
ANTIMICROBIAL RESISTANCE
EPIDEMIOLOGY
EVOLUTION
EVOLUTIONARY BIOLOGY
GENOMICS
INFECTIOUS DISEASE
MICROBIOLOGY
TRANSMISSION RECONSTRUCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115167
Acceder
id CONICETDig_9b587ea42f5a7453932815ebdb860f76
oai_identifier_str oai:ri.conicet.gov.ar:11336/115167
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosisEldholm, VegardRieux, AdrienMonteserin, JohanaMontana Lopez, JulianaPalmero, DomingoLópez, Beatriz GracielaRitacco, Gloria VivianaDidelot, XavierBalloux, FrancoisHIVMYCOBACTERIUM TUBERCULOSISANTIMICROBIAL RESISTANCEEPIDEMIOLOGYEVOLUTIONEVOLUTIONARY BIOLOGYGENOMICSINFECTIOUS DISEASEMICROBIOLOGYTRANSMISSION RECONSTRUCTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.Fil: Eldholm, Vegard. Norwegian Institute of Public Health; NoruegaFil: Rieux, Adrien. University College London; Estados UnidosFil: Monteserin, Johana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Montana Lopez, Juliana. University College London; Estados UnidosFil: Palmero, Domingo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: López, Beatriz Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Ritacco, Gloria Viviana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Didelot, Xavier. Imperial College London; Reino UnidoFil: Balloux, Francois. University College London; Estados UnidoseLife Sciences Publications2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115167Eldholm, Vegard; Rieux, Adrien; Monteserin, Johana; Montana Lopez, Juliana; Palmero, Domingo; et al.; Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis; eLife Sciences Publications; eLife; 5; 8-2016; 1-192050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/16644info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978521/info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.16644info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:14:01Zoai:ri.conicet.gov.ar:11336/115167instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:14:02.225CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
spellingShingle Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
Eldholm, Vegard
HIV
MYCOBACTERIUM TUBERCULOSIS
ANTIMICROBIAL RESISTANCE
EPIDEMIOLOGY
EVOLUTION
EVOLUTIONARY BIOLOGY
GENOMICS
INFECTIOUS DISEASE
MICROBIOLOGY
TRANSMISSION RECONSTRUCTION
title_short Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_full Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_fullStr Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_full_unstemmed Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
title_sort Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis
dc.creator.none.fl_str_mv Eldholm, Vegard
Rieux, Adrien
Monteserin, Johana
Montana Lopez, Juliana
Palmero, Domingo
López, Beatriz Graciela
Ritacco, Gloria Viviana
Didelot, Xavier
Balloux, Francois
author Eldholm, Vegard
author_facet Eldholm, Vegard
Rieux, Adrien
Monteserin, Johana
Montana Lopez, Juliana
Palmero, Domingo
López, Beatriz Graciela
Ritacco, Gloria Viviana
Didelot, Xavier
Balloux, Francois
author_role author
author2 Rieux, Adrien
Monteserin, Johana
Montana Lopez, Juliana
Palmero, Domingo
López, Beatriz Graciela
Ritacco, Gloria Viviana
Didelot, Xavier
Balloux, Francois
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HIV
MYCOBACTERIUM TUBERCULOSIS
ANTIMICROBIAL RESISTANCE
EPIDEMIOLOGY
EVOLUTION
EVOLUTIONARY BIOLOGY
GENOMICS
INFECTIOUS DISEASE
MICROBIOLOGY
TRANSMISSION RECONSTRUCTION
topic HIV
MYCOBACTERIUM TUBERCULOSIS
ANTIMICROBIAL RESISTANCE
EPIDEMIOLOGY
EVOLUTION
EVOLUTIONARY BIOLOGY
GENOMICS
INFECTIOUS DISEASE
MICROBIOLOGY
TRANSMISSION RECONSTRUCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.
Fil: Eldholm, Vegard. Norwegian Institute of Public Health; Noruega
Fil: Rieux, Adrien. University College London; Estados Unidos
Fil: Monteserin, Johana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Montana Lopez, Juliana. University College London; Estados Unidos
Fil: Palmero, Domingo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: López, Beatriz Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Didelot, Xavier. Imperial College London; Reino Unido
Fil: Balloux, Francois. University College London; Estados Unidos
description The tuberculosis (TB) epidemic is fueled by a parallel Human Immunodeficiency Virus (HIV) epidemic, but it remains unclear to what extent the HIV epidemic has been a driver for drug resistance in Mycobacterium tuberculosis (Mtb). Here we assess the impact of HIV co-infection on the emergence of resistance and transmission of Mtb in the largest outbreak of multidrug-resistant TB in South America to date. By combining Bayesian evolutionary analyses and the reconstruction of transmission networks utilizing a new model optimized for TB, we find that HIV co-infection does not significantly affect the transmissibility or the mutation rate of Mtb within patients and was not associated with increased emergence of resistance within patients. Our results indicate that the HIV epidemic serves as an amplifier of TB outbreaks by providing a reservoir of susceptible hosts, but that HIV co-infection is not a direct driver for the emergence and transmission of resistant strains.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115167
Eldholm, Vegard; Rieux, Adrien; Monteserin, Johana; Montana Lopez, Juliana; Palmero, Domingo; et al.; Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis; eLife Sciences Publications; eLife; 5; 8-2016; 1-19
2050-084X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115167
identifier_str_mv Eldholm, Vegard; Rieux, Adrien; Monteserin, Johana; Montana Lopez, Juliana; Palmero, Domingo; et al.; Impact of HIV co-infection on the evolution and transmission of multidrug-resistant tuberculosis; eLife Sciences Publications; eLife; 5; 8-2016; 1-19
2050-084X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/16644
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978521/
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.16644
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782546382159872
score 12.982451

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