Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
- Autores
- Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; Fabre, Bibiana; Wenzel, Natasha; Wu, Hau Tieng; Frasch, Martin Gerbert; Lobmaier, Silvia M.
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.
Fil: Zimmermann, Peter. Technische Universitat München; Alemania
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Sharma, Ritika. Technische Universitat München; Alemania
Fil: Müller, Alexander. Technische Universitat München; Alemania
Fil: Zelgert, Camilla. Technische Universitat München; Alemania
Fil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Wenzel, Natasha. University of Washington; Estados Unidos
Fil: Wu, Hau Tieng. University of Duke; Estados Unidos
Fil: Frasch, Martin Gerbert. University of Washington; Estados Unidos
Fil: Lobmaier, Silvia M.. Technische Universitat München; Alemania - Materia
-
iron
prenatal stress
hepcidin
transferrin - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/214247
Ver los metadatos del registro completo
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Prenatal stress perturbs fetal iron homeostasis in a sex specific mannerZimmermann, PeterAntonelli, Marta CristinaSharma, RitikaMüller, AlexanderZelgert, CamillaFabre, BibianaWenzel, NatashaWu, Hau TiengFrasch, Martin GerbertLobmaier, Silvia M.ironprenatal stresshepcidintransferrinhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.Fil: Zimmermann, Peter. Technische Universitat München; AlemaniaFil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Sharma, Ritika. Technische Universitat München; AlemaniaFil: Müller, Alexander. Technische Universitat München; AlemaniaFil: Zelgert, Camilla. Technische Universitat München; AlemaniaFil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Wenzel, Natasha. University of Washington; Estados UnidosFil: Wu, Hau Tieng. University of Duke; Estados UnidosFil: Frasch, Martin Gerbert. University of Washington; Estados UnidosFil: Lobmaier, Silvia M.. Technische Universitat München; AlemaniaNature2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214247Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; et al.; Prenatal stress perturbs fetal iron homeostasis in a sex specific manner; Nature; Scientific Reports; 12; 1; 12-2022; 1-102045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-13633-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:33Zoai:ri.conicet.gov.ar:11336/214247instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:33.477CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner |
title |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner |
spellingShingle |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner Zimmermann, Peter iron prenatal stress hepcidin transferrin |
title_short |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner |
title_full |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner |
title_fullStr |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner |
title_full_unstemmed |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner |
title_sort |
Prenatal stress perturbs fetal iron homeostasis in a sex specific manner |
dc.creator.none.fl_str_mv |
Zimmermann, Peter Antonelli, Marta Cristina Sharma, Ritika Müller, Alexander Zelgert, Camilla Fabre, Bibiana Wenzel, Natasha Wu, Hau Tieng Frasch, Martin Gerbert Lobmaier, Silvia M. |
author |
Zimmermann, Peter |
author_facet |
Zimmermann, Peter Antonelli, Marta Cristina Sharma, Ritika Müller, Alexander Zelgert, Camilla Fabre, Bibiana Wenzel, Natasha Wu, Hau Tieng Frasch, Martin Gerbert Lobmaier, Silvia M. |
author_role |
author |
author2 |
Antonelli, Marta Cristina Sharma, Ritika Müller, Alexander Zelgert, Camilla Fabre, Bibiana Wenzel, Natasha Wu, Hau Tieng Frasch, Martin Gerbert Lobmaier, Silvia M. |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
iron prenatal stress hepcidin transferrin |
topic |
iron prenatal stress hepcidin transferrin |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis. Fil: Zimmermann, Peter. Technische Universitat München; Alemania Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Sharma, Ritika. Technische Universitat München; Alemania Fil: Müller, Alexander. Technische Universitat München; Alemania Fil: Zelgert, Camilla. Technische Universitat München; Alemania Fil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina Fil: Wenzel, Natasha. University of Washington; Estados Unidos Fil: Wu, Hau Tieng. University of Duke; Estados Unidos Fil: Frasch, Martin Gerbert. University of Washington; Estados Unidos Fil: Lobmaier, Silvia M.. Technische Universitat München; Alemania |
description |
The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/214247 Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; et al.; Prenatal stress perturbs fetal iron homeostasis in a sex specific manner; Nature; Scientific Reports; 12; 1; 12-2022; 1-10 2045-2322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/214247 |
identifier_str_mv |
Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; et al.; Prenatal stress perturbs fetal iron homeostasis in a sex specific manner; Nature; Scientific Reports; 12; 1; 12-2022; 1-10 2045-2322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-13633-z |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature |
publisher.none.fl_str_mv |
Nature |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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