Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties

Autores
Duque Lizarazo, Fanny Melina; Falcone, Ruben Dario; Correa, Nestor Mariano
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, alginate nanoparticles (ALG-NPs) were synthesized using reverse micelles (RMs) as nanoreactors to investigate how interfacial charge influences their structure, size, and encapsulation properties. Three types of RMs were employed: (i) anionic RMs formed by sodium bis(2-ethylhexyl)sulfosuccinate (AOT) in isopropyl myristate, (ii) cationic RMs formed by benzyl-hexadecyl-dimethylammonium chloride (BHDC) in toluene, and (iii) nonionic RMs formed by 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol (TX-100) in cyclohexane. ALG-NPs were synthesized at varying water contents (W0 = [H2O]/[surfactant]) and resuspended in water at pH 6.5 for characterization. Dynamic light scattering revealed that nanoparticle size is highly dependent on the RM template. ALG-NPs synthesized in AOT RMs were the smallest, with their size increasing as W0 increased, a trend also observed for TX-100 RMs. In contrast, the opposite behavior was observed in BHDC RMs, where nanoparticle size decreased with increasing W0. This difference reflects the degree of crosslinking with Ca2+ ions as influenced by interfacial charge. Using N,N-dimethyl-6- propionyl-2-naphthylamine (PRODAN) and curcumin, we found that AOT-based ALG-NPs were the most compact and rigid, offering prolonged protection for curcumin against degradation under ambient conditions. This study underscores the potential of tailoring ALG-NPs through precise control of interfacial environments, offering new opportunities for applications in food technology, nutraceuticals, and biotechnology. By stabilizing bioactive compounds and enhancing bioavailability, these findings pave the way for innovative functional formulations.
Fil: Duque Lizarazo, Fanny Melina. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Falcone, Ruben Dario. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Correa, Nestor Mariano. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Materia
ALGINATE
NANOPARTICLES
REVERSE MICELLES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/273032
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/273032
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation PropertiesDuque Lizarazo, Fanny MelinaFalcone, Ruben DarioCorrea, Nestor MarianoALGINATENANOPARTICLESREVERSE MICELLEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this work, alginate nanoparticles (ALG-NPs) were synthesized using reverse micelles (RMs) as nanoreactors to investigate how interfacial charge influences their structure, size, and encapsulation properties. Three types of RMs were employed: (i) anionic RMs formed by sodium bis(2-ethylhexyl)sulfosuccinate (AOT) in isopropyl myristate, (ii) cationic RMs formed by benzyl-hexadecyl-dimethylammonium chloride (BHDC) in toluene, and (iii) nonionic RMs formed by 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol (TX-100) in cyclohexane. ALG-NPs were synthesized at varying water contents (W0 = [H2O]/[surfactant]) and resuspended in water at pH 6.5 for characterization. Dynamic light scattering revealed that nanoparticle size is highly dependent on the RM template. ALG-NPs synthesized in AOT RMs were the smallest, with their size increasing as W0 increased, a trend also observed for TX-100 RMs. In contrast, the opposite behavior was observed in BHDC RMs, where nanoparticle size decreased with increasing W0. This difference reflects the degree of crosslinking with Ca2+ ions as influenced by interfacial charge. Using N,N-dimethyl-6- propionyl-2-naphthylamine (PRODAN) and curcumin, we found that AOT-based ALG-NPs were the most compact and rigid, offering prolonged protection for curcumin against degradation under ambient conditions. This study underscores the potential of tailoring ALG-NPs through precise control of interfacial environments, offering new opportunities for applications in food technology, nutraceuticals, and biotechnology. By stabilizing bioactive compounds and enhancing bioavailability, these findings pave the way for innovative functional formulations.Fil: Duque Lizarazo, Fanny Melina. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Falcone, Ruben Dario. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Correa, Nestor Mariano. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaRoyal Society of Chemistry2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/273032Duque Lizarazo, Fanny Melina; Falcone, Ruben Dario; Correa, Nestor Mariano; Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties; Royal Society of Chemistry; RSC Advances; 15; 10; 3-2025; 7926-79372046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/d4ra08616cinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:03:50Zoai:ri.conicet.gov.ar:11336/273032instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:03:50.652CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
title Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
spellingShingle Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
Duque Lizarazo, Fanny Melina
ALGINATE
NANOPARTICLES
REVERSE MICELLES
title_short Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
title_full Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
title_fullStr Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
title_full_unstemmed Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
title_sort Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties
dc.creator.none.fl_str_mv Duque Lizarazo, Fanny Melina
Falcone, Ruben Dario
Correa, Nestor Mariano
author Duque Lizarazo, Fanny Melina
author_facet Duque Lizarazo, Fanny Melina
Falcone, Ruben Dario
Correa, Nestor Mariano
author_role author
author2 Falcone, Ruben Dario
Correa, Nestor Mariano
author2_role author
author
dc.subject.none.fl_str_mv ALGINATE
NANOPARTICLES
REVERSE MICELLES
topic ALGINATE
NANOPARTICLES
REVERSE MICELLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this work, alginate nanoparticles (ALG-NPs) were synthesized using reverse micelles (RMs) as nanoreactors to investigate how interfacial charge influences their structure, size, and encapsulation properties. Three types of RMs were employed: (i) anionic RMs formed by sodium bis(2-ethylhexyl)sulfosuccinate (AOT) in isopropyl myristate, (ii) cationic RMs formed by benzyl-hexadecyl-dimethylammonium chloride (BHDC) in toluene, and (iii) nonionic RMs formed by 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol (TX-100) in cyclohexane. ALG-NPs were synthesized at varying water contents (W0 = [H2O]/[surfactant]) and resuspended in water at pH 6.5 for characterization. Dynamic light scattering revealed that nanoparticle size is highly dependent on the RM template. ALG-NPs synthesized in AOT RMs were the smallest, with their size increasing as W0 increased, a trend also observed for TX-100 RMs. In contrast, the opposite behavior was observed in BHDC RMs, where nanoparticle size decreased with increasing W0. This difference reflects the degree of crosslinking with Ca2+ ions as influenced by interfacial charge. Using N,N-dimethyl-6- propionyl-2-naphthylamine (PRODAN) and curcumin, we found that AOT-based ALG-NPs were the most compact and rigid, offering prolonged protection for curcumin against degradation under ambient conditions. This study underscores the potential of tailoring ALG-NPs through precise control of interfacial environments, offering new opportunities for applications in food technology, nutraceuticals, and biotechnology. By stabilizing bioactive compounds and enhancing bioavailability, these findings pave the way for innovative functional formulations.
Fil: Duque Lizarazo, Fanny Melina. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Falcone, Ruben Dario. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Correa, Nestor Mariano. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
description In this work, alginate nanoparticles (ALG-NPs) were synthesized using reverse micelles (RMs) as nanoreactors to investigate how interfacial charge influences their structure, size, and encapsulation properties. Three types of RMs were employed: (i) anionic RMs formed by sodium bis(2-ethylhexyl)sulfosuccinate (AOT) in isopropyl myristate, (ii) cationic RMs formed by benzyl-hexadecyl-dimethylammonium chloride (BHDC) in toluene, and (iii) nonionic RMs formed by 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol (TX-100) in cyclohexane. ALG-NPs were synthesized at varying water contents (W0 = [H2O]/[surfactant]) and resuspended in water at pH 6.5 for characterization. Dynamic light scattering revealed that nanoparticle size is highly dependent on the RM template. ALG-NPs synthesized in AOT RMs were the smallest, with their size increasing as W0 increased, a trend also observed for TX-100 RMs. In contrast, the opposite behavior was observed in BHDC RMs, where nanoparticle size decreased with increasing W0. This difference reflects the degree of crosslinking with Ca2+ ions as influenced by interfacial charge. Using N,N-dimethyl-6- propionyl-2-naphthylamine (PRODAN) and curcumin, we found that AOT-based ALG-NPs were the most compact and rigid, offering prolonged protection for curcumin against degradation under ambient conditions. This study underscores the potential of tailoring ALG-NPs through precise control of interfacial environments, offering new opportunities for applications in food technology, nutraceuticals, and biotechnology. By stabilizing bioactive compounds and enhancing bioavailability, these findings pave the way for innovative functional formulations.
publishDate 2025
dc.date.none.fl_str_mv 2025-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/273032
Duque Lizarazo, Fanny Melina; Falcone, Ruben Dario; Correa, Nestor Mariano; Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties; Royal Society of Chemistry; RSC Advances; 15; 10; 3-2025; 7926-7937
2046-2069
CONICET Digital
CONICET
url http://hdl.handle.net/11336/273032
identifier_str_mv Duque Lizarazo, Fanny Melina; Falcone, Ruben Dario; Correa, Nestor Mariano; Tailoring Alginate Nanoparticles: Influence of Reverse Micelle Templates on Structure, Size, and Encapsulation Properties; Royal Society of Chemistry; RSC Advances; 15; 10; 3-2025; 7926-7937
2046-2069
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/d4ra08616c
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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