Prenatal stress perturbs fetal iron homeostasis in a sex specific manner

Autores
Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; Fabre, Bibiana; Wenzel, Natasha; Wu, Hau Tieng; Frasch, Martin Gerbert; Lobmaier, Silvia M.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.
Fil: Zimmermann, Peter. Technische Universitat München; Alemania
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Sharma, Ritika. Technische Universitat München; Alemania
Fil: Müller, Alexander. Technische Universitat München; Alemania
Fil: Zelgert, Camilla. Technische Universitat München; Alemania
Fil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Wenzel, Natasha. University of Washington; Estados Unidos
Fil: Wu, Hau Tieng. University of Duke; Estados Unidos
Fil: Frasch, Martin Gerbert. University of Washington; Estados Unidos
Fil: Lobmaier, Silvia M.. Technische Universitat München; Alemania
Materia
iron
prenatal stress
hepcidin
transferrin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214247
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/214247
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network_name_str CONICET Digital (CONICET)
spelling Prenatal stress perturbs fetal iron homeostasis in a sex specific mannerZimmermann, PeterAntonelli, Marta CristinaSharma, RitikaMüller, AlexanderZelgert, CamillaFabre, BibianaWenzel, NatashaWu, Hau TiengFrasch, Martin GerbertLobmaier, Silvia M.ironprenatal stresshepcidintransferrinhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.Fil: Zimmermann, Peter. Technische Universitat München; AlemaniaFil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Sharma, Ritika. Technische Universitat München; AlemaniaFil: Müller, Alexander. Technische Universitat München; AlemaniaFil: Zelgert, Camilla. Technische Universitat München; AlemaniaFil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Wenzel, Natasha. University of Washington; Estados UnidosFil: Wu, Hau Tieng. University of Duke; Estados UnidosFil: Frasch, Martin Gerbert. University of Washington; Estados UnidosFil: Lobmaier, Silvia M.. Technische Universitat München; AlemaniaNature2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214247Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; et al.; Prenatal stress perturbs fetal iron homeostasis in a sex specific manner; Nature; Scientific Reports; 12; 1; 12-2022; 1-102045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-13633-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:10:37Zoai:ri.conicet.gov.ar:11336/214247instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:10:37.998CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
title Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
spellingShingle Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
Zimmermann, Peter
iron
prenatal stress
hepcidin
transferrin
title_short Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
title_full Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
title_fullStr Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
title_full_unstemmed Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
title_sort Prenatal stress perturbs fetal iron homeostasis in a sex specific manner
dc.creator.none.fl_str_mv Zimmermann, Peter
Antonelli, Marta Cristina
Sharma, Ritika
Müller, Alexander
Zelgert, Camilla
Fabre, Bibiana
Wenzel, Natasha
Wu, Hau Tieng
Frasch, Martin Gerbert
Lobmaier, Silvia M.
author Zimmermann, Peter
author_facet Zimmermann, Peter
Antonelli, Marta Cristina
Sharma, Ritika
Müller, Alexander
Zelgert, Camilla
Fabre, Bibiana
Wenzel, Natasha
Wu, Hau Tieng
Frasch, Martin Gerbert
Lobmaier, Silvia M.
author_role author
author2 Antonelli, Marta Cristina
Sharma, Ritika
Müller, Alexander
Zelgert, Camilla
Fabre, Bibiana
Wenzel, Natasha
Wu, Hau Tieng
Frasch, Martin Gerbert
Lobmaier, Silvia M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv iron
prenatal stress
hepcidin
transferrin
topic iron
prenatal stress
hepcidin
transferrin
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.
Fil: Zimmermann, Peter. Technische Universitat München; Alemania
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Sharma, Ritika. Technische Universitat München; Alemania
Fil: Müller, Alexander. Technische Universitat München; Alemania
Fil: Zelgert, Camilla. Technische Universitat München; Alemania
Fil: Fabre, Bibiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Wenzel, Natasha. University of Washington; Estados Unidos
Fil: Wu, Hau Tieng. University of Duke; Estados Unidos
Fil: Frasch, Martin Gerbert. University of Washington; Estados Unidos
Fil: Lobmaier, Silvia M.. Technische Universitat München; Alemania
description The adverse effects of maternal prenatal stress (PS) on child’s neurodevelopment warrant the establishment of biomarkers that enable early interventional therapeutic strategies. We performed a prospective matched double cohort study screening 2000 pregnant women in third trimester with Cohen Perceived Stress Scale-10 (PSS-10) questionnaire; 164 participants were recruited and classified as stressed and control group (SG, CG). Fetal cord blood iron parameters of 107 patients were measured at birth. Transabdominal electrocardiograms-based Fetal Stress Index (FSI) was derived. We investigated sex contribution to group differences and conducted causal inference analyses to assess the total effect of PS exposure on iron homeostasis using a directed acyclic graph (DAG) approach. Differences are reported for p < 0.05 unless noted otherwise. Transferrin saturation was lower in male stressed neonates. The minimum adjustment set of the DAG to estimate the total effect of PS exposure on fetal ferritin iron biomarkers consisted of maternal age and socioeconomic status: SG revealed a 15% decrease in fetal ferritin compared with CG. Mean FSI was higher among SG than among CG. FSI-based timely detection of fetuses affected by PS can support early individualized iron supplementation and neurodevelopmental follow-up to prevent long-term sequelae due to PS-exacerbated impairment of the iron homeostasis.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214247
Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; et al.; Prenatal stress perturbs fetal iron homeostasis in a sex specific manner; Nature; Scientific Reports; 12; 1; 12-2022; 1-10
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214247
identifier_str_mv Zimmermann, Peter; Antonelli, Marta Cristina; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; et al.; Prenatal stress perturbs fetal iron homeostasis in a sex specific manner; Nature; Scientific Reports; 12; 1; 12-2022; 1-10
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-13633-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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